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Topic Review
Transport of Nanoparticles into Plants
The transport of matter into plants, also known as plant uptake, is a crucial process for the growth and development of plants. Plants require various essential nutrients, water, and gases for their survival and growth. The transport in plants extends beyond water, nutrients, and gases, encompassing the movement of various particles or nanoparticles, as well as other exogenous materials. This includes genetic material such as double-stranded RNA (dsRNA). Nanoparticles can be transported into plants for several reasons, often as a result of environmental exposure or as a part of research and development efforts. The transport of nanoparticles into plants can have various implications, both beneficial and potentially concerning, depending on the type of nanoparticles and the intended purpose. 
  • 1.3K
  • 19 Jan 2024
Topic Review
Gastric Outlet Obstruction Management
Gastric outlet obstruction (GOO) poses a common and challenging clinical scenario, characterized by mechanical blockage in the pylorus, distal stomach, or duodenum, resulting in symptoms such as nausea, vomiting, abdominal pain, and early satiety. Its diverse etiology encompasses both benign and malignant disorders. The spectrum of treatment modalities extends from conservative approaches to more invasive interventions, incorporating procedures like surgical gastroenterostomy (SGE), self-expandable metallic stents (SEMSs) placement, and the advanced technique of endoscopic ultrasound-guided gastroenterostomy (EUS-GE). While surgery is favored for longer life expectancy, stents are preferred in malignant gastric outlet stenosis. The novel EUS-GE technique, employing a lumen-apposing self-expandable metal stent (LAMS), combines the immediate efficacy of stents with the enduring benefits of gastroenterostomy. 
  • 1.3K
  • 17 Feb 2024
Topic Review
Nanotechnologies for Drug Delivery to the Brain
Drug delivery to the brain has been one of the toughest challenges researchers have faced to develop effective treatments for brain diseases. Owing to the blood–brain barrier (BBB), only a small portion of administered drug can reach the brain. A consequence of that is the need to administer a higher dose of the drug, which, expectedly, leads to a variety of unwanted side effects. Research in a variety of different fields has been underway for the past couple of decades to address this very serious and frequently lethal problem. One area of research that has produced optimistic results in recent years is nanomedicine. Nanomedicine is the science birthed by fusing the fields of nanotechnology, chemistry and medicine into one. Many different types of nanomedicine-based drug-delivery systems are currently being studied for the sole purpose of improved drug delivery to the brain.
  • 1.3K
  • 26 Jan 2022
Topic Review
THz Sensing of Human Skin
The non-ionizing and non-invasive nature of THz radiation, combined with its high sensitivity to water, has made THz imaging and spectroscopy highly attractive for in vivo biomedical applications for many years. Among them, the skin is primarily investigated due to the short penetration depth of THz waves caused by the high attenuation by water in biological samples. A complete model of skin describing the THz-skin interaction to reveal the optical properties of the skin from the measured THz spectrum is needed. It is crucial that the correct model is used, not just to ensure compatibility between different works, but more importantly to ensure the reliability of the data and conclusions.
  • 1.3K
  • 08 Jun 2021
Topic Review
Hormone Therapy for Castration-Resistant Prostate Cancer
Prostate cancer (PCa) is the most common cancer and the second deadliest cancer among men in the United States, which is mainly due to metastatic disease. In general, surgery or radiation is potentially a curative treatment for localized disease. Since PCa is characterized as a typical androgen-dependent disease, hormone therapy (i.e., androgen deprivation therapy (ADT)) is the most effective therapy to control metastatic disease. However, almost all patients eventually develop castration-resistant PCa (CRPC) within 12 to 18 months, with a median survival of 14 to 26 months. Nowadays, new anti-androgens (Enzalutamide or Abiraterone), radiotherapy (Radium-223) or immunotherapy (sipuleucel-T) have been approved for metastatic CRPC (mCRPC) patients to prolong the overall survival. Inevitably, mCRPC further acquires resistance and becomes therapy- and castration-resistant PCa (t-CRPC), which is considered as an end-stage disease without effective therapy, and on which new therapeutic strategies have been actively explored.
  • 1.3K
  • 24 Aug 2022
Topic Review
Traffic Flow Forecasting Technology
The sustainable development of mankind is a matter of concern to the whole world. Environmental pollution and haze diffusion have greatly affected the sustainable development of mankind. According to previous research, vehicle exhaust emissions are an important source of environmental pollution and haze diffusion. The sharp increase in the number of cars has also made the supply of energy increasingly tight. In this entry, we have explored the use of intelligent navigation technology based on data analysis to reduce the overall carbon emissions of vehicles on road networks. We have implemented a traffic flow prediction method using a genetic algorithm and particle-swarm-optimization-enhanced support vector regression, constructed a model for predicting vehicle exhaust emissions based on predicted road conditions and vehicle fuel consumption, and built our low-carbon-emission-oriented navigation algorithm based on a spatially optimized dynamic path planning algorithm. The results show that our method could help to significantly reduce the overall carbon emissions of vehicles on the road network, which means that our method could contribute to the construction of low-carbon-emission intelligent transportation systems and smart cities.
  • 1.3K
  • 29 Jan 2021
Topic Review
PKSIII
A putative Type III Polyketide synthase (PKSIII) encoding gene was identified from a marine yeast, Naganishia uzbekistanensis strain Mo29 (UBOCC-A-208024) (formerly named as Cryptococcus sp.) isolated from deep-sea hydrothermal vents. This gene is part of a distinct phylogenetic branch compared to all known terrestrial fungal sequences. This new gene encodes a C-terminus extension of 74 amino acids compared to other known PKSIII proteins like Neurospora crassa. Full-length and reduced versions of this PKSIII were successfully cloned and overexpressed in a bacterial host, Escherichia coli BL21 (DE3). Both proteins showed the same activity, suggesting that additional amino acid residues at the C-terminus are probably not required for biochemical functions. We demonstrated by LC-ESI-MS/MS that these two recombinant PKSIII proteins could only produce tri- and tetraketide pyrones and alkylresorcinols using only long fatty acid chain from C8 to C16 acyl-CoAs as starter units, in presence of malonyl-CoA. In addition, we showed that some of these molecules exhibit cytotoxic activities against several cancer cell lines.
  • 1.3K
  • 13 Jan 2021
Topic Review
Strategies for Identification of Neoantigens
This entry provides an overview of currently available approaches applied for neoantigens discovery—tumor-specific peptides that appeared due to the mutation process and distinguish tumors from normal tissues. Focusing on genomics-based approaches and computational pipelines, we cover all steps required for selecting appropriate candidate peptides starting from NGS-derived data. Moreover, additional approaches such as mass-spectrometry-based and structure-based methods are discussed highlighting their advantages and disadvantages. This review also provides a description of available complex bioinformatics pipelines ensuring automated data processing resulting in a list of neoantigens. We propose the possible ideal pipeline that could be implemented in the neoantigens identification process. We discuss the integration of results generated by di erent approaches to improve the accuracy of neoantigens selection.
  • 1.3K
  • 08 Apr 2021
Topic Review
Pathophysiology of ALS
Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of the motor system. It is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and paralysis. ALS is incurable and has a bleak prognosis, with median survival of 3–5 years after the initial symptomatology.
  • 1.3K
  • 26 Jul 2021
Topic Review
Selenium Nanoparticles in Aquaculture
Balanced aquafeed is the key factor for enhancing the productivity of aquatic animals. In this context, aquatic animals require optimal amounts of lipids, proteins, carbohydrates, vitamins, and minerals. The original plant and animals’ ingredients in the basal diets are insufficient to provide aquafeed with suitable amounts of minerals. Concurrently, elements should be incorporated in aquafeed in optimal doses, which differ based on the basal diets’ species, age, size, and composition. Selenium is one of the essential trace elements involved in various metabolic, biological, and physiological functions. Se acts as a precursor for antioxidative enzyme synthesis leading to high total antioxidative capacity. Further, Se can enhance the immune response and the tolerance of aquatic animals to infectious diseases. Several metabolic mechanisms, such as thyroid hormone production, cytokine formation, fecundity, and DNA synthesis, require sufficient Se addition. The recent progress in the nanotechnology industry is also applied in the production of Se nanoparticles. Indeed, Se nanoparticles are elaborated as more soluble and bioavailable than the organic and non-organic forms. In aquaculture, multiple investigations have elaborated the role of Se nanoparticles on the performances and wellbeing of aquatic animals.
  • 1.3K
  • 09 Sep 2021
Topic Review
The Italian Alpine and Subalpine trouts
Among the valid nominal taxa of the native trouts described in the Italian peninsula and the major Italian islands, Salmo cettii Rafinesque-Schmaltz 1810 was described from Sicily (type locality: Val Demone in northeastern Sicily and Val di Noto in southeastern Sicily, no types known). S. marmoratus (Cuvier 1829) is a subendemism of northern Italy described from the “lacs de Lombardie" (syntypes not available). S. cenerinus Nardo 1847 was described from northeastern Italy (type locality: not far from the sea, in rivers draining to the Venetian lagoon; no types known). The original description of S. cenerinus was written from the late 1700s to the early 1800s by S. Chiereghin, and published posthumously; a summary of this description was first published by Nardo. S. macrostigma (Duméril 1858) has been considered by several authors as an Italian trout; however, it was described from North Africa (type locality: Oued-el-Abaïch, Kabylie, Algeria). S. ghigii Pomini 1941 was described from central Italy (type locality: Sagittario River; no types known). S. fibreni Zerunian and Gandolfi 1990, described from the Lake Posta Fibreno in central Italy, and S. carpio Linnaeus 1758, described from Lake Garda, are restricted endemisms defined by ecomorphological and genetic traits. The island of Sardinia might host an undescribed Salmo species (Segherloo et al.).
  • 1.3K
  • 28 Apr 2022
Topic Review
Alcohol Use Disorder and the Brain
Alcohol use disorder (AUD) can be defined as a chronically relapsing disorder characterized by the compulsion to ingest alcohol, the loss of control in limiting alcohol intake despite adverse health, social, and occupational consequences, and the emergence of a negative emotional state that can involve feelings of anxiety, irritability, and dysphoria when access to alcohol is prevented, reflecting a state of motivational withdrawal.
  • 1.3K
  • 31 May 2022
Topic Review
Current Methodologies for Visualizing ATP in Living Cells
Measuring total ATP levels within cellular compartmental pools in real-time presents a newer and more innovative approach to qualitatively analyzing ATP. Although this method is not precisely quantitative, it can be helpful in determining changes in ATP concentrations in one region of a cell compared to another in a variety of disease states. The overall goal of these assays and imaging methodologies are to evaluate and visualize dynamic ATP trends, such as usage and depletion, between cells and their sub-compartments. However, semi-quantitative evaluation of the relative ATP signal is feasible. The currently developed technologies that utilize this approach to ATP quantification are mainly genetically encoded biosensors. In conjunction with a fluorescent or bioluminescent protein, most of these biosensors harness the folding capabilities of the ϵ subunit of the bacterial ATP synthase subunit. The bacterial ATP synthase protein comprises a β-barrel domain located at the N terminus and an α-helical domain with two α-helices located at the C terminus. Upon ATP binding, the two α-helices interact and refine their conformational structure of the ϵ subunit, leading to fluorescent/bioluminescent illumination, indicating that ATP is present. Overall, this subunit adopts two different conformations: open (ATP-free) or closed (ATP-bound). The uses and applicability of this technology are limitless. 
  • 1.3K
  • 24 Jun 2022
Topic Review
Wearing Course Materials Modified with Waste Plastic
Roads and bridges are one of the most crucial components of infrastructure engineering and they play a vital role in lifetimes. Bituminous mixture is a composite material made up of other distinct materials, employed in a range of civil engineering tasks, such as the construction of roads. It consists of mineral aggregate, bitumen, and air voids, which are the main components of bituminous mixture, blended and then laid and compacted to form the surface of roads. Asphalt pavement or flexible pavement is widely employed throughout the globe. Asphalt pavement has good riding quality, and it is much cheaper to construct, in comparison to concrete or rigid pavements. HMA mixtures for asphalt pavement are divided into three main categories: dense-graded mixture, open-graded mixture, and gap-graded mixture.
  • 1.3K
  • 30 Aug 2022
Topic Review
Health Software
Medical software is any software item or system used within a medical context, such as reducing the paperwork, tracking patient activity.  standalone software used for diagnostic or therapeutic purposes; software embedded in a medical device (often referred to as "medical device software"); software that drives a medical device or determines how it is used; software that acts as an accessory to a medical device; software used in the design, production, and testing of a medical device; or software that provides quality control management of a medical device.
  • 1.3K
  • 20 Oct 2022
Topic Review
The Additive Manufacturing Technology
Additive manufacturing is defined as a process based on the superposition of layers of materials in order to obtain 3D (three-dimensional) parts.
  • 1.3K
  • 30 Nov 2022
Topic Review
Tumor Microenvironment in Osteosarcoma Cells
Osteosarcoma (OS) is a malignancy that is becoming increasingly common in adolescents. OS stem cells (OSCs) form a dynamic subset of OS cells that are responsible for malignant progression and chemoradiotherapy resistance. The unique properties of OSCs, including self-renewal, multilineage differentiation and metastatic potential, 149 depend closely on their tumor microenvironment.
  • 1.3K
  • 30 Dec 2022
Topic Review
Modulating T Cell Responses by Targeting CD3
The CD3-T cell receptor (TCR) is the canonical receptor complex on T cells. It provides the “first signal” that initiates T cell activation and determines the specificity of the immune response. The TCR confers the binding specificity whilst the CD3 subunits facilitate signal transduction necessary for T cell activation. While the mechanisms through which antigen sensing and signal transduction occur in the CD3–TCR complex are still under debate, revelations regarding the intricate 3D structure of the CD3–TCR complex might open the possibility of modulating its activity by designing targeted drugs and tools, including aptamers.
  • 1.3K
  • 15 Mar 2023
Topic Review
Visualization Techniques in Endoscopic Skull Base Surgery
Skull base surgery has undergone significant progress following key technological developments. From early candle-lit devices to the modern endoscope, refinements in visualization techniques have made endoscopic skull base surgery (ESBS) a standard practice for treating a variety of conditions. The endoscope has also been integrated with other technologies to enhance visualization, including fluorescence agents, intraoperative neuronavigation with augmented reality, and the exoscope. 
  • 1.3K
  • 06 May 2023
Topic Review
Viral Vector-Based Gene Therapy
Gene therapy is a technique involving the modification of an individual’s genes for treating a particular disease. The key to effective gene therapy is an efficient carrier delivery system. Viral vectors that have been artificially modified to lose their pathogenicity are used widely as a delivery system, with the key advantages of their natural high transduction efficiency and stable expression. With decades of development, viral vector-based gene therapies have achieved promising clinical outcomes. Long-term gene therapy involves the administration of a specific genetic material (i.e., DNA or RNA) via a carrier, referred to as a “delivery vector,” which facilitates the entry of the foreign genetic material into target cells. The delivery vectors are of two types: viral vectors and non-viral vectors. The commonly used viral vectors are adeno-associated viruses (AAVs), adenoviruses (Ads), or lentiviruses (LVs).
  • 1.3K
  • 09 May 2023
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