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Topic Review
Impact of the Digital Economy on Health Industry
Health is a basic need of the people and an important foundation for economic and social development. In developed economies such as the United States, Europe, and Japan, the health industry has become a huge driving force for the growth of the entire national economy, and the added value of the health industry in these economies has accounted for more than 15% of their GDP.
  • 1.3K
  • 28 Aug 2023
Topic Review
Tirzepatide in Type 2 Diabetes
Tirzepatide (TZP) is a once-weekly glucagon-like peptide 1 (GLP-1) and glucose-dependent-insulinotropic-polypeptide (GIP) receptor co-agonist approved for T2D. TZP provides promising evidence in improving glucose control and weight loss in T2D and obesity across preclinical and human studies, including data from the SURPASS program. TZP dramatically changes the clinical course of T2D in different clinical scenarios. 
  • 1.3K
  • 19 Feb 2024
Topic Review
RNA-Binding Proteins Regulating
The majority of the genome is transcribed into pieces of non-(protein) coding RNA, among which long non-coding RNAs (lncRNAs) constitute a large group of particularly versatile molecules that govern basic cellular processes including transcription, splicing, RNA stability, and translation. The frequent deregulation of numerous lncRNAs in cancer is known to contribute to virtually all hallmarks of cancer. The post-transcriptional regulation of lncRNAs is mediated by RNA-binding proteins (RBPs). Interestingly, RBPs themselves are commonly deregulated in cancer and could thus constitute a major contribution to the deregulation of cancer-associated lncRNAs. Discussed here are four examples of well-known RBPs that regulate the transport or localization of cancer-associated lncRNAs and thereby impact the functionality of these lncRNAs. So far, out of the vast number of RBPs that exist, only a relatively small number has been found to specifically guide the transport or localization of cancer-related lncRNAs. In general, there is still a lack of knowledge about how lncRNAs are shuttled between or retained within different cellular compartments and future research will have to shed more light on these regulatory mechanisms.
  • 1.3K
  • 29 Oct 2020
Topic Review
Phosphate Accumulation
Recent studies have shown various metabolic and transcriptomic interactions between sulfur (S) and phosphorus (P) in plants. However, most studies have focused on the effects of phosphate (Pi) availability and P signaling pathways on S homeostasis, whereas the effects of S availability on P homeostasis remain largely unknown. In this study, we investigated the interactions between S and P from the perspective of S availability. We investigated the effects of S availability on Pi uptake, transport, and accumulation in Arabidopsis thaliana grown under sulfur sufficiency (+S) and deficiency (−S). Total P in shoots was significantly increased under −S owing to higher Pi accumulation. This accumulation was facilitated by increased Pi uptake under −S. In addition, −S increased root-to-shoot Pi transport, which was indicated by the increased Pi levels in xylem sap under −S. The −S-increased Pi level in the xylem sap was diminished in the disruption lines of PHT1;9 and PHO1, which are involved in root-to-shoot Pi transport. Our findings indicate a new aspect of the interaction between S and P by listing the increased Pi accumulation as part of −S responses and by highlighting the effects of −S on Pi uptake, transport, and homeostasis.
  • 1.3K
  • 29 Oct 2020
Topic Review
Human Pluripotent Stem Cell-derived Cardiomyocytes
Atrial fibrillation (AF) is a type of sustained arrhythmia in humans often characterized by devastating alterations to the cardiac conduction system as well as the structure of the atria. AF can lead to decreased cardiac function, heart failure, and other complications. Long non-coding RNAs (lncRNAs) have been shown to play important roles in the cardiovascular system, including AF; however, a large group of lncRNAs is not conserved between mouse and human. Furthermore, AF has complex networks showing variations in mechanisms in different species, making it challenging to utilize conventional animal models to investigate the functional roles and potential therapeutic benefits of lncRNAs for AF. Fortunately, pluripotent stem cell (PSC)-derived cardiomyocytes (CMs) offer a reliable platform to study lncRNA functions in AF because of certain electrophysiological and molecular similarities with native human CMs.
  • 1.3K
  • 27 Oct 2020
Topic Review
Developing a Wine Experience Scale
       This study develops a scale to measure wine tourism experiences and was tested in Portugal, in Porto and Madeira wine cellars. The resulting 18-item wine experience scale comprises four major dimensions: (1) Wine storytelling, (2) wine tasting excitement, (3) wine involvement, and (4) winescape. This is the first scale that comprises the dimensions of experience with wine senses, applied in a relevant wine destination where research is still limited. The results are relevant in boosting the increasingly recognized awareness of Portugal as wine tourism, as well as bringing experience scales to the body of knowledge.
  • 1.3K
  • 09 Oct 2020
Topic Review
Smart Specialisation
Smart specialisation is a concept that catalyses sources of financing and that concentrates the ways of influencing the innovative potential in the regions. 
  • 1.3K
  • 27 Oct 2020
Topic Review
Tripartite Motif Family
The tripartite motif (TRIM) family comprises at least 80 members in humans, with most having ubiquitin or SUMO E3 ligase activity conferred by their N-terminal RING domain. TRIMs regulate a wide range of processes in ubiquitination- or sumoylation-dependent manners in most cases, and fewer as adaptors. Their roles in the regulation of viral infections, autophagy, cell cycle progression, DNA damage and other stress responses, and carcinogenesis are being increasingly appreciated, and their E3 ligase activities are attractive targets for developing specific immunotherapeutic strategies for immune diseases and cancers.
  • 1.3K
  • 22 Sep 2021
Topic Review
OSN-TFC Membranes for Non-Polar Solvents
separation system owing to its excellent cost and energy saving efficiency, easy scale-up in the narrow area and mild operation conditions. Membrane properties are the key part in terms of determining the separation efficiency in the OSN system. In this entry, the recently reported OSN thin-film composite (TFC) membranes were investigated to understand insight of membrane materials and performance.
  • 1.3K
  • 23 Mar 2021
Topic Review
Distributed Ledger Technology
"Distributed Ledger Technology (DLT) is a term used to represent a digital network of distributed models, consisting of blockchain-based ledgers, and collaborating on shared tasks and activities. Blockchain technology is a data structure, composed of “blocks”, that are cryptographically linked together in a chained sequence using cryptographic hashes, secured against manipulations. Due to wider functionality, DLT is a commonly used term for a computer-based system consisting of distributed ledger-based data structures, which can provide increased levels of trust, service availability, resiliency, and security of digital systems, as well as distributed storage, computation, and control."
  • 1.3K
  • 27 Apr 2021
Topic Review
Pharmaceutical Pollution: The Brazilian Context
The occurrence of pharmaceuticals in the environment is an everyday recognized concern worldwide, and drugs as environmental contaminants have been detected in water and soil systems, posing risks to humans and wildlife. Drugs in wastewater, groundwater, and even drinking water occur in several countries, including Brazil, where the pharmaceutical market is expanding over the years. The adverse, harmful effects of pharmaceuticals in the environment range from the spreading of antimicrobial resistance and species survival to the interference with reproduction and increased cancer incidence in humans. The awareness of emerging contaminants in the environment, besides the joint effort of authorities, consumers, and the general public nationwide, will be required to avoid pharmaceutical/drug pollution and achieve an eco-friendly environment and a sustainable society.
  • 1.3K
  • 03 Jun 2021
Topic Review
Defective Uteroplacental Vascular Remodeling in Preeclampsia
Preeclampsia is a subtype of hypertensive disorders of pregnancy (HDP), defined as hypertension (systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg) newly developed at or after 20 weeks of pregnancy with at least one of following conditions: proteinuria (≥1 + dipstick; ≥30 mg/mmol protein:creatinine ratio; or ≥300 mg/24 h), maternal organ dysfunction (hepatic, renal, hematological, or neurological conditions), or uteroplacental dysfunction (such as abnormal umbilical artery Doppler wave form analysis, fetal growth restriction, or stillbirth)
  • 1.3K
  • 09 Nov 2021
Topic Review
Gut-Microbial Metabolites and Probiotics in Type 2 Diabetes
Type 2 diabetes (T2D) is a worldwide prevalent metabolic disorder defined by high blood glucose levels due to insulin resistance (IR) and impaired insulin secretion. Disturbances of gut microbiota have been widely found in T2D patients and contribute to the development of IR.
  • 1.3K
  • 01 Dec 2021
Topic Review
Plants Iron Deficiency
Iron is an essential element for plant growth and development. While abundant in soil, the available Fe in soil is limited. In this regard, plants have evolved a series of mechanisms for efficient iron uptake, allowing plants to better adapt to iron deficient conditions. These mechanisms include iron acquisition from soil, iron transport from roots to shoots, and iron storage in cells. The mobilization of Fe in plants often occurs via chelating with phytosiderophores, citrate, nicotianamine, mugineic acid, or in the form of free iron ions. 
  • 1.3K
  • 29 Jan 2022
Topic Review
Vibrational Imaging Techniques and Hard Dental Tissues
Raman Microspectroscopy (RMS) represents an innovative tool to in vitro situation hard dental tissues. In fact, this vibrational technique has the advantage of providing, at the same time and on the same sample, a morpho-chemical correlation between the microscopic information from the visual analysis of the sample and its chemical and macromolecular composition. Moreover, thanks to the light scattering, it is possible to simultaneously perform the imaging analysis of both the inorganic and organic components of teeth, at a high spatial resolution level and in a confocal mode. The identification of specific Raman markers representative of sound and pathological hard dental tissues is crucial to improve the diagnosis of several dental pathologies and to detect dental lesions at an early stage when they are not visually detectable .
  • 1.3K
  • 25 Apr 2022
Topic Review
Covalent Reversible Inhibitors of Cysteine Proteases
Serine and cysteine proteases are a class of drug targets that could greatly benefit from the features of the nitrile group as a warhead for the design and discovery of innovative and effective drugs.
  • 1.3K
  • 05 May 2022
Topic Review
Spinal Cord Injury and Loss of Cortical Inhibition
Amongst the consequences of spinal cord injury (SCI) on the central nervous system, the loss of inhibition is a common finding, albeit not always observed, and it is likely to fluctuate over time. Changes in cortical excitability involve a plethora of mechanisms, which individual effects may combine in complex and variable outcomes on the process of functional and structural recovery. 
  • 1.3K
  • 25 May 2022
Topic Review
Hyperspectral Imaging Applied to Sediment Core Analysis
The color analysis of sediment in the laboratory has followed important technological developments in closely related fields, such as the analysis of soils and sedimentary rocks, as well as in more distant fields, such as remote sensing. This has led to the development of sensors allowing the analysis of color and, more generally, of the electromagnetic spectrum of light to answer problems of rapidity, high resolution, automation, and increasing the amount of interesting information remotely without affecting the sample. The hyperspectral imaging sensor will be the focus of this practical guide. 
  • 1.3K
  • 23 Jun 2022
Topic Review
Innovative Treatments for Glioblastoma
Glioblastoma multiforme (GBM) is a grade IV glioma considered the most fatal cancer of the central nervous system (CNS), with less than a 5% survival rate after five years. The tumor heterogeneity, the high infiltrative behavior of its cells, the low resistance of the brain to ionizing radiations and the blood–brain barrier (BBB) that limits the access of therapeutic drugs to the brain are the main reasons hampering the current standard treatment efficiency.
  • 1.3K
  • 30 Jun 2022
Topic Review
Pituitary Apoplexy
Pituitary apoplexy is a rare syndrome, graded from asymptomatic subclinical apoplexy to a life-threatening condition due to pituitary ischemia or haemorrhage of an enlarged pituitary gland. The risk factors and the molecular underlying mechanisms are yet to be elucidated. 
  • 1.3K
  • 26 Aug 2022
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