Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Molluscivorous and Vermivorous Conus Species
It is generally believed that more than 700 Conus species have evolved during the last 50 million years. With the highest species abundance occurring in southeast Asia, most Conus can be found in the shallow waters of tropical and subtropical oceans. Conus is widely distributed in rocky shores, sandy beaches, coral reefs and intertidal waters, with depths reaching up to over 600 m. Nowadays, Conus species are generally overexploited, and some species are now endangered. Exploring these waters of potentially high species diversity could enrich our understanding of their population’s genetic structure and provide the missing pieces for clarifying Conus evolution. As the conotoxin compounds vary greatly throughout the growth stages and across geolocations within the same species, further investigation of these species-specific regional distribution differences may provide crucial insights for artificial breeding and harvesting specific bioactive compounds in the future.
  • 1.9K
  • 18 Feb 2022
Topic Review
Vasopressor-Sparing and Patients with Shock
Vasopressor therapy is to restore organ perfusion so as to limit the risk of multiple organ failure and death.
  • 1.9K
  • 11 Nov 2021
Topic Review
Thymus algeriensis Boiss. and Reut.
The word Thymus comes from the Greek “thyo”, which means “offering” (to be burnt) and “perfume” because of the pleasant smell that the plant gives off naturally when burnt. T. algeriensis Boiss. and Reut. are classified in section Hyphodromi (A. Kerner) Haläcsy and subsection Subbracteati (Klokov) Jalas. It belongs to the order Lamiale, subfamily Nepetoideae, and tribe Menthae.
  • 1.9K
  • 30 Dec 2022
Topic Review
SARS-CoV-2 Main Protease
The main protease (Mpro) of the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was subjected to hyphenated pharmacophoric-based and structural-based virtual screenings using a library of microbial natural products (>24,000 compounds). Subsequent filtering of the resulted hits according to Lipinski’s rules was applied to select only the drug-like molecules. Top-scoring hits were further filtered out depending on their ability to show constant good binding affinities towards the molecular dynamic simulation (MDS)-derived enzyme’s conformers. Final MDS experiments were performed on the ligand-protein complexes to verify their binding modes and calculate their binding free energy. Consequently, a final selection of six compounds of microbial origin was proposed to possess high potential as anti-SARS-CoV-2 drug candidates. Our study provides insight into the role of the Mpro structural flexibility during interactions with the possible inhibitors and sheds light on the structure-based design of anti-coronavirus disease 2019 (COVID-19) therapeutics targeting SARS-CoV-2
  • 1.9K
  • 26 Oct 2020
Topic Review
Cobalt–Chromium Dental Alloys
Co–Cr dental alloys consist of Co, Cr and also other metals (e.g., gallium, iron, molybdenum, nickel, ruthenium, tungsten). Since the 1990s, regulations have emerged to protect European patients and also monitor recent scientific knowledge. The use of metals and, therefore, dental alloys has been highly regulated by directives and regulations. Europe has, therefore, developed a regulatory package to protect all players involved in alloys, whether they are metal producers, manufacturers of alloys and medical devices, healthcare professionals and patients. Objective information is provided about Co–Cr dental alloys, with regard to both the latest toxicological data and regulatory developments from 2020–2025. The release of metal ions and the problem of wear particles are also discussed. With the recent change of regulatory status of Co, it is necessary to know the many repercussions (economic, technical etc.) of their use precisely in order to then allow actors to modify their daily work. The legislative changes also bring the need to propose new alternatives to Co-Cr dental alloys.  
  • 1.9K
  • 21 Jan 2021
Topic Review
Promising Lead Compounds for Resistant-Tuberculosis
According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities. Incomplete therapeutic regimen, meager dosing, and the capability of the latent and/or active state tubercular bacilli to abide and do survive against contemporary first-line and second-line antitubercular drugs escalate the prevalence of drug-resistant tuberculosis. To explore and identify the most potential antitubercular drug candidate among various reported compounds, here we focused to highlight the promising lead derivatives of isoniazid, coumarin, griselimycin, and antimicrobial peptides. The aim of the present review is to fascinate significant lead compounds in the development of potential clinical drug candidates that might be more precise and effective against drug-resistant tuberculosis, the world research looking for a long time.
  • 1.9K
  • 10 Dec 2020
Topic Review
Medicinal Value of Black Mulberry
Roughly 100 species of Morus have been described, such as Morus alba (white mulberry), Morus rubra (red mulberry), and Morus nigra (black mulberry). The mulberry plant is monoecious or dioecious, reaching up to 10–12 m in height. Morus nigra (Moraceae family) is commonly distributed in Asia, Africa, Europe, and America. Given its therapeutic properties, the leaves, root barks, branches, and fruits are traditionally used in medicinal preparations to manage diabetes mellitus, atherosclerosis, hyperlipidemia, and hypertension. Various extracts of mulberry leaves were studied over the years, investigating their bioactive compounds’ pharmaceutical in public health concerns, such as diabetes, hepatic diseases, and cardiovascular diseases. This entry is based on a literature review and highlights the beneficial and therapeutic action of black mulberry extracts and their confirmed or hypothesized mechanism of action in diabetes, hepatic disorders, and cardiovascular disease, as indicated by the results of in vivo and in vitro studies, on cell lines, human and animal models.
  • 1.9K
  • 10 May 2021
Topic Review
Frankincense Extracts
Boswellia serrata counts among the most intensively studied anti-inflammatory medicinal plants with more than 650 publications recorded in the PubMed literature database up to now. In folk medicine lipophilic frankincense extracts are used as alternatives to anti-inflammatory steroidal drugs (i.e., glucocorticoids) or nonsteroidal anti-inflammatory drugs (NSAIDs) for the treatment of diseases associated with inflammation like rheumatoid arthritis, osteoarthritis, asthma, atopic dermatitis, and inflammatory bowel diseases.
  • 1.9K
  • 11 May 2021
Topic Review
Quercetin a Natural Therapeutic Candidate
This manuscript was provided as a comprehensive review of the anti-influenza virus effect of quercetin and its derivatives with critical evaluation. We provided different classifications and focused on viral pathogenesis, animal models, human studies, in silico and docking studies and molecular pathways of quercetin and derivatives effects comprehensively which is not included in similar articles. This review is a multidisciplinary collection of cell biology, biotechnology, drug development, and virus investigation.
  • 1.9K
  • 11 Jan 2021
Topic Review
Antibiotics in Avian Species
Bacterial infections are commonly diagnosed and treated with antibiotics in the avian species. Infected birds can spread zoonotic diseases such as influenza, psittacosis, pasteurellosis, and campylobacteriosis to humans, especially if they are in close contact with them, such as pet-owner settings, zoos, or pet shops. The elimination of bacterial infections in birds is therefore important for both human and avian health.
  • 1.9K
  • 08 Jun 2022
Topic Review
Eight Promising Radionuclides for TAT
Among all existing radionuclides, only a few are of interest for therapeutic applications and more specifically for targeted alpha therapy (TAT). Actinium-225, astatine-211, bismuth-212, bismuth-213, lead-212, radium-223, terbium-149 and thorium-227 are considered as the most suitable. Despite common general features, they all have their own physical characteristics that make them singular and so promising for TAT. These radionuclides were largely studied over the last two decades, leading to a better knowledge of their production process and chemical behavior,allowing for an increasing number of biological evaluations. The aim of this review is to summarize the main properties of these eight chosen radionuclides. An overview from their availability to the resulting clinical studies, by way of chemical design and preclinical studies is discussed.
  • 1.9K
  • 13 Jul 2021
Topic Review
Excipients Used for Modified Nasal Drug Delivery
Intranasal absorption is a favored route because it avoids the gastrointestinal and hepatic metabolism, leading to an increase in drug bioavailability, and a reduction in the side effects and the required dose administered. The ongoing challenging task in the field of nasal drug delivery is the maintenance of an efficient concentration of the active substance in the target area for an adequate period of time. 
  • 1.9K
  • 27 Sep 2022
Topic Review
Mechanisms of Resistance to Gemcitabine
Gemcitabine is still the standard-of-care chemotherapeutic drug for pancreatic ductal adenocarcinoma (PDAC). However, the response rate is quite low. There are multiple mechanisms and participants in gemcitabine resistance.
  • 1.9K
  • 01 Jun 2022
Topic Review
Drug Discovery Research around Tetanus Toxin Fragment C
Tetanus caused by the tetanus toxin (TT) is a fatal illness, which despite the existence of a vaccine, led to an estimated 34,684 deaths in 2019. TT is a neurotoxin produced by Clostridium tetani, a Gram-positive pathogenic bacterium, mainly found in soil and the gastrointestinal tracts of animals. TT induces the inhibition of neurotransmitter release, leading to spastic paralysis in a four-step process. First, TT binds to specific receptors, mainly composed of lipids and gangliosides, found at the neuromuscular junction (NMJ). Another receptor is reached by TT after these first bindings: a protein receptor responsible for its internalization (second step). This double receptor binding is responsible for the high affinity between TT and nerve cells. Third, TT is then transported into the cell body via axonal retrograde transport. In the last step, the proteolytic cleavage by TT of the VAMP/synaptobrevin, a neuronal substrate, leads to the inhibition of neurotransmitter release. All of these biological properties can be distinct associated parts of the TT structure. TT is a 150.7 kDa protein composed of a 52.4 kDa light chain and a 98.3 kDa heavy chain linked by a disulfide bond.
  • 1.9K
  • 26 Aug 2022
Topic Review
Spray Drying for Direct Compression
Direct compression is a simple, quick and cost-effective drug manufacturing approaches of tableting.
  • 1.9K
  • 25 Feb 2021
Topic Review
Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance
Efflux pump inhibitors, small molecules capable of restoring the effectiveness of existing antibiotics, are considered potential solutions to antibiotic resistance and have been an active area of research in recent years. Efflux pump inhibitors block efflux pumps through one or more processes, which can inactivate drug transport. 
  • 1.8K
  • 05 Feb 2024
Topic Review
Phytochemicals mitigate AD mitochondrial dysfunctions
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a decline in cognitive function and neuronal damage. Although the precise pathobiology of AD remains elusive, accumulating evidence suggests that mitochondrial dysfunction is one of the underlying causes of AD. Mutations in mitochondrial or nuclear DNA that encode mitochondrial components may cause mitochondrial dysfunction. In particular, the dysfunction of electron transport chain complexes, along with the interactions of mitochondrial pathological proteins are associated with mitochondrial dysfunction in AD. Mitochondrial dysfunction causes an imbalance in the production of reactive oxygen species, leading to oxidative stress (OS) and vice versa. Neuroin-flammation is another potential contributory factor that induces mitochondrial dysfunction. Phy-tochemicals or other natural compounds have the potential to scavenge oxygen free radicals and enhance cellular antioxidant defense systems, thereby protecting against OS-mediated cellular damage. Phytochemicals can also modulate other cellular processes, including autophagy and mitochondrial biogenesis.
  • 1.8K
  • 25 Mar 2021
Topic Review
Nanoemulsions
Nanoemulsions (NEs) are lipophilic systems with nanoscale globules that can be absorbed e.g. through the nasal mucosa, and are therefore being explored for nose-to-brain delivery of drugs. These can be either oil-in-water (o/w) or water-in-oil (w/o) emulsions. Especially, o/w NEs are a promising option for the encapsulation of lipophilic drugs, protecting them from enzymatic degradation, increasing their solubility in liquid media, modulating their drug release, and improving their bioavailability.
  • 1.8K
  • 04 Jan 2021
Topic Review
Secondary Metabolites Based-Plant Origin
Natural products are compounds produced by living organisms and can be divided into two main categories: primary (PMs) and secondary metabolites (SMs). Plant PMs are crucial for plant growth and reproduction since they are directly involved in living cell processes, whereas plant SMs are organic substances directly involved in plant defense and resistance. SMs are divided into three main groups: terpenoids, phenolics and nitrogen-containing compounds. The SMs contain a variety of biological capabilities that can be used as flavoring agents, food additives, plant-disease control, strengthen plant defenses against herbivores and, additionally, it can help plant cells to be better adapted to the physiological stress response. 
  • 1.8K
  • 28 Feb 2023
Topic Review
Human Endogenous Retrovirus in Neurodegeneration
Human endogenous retroviruses (HERVs) are ancient retroviral DNA sequences established into germline. They contain regulatory elements and encoded proteins few of which may provide benefits to hosts when co-opted as cellular genes. Their tight regulation is mainly achieved by epigenetic mechanisms, which can be altered by environmental factors, e.g., viral infections, leading to HERV activation. This review summarizes the recent advances on the epigenetic mechanisms controlling HERV expression and the pathogenic effects triggered by HERV de-repression leading to neurological diseases, inflammatory processes and neurodegeneration.
  • 1.8K
  • 04 Jun 2021
  • Page
  • of
  • 54
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback