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Topic Review
Ultrasound Technology Applied in Food Industry
An efficient microbiological decontamination protocol is required to guarantee safe food products for the final consumer to avoid foodborne illnesses. Ultrasound and non-thermal technology combinations represent innovative methods adopted by the food industry for food preservation and safety. Ultrasound power is commonly used with a frequency between 20 and 100 kHz to obtain an “exploit cavitation effect”. Microbial inactivation via ultrasound derives from cell wall damage, the oxidation of intracellular amino acids and DNA changing material.
  • 1.2K
  • 07 Apr 2023
Topic Review
Tick Immunobiology
Ticks are hematophagous ectoparasites that infest a diverse number of vertebrate hosts. The tick immunobiology plays a significant role in establishing and transmitting many pathogens to their hosts. To control tick infestations, the acaricide application is a commonly used method with severe environmental consequences and the selection of tick-resistant populations.
  • 1.2K
  • 29 Nov 2021
Topic Review
Treatment Combinations with DNA Vaccines
Metastatic castration-resistant prostate cancer (mCRPC) is a challenging disease to treat, with poor outcomes for patients. One antitumor vaccine, sipuleucel-T, has been approved as a treatment for mCRPC. DNA vaccines are another form of immunotherapy under investigation. DNA immunizations elicit antigen-specific T cells that cause tumor cell lysis, which should translate to meaningful clinical responses. They are easily amenable to design alterations, scalable for large-scale manufacturing, and thermo-stable for easy transport and distribution. Hence, they offer advantages over other vaccine formulations. However, clinical trials with DNA vaccines as a monotherapy have shown only modest clinical effects against tumors. Standard therapies for CRPC including androgen-targeted therapies, radiation therapy and chemotherapy all have immunomodulatory effects, which combined with immunotherapies such as DNA vaccines, could potentially improve treatment. In addition, many investigational drugs are being developed which can augment antitumor immunity, and together with DNA vaccines can further enhance antitumor responses in preclinical models.
  • 1.2K
  • 20 Oct 2020
Topic Review
Retroviral Genome Packaging
Retroviruses selectively package two copies of their RNA genomes from a cellular milieu that includes a substantial excess of host and non-genomic viral RNAs. Present understanding of the structural determinants and mechanism of retroviral genome packaging has been derived from combinations of genetic experiments, phylogenetic analyses, nucleotide accessibility mapping, in silico RNA structure predictions, and biophysical studies. Genetic experiments provided early clues regarding the protein and RNA elements required for packaging, and nucleotide accessibility mapping experiments provided insights into the secondary structures of functionally important elements in the genome. Three-dimensional structural determinants of packaging were primarily derived by nuclear magnetic resonance (NMR) spectroscopy. A key advantage of NMR, relative to other methods for determining biomolecular structure (such as X-ray crystallography), is that it is well suited for studies of conformationally dynamic and heterogeneous systems—a hallmark of the retrovirus packaging machinery.
  • 1.2K
  • 06 Nov 2020
Topic Review
Cetuximab
Cetuximab is a human/mouse chimeric monoclonal antibody targeting epidermal growth factor receptor (EGFR), first approved in the world.
  • 1.2K
  • 12 Jan 2021
Topic Review
Transfer Learning in Breast Cancer
Transfer learning is a machine learning approach that reuses a learning method developed for a task as the starting point for a model on a target task. The goal of transfer learning is to improve performance of target learners by transferring the knowledge contained in other (but related) source domains. As a result, the need for large numbers of target-domain data is lowered for constructing target learners. Due to this immense property, transfer learning techniques are frequently used in ultrasound breast cancer image analyses. In this study, we focus on transfer learning methods applied on ultrasound breast image classification and detection from the perspective of transfer learning approaches, pre-processing, pre-training models, and convolutional neural network (CNN) models. Finally, comparison of different works is carried out, and challenges—as well as outlooks—are discussed.
  • 1.2K
  • 25 Feb 2021
Topic Review
Site Directed Spin Labeling
Site-directed spin labeling (SDSL) is a molecular biology technique in which paramagnetic spin labels are incorporated into the specific site of bio-macromolecules for investigation of structure and dynamic properties using electron paramagnetic resonance (EPR) spectroscopy. In SDSL, all native nondisulfide bonded cysteines are eliminated by changing them with another amino acid such as serine or an alanine. A unique cysteine residue is then incorporated into a recombinant protein using site-directed mutagenesis technique, and further reacted with sulfhydryl-specific nitroxide reagent to covalently generate a stable spin label side-chain. The development of SDSL approaches extended the application of EPR to almost any biological systems. Site-directed spin labeling  (SDSL) combined with EPR spectroscopy can provide structural dynamics of spin label side-chain, solvent accessibility, solvent polarity, and intra- or intermolecular distances between two spin labels of macromolecules.
  • 1.2K
  • 27 Apr 2021
Topic Review
Implantation-Based Genetic Modeling of BTC
Biliary tract cancer (BTC) is often refractory to conventional therapeutics and is difficult to diagnose in the early stages. Implantation-based models have recently drawn attention for their convenience, flexibility, and scalability. 
  • 1.2K
  • 12 Oct 2021
Topic Review
Dye Sensitized Solar Cells
DSSCs are functional and efficient even in diffuse light, therefore they can generate electricity in the morning, evening and even indoors. Even as silicon prices fall and silicon-based photovoltaics become cheaper, DSSCs have great potential as they can be used in additional applications such as indoor and diffuse light. With a variety of fields of application, huge quantities of DSSCs could be produced in the future. With low production costs and no necessity for toxic compounds DSSCs are a potential product, which could circulate in the loops of a circular economy.
  • 1.2K
  • 02 Aug 2021
Topic Review
Asphyxia in Newborn Canines
Morphological variability in canines is associated with the mother’s size and weight, which likely affects the birth weight of the puppies and their metabolic status. Identifying physio-metabolic alterations in the blood from the umbilical vein to evaluate the concentration of gases, glucose, lactate, calcium, hematocrit levels, and blood pH of newborn puppies will make it possible to determine the risk of complications due to intrauterine asphyxia.
  • 1.2K
  • 20 Aug 2021
Topic Review
Protein-based Subunit Nanovaccine
Protein-based subunit nanovaccines are typically composed of native or altered protein antigens that can self-assemble into nanoparticles, or antigens associated with nanoparticles through covalent or noncovalent interactions. Characteristically, nanovaccines are 1 to 1000 nm in size which generally facilitates the induction of stronger immune responses.
  • 1.2K
  • 18 Oct 2021
Topic Review
Global Isotopic Hydrograph Separation
Isotopic Hydrograph Separation (IHS) is a novel research field that has shown a great shift in separating runoff into pre-event and event water throughout its production lifetime.
  • 1.2K
  • 24 Sep 2021
Topic Review
Acquisition of Brassica Yellows Virus
Brassica yellows virus (BrYV) is a tentative species of the genus Polerovirus, which occurs widely, and mostly damages Brassicaceae plants in East Asia. Because BrYV cannot be transmitted mechanically, an insect-based transmission method is required for further virus research. Here, a reliable and unrestricted method is described, in which non-viruliferous aphids (Myzus persicae) acquired BrYV from transgenic Arabidopsis thaliana, harboring the full-length viral genome germinated from seeds and its frozen leaves. The aphids then transmitted the virus to healthy plants. There was no significant difference in acquisition rates between fresh and frozen infected leaves, although the transmission rate from frozen infected leaves was lower compared to fresh infected leaves. This simple novel method may be used to preserve viral inocula, evaluate host varietal resistance to BrYV, and investigate interactions among BrYV, aphids, and hosts. 
  • 1.2K
  • 03 Oct 2021
Topic Review
Machine Learning in Tribology
Tribology has been and continuous to be one of the most relevant fields in today’s society, being present in almost aspects of our lives. The importance of friction, lubrication and wear is also reflected by the significant share of today’s world energy consumption. The understanding of tribology can pave the way for novel solutions for future technical challenges.
  • 1.2K
  • 21 Oct 2021
Topic Review
Antimicrobial Resistance and Inorganic Nanoparticles
A bacterium becomes resistant due to the transfer of genes encoding antibiotic resistance. Bacteria constantly mutate; therefore, their defense mechanisms change constantly.  Nanotechnology plays a key role in antimicrobial resistance due to materials modified at the nanometer scale, allowing large numbers of molecules to assemble to have a dynamic interface. These nanomaterials act as carriers, and their design is mainly focused on introducing the temporal and spatial release of the payload of antibiotics. In addition, they generate new antimicrobial modalities for the bacteria, which are not capable of protecting themselves.
  • 1.2K
  • 18 Dec 2021
Topic Review
Enumeration of Brettanomyces in Wine Using Impedance
Brettanomyces bruxellensis is a wine spoilage concern in wineries around the world. In order to maintain wine quality during storage and ageing, it is imperative to control and monitor this yeast. Being a fastidious slow growing yeast, which requires 5 to 14 days of incubation for visible growth in agar plates, it is difficult to detect growth (colonies) by conventional agar plate count method. Yeast enumeration by impedance was investigated because previous research using other microorganisms has shown that it is potentially faster than plate counting. The relationship between plate counting and impedance detection times was investigated for Brettanomyces inoculated in red wine samples. A linear relationship between log plate count concentrations and impedance detection times was found. Incubation time was reduced from 120 h down to 0.9 and 57.7 h for samples with 6.7 × 10E7 and 1.8 × 10E2 cfu/mL, respectively, using the ‘indirect’ impedance method. The ‘indirect’ impedance method has the potential to be used by the wine industry to control and monitor the Brettanomyces numbers in wines.
  • 1.2K
  • 17 Mar 2022
Topic Review
The Geometric World of Fishes
Spatial orientation may be led by the distinctive geometry of an environment: fish can use metric and left-right direction to reach convenient locations, such as a foraging site. This remarkable capacity requires to handle the macrostructural characteristics of space, which are based on the Euclidean concepts of point, surface, and boundary.
  • 1.2K
  • 29 Aug 2022
Topic Review
Pulmonary Ultrasound during COVID 19
In practical terms, lung ultrasound (LUS) can be considered as an equally accurate alternative for CT in many situations where CT is not easily accessible or when molecular tests are not available. The use of lung ultrasound (LUS) as a triage tool has been proposed since the beginning of the COVID-19 pandemicand subsequent studies have confirmed its role. The high sensitivity of ultrasound for the superficial lesions of the lung from the interstitial stages represents its great value.
  • 1.2K
  • 15 Apr 2022
Topic Review
Separation and Analytical Techniques Used in Snake Venomics
The deleterious consequences of snake envenomation are due to the extreme protein complexity of snake venoms. Therefore, the identification of their components is crucial for understanding the clinical manifestations of envenomation pathophysiology and for the development of effective antivenoms. In addition, snake venoms are considered as libraries of bioactive molecules that can be used to develop innovative drugs. Numerous separation and analytical techniques are combined to study snake venom composition including chromatographic and electrophoretic techniques.
  • 1.2K
  • 28 Jul 2022
Topic Review
Advances in Curcumin Formulations
Traditional clinical procedures for treating or removing tumors, such as chemotherapy, radiotherapy, and surgical dissection, are widely used. Although chemotherapy remains a very efficient strategy in the battle against cancer, it is typically associated with substantial drawbacks and side effects. Therefore, there remains the possibility that tumors that have been surgically removed may return and may also be resistant to radiation treatment. Marine and terrestrial natural products are far more favorable for improving treatment outcomes in disorders with complicated pathological behavior. Due to their biochemical structures, natural compounds can affect numerous cellular targets, such as genes and proteins. Herbal preparations and their related natural products offer a pivotal role in cancer chemotherapy and chemoprevention. As they are safe and able to minimize the side effects on healthy cells, selected medicinal plants have been developed to address a variety of malignancies. Curcumin is a polyphenol derivative found in the turmeric plant (Curcuma longa L.), and provides chemopreventive, antitumor, chemo-, and radio-sensitizing properties. 
  • 1.2K
  • 08 Oct 2022
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