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Topic Review
Different Sources of Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are pluripotent stem cells found in the bone marrow and are important for making and repairing bone tissue such as cartilage, bone, and fat in the bone marrow. With age and disease, mesenchymal stem cells are primarily transformed into lipid-accumulating adipocytes.
  • 751
  • 30 Mar 2022
Topic Review
Multilayer Mesenchymal Stem Cell Sheets
Cell and gene therapies have been developing dramatically over the past decade. To face and adapt to the development of these new therapies, the Food and Drug Administration (FDA) wrote and updated new guidelines from 2016 and keep updating them. Mesenchymal stem cells (MSCs) are the most used cells for treatment, far ahead from the induced pluripotent stem cells (iPSCs), based on registered clinical trials at clinicaltrials.gov. They are widely used because of their differentiation capacity and their anti-inflammatory properties, but some controversies still require clear answers. Additional studies are needed to determine the dosage, the number, and the route of injections (location and transplantation method), and if allogenic MSCs are safe compared to autologous MSC injection, including their long-term effect. In this review, we summarized the research our company is conducting with the adipose stromal cells in engineering cell sheets and their potential application
  • 750
  • 22 Sep 2021
Topic Review
Carbohydrates for Drug Delivery and Tissue Engineering
Carbohydrate-based biomaterials are a unique platform for active molecular transport and targeted drug delivery, providing biocompatibility, biodegradability, and a reduction in toxic side effects.
  • 749
  • 27 Jun 2023
Topic Review
Emerging Trends in Biodegradable Microcarriers for Therapeutic Applications
Microcarriers (MCs) are adaptable therapeutic instruments that may be adjusted to specific therapeutic uses, making them an appealing alternative for regenerative medicine and drug delivery. MCs can be employed to expand therapeutic cells. MCs can be used as scaffolds for tissue engineering, as well as providing a 3D milieu that replicates the original extracellular matrix, facilitating cell proliferation and differentiation. Drugs, peptides, and other therapeutic compounds can be carried by MCs. The surface of the MCs can be altered, to improve medication loading and release, and to target specific tissues or cells. Allogeneic cell therapies in clinical trials require enormous volumes of stem cells, to assure adequate coverage for several recruitment locations, eliminate batch to batch variability, and reduce production costs. Commercially available microcarriers necessitate additional harvesting steps to extract cells and dissociation reagents, which reduces cell yield and quality. To circumvent such production challenges, biodegradable microcarriers have been developed.
  • 748
  • 24 Mar 2023
Topic Review
Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways
The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaffolding performance, cellular interactions and their physico-chemical and biological properties in comparison to analogue composites without nanoparticles. Combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine. 
  • 746
  • 28 Feb 2022
Topic Review
Extracellular Vesicles as Novel Treatments
Mesenchymal stem/stromal cells (MSCs) represent a promising therapy for musculoskeletal diseases. There is compelling evidence indicating that MSC effects are mainly mediated by paracrine mechanisms and in particular by the secretion of extracellular vesicles (EVs). Many studies have thus suggested that EVs may be an alternative to cell therapy with MSCs in tissue repair.
  • 745
  • 14 Oct 2021
Topic Review
Bone Cell Function and Importance
The main functions of bone tissue include: structural support; protection of internal organs and soft tissues from damage; locomotion; mineral storage; production of blood cells; endocrine regulation.
  • 744
  • 22 Jan 2024
Topic Review
Cortical Bone Stem Cells
The newly established mouse cortical-bone-derived stem cells (mCBSCs) are unique stem cells compared to mouse mesenchymal stem cells (mMSCs). The mCBSC-treated hearts after myocardial infarction have been reported to have greater improvement in myocardial structure and functions. 
  • 742
  • 09 Nov 2021
Topic Review
Heterotypic Multicellular Spheroids as Models of Sprouting Angiogenesis
Sprouting angiogenesis is the common response of live tissues to physiological and pathological angiogenic stimuli. Its accurate evaluation is of utmost importance for basic research and practical medicine and pharmacology and requires adequate experimental models. A variety of assays for angiogenesis were developed, none of them perfect. In vitro approaches are generally less physiologically relevant due to the omission of essential components regulating the process. However, only in vitro models can be entirely non-xenogeneic. The limitations of the in vitro angiogenesis assays can be partially overcome using 3D models mimicking tissue O2 and nutrient gradients, the influence of the extracellular matrix (ECM), and enabling cell-cell interactions.
  • 739
  • 25 Jan 2022
Topic Review
3D Dynamic Cell Culture Systems
The traditional two-dimensional (2D) cell culture methods have a long history of mimicking in vivo cell growth. 3D cell carriers have been gradually developed to provide a 3D matrix-like structure for cell attachment, proliferation, differentiation, and communication in static and dynamic culture conditions. 3D cell carriers in dynamic culture systems could primarily provide different mechanical stimulations which further mimic the real in vivo microenvironment.
  • 734
  • 30 Jan 2023
Topic Review
Extracellular Matrix (ECM)
In tissues and organs, the extracellular matrix (ECM) is an essential extracellular element that surrounds cells, characterised by its sophisticated nanoarchitecture. It is a highly hydrated structure composed of cell-secreted proteins (e.g., collagen, fibronectin, elastin, etc.), macromolecules (e.g., polysaccharides, hyaluronan, glycosaminoglycans—GAGs—and proteoglycans—PGs), and specialised soluble factors (e.g., ions, growth factor, cytokines, and hormones).
  • 733
  • 09 Oct 2023
Topic Review
Bone Remodeling in Osteoarthritis
Bone morphogenesis (osteogenesis) is the process of formation and maintenance of bone tissue and is the result of bone formation and bone resorption. Both processes, bone formation (osteoproduction) and bone resorption (osteoresorption), are functionally balanced in the creation and maintenance of optimal functional structure, or homeostasis, of the skeletal system according to functional demands. Deviation from the physiological balance of these processes is manifested in pathological osteogenesis. One morphological substrate of pathological osteogenesis is osteophyte formation in osteoarthritis (OA).
  • 731
  • 20 Sep 2023
Topic Review
Cardiac Repair and Regeneration
After more than 20 years following the introduction of regenerative medicine to address the problem of cardiac diseases, still questions arise as to the best cell types and materials to use to obtain effective clinical translation. Now that it is definitively clear that the heart does not have a consistent reservoir of stem cells that could give rise to new myocytes, and that there are cells that could contribute, at most, with their pro-angiogenic or immunomodulatory potential, there is fierce debate on what will emerge as the winning strategy.
  • 727
  • 23 May 2023
Topic Review
Fibrinogen-Thrombin-Impregnated Collagen Patch
Surgery for major salivary gland tumors, including parotidectomy, is routinely performed by head and neck surgeons.
  • 724
  • 07 Feb 2022
Topic Review
Cell-Based Therapeutic Strategies for Skin Replacement
The immune system has a crucial role in skin wound healing and the application of specific cell-laden immunomodulating biomaterials emerged as a possible treatment option to drive skin tissue regeneration. Cell-laden tissue-engineered skin substitutes have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. In particular, mesenchymal stem cells with their immunomodulatory properties can create a specific immune microenvironment to reduce inflammation, scarring, and support skin regeneration. 
  • 724
  • 09 Feb 2022
Topic Review
STAT3 Enhances Sensitivity of Glioblastoma to Cell Death
Glioblastoma is the most common primary brain cancer in adults. One reason for the development and malignancy of this tumor is the misregulation of certain cellular proteins. The oncoprotein Signal Transducer and Activator of Transcription (STAT3) that is frequently overactive in glioblastoma cells is associated with more aggressive disease and decreased patient survival. Autophagy is a form of cellular self digestion that normally maintains cell integrity and provides nutrients and basic building blocks required for growth. While glioblastoma is known to be particularly resistant to conventional therapies, recent research has suggested that these tumors are more sensitive to excessive overactivation of autophagy, leading to autophagy-dependent tumor cell death.
  • 722
  • 26 Jan 2022
Topic Review
NSCLC’s TIME
Immune checkpoint blockade (ICB) has become a major treatment for lung cancer. Better understanding of the tumor immune micro-environment (TIME) in non-small cell lung cancer (NSCLC) is urgently needed to better treat it with this type of therapy. In this review, we describe and explore how NSCLC’s TIME relates to response to ICB, as well as how to treat those with unresponsive types of TIME, which will significantly impact future research in lung cancer immunotherapy. 
  • 721
  • 28 Jun 2021
Topic Review
HIV-1M
The Congo Basin region is believed to be the site of the cross-species transmission event that yielded HIV-1 group M (HIV-1M). It is thus likely that the virus has been present and evolving in the region since that cross-species transmission. 
  • 719
  • 20 May 2021
Topic Review
3D Bioprinting of Hyaline Articular Cartilage
Hyaline articular cartilage (HAC) is a smooth, wear-resistant, highly specialized hyaline cartilage covering the epiphyses and certain anatomical areas of the bone within the synovial joint capsule. HAC reduces friction, allowing smooth joint movement. The emergence of biofabrication technologies, including three-dimensional (3D) bioprinting, at the end of the 20th century, allowed reconstructive interventions to get a second wind. Three-dimensional bioprinting creates volume constraints that mimic the structure and function of natural tissue due to the combinations of biomaterials, living cells, and signal molecules to create.
  • 717
  • 27 Jun 2023
Topic Review
MSCs and Their Derivates for Osteochondral Regeneration
Healing of articular cartilage defects presents a challenging issue, due to its regenerative shortcomings. Lacking vascularity and innervation of cartilage and low proliferative potential of chondrocytes are the main reasons for the limited healing potential of articular cartilage. Traditional reparative approaches are limited in their efficiency, hence there is a demand for novel reparative treatments. Mesenchymal stromal cells, preferred for clinical uses, can be readily derived from various sources and have been proven to have a therapeutic effect on cartilage and subchondral bone.
  • 714
  • 09 Mar 2022
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