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Topic Review
Adelaide Superbasin
The Adelaide Superbasin is a series of geologically related rift to passive margin sedimentary basins formed during the Neoproterozoic to Cambrian. They are located at the south-eastern margin of Proterozoic Australia.
  • 1.3K
  • 18 Apr 2022
Topic Review
Ultrasound-Responsive Nanocarriers for Breast Cancer Chemotherapy
Breast cancer is the most common type of cancer and is treated with surgical intervention, radiotherapy, chemotherapy, or a combination of these regimens. Despite its ample use, chemotherapy has limitations such as bioavailability, adverse side effects, high-dose requirements, low therapeutic indices, multiple drug resistance development, and non-specific targeting. Drug delivery vehicles or carriers, of which nanocarriers are prominent, have been introduced to overcome chemotherapy limitations. Nanocarriers have been preferentially used in breast cancer chemotherapy because of their role in protecting therapeutic agents from degradation, enabling efficient drug concentration in target cells or tissues, overcoming drug resistance, and their relatively small size. However, nanocarriers are affected by physiological barriers, bioavailability of transported drugs, and other factors. To resolve these issues, the use of external stimuli has been introduced, such as ultrasound, infrared light, thermal stimulation, microwaves, and X-rays. Recently, ultrasound-responsive nanocarriers have become popular because they are cost-effective, non-invasive, specific, tissue-penetrating, and deliver high drug concentrations to their target.
  • 1.3K
  • 29 Sep 2022
Topic Review
Insights into Postoperative Cognitive Impairment Induced by Anesthesia
Cognitive impairment after surgery is a common problem, affects mainly the elderly, and can be divided into postoperative delirium and postoperative cognitive dysfunction. Both phenomena are accompanied by neuroinflammation; however, the precise molecular mechanisms underlying cognitive impairment after anesthesia are not yet fully understood. Anesthesiological drugs can have a longer-term influence on protein transcription, thus, epigenetics is a possible mechanism that impacts on cognitive function. Epigenetic mechanisms may be responsible for long-lasting effects and may implicate novel therapeutic approaches.
  • 1.3K
  • 19 Oct 2022
Topic Review
Services in the Internal Market Directive 2006
The Services in the Internal Market Directive 2006/123/EC (also called the "Bolkestein Directive") is an EU law aiming at establishing a single market for services within the European Union (EU). Drafted under the leadership of the former European Commissioner for the Internal Market Frits Bolkestein, it has been popularly referred to by his name. It was seen as an important kick-start to the Lisbon Agenda which, launched in 2000, was an agreed strategy to make the EU "the world's most dynamic and competitive economy" by 2010. The Bolkestein Directive was harshly criticised by left-wing European politicians, who stated that it would lead to competition between workers in different parts of Europe – hence the expression "Polish plumber" – resulting in social dumping. After the 2004 original draft had been substantially amended, the proposal was approved on 12 December 2006 by the European Parliament and Council, and adopted as the Directive 2006/123/EC.
  • 1.3K
  • 27 Oct 2022
Topic Review
Consequences of Geopolitics and COVID-19 on Economic Performance
The COVID-19 crisis and the war between Russia and Ukraine affects the world economy badly. The western countries’ economic sanctions on Russia and the Russian government’s reverse sanctions on western countries create pressure on the world economy. Countries over the world registered less economic growth, high inflation rate, and high government debt in 2022 compared to the fiscal period of 2019–2021. The emerging economies and developing countries of Europe were badly affected by the crisis as the level of inflation rate hit 27 percent and the economic growth of the region registered a negative 2.9 percent. It also found rising interest rates, exchange rate volatility, risk of stagflation, and rising energy prices are the short-term risks to economies. The issue of sustainable development goals and green aspects, risk of hyperinflation, and risk of economic recession are the long-term strategic challenges or risks to economies. Bailout and debt relief were found to be necessary for those countries badly affected by the crisis. Policymakers should facilitate financial policies and should switch from general assistance to targeted support of viable enterprises. 
  • 1.3K
  • 11 Nov 2022
Topic Review
Ko Fight
A ko (Japanese: コウ, 劫, kō, from the translation of the Sanskrit term kalpa) fight is a tactical and strategic phase that can arise in the game of go.
  • 1.3K
  • 28 Nov 2022
Topic Review
Metaverse and Neurorehabilitation
The metaverse is a new technology thought to provide a deeper, persistent, immersive 3D experience combining multiple different virtual approaches in a full continuum of physical–digital interaction spaces. Different from virtual reality (VR) and augmented reality (AR), the metaverse has a service-oriented solid model with an emphasis on social and content dimensions. The fundamental innovations that could be brought about by the metaverse rely on the evolution of immersive experience and on the employment of multiple technologies—artificial intelligence, internet of things, blockchain, etc.—to facilitate the virtuality–reality interconnection by mimicking brain functioning. In particular, AI tools (i.e., deep learning) will bring insights into new treatment approaches, leading to a profound impact on personalized medicine for mental health conditions. The complexity of the metaverse is discussed, which could be considered the future of neurorehabilitation.
  • 1.3K
  • 30 Nov 2022
Topic Review
Shoreline Mapping Using Airborne LiDAR
Since the shorelines are important geographical boundaries, monitoring shoreline change plays an important role in integrated coastal management. With the evolution of remote sensing technology, many studies have used optical images to measure and to extract shoreline. However, some factors limit the use of optical imaging on shoreline mapping. Considering that airborne LiDAR data can provide more accurate topographical information, they are used to map shorelines. There are two major types of airborne LiDAR systems that are commonly used in shoreline area surveys: the airborne laser topographic scanning system (ALT) and the airborne laser bathymetric scanning system (ALB).
  • 1.3K
  • 20 Feb 2023
Topic Review
Trans Women’s Health Conditions in Sex Work
Because of employment segregation, which leads to economic and social constraints, some trans women engage in sex work to satisfy basic needs and to achieve financial autonomy. In general, trans women sex workers, broadly known as women who exchange sex for money or other goods, experience widespread violations of their human rights due to the intersection of transgender stigma, sex work stigma, and other marginalized identities facing personal struggles related to their bodies and health.
  • 1.3K
  • 28 Nov 2023
Topic Review
State-of the-Art Constraint-Based Modeling of Microbial Metabolism
Methanotrophy is the ability of an organism to capture and utilize the greenhouse gas, methane, as a source of energy-rich carbon. Over the years, significant progress has been made in understanding of mechanisms for methane utilization, mostly in bacterial systems, including the key metabolic pathways, regulation and the impact of various factors (iron, copper, calcium, lanthanum, and tungsten) on cell growth and methane bioconversion. The implementation of -omics approaches provided vast amount of heterogeneous data that require the adaptation or development of computational tools for a system-wide interrogative analysis of methanotrophy. The genome-scale mathematical modeling of its metabolism has been envisioned as one of the most productive strategies for the integration of muti-scale data to better understand methane metabolism and enable its biotechnological implementation. 
  • 1.3K
  • 03 Jan 2024
Topic Review
Secondary Metabolites of Purpureocillium lilacinum
Fungi can synthesize a wealth of secondary metabolites, which are widely used in the exploration of lead compounds of pharmaceutical or agricultural importance. Beauveria, Metarhizium, and Cordyceps are the most extensively studied fungi in which a large number of biologically active metabolites have been identified. However, relatively little attention has been paid to Purpureocillium lilacinum. P. lilacinum are soil-habituated fungi that are widely distributed in nature and are very important biocontrol fungi in agriculture, providing good biological control of plant parasitic nematodes and having a significant effect on Aphidoidea, Tetranychus cinnbarinus, and Aleyrodidae. At the same time, it produces secondary metabolites with various biological activities such as anticancer, antimicrobial, and insecticidal. 
  • 1.3K
  • 13 Jan 2022
Topic Review
Axenfeld-Rieger Syndrome
Axenfeld-Rieger syndrome is primarily an eye disorder, although it can also affect other parts of the body. This condition is characterized by abnormalities of the front part of the eye, an area known as the anterior segment. For example, the colored part of the eye (the iris), may be thin or poorly developed. The iris normally has a single central hole, called the pupil, through which light enters the eye. People with Axenfeld-Rieger syndrome often have a pupil that is off-center (corectopia) or extra holes in the iris that can look like multiple pupils (polycoria). This condition can also cause abnormalities of the cornea, which is the clear front covering of the eye.
  • 1.2K
  • 24 Dec 2020
Topic Review
RAB11-Mediated Trafficking and Human Cancers
RAB11 isoforms function as membrane organizers connecting the transport of cargoes towards the plasma membrane with the assembly of autophagic precursors and the generation of cellular protrusions. These processes dramatically impact normal cell physiology and their alteration significantly affects the survival, progression and metastatization as well as the accumulation of toxic materials of cancer cells. 
  • 1.2K
  • 28 Jan 2021
Topic Review
Proton radiobiology: DNA damage response
Clinical use of proton radiation has massively increased over the past years. The main reason for this is the beneficial depth-dose distribution of protons that allows to reduce toxicity to normal tissues surrounding the tumor. Despite the experience in the clinical use of protons, the radiobiology after proton irradiation compared to photon irradiation remains to be completely elucidated. Proton radiation may lead to differential damages and activation of biological processes.
  • 1.2K
  • 08 Mar 2021
Topic Review
Saliva in SARS-COV-2 Detection
In the wake of the COVID-19 pandemic, it is crucial to assess the application of a multitude of effective diagnostic specimens for conducting mass testing, for accurate diagnosis and to formulate strategies for its prevention and control. As one of the most versatile and amenable specimen options, saliva offers great advantages for widespread screening strategies due to its non-invasive properties, cost-effectiveness, excellent stability and minimal risk of cross-infection. 
  • 1.2K
  • 01 Jun 2021
Topic Review
Angiotensin-Converting Enzyme 2
The interaction between the membrane spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the transmembrane angiotensin-converting enzyme 2 (ACE2) receptor of the human epithelial host cell is the first step of infection, which has a critical role for viral pathogenesis of the current coronavirus disease-2019 (COVID-19) pandemic.
  • 1.2K
  • 24 Sep 2021
Topic Review
Mast Cells in Allergy/Inflammation Regulation
It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a quick response to the various stimulants, including—but not limited to—allergens, pathogen-associated molecular patterns (PAMPs), and damage-associated molecular patterns (DAMPs). MCs highly express receptors of these ligands and proteases (e.g., tryptase, chymase) and cytokines (TNF), and other granular components (e.g., histamine and serotonin) and aggravate the allergic reaction and inflammation. On the other hand, accumulated evidence has revealed that MCs also possess immune-regulatory functions, suppressing chronic inflammation and allergic reactions on some occasions. IL-2 and IL-10 released from MCs inhibit excessive immune responses. 
  • 1.2K
  • 12 Oct 2021
Topic Review
Neurodegenerative Proteins in Epilepsy
Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic strategies against epileptogenesis, neurodegenerative proteins have recently gained increased attention. Owing to the fact that neurodegenerative disease and epileptogenesis possibly share a common underlying mechanism, targeting neurodegenerative proteins against epileptogenesis might represent a promising therapeutic approach.
  • 1.2K
  • 04 Aug 2021
Topic Review
Sustainable Supply Chains from SMEs
Sustainable development (SD) has become a primary objective in enterprise strategy systems, and is achieved via the integration and balancing of the three dimensions of sustainable development: economic, social, and environmental [1]. Increasingly complex global-scale production, transportation networks, and value chains extend SD to entire supply chains. All the partners in a network, not only a single company, must confront future environmental challenges. The manufacturing industry accounts for 30% of Taiwan’s GDP and encompasses industries, such as IC and computer products, that are exported worldwide [2,3]. The manufacturing industry is the driving force of Taiwan’s economy, aiding its ability to meet stakeholder expectations of environmental regulations and compliance. It is critical for manufacturers to develop a high-value manufacturing strategy to ensure the sustainability of the national economy. The concept of sustainable supply chain management is very important to the business strategies of small- and medium-sized enterprises [4]. Companies can enhance added value through numerous methods, among which one of the most crucial is the enhancement of both their corporate image and customer loyalty by the demonstration of a contribution to society through products, services, or local care [5].
  • 1.2K
  • 16 Aug 2021
Topic Review
Mastiha
Mastiha is a natural product of the Mediterranean basin with several health benefits due to its bioactive compounds, namely terpenes, phenolic compounds, phytosterols, arabino-galactanes proteins. It appears as a dried resinous exudate from stems and branches of the tree Pistacia lentiscus (Pistacia lentiscus L. var latifolius Coss or Pistacia lentiscus var. Chia).
  • 1.2K
  • 08 Sep 2021
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