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Topic Review
“Omics” Biomarkers in Pancreatic Cancer
Pancreatic cancer is one of the most fatal malignancies and the seventh leading cause of cancer-related deaths related to late diagnosis, poor survival rates, and high incidence of metastasis. 
  • 1.2K
  • 18 May 2021
Topic Review
Septins in Infections
Human septins comprise a family of 13 genes that encode conserved GTP-binding proteins. They form nonpolar complexes, which assemble into higher-order structures, such as bundles, scaffolding structures, or rings. Septins are counted among the cytoskeletal elements. They interact with the actin and microtubule networks and can bind to membranes. Many cellular functions with septin participation have been described in the literature, including cytokinesis, motility, forming of scaffolding platforms or lateral diffusion barriers, vesicle transport, exocytosis, and recognition of micron-scale curvature. Septin dysfunction has been implicated in diverse human pathologies, including neurodegeneration and tumorigenesis. Moreover, septins are thought to affect the outcome of host–microbe interactions. Implication of septins has been demonstrated in fungal, bacterial, and viral infections. Knowledge on the precise function of a particular septin in the different steps of the virus infection and replication cycle is still limited. Published data for vaccinia virus (VACV), hepatitis C virus (HCV), influenza A virus (H1N1 and H5N1), human herpesvirus 8 (HHV-8), and Zika virus (ZIKV), all of major concern for public health, will be discussed here.
  • 1.2K
  • 26 Mar 2021
Topic Review
Shiga Toxin-Producing Escherichia coli
Shiga toxins (Stx) of Shiga toxin-producing Escherichia coli (STEC) are generally encoded in the genome of lambdoid bacteriophages, which spend the most time of their life cycle integrated as prophages in specific sites of the bacterial chromosome. Upon spontaneous induction or induction by chemical or physical stimuli, the stx genes are co-transcribed together with the late phase genes of the prophages. After being assembled in the cytoplasm, and after host cell lysis, mature bacteriophage particles are released into the environment, together with Stx. As members of the group of lambdoid phages, Stx phages share many genetic features with the archetypical temperate phage Lambda, but are heterogeneous in their DNA sequences due to frequent recombination events. In addition to Stx phages, the genome of pathogenic STEC bacteria may contain numerous prophages, which are either cryptic or functional. These prophages may carry foreign genes, some of them related to virulence, besides those necessary for the phage life cycle.
  • 1.2K
  • 13 Apr 2021
Topic Review
Natural Photosensitizers in APDT
Antimicrobial photodynamic therapy (APDT) is constantly evolving and can minimize this antimicrobial resistance problem. Reactive oxygen species produced when nontoxic photosensitizers are exposed to light are the main functional components of APDT responsible for microbial destruction; therefore, APDT has a broad spectrum of target pathogens, such as bacteria, fungi, and viruses. Various photosensitizers, including natural extracts, compounds, and their synthetic derivatives, are being investigated. Light, oxygen, and PSs in precise cooperation are the key factors determining APDT efficiency and are responsible for ROS production and the inactivation of the targeted cells.
  • 1.2K
  • 01 Jun 2021
Topic Review
Value Capture for Public Amenities
Land for public use is a vital need in any city, which is why government guidelines and legislation are applied to procure them through various policies such as land expropriation, consolidation and re-division. As land in city centers becomes increasingly scarce, and growth pushes cities to their limits, allocating land for public use becomes more challenging and requires new solutions. Examples include progressive taxation, redefining property rights, incentivizing owners, and introducing value capture instruments. Value capture enables cities to utilize unearned increments, meaning the increase in property value as a result of government intervention to which a property owner has not contributed. Statutory planning can create value uplift that can be harnessed through value capture tools to supply a range of public benefits to the community, including land for public utilities. Value capture instruments such as  density bonuses or land readjustment, can help decision-makers create public amenities including soft and hard infrastructure. 
  • 1.2K
  • 01 Jun 2021
Topic Review
Copper Chelators and cDDP Resistance
The platinum (Pt)-containing antitumor drugs including cisplatin (cis-diamminedichloroplatinum II, cDDP), carboplatin, and oxaliplatin, have been the mainstay of cancer chemotherapy. These drugs are effective in treating many human malignancies. The major cell-killing target of Pt drugs is DNA. Recent findings underscored the important roles of Pt drug transport system in cancer therapy. It was demonstrated that by reducing cellular Cu bioavailable levels by Cu chelators, hCtr1 is transcriptionally upregulated by transcription factor Sp1, which binds the promoters of Sp1 and hCtr1. In contrast, elevated Cu poisons Sp1, resulting in suppression of hCtr1 and Sp1, constituting the Cu-Sp1-hCtr1 mutually regulatory loop.
  • 1.2K
  • 21 Jun 2021
Topic Review
Triazine-Based Liquid Crystal Dendrimers
Most triazine-based liquid crystalline (LC) dendrimers reported thus far are the main-chain LC macromolecules with long flexible chains at their periphery and attached to internal rigid or semi-rigid frameworks. Their formation of mesogenic phases often depends on the intermolecular face-to-face π–π interactions between dendritic molecules, which are unusual. Their mesogenic phases can also be formed by incorporation of mesogenic units to the dendritic skeletons through long flexible chains, as most side-chain LC dendrimers, in which the peripheral mesogenic units generally play the important roles. For main-chain triazine-based dendrimers, their morphology is maintained by restricted freedom of rigid or semi-rigid connecting units, and their formations of LC phases are therefore not straightforward to be controlled.
  • 1.2K
  • 25 Aug 2021
Topic Review
Primary Immunodeficiency Disorders and Autoimmunity
Primary immunodeficiency disorders (PIDs) patients can develop an immune dysregulation of variable degree, which is responsible for a clinical picture featured by infectious complications and autoimmunity. Autoimmune manifestations are observed with considerable frequency in patients with primary antibody deficiencies, including common variable immunodeficiency (CVID) and selective IgA deficiency (sIgAD), but can also be evidenced in patients with combined immunodeficiency disorders (CID).
  • 1.2K
  • 29 Oct 2021
Topic Review
Application of Nanotechnologies in Ischemic Heart Disease
Nanotechnology focuses on atomic and molecular structures with dimensions of 0.1–100 nm. The resulting nanomaterials exhibit distinct mechanical, electrical, thermal, magnetic and imaging features that facilitate novel and unique applications in different branches of science, such as nanomedicine, nanobiology and nanobiotechnology.
  • 1.2K
  • 09 Nov 2021
Topic Review
Blockchain Technology in Higher Education Arena
Blockchain technology is an advantage over existing ones in that it maintains blockchain record permanence, and the number of blockchain-based products is limited in higher education.
  • 1.2K
  • 29 Nov 2021
Topic Review
Telomeres and Cancer
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin complex, and the CST complex, synergizing with DNA replication, repair, and the RNA metabolism pathway components. As dysfunctional telomere maintenance and telomerase activation are associated with several human diseases, including cancer, the molecular mechanisms behind telomere length regulation and protection need particular emphasis. Cancer cells exhibit telomerase activation, enabling replicative immortality. Telomerase reverse transcriptase (TERT) activation is involved in cancer development through diverse activities other than mediating telomere elongation.
  • 1.2K
  • 23 Mar 2022
Topic Review
Information System for Security Auditing
Information security and cybersecurity management play a key role in modern enterprises. There is a plethora of standards, frameworks, and tools, ISO 27000 and the NIST Cybersecurity Framework being two relevant families of international Information Security Management Standards (ISMSs). Globally, these standards are implemented by dedicated tools to collect and further analyze the information security auditing that is carried out in an enterprise. The overall goal of the auditing is to evaluate and mitigate the information security risk. The risk assessment is grounded by auditing processes, which examine and assess a list of predefined controls in a wide variety of subjects regarding cybersecurity and information security. For each control, a checklist of actions is applied and a set of corrective measures is proposed, in order to mitigate the flaws and to increase the level of compliance with the standard being used. The auditing process can apply different ISMSs in the same time frame. However, as these processes are time-consuming, involve on-site interventions, and imply specialized consulting teams, the methodology usually adopted by enterprises consists of applying a single ISMS and its existing tools and frameworks. This strategy brings overall less flexibility and diversity to the auditing process and, consequently, to the assessment results of the audited enterprise.
  • 1.2K
  • 05 May 2022
Topic Review Peer Reviewed
Solid Lipid Nanoparticles
Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, and prolong the circulation time of various drugs. SLNs have been applied in the oral, parenteral, transdermal, intranasal, ocular, and pulmonary drug delivery of different drugs, with enhanced safety, bioavailability, and overall therapeutic effects. In this entry, the authors summarize the primary features of SLNs, methods to prepare SLNs, and recent applications of SLNs in drug delivery. Owing to their advantages, SLNs are potential drug delivery systems to improve the management of various diseases and will, soon, be available for clinical use. 
  • 1.2K
  • 24 May 2022
Topic Review
Biomolecular Paradigm of Active Resolution Mechanisms in Heart
Inflammation is a complex program of active processes characterized by the well-orchestrated succession of an initiation and a resolution phase aiming to promote homeostasis. When the resolution of inflammation fails, the tissue undergoes an unresolved inflammatory status which, if it remains uncontrolled, can lead to chronic inflammatory disorders due to aggravation of structural damages, development of a fibrous area, and loss of function. Various human conditions show a typical unresolved inflammatory profile. Inflammatory diseases include cancer, neurodegenerative disease, asthma, right heart disease, atherosclerosis, myocardial infarction, or atrial fibrillation. New evidence has started to emerge on the role, including pro-resolution involvement of chemical mediators in the acute phase of inflammation. Although flourishing knowledge is available about the role of specialized pro-resolving mediators in neurodegenerative diseases, atherosclerosis, obesity, or hepatic fibrosis, little is known about their efficacy to combat inflammation-associated arrhythmogenic cardiac disorders. It has been shown that resolvins, including RvD1, RvE1, or Mar1, are bioactive mediators of resolution. Resolvins can stop neutrophil activation and infiltration, stimulate monocytes polarization into anti-inflammatory-M2-macrophages, and activate macrophage phagocytosis of inflammation-debris and neutrophils to promote efferocytosis and clearance.
  • 1.2K
  • 27 May 2022
Topic Review
Ocimum Species
Ocimum is known to be one of the medicinal plants that have been used traditionally by local people. This plant contains components of secondary metabolites such as phenolics, flavonoids, steroids, terpenoids, and alkaloids.
  • 1.2K
  • 31 Oct 2022
Topic Review
The Structure of Diphtheria Toxin
Only three Corynebacterium species are known to produce a lethal exotoxin called diphtheria toxin. These are C. diphtheriae, C. ulcerans and C. pseudotuberculosis. 
  • 1.2K
  • 03 Nov 2022
Topic Review
Skiffing
Skiffing refers to the sporting and leisure activity of rowing (or more correctly sculling) a Thames skiff. The skiff is a traditional hand built clinker-built wooden craft of a design which has been seen on the River Thames and other waterways in England and other countries since the 19th century. Sculling is the act of propelling the boat with a pair of oars (or blades), as opposed to rowing which requires both hands on a single oar.
  • 1.2K
  • 03 Nov 2022
Topic Review
Geocoding
Geocoding is the process of taking input text, such as an address or the name of a place, and returning a latitude/longitude location on the Earth's surface for that place. Reverse geocoding, on the other hand, converts geographic coordinates to a description of a location, usually the name of a place or an addressable location. Geocoding relies on a computer representation of address points, the street / road network, together with postal and administrative boundaries. The geographic coordinates representing locations often vary greatly in positional accuracy. Examples include building centroids, land parcel centroids, interpolated locations based on thoroughfare ranges, street segments centroids, postal code centroids (e.g. ZIP codes, CEDEX), and Administrative division Centroids.
  • 1.2K
  • 10 Nov 2022
Topic Review
JavaServer Faces
JavaServer Faces (JSF) is a Java specification for building component-based user interfaces for web applications and was formalized as a standard through the Java Community Process being part of the Java Platform, Enterprise Edition. It is also a MVC web framework that simplifies construction of user interfaces (UI) for server-based applications by using reusable UI components in a page. JSF 2 uses Facelets as its default templating system. Other view technologies such as XUL or plain Java can also be employed. In contrast, JSF 1.x uses JavaServer Pages (JSP) as its default templating system.
  • 1.2K
  • 25 Nov 2022
Topic Review
Smart Energy Subsystem
A smart grid (SG), considered as a future electricity grid, utilizes bidirectional electricity and information flow to establish automated and widely distributed power generation. The SG provides a delivery network that has distributed energy sources, real-time asset monitoring, increased power quality, increased stability and reliability, and two-way information sharing.
  • 1.2K
  • 06 Jan 2023
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