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Topic Review
Mazer (Drinking Vessel)
A mazer is a special type of wooden drinking vessel, a wide cup or shallow bowl without handles, with a broad flat foot and a knob or boss in the centre of the inside, known technically as the print or boss. They vary from simple wood pieces all in wood to those ornamented with metalwork, often in silver or silver-gilt. They use dense impervious woods such as maple, beech and walnut wood, and get their name from the spotted or birdseye marking on the wood (Ger. Maser, spot, marking, especially on wood; cf. "measles"), or possibly maserle as a name for Acer campestre. They are a north European medieval tradition, mostly made from the 11th (or earlier) to the 16th centuries.
  • 1.3K
  • 30 Nov 2022
Topic Review
Generation Z Consumer Online Fashion Resale Participation
The fashion industry has recently embraced a circular economy due to the increased consumer awareness of environmental issues, especially among younger generations. However, it is unclear if younger consumers, especially Generation Z, are willing to consistently engage in sustainable consumption patterns, such as buying and selling pre-owned fashion products through online resale platforms.
  • 1.3K
  • 29 May 2023
Topic Review
Aluminosilicate Clay Minerals
The current focus on renewable energy sources and the circular economy favors the thermal conversion of low-quality fuels, such as biomass and waste. However, the main limitation of their usability in the power sector is the risk of slagging, fouling, ash deposition, and high-temperature corrosion. These problems may be avoided or significantly mitigated by the application of aluminosilicate clay minerals as fuel additives.
  • 1.3K
  • 13 Jun 2023
Topic Review Peer Reviewed
Food, Climate Change, and the Challenge of Innovation
Climate change is a shift in the climate’s condition that lasts for an extended period, usually decades or longer, and that may be detected by changes in the mean and variability of its parameters. The full spectrum of players and their related value-adding activities, that are a part of the food supply chain, including the disposal of food items derived from agriculture, forestry, or fisheries, are collectively called food systems. Food systems are a component of their larger economic, social, and environmental contexts. Finally, food security is the condition in which all individuals consistently have physical and financial access to adequate safe, nutritious food that satisfies their dietary needs and food choices for an active and healthy life. Climate change and its relationships with food systems and security are complex since food systems significantly contribute to climate change. However, climate change impacts food systems unpredictably, leading to food insecurity through adverse impacts on the four dimensions of food security: utilization, access, food availability, and stability. Climate change adaptation plans are urgent and include measures such as flood and climate protection, waste management and recycling, climate-smart agriculture, and analytical climatic conditions innovation equipment on agricultural processes and activities. Nevertheless, addressing the climate crisis and its adverse impacts on food security through the activation and promotion of innovation needs reliable information and intervention in many different but interconnected fields, such as institutional design, philanthropy, novel partnerships, finance, and international cooperation. In this context, this paper analyses the relationship between climate change, agriculture, and global–local strategies to ensure food security and also discusses policies’ role in fostering innovation for supporting local agro-food systems and their capacity to sustain societal needs.
  • 1.3K
  • 22 Jul 2026
Topic Review
YAP-TEAD Interaction Disruptors
This a entry that comprehensively covers the modalities that act as disruptors of the YAP-TEAD interaction. The transcriptional co-activator YAP (Yes-associated protein) by pairing with the transcription factor TEAD (TEA domain) orchestrates the expression of several oncogenic transcriptional programs. These programs are seen in a proportion of all solid tumors. Therefore, the disruption of YAP-TEAD interaction is proposed as an attractive option to target cancers.
  • 1.3K
  • 11 Jan 2021
Topic Review
Optimal Interpolation for infrared satellite data
Thermal infrared remote sensing measurements are blinded to surface emissions under cloudiness because infrared sensors cannot penetrate thick cloud layers. Therefore, surface and atmospheric parameters can be retrieved only in clear sky conditions giving origin to spatial fields flagged with missing pieces of information. Motivated by this we present a methodology to retrieve missing values of some interesting geophysical variables retrieved from spatially scattered infrared satellite observations in order to yield level 3 (L3), regularly gridded, data. The technique is based on a 2-Dimensional (2D) Optimal Interpolation (OI) scheme. The goodness of the approach has been tested on 15-min temporal resolution Spinning Enhanced Visible and Infrared Imager (SEVIRI) emissivity and surface temperature (ST) products over South Italy (land and sea), on Infrared Atmospheric Sounding Interferometer (IASI) atmospheric ammonia (NH3) concentration over North Italy and carbon monoxide (CO), sulfur dioxide (SO2) and NH3 concentrations over China. Sea surface temperature (SST) retrievals have been compared with gridded data from MODIS (Moderate-resolution Imaging Spectroradiometer) observations. For gases concentration, we have considered data from 3 different emission inventories, that is, Emissions Database for Global Atmospheric Research v3.4.2 (EDGARv3.4.2), the Regional Emission inventory in ASiav3.1 (REASv3.1) and MarcoPolov0.1, plus an independent study.
  • 1.3K
  • 30 Oct 2020
Topic Review
Nociceptive TRP Channel
Transient receptor potential (TRP) channels have emerged as key molecular identities in the sensory transduction of pain-producing stimuli. The ability of nociceptors to behave as noxious stimuli detectors relies on the presence of specialized transducing molecules at their peripheral nerve terminals capable of transforming the harmful physical (thermal and mechanical) and chemical stimuli into generator potentials. Upon nerve terminal stimulation, the output signal conveying to the central nervous system depends on the properties of transducer channels which produce generator potentials. Voltage-gated channels subsequently translate it into action potential firing. Nociceptive TRP channels are among the most studied transducer channels expressed in nociceptors and play a pivotal role in the study of pain.
  • 1.3K
  • 09 Feb 2021
Topic Review
Applications of Cactus Pear (Opuntia spp.) Peel
Cactus pear is the fruit of the nopal cactus, is native to the arid and semi-arid regions of Mexico and Mesoamerica and has spread to many regions. This fruit is commonly known as cactus pera fruit, prickly pear, tuna (Mexico), higo (Colombia) higo chumbo (Spain), fico d’India, figue de barbarie (France), among others. Cactus pear by-products are rich in bioactive compounds such as phenolics, flavonoids, pigments, fibers, polysaccharides and fatty acids. They can provide many health benefits such as inhibition and protection against free radicals, cytotoxic activity against some cancer cell lines as well as the reduction of atherosclerosis and glycaemia. However, many studies have been performed by using the pear peel for multiple purposes such as for pigment extraction a preservative for margarine, as snacks, a dietary supplement with hypoglycemic properties and in wastewater treatment.
  • 1.3K
  • 25 Nov 2022
Topic Review
Collaborative Cybersecurity Networked Organisations
The requirements to the governance of collaborative networked organisations (CNOs) can be structured in 33 categories: Geographical Representation or exclusion; Supply chain security; Involvement of external stakeholders; Standards and methodologies; Representation on senior governance bodies; Decision making principles; Auditing; Dispute/conflict management arrangements; Confidentiality & Security; IPR management; Ethics code; Use of slave labour or labour of minors; Green policies; Gender policies and representation; Transparency; Accountability ; Anti-corruption/ integrity policies; Innovation; Adaptiveness; Cohesion; Trust; Sustainability; Resilience; Communication and engagement; Knowledge management; Long-term perspective on collaboration; Interoperability; Leadership; Organisational culture; Competences; Risk management; Evidence-based decision-making; and Competitiveness. As a result of a comprehensive study for CNOs in the field of cybersecurity these governance issues have been structured in two groups (of governance objectives and CNO features) and four tiers in terms of priority. While the governance categories are universally applicable, their prioritisation is relevant for CNOs in the field of cybersecurity.
  • 1.3K
  • 28 Oct 2020
Topic Review
Indomethacin Increases HSA-Quercetin Binding
Human serum albumin (HSA) is the most abundant carrier protein in the human body. Competition for the same binding site between different ligands can lead to an increased active concentration or a faster elimination of one or both ligands. Indomethacin and quercetin both bind to the binding site located in the IIA subdomain. To determine the nature of the HSA-indomethacin-quercetin interactions, spectrofluorometric, docking, molecular dynamics studies, and quantum chemical calculations were performed. The results show that the indomethacin and quercetin binding sites do not overlap. Moreover, the presence of quercetin does not influence the binding constant and position of indomethacin in the pocket. However, binding of quercetin is much more favorable in the presence of indomethacin, with its position and interactions with HSA significantly changed. These results provide a new insight into drug-drug interactions, which can be important in situations when displacement from HSA or other proteins is undesirable or even desirable. This principle could also be used to deliberately prolong or shorten the xenobiotics' half-life in the body, depending on the desired outcomes.
  • 1.3K
  • 06 Nov 2020
Topic Review
Histone Lysine Methylation
The level and state of histone lysine methylation depends not only on the activity of histone methyltransferases (KMTs) but also on the counteracting activity of histone lysine demethylases (KDMs). The variety of methylation sites and differentially methylated states describes the level of complexity of signaling mediated by histone lysine methylation, which is involved in transcription regulation, gene silencing, genome stability and RNA processing.
  • 1.3K
  • 10 Feb 2021
Topic Review
GPCR
G protein-coupled receptors (GPCRs) are cell surface receptors that respond to a wide variety of stimuli, from light, odorants, hormones, and neurotransmitters to proteins and extracellular calcium. GPCRs represent the largest family of signaling proteins targeted by many clinically used drugs.
  • 1.3K
  • 30 Apr 2021
Topic Review
Transport Poverty in Chinese Cities
The widening income gap in post-reform China has given rise to social inequality. Among those, transport poverty and inequality have significantly affected the daily life of low-income groups. It was found that the most common causes of transport poverty include: a lack of access to private vehicles; uneven access to alternative transport options; inadequate public transport provision; jobs-housing imbalance; and the hukou system (a system of household registration which aims to regulate population distribution and rural-to-urban migration). The main impacts of transport poverty include: curtailed mobility and longer travel times; higher household expenditures on travel; reduced access to jobs and essential services; higher household expenditures on travel; and health and environmental issues.
  • 1.3K
  • 18 May 2021
Topic Review
Herbivory Exclosure
Large wild herbivores are important and natural components of forest ecosystems, but through their browsing activities have the potential to influence the structure and composition of forest communities, thus timber production and ecosystem dynamics.
  • 1.3K
  • 25 Jun 2021
Topic Review
Dengue Detection
The dengue virus (DENV) is a vector-borne flavivirus that infects around 390 million individuals each year with 2.5 billion being in danger. Having access to testing is paramount in preventing future infections and receiving adequate treatment. Currently, there are numerous conventional methods for DENV testing, such as NS1 based antigen testing, IgM/IgG antibody testing, and Polymerase Chain Reaction (PCR).
  • 1.3K
  • 05 Jul 2021
Topic Review
Antidiabetic Potential of Medicinal Plants
Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. 
  • 1.3K
  • 04 Aug 2021
Topic Review
Tumor Heterogeneity in ESCC
Esophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy, with hitherto dismal clinical outcome. Genomic analyses of patient samples reveal a complex heterogeneous landscape for ESCC, which presents in both intertumor and intratumor forms, manifests at both genomic and epigenomic levels, and contributes significantly to tumor evolution, drug resistance, and metastasis.
  • 1.3K
  • 12 Oct 2021
Topic Review
Keratinophilic Fungi from Feathers of Birds
Although keratinophilic fungi on avian feathers have been widely described, data from European literature are quite lacking regarding Mediterranean countries. The aim of the present study was therefore to evaluate the occurrence of fungal species on feathers of different avian species in Italy. A total of 378 feather samples from both aquatic (n = 254) and terrestrial birds (n = 124), for a total of 30 bird species, were cultured for keratinophilic fungi. Fungal isolates were recognized by their macro- and micro-scopical morphology, and results were corroborated by PCR and sequencing. Keratinophilic fungi belonging to 11 different species (Scopulariopsis brevicaulis, Chrysosporium keratinophilum, Trichophyton terrestre, Microsporum gypseum, Sepedonium sp., Chrysosporium pannorum, Myriodontium sp., Chrysosporium tropicum, Chrysosporium pruinosum, Chrysosporium luteum and Aphanoascus fulvescens) were isolated from 71 animals (18.8%). The frequency of isolation of keratinophilic species from terrestrial birds was significantly higher in waterfowl. Migratory birds in Italy have been proven to carry pathogenic fungi such as dermatophytes, (A. platyrhyncos, A. crecca, E. rubecula), besides saprophytic species.
  • 1.3K
  • 16 Dec 2021
Topic Review
ROS in the Pathogenesis of CHF Development
With respect to structural and functional cardiac disorders, heart failure (HF) is divided into HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Oxidative stress contributes to the development of both HFrEF and HFpEF. Identification of a broad spectrum of reactive oxygen species (ROS)-induced pathways in preclinical models has provided new insights about the importance of ROS in HFrEF and HFpEF development. 
  • 1.3K
  • 15 Mar 2022
Topic Review
Millimeter-Wave Radar Road Traffic Target Detection
Using millimeter-wave radar as a monitoring system has raised increased in various fields attributed to its high detection accuracy and weather resistance. In road traffic applications, accurate acquisition of moving target information such as pedestrians and vehicles on the road is one of traffic radar’s most basic and essential tasks. With the development of intelligent transportation systems, the timely reflection of road conditions and realization of traffic accident warnings become necessary, which puts higher requirements on the low processing delay of radar systems.
  • 1.3K
  • 29 Apr 2022
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