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Santini, A. Antidiabetic Potential of Medicinal Plants. Encyclopedia. Available online: (accessed on 15 June 2024).
Santini A. Antidiabetic Potential of Medicinal Plants. Encyclopedia. Available at: Accessed June 15, 2024.
Santini, Antonello. "Antidiabetic Potential of Medicinal Plants" Encyclopedia, (accessed June 15, 2024).
Santini, A. (2021, August 02). Antidiabetic Potential of Medicinal Plants. In Encyclopedia.
Santini, Antonello. "Antidiabetic Potential of Medicinal Plants." Encyclopedia. Web. 02 August, 2021.
Antidiabetic Potential of Medicinal Plants

Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. 

Diabetes mellitus medicinal plants antidiabetic hypoglycemic antihyperglycemic

1. Introduction

Diabetes mellitus (DM) is a serious, chronic, and complex metabolic disorder of multiple aetiologies with profound consequences, both acute and chronic [1]. Also known only as diabetes, DM and its complications affect people both in the developing and developed countries, leading to a major socioeconomic challenge. It is estimated that 25% of the world population is affected by this disease [2]. Genetic and environmental factors contribute significantly to the development of diabetes [3]. During the development of diabetes, the cells of the body cannot metabolize sugar properly due to deficient action of insulin on target tissues resulting from insensitivity or lack of insulin (a peptide hormone that regulates blood glucose). The inability of insulin to metabolize sugar occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. This triggers the body to break down its own fat, protein, and glycogen to produce sugar, leading to the presence of high sugar levels in the blood with excess by-products called ketones being produced by the liver [4][5]. Diabetes is distinguished by chronic hyperglycemia with disturbances in the macromolecules’ metabolism as a result of impairments in insulin secretion, insulin action, or both. Diabetes causes long-term damage, dysfunction, and failure of various organ systems (heart, blood vessels, eyes, kidneys, and nerves), leading to disability and premature death [6]. The severity of damage triggered by hyperglycemia on the respective organ systems may be related to how long the disease has been present and how well it has been controlled. Several symptoms such as thirst, polyuria, blurring of vision, and weight loss also accompany diabetes [7].

2. Medicinal Plants as an Alternative Source of Antidiabetic Agents

Natural products, particularly of plant origin, are the main quarry for discovering promising lead candidates and play an imperative role in the upcoming drug development programs [8][9][10]. Ease of availability, low cost, and least side effects make plant-based preparations the main key player of all available therapies, especially in rural areas [11]. Moreover, many plants provide a rich source of bioactive chemicals, which are free from undesirable side effects and possess powerful pharmacological actions [12][13][14][15][16][17][18]. Plants also have always been an exemplary source of drugs with many of the currently available drugs being obtained directly or indirectly from them [2][13][14][15]. The recent review of Durazzo et al. [19] gives a current snapshot of the strict interaction between the main biologically active compounds in plants and botanicals by giving a mini overview of botanicals features, a definition of the study, and examples of innovative (i.e., an assessment of the interaction of bioactive compounds, chemometrics, and the new goal of biorefineries) and a description of existing databases (i.e., plant metabolic pathways, food composition, bioactive compounds, dietary supplements, and dietary markers); in this regard, the authors marked the need for categorization of botanicals as useful tools for health research [19].
For centuries, many plants have been considered a fundamental source of potent antidiabetic drugs. In developing countries, particularly, medicinal plants are used to treat diabetes to overcome the burden of the cost of conventional medicines to the population [2]. Nowadays, treatments of diseases including diabetes using medicinal plants are recommended [20] because these plants contain various phytoconstituents such as flavonoids, terpenoids, saponins, carotenoids, alkaloids, and glycosides, which may possess antidiabetic activities [21]. Also marked by Durazzo et al. [19], the combined action of biologically active compounds (i.e., polyphenols, carotenoids, lignans, coumarins, glucosinolates, etc.) leads to the potential beneficial properties of each plant matrix, and this can represent the first step for understanding their biological actions and beneficial activities. Generally, the main current approaches of study [22][23] of the interactions of phytochemicals can be classified: (i) model system development of interactions [24][25][26]; (ii) study of extractable and nonextractablecompounds [27][28]; or (iii) characterization of biologically active compound-rich extracts [29][30].
The antihyperglycemic effects resulting from treatment with plants are usually attributed to their ability to improve the performance of pancreatic tissue, which is done by increasing insulin secretions or by reducing the intestinal absorption of glucose [2].
The number of people with diabetes today has been growing and causing increasing concerns in the medical community and the public. Despite the presence of antidiabetic drugs in the pharmaceutical market, the treatment of diabetes with medicinal plants is often successful. Herbal medicines and plant components with insignificant toxicity and no side effects are notable therapeutic options for the treatment of diabetes around the world [31]. Most tests have demonstrated the benefits of medicinal plants containing hypoglycemic properties in diabetes management. Ríos et al. [32] described medicinal plants (i.e., aloe, banaba, bitter melon, caper, cinnamon, cocoa, coffee, fenugreek, garlic, guava, gymnema, nettle, sage, soybean, green and black tea, turmeric, walnut, and yerba mate) used for treating diabetes and its comorbidities and the mechanisms of natural products as antidiabetic agents, with attention to compounds of high interest such as fukugetin, palmatine, berberine, honokiol, amorfrutins, trigonelline, gymnemic acids, gurmarin, and phlorizin. The current review of Bindu and Narendhirakannan [33] has categorized and described from literature 81 plants native to Asian countries with antidiabetic, antihyperglycemic, hypoglycemic, anti-lipidemic, and insulin-mimetic properties.
In the Artemisia genus, Artemisia absinthium is one of the traditional medicinal plant used for diabetes treatment [34]Artemisia afra is one of the popular herbal medicines used in the southern part of Africa [35]Artemisia herba-alba is a traditional medicinal plant [36], and its aqueous extract of the leaves and barks reduces blood glucose levels [37]Solanum americanum is a traditional medicine used in Guatemala [38], while Solanum viarum is used in India [39]Terminalia arjuna is a plant used in India and Bangladesh [40] and exhibits amylase inhibition (IC50 value of 302 μg/mL) [41]Terminalia chebula is a medicinal plant used in India [42], Bangladesh [43], Thailand [44], and Iran [45]Euphorbia ligularia [46]Euphorbia neriifolia [47], and Euphorbia caducifolia [48] are some of the plants traditionally used in India. Similarly, Euphorbia thymifolia and Euphorbia hirta are used in Bangladesh [49][50], and Euphorbia kansui is a Korean traditional medicinal plant used for diabetes treatment [51]Allium cepaMangifera indicaMurraya koenigii, and Phyllanthus amarus reduce triglycerides (TG), total cholesterol (TC), and very low-density lipoproteins (VLDL) levels and exhibit antidiabetic and hypolipidemic effects [52].

3. Medicinal Plants with Antidiabetic Potential

3.1. Preclinical In Vitro/In Vivo (Animal) Studies

Several plant species having hypoglycemic activity have been available in the literature; most of these plants contain bioactive compounds such glycosides, alkaloids, terpenoids, flavonoids, carotenoids, etc., that are frequently implicated as having an antidiabetic effect. In this section, plant species with antidiabetic potential will be organized in alphabetical order (Table 1).
Table 1. Plant extracts with antidiabetic potential.
Species Extract Part of the Plant Dosage (mg/kg) Experimental Model Induction of Diabetes Reference
Acacia arabica chloroform bark 250, 500 male Wistar rats and albino mice alloxan [53]
chloroform bark 100, 200 female albino rats streptozotocin [54]
Achyranthes rubrofusca aqueous and ethanolic leaves 200 rats alloxan [55]
Albizzia lebbeck methanol/dichloro-methane stem bark 100, 200, 300, 400 male albino Wistar rats streptozotocin [56]
methanolic bark 200, 350, 620 female Sprague–Dawley rats streptozotocin-nicotinamide [57]
Aloe vera aqueous leaves 130 swiss albino mice streptozotocin [58]
ethanolic leaves 300 male albino Wistar rats streptozotocin [59]
Amaranthus tricolor methanolic whole plant 50, 100, 200, 400 male swiss albino mice glucose-induced hyperglycemia [60]
Anacardium occidentale aqueous leaves 175 male albino Wistar rats streptozotocin [61]
methanolic leaves 100 female albino mice streptozotocin [62]
Azadirachta indica ethanolic leaves 200 adult rabbits alloxan [63]
Barleria prionitis ethanolic leaves and root 200 adult albino rats alloxan [64]
Bauhinia thoningii aqueous leaves 500 Wistar albino rats alloxan [65]
Caesalpinia ferrea aqueous stem bark 300, 450 male Wistar rats streptozotocin [66]
Camellia sinensis crude tea leaves 0.5 mL/day male albino mice streptozotocin [67]
Casearia esculenta Roxb aqueous root 200, 300 male albino Wistar rats streptozotocin [68]
Cassia fistula ethanolic stem bark 250, 500 Wistar rats alloxan [69]
Cassia grandis aqueous and ethanolic stem 150 male albino Wistar rats alloxan [70]
Catharanthus roseus dichloromethane-methanol leaves and twigs 500 male Sprague–Dawley rats streptozotocin [71]
ethanolic leaves 100, 200 male Wistar rats streptozotocin [72]
Cecropia pachystachya methanolic leaves 80 male Wistar rats alloxan [73]
Ceriops decandra ethanolic leaves 30, 60, 120 male albino Wistar rats alloxan [74]
Chiliadenus iphionoides ethanolic aerial parts 1000 male and female diabetes-prone Psammomys obesus - [75]
Cinnamomum cassia ethanolic bark 200, 300 male Kunming mice streptozotocin [76]
Cinnamomum japonica ethanolic bark 200, 300 male Kunming mice streptozotocin [76]
Citrullus colocynthis aqueous root 2000 male and female Wistar rats and Swiss albino mice alloxan [77]
aqueous seed 1, 2 mL/kg male Wistar albino rats alloxan [78]
Coscinium fenestratum ethanolic stem 250 male albino Wistar rats streptozotocin-nicotinamide [79]
Eucalyptus citriodora aqueous leaves 250, 500 albino rats alloxan [80]
Gymnema sylvestre ethanolic leaves 100 male Sprague–Dawley rats streptozotocin [81]
Heinsia crinata ethanolic leaves 450–1350 rats alloxan [82]
Helicteres isora butanol and aqueous ethanol roots 250 male Wistar rats alloxan [83]
Momordica charantia aqueous pulp 13.33 g pulp/kg male albino Wistar rats alloxan [84]
ethanolic fruit 200 adult rabbits alloxan [63]
ethanolic fruit 400 male Sprague–Dawley rats streptozotocin [85]
Moringa oleifera methanolic pod 150, 300 Wistar albino rats streptozotocin [86]
- leaves 50 male Sprague–Dawley rats alloxan [87]
Murraya koenigii aqueous leaves 200, 300, 400 male albino rabbits alloxan [88]
ethanolic leaves 100, 250 male albino Swiss mice dexamethasone [89]
Opuntia ficus-indica petroleum ether stems 200 male ICR mice streptozotocin [90]
Origanum vulgare methanolic leaves 5 male C57BL/6 mice streptozotocin [91]
Passiflora nitida hydro-ethanolic leaves 50 female Wistar rats streptozotocin [92]
Paspalum scrobiculatum aqueous and ethanolic grains 250, 500 male Wistar albino rats alloxan [93]
Persea americana hydro-alcoholic leaves 150, 300 male Wistar rats streptozotocin [94]
aqueous seed 20, 30, 40 g/L male Wistar albino rats alloxan [95]
Phoenix dactylifera ethanolic leaves 50-400 male Wistar rats alloxan [96]
Phyllanthus niruri aqueous leaves 200, 400 male Wistar rats streptozotocin-nicotinamide [97]
Phyllanthus simplex petroleum ether, ethyl acetate, methanol and water fraction   100–400 rats alloxan [98]
Picralima nitida methanolic steam bark and leaves 75, 150, 300 Wistar rats streptozotocin [99]
Piper longum aqueous root 200, 300, 400 male Wistar albino rats streptozotocin [100]
Sonchus oleraceus hydro-alcoholic whole plant 75, 150, 300 Wistar rats streptozotocin [99]
Syzygium jambolana ethanolic seed 200 adult rabbits alloxan [63]
Tamarindus indica ethanolic stem bark 250, 500 Wistar rats alloxan [69]
ethanolic seed coat 500 Wistar albino rats alloxan [101]
Terminalia chebula chloroform seed 100, 200, 300 male Sprague–Dawley rats streptozotin [102]
Terminalia catappa petroleum ether, methanol and aqueous fruit 68, 40, 42 Wistar albino rats and mice alloxan [103]
Trigonella foenum-graecum ethanolic seed 100, 500, 1000, 2000 male Wistar albino rats alloxan [104]
hydro-alcoholic seed 500, 1000, 2000 Sprague–Dawley rats alloxan [105]
Vaccinium arctostaphylos ethanolic fruit 200, 400 male Wistar rats alloxan [106]
Vernonia amygdalina aqueous leaves 100 Wistar albino rats alloxan [107]
Witheringia solanacea aqueous leaves 500, 1000 male Sprague–Dawley rats GTT [108]
Zaleya decandra ethanolic roots 200 Wistar albino rats alloxan [109]
Zizyphus mauritiana petroleum ether, chloroform, acetone, ethanol and aqueous fruit 200, 400 female Wistar rats alloxan [110]
* unless otherwise noted, GTT glucose tolerance test; ICR Institute of Cancer Research.

3.1.1. Acacia arabica (Fabaceae)

Two doses of chloroform extracts of Acacia arabica (250 and 500 mg/kg, p.o. (orally) for two weeks) were evaluated in alloxan-induced diabetic albino rats [53]. The results of this study showed an antidiabetic effect in the two doses tested, decreasing serum glucose level and restoring TC, TG, and high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels. Additionally, in this study chloroform extracts of Benincasa hispida fruit, Tinispora cordifolia stem, Ocimum sanctum aerial parts, and Jatropha curcus leaves were evaluated, showing similar effects.
In another study performed in streptozotocin-induced diabetic rats, the extract of Acacia arabica (100 and 200 mg/kg, p.o. for 21 days) provoked a significantly decrease in serum glucose, TC, TG, LDL, and malonyldialdehyde (MDA) levels and a significantly increase in HDL and coenzyme Q10 in a dose-dependent manner [54].

3.1.2. Achyranthes rubrofusca (Amaranthaceae)

Hypoglycemic activity of the aqueous and ethanolic extracts of Achyranthes rubrofusca leaves was studied in alloxan-induced diabetic rats [55]. The two extracts (200 mg/kg, p.o. for 28 days) significantly decreased the blood glucose level and increased pancreatic enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione levels. Better results were obtained with the aqueous extract but were not statistically significant.

3.1.3. Albizzia lebbeck (Fabaceae)

Oral administration of a methanol/dichloromethane extract from Albizzia lebbeck Benth. stem bark (100, 200, 300, or 400 mg/k, for 30 days) was evaluated in streptozotocin-induced diabetic rats [56]. The treatment significantly decreased fasting blood glucose (FBG) and glycated hemoglobin and enhanced plasma insulin levels. Moreover, it significantly decreased the levels of TC, TG, LDL, and VLDL and significantly increased the level of HDL. The treatment also resulted in a marked increase in reduced glutathione, glutathione peroxidase, CAT, and SOD and a diminished level of lipid peroxidation in liver and kidneys of streptozotocin-induced diabetic rats. Moreover, the histopathological analysis of the pancreas, liver, kidney, and heart showed that the treatment protected these organs in diabetic rats and reduced the lesions in a dose-dependent manner. In another study in streptozotocin-nicotinamide-induced diabetic rats, the methanolic extract of Albizzia lebbeck bark significantly decreased the level of serum glucose, creatinine, urea, TC, TG, LDL, and VLDL and increased HDL level [57].

3.1.4. Aloe vera (Asphodelaceae)

Aloe vera extract was evaluated in streptozotocin-induced diabetic mice and in mouse embryonic NIH/3T3 cells [58]. Administration of an extract at a dosage of 130 mg/kg per day for four weeks resulted in a significant decrease in blood glucose, TG, LDL, and TC, an effect comparable to that of metformin. Moreover, this study showed that a lyophilized aqueous aloe extract (1 mg/mL) upregulated GLUT-4 mRNA synthesis in NIH/3T3 cells. In a more recent study, Aloe vera extract (300 mg/kg) exerted antidiabetic effects by improving insulin secretion and pancreatic β-cell function by restoring pancreatic islet mass in streptozotocin-induced diabetic rats [59].

3.1.5. Amaranthus tricolor (Amaranthaceae)

Methanolic extract of Amaranthus tricolor whole plant at different doses (50, 100, 200, or 400 mg/kg) was administered one hour before glucose administration in the oral glucose tolerance test (GTT) [60]. The results of this study showed significant antihyperglycemic activity in glucose-loaded mice at all doses of the extract tested, with the maximum effect observed at the maximum dose tested and with an effect comparable to glibenclamide (10 mg/kg).

3.1.6. Anacardium occidentale (Anacardiaceae)

Hypoglycemic role of Anacardium occidentale was reported in streptozotocin-induced diabetic rats [61]. The rats were treated with 175 mg/kg of the aqueous extract, twice daily, beginning 2 days before streptozotocin injection. Three days after streptozotocin administration, there was a significantly lower blood glucose level in pretreated rats compared to control diabetic rats. Moreover, the treatment prevented glycosuria, body weight loss, polyphagia, and polydipsia. A more recent study performed with 100 mg/kg of methanol extract for 30 days showed a decrease of blood glucose levels of streptozotocin-induced diabetic rats and comparable effects to the standard drug Pioglitazone [62].

3.1.7. Azadirachta indica (Meliaceae)

One study was designed to evaluate the hypoglycemic effects of different plant extracts (Azadirachta indica leaves, Momordica charantia fruits, and Syzygium jambolana seeds) in single and in combined formulation in alloxan-induced diabetic rabbits [63]. Treatment of diabetes with plant extracts started at 8 days after alloxan injection. A dose of 200 mg/kg of an ethanol extract from the leaves of Azadirachtaindica caused a hypoglycemic effect 72 h after administration in diabetic rabbits, with a persistence of up to 24 h.

3.1.8. Barleria prionitis (Acanthaceae)

Antidiabetic activity of alcoholic extracts of leaf and root of Barleria prionitis (200 mg/kg, p.o. for 14 days) was tested in alloxan-induced diabetic rats [64]. Animals treated with leaf extract significantly decreased blood glucose and glycosylated hemoglobin levels. Moreover, serum insulin and liver glycogen levels were significantly increased. The root extract showed a moderate but nonsignificant antidiabetic activity.

3.1.9. Bauhinia thoningii (Fabaceae)

A study conducted on alloxan-induced diabetic rats showed the antidiabetic effect of aqueous leaf extract from Bauhinia thoningii [65]. The extract administered orally at a dose of 500 mg/kg for seven days provoked a significant reduction in blood glucose, LDL, and coronary risk index.

3.1.10. Caesalpinia ferrea (Fabaceae)

Aqueous extract of the stem bark of Caesalpinia ferrea (300 and 450 mg/kg, daily for four weeks) was administered orally to streptozotocin-induced diabetic rats [66]. The results of this study showed a significant reduction of blood glucose levels and an improvement of the metabolic state of the animals (low levels of TC, TG, and epididymis adipose tissue).

3.1.11. Camellia sinensis (Theaceae)

The hypoglycemic activity of the crude tea leaves extract of Camellia sinensis was investigated on streptozotocin-induced diabetic mice [67]. The tea (0.5 mL/day) was administered for 15 and 30 days and caused antihyperglycemic and hypolipidemic (TG and TC) activities in diabetic rats. Moreover, protective effects such as recovery of certain altered hematobiochemical parameters—creatinine, urea, uric acid, aspartate aminotransferase (AST), and alanine aminotransferase (ALT)—and reduced body weight were observed.

3.1.12. Casearia esculenta (Flacourtiaceae)

The extract of Casearia esculenta root in streptozotocin-induced diabetic rats (200 and 300 mg/kg, p.o. for 45 days) significantly restored levels of glucose, urea, uric acid, creatinine, and albumin; the albumin/globulin ratio; and the activities of diagnostic marker enzymes AST, ALT, alkaline phosphatase (ALP), and γ-glutamyltranspeptidase (GGT) [68].

3.1.13. Cassia fistula (Fabaceae)

Alcoholic extracts of stem bark of Cassia fistula administered to alloxan-induced diabetic rats at 250 or 500 mg/kg for 21 days significantly decreased blood glucose levels [69]. The extract also recovered normal levels of serum cholesterol, TG, creatinine, albumin, total proteins, and body weight. Moreover, the alcoholic extract showed significant antioxidant activity by reducing 2,2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide, and hydroxyl radical induced in vitro.

3.1.14. Cassia grandis (Fabaceae)

The aqueous and ethanolic extracts of Cassia grandis (150 mg/kg, p.o. for 10 days treatment) were evaluated for antidiabetic activity by a GTT in normal rats and alloxan-induced diabetic rats [70]. The two extracts showed antidiabetic potential, decreasing the blood glucose, TC, and TG levels.

3.1.15. Catharanthus roseus (Apocynaceae)

Dichloromethane-methanol extracts of Catharanthus roseus leaves and twigs in streptozotocin-induced diabetic rats significantly reduced blood glucose levels and hepatic enzyme activities of glycogen synthase, glucose 6-phosphate-dehydrogenase, succinate dehydrogenase, and malate dehydrogenase [71]. In another study performed in streptozotocin-induced diabetic rats, the ethanolic extracts of Catharanthus roseus (100 and 200 mg/kg) detrained the glucose transport system in the liver for 4 weeks and significantly amplified the expression of the GLUT gene [72].

3.1.16. Cecropia pachystachya (Urticaceae)

The hypoglycemic effect of the methanolic extract from the leaves of Cecropia pachystachya was tested in normal, glucose loading, and alloxan-induced diabetic rats [73]. The methanolic extract provoked a significant hypoglycemic effect, which resulted in a 68% reduction of blood glucose after 12 h of induction. Moreover, the extract presented relevant antioxidant activity with IC50 = 3.1 µg/mL (DPPH assay) and EC50 = 10.8 µg/mL (reduction power).

3.1.17. Ceriops decandra (Rhizophoraceae)

The antidiabetic effects of daily oral administration of an ethanolic extract from Ceriops decandra leaves (30, 60, and 120 mg/kg) for 30 days were evaluated in normal and alloxan-induced diabetic rats [74]. Oral administration of 120 mg/kg of the extract modulated all the determined parameters (blood glucose, hemoglobin, liver glycogen, and some carbohydrate metabolic enzymes) to levels seen in control rats. Furthermore, these dose effects were comparable to those of glibenclamide.

3.1.18. Chiliadenus iphionoides (Asteraceae)

The ethanolic extracts of Chiliadenus iphionoides aerial parts increased insulin secretion from β cells and glucose uptake by adipocytes and skeletal myotubes, in vitro [75]. Moreover, a 30-day oral starch tolerance test was performed on a sand rat, showing hypoglycemic activity.

3.1.19. Cinnamomum cassia and Cinnamomum japonica (Lauraceae)

Cinnamon bark extracts were administered at doses of 200 and 300 mg/kg for 14 days in high-fat, diet-fed, and low-dose streptozotocin-induced diabetic mice [76]. The results of this study showed that Cinnamomum cassia and Cinnamomum japonica bark extracts significantly decreased blood glucose concentration. Also, cinnamon extracts significantly increased the consumption of extracellular glucose in insulin-resistant HepG2 cells and normal HepG2 cells compared with controls, suggesting an insulin sensitivity improvement.

3.1.20. Citrullus colocynthis (Cucurbitaceae)

The effect of root extracts of Citrullus colocynthis was investigated on the biochemical parameters of normal and alloxan-induced diabetic rats [77]. Aqueous extracts of the roots showed a significant reduction in blood sugar levels when compared with chloroform and ethanol extracts. Moreover, the aqueous extract improved body weight and serum creatinine, urea, protein, and lipids and restored levels of total bilirubin, conjugated bilirubin, AST, ALT, and ALP. In another study in alloxan-induced diabetic rats, Citrullus colocynthis aqueous seed extract stabilized animal body weight and ameliorated hyperglycemia in a dose- and time-dependent manner, which was attributable to the regenerative effect on β cells and intra-islet vasculature [78].

3.1.21. Coscinium fenestratum (Menispermaceae)

Alcoholic extract of the stems of Coscinium fenestratum in streptozotocin-nicotinamide-induced diabetic rats regulates glucose homeostasis and decreased gluconeogenesis [79]. The drug also has a protective action on cellular antioxidant defense.

3.1.22. Eucalyptus citriodora (Myrtaceae)

Aqueous extract of Eucalyptus citriodora leaf in alloxan-induced diabetic rats (250 and 500 mg/kg, p.o. for 21 days) significantly reduced blood glucose levels [80].

3.1.23. Gymnema sylvestre (Apocynaceae)

An ethanolic extract of Gymnema sylvestre leaf (100 mg/kg, p.o. for 4 weeks) was examined in vitro and in vivo to investigate the role of antioxidants in streptozotocin-induced diabetic rats [81]. The ethanol extract showed antihyperglycemic activity and improved the antioxidant status in diabetic rats. Moreover, the extract showed in vitro antioxidant activity in thiobarbituric acid (TBA), SOD, and 2,2-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid assays.

3.1.24. Heinsia crinata (Rubiaceae)

Ethanolic extract of Heinsia crinata leaf in alloxan-induced diabetic rats (450–1350 mg/kg, p.o. for two weeks) significantly reduced the FBG levels [82].

3.1.25. Helicteres isora (Sterculiaceae)

Butanol and aqueous ethanol extracts of Helicteres isora root (250 mg/kg, p.o. for 10 days) were investigated in alloxan-induced diabetic rats [83]. The two treatments reduced blood glucose, TC, TG, and urea levels. Further histological examination showed the restoration of pancreatic islets, kidney glomeruli, and liver to their normal sizes.

3.1.26. Momordica charantia (Cucurbitaceae)

One study evaluated the antihyperglycemic and antioxidative potential of aqueous extracts of Momordic charantia pulp and Trigonella foenum-graecum seed in alloxan-induced diabetic rats [84]. The Momordica charantia extract treatment for 30 days significantly decreased the blood glucose levels and showed antioxidant potential to protect vital organs such as heart and kidney against damage caused by diabetes-induced oxidative stress. Furthermore, a similar activity was found with the Trigonella foenum-graecum extract treatment. In another study already reported [63], an antidiabetic effect from Momordica charantia leaves (200 mg/kg) was observed in rabbits 72 h after they were fed a methanolic extract. In a recent study performed in streptozotocin-induced diabetic rat, the treatment of 400 mg/kg of ethanol extract significantly decreased body weight, serum glucose, insulin TNF-α, and interleukin 6 (IL-6) [85].

3.1.27. Moringa oleifera (Moringaceae)

One study investigated the antidiabetic and antioxidant effects of methanol extracts of Moringa oleifera pods (150 and 300 mg/kg, p.o. for 21 days) in streptozotocin-induced diabetic rats [86]. Both doses induced a significant reduction in serum glucose and nitric oxide levels, with a concomitant increase in serum insulin and protein levels. Furthermore, the methanol extracts increased antioxidant levels in pancreatic tissue and concomitantly decreased TBA levels. Additionally, a histological pancreas examination showed that Moringa oleifera treatment significantly reversed the histoarchitectural damage to islet cells provoked by induced diabetes. In a recent study performed in alloxan-induced diabetic rats, the consumption of the Moringa oleifera leaves showed a hypoglycemic effect and prevented body weight loss [87].

3.1.28. Murraya koenigii (Rutaceae)

Aqueous extract of Murraya koenigii leaf in alloxan-induced diabetic rats (200, 300, and 400 mg/kg) significantly reduced blood glucose level and was found to have a beneficial effect on carbohydrate metabolism [88]. Moreover, the ethanolic extract of this plant, in mice, ameliorates dexamethasone-induced hyperglycemia and insulin resistance in part by increasing glucose disposal into skeletal muscle [89].

3.1.29. Opuntia ficus-indica (Cactaceae)

Various extracts from edible Opuntia ficus-indica (petroleum ether, ethyl acetate, butanolic, aqueous, and water parts) and a standard drug as a positive control (dimethyl biguanide, 100 mg/kg) were tested in streptozotocin-induced diabetic mice [90]. The results of this study showed that all extracts tested significantly decreased blood glucose levels and maintained body weight, except the aqueous extract. Mainly, the petroleum ether extract showed a remarkable decrease in blood glucose levels.

3.1.30. Origanum vulgare (Lamiaceae)

The phytochemical analysis of methanolic extract from Origanum vulgare showed an enriched composition in biophenols, and it has demonstrated in vitro antioxidant activity in DPPH assays [91]. An in vivo study performed in streptozotocin-induced diabetic mice with methanolic and aqueous extract showed that aqueous extract had no impact on diabetes induction, while methanolic extract reduced diabetes incidence and preserved normal insulin secretion. Moreover, methanolic extract upregulated antioxidant enzymes (SOD, CAT, glutathione reductase, and peroxidase), attenuated pro-inflammatory activity, and showed cytoprotective activity.


  1. Soumya, D.; Srilatha, B. Late stage complications of diabetes and insulin resistance. J. Diabetes Metab. 2011, 2, 1000167.
  2. Arumugam, G.; Manjula, P.; Paari, N. A review: Anti diabetic medicinal plants used for diabetes mellitus. J. Acute Dis. 2013, 2, 196–200.
  3. Murea, M.; Ma, L.; Freedman, B.I. Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications. Rev. Diabet. Stud. 2012, 9, 6–22.
  4. Buowari, O. Chapter 8: Diabetes mellitus in developing countries and case series. In Diabetes Mellitus—Insights and Perspectives; InTechOpen: Rijeka, Croatia, 2013.
  5. Folorunso, O.; Oguntibeju, O. Chapter 5: The role of nutrition in the management of diabetes mellitus. In Diabetes Mellitus—Insights and Perspectives; InTechOpen: Rijeka, Croatia, 2013.
  6. Salsali, A.; Nathan, M. A review of types 1 and 2 diabetes mellitus and their treatment with insulin. Am. J. 2006, 13, 349–361.
  7. Sperling, M.; Tamborlane, M.; Batteling, T.; Weinzimer, S.; Phillip, M. Pediatric endocrinology. In Chapter 19: Diabetes mellitus, 4th ed.; Elsevier: Amsterdam, The Netherlands, 2014.
  8. Sharifi-Rad, M.; Nazaruk, J.; Polito, L.; Morais-Braga, M.F.B.; Rocha, J.E.; Coutinho, H.D.M.; Salehi, B.; Tabanelli, G.; Montanari, C.; del Mar Contreras, M.; et al. Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications. Microbiol. Res. 2018, 215, 76–88.
  9. Salehi, B.; Kumar, N.V.A.; Şener, B.; Sharifi-Rad, M.; Kılıç, M.; Mahady, G.B.; Vlaisavljevic, S.; Iriti, M.; Kobarfard, F.; Setzer, W.N. Medicinal plants used in the treatment of human immunodeficiency virus. Int. J. Mol. Sci. 2018, 19, 1459.
  10. Sharifi-Rad, M.; Salehi, B.; Sharifi-Rad, J.; Setzer, W.N.; Iriti, M. Pulicaria vulgaris Gaertn. essential oil: An alternative or complementary treatment for leishmaniasis. Cell. Mol. Biol. 2018, 64, 18–21.
  11. Arya, V.; Gupta, V.; Ranjeet, K. A review on fruits having anti-diabetic potential. J. Chem. Pharm. Res. 2011, 3, 204–212.
  12. Singab, A.; Youssef, F.; Ashour, M. Medicinal plants with potential antidiabetic activity and their assessment. Med. Aromat Plants 2014, 3.
  13. Mishra, A.P.; Sharifi-Rad, M.; Shariati, M.A.; Mabkhot, Y.N.; Al-Showiman, S.S.; Rauf, A.; Salehi, B.; Župunski, M.; Sharifi-Rad, M.; Gusain, P. Bioactive compounds and health benefits of edible Rumex species—A review. Cell. Mol. Biol. 2018, 64, 27–34.
  14. Mishra, A.P.; Saklani, S.; Salehi, B.; Parcha, V.; Sharifi-Rad, M.; Milella, L.; Iriti, M.; Sharifi-Rad, J.; Srivastava, M. Satyrium nepalense, a high altitude medicinal orchid of Indian Himalayan region: Chemical profile and biological activities of tuber extracts. Cell. Mol. Biol. 2018, 64, 35–43.
  15. Abdolshahi, A.; Naybandi-Atashi, S.; Heydari-Majd, M.; Salehi, B.; Kobarfard, F.; Ayatollahi, S.A.; Ata, A.; Tabanelli, G.; Sharifi-Rad, M.; Montanari, C. Antibacterial activity of some lamiaceae species against Staphylococcus aureus in yoghurt-based drink (Doogh). Cell. Mol. Biol. 2018, 64, 71–77.
  16. Mishra, A.P.; Saklani, S.; Sharifi-Rad, M.; Iriti, M.; Salehi, B.; Maurya, V.K.; Rauf, A.; Milella, L.; Rajabi, S.; Baghalpour, N. Antibacterial potential of Saussurea obvallata petroleum ether extract: A spiritually revered medicinal plant. Cell. Mol. Biol. 2018, 64, 65–70.
  17. Sharifi-Rad, J.; Tayeboon, G.S.; Niknam, F.; Sharifi-Rad, M.; Mohajeri, M.; Salehi, B.; Iriti, M.; Sharifi-Rad, M. Veronica persica Poir. Extract—antibacterial, antifungal and scolicidal activities, and inhibitory potential on acetylcholinesterase, tyrosinase, lipoxygenase and xanthine oxidase. Cell. Mol. Biol. 2018, 64, 50–56.
  18. Sharifi-Rad, M.; Roberts, T.H.; Matthews, K.R.; Bezerra, C.F.; Morais-Braga, M.F.B.; Coutinho, H.D.M.; Sharopov, F.; Salehi, B.; Yousaf, Z.; Sharifi-Rad, M.; et al. Ethnobotany of the genus Taraxacum—Phytochemicals and antimicrobial activity. Phytother. Res. 2018, 32, 2131–2145.
  19. Durazzo, A.; D’Addezio, L.; Camilli, E.; Piccinelli, R.; Turrini, A.; Marletta, L.; Marconi, S.; Lucarini, M.; Lisciani, S.; Gabrielli, P. From plant compounds to botanicals and back: A current snapshot. Molecules 2018, 23, 1844.
  20. Kooti, W.; Moradi, M.; Akbari, S.; Sharafi-Ahvazi, N.; AsadiSamani, M.; Ashtary-Larky, D. Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. J. HerbMed Pharm. 2015, 4, 1–9.
  21. Afrisham, R.; Aberomand, M.; Ghaffari, M.; Siahpoosh, A.; Jamalan, M. Inhibitory effect of Heracleum persicum and Ziziphus jujuba on activity of alpha-amylase. J. Bot. 2015, 2015, 824683.
  22. Durazzo, A.; Lucarini, M. A current shot and re-thinking of antioxidant research strategy. Braz. J. Anal. Chem. 2017, 5, 9–11.
  23. Durazzo, A. Study approach of antioxidant properties in foods: Update and considerations. Foods 2017, 6, 17.
  24. Heo, H.J.; Kim, Y.J.; Chung, D.; Kim, D.-O. Antioxidant capacities of individual and combined phenolics in a model system. Food Chem. 2007, 104, 87–92.
  25. Durazzo, A.; Turfani, V.; Azzini, E.; Maiani, G.; Carcea, M. Phenols, lignans and antioxidant properties of legume and sweet chestnut flours. Food Chem. 2013, 140, 666–671.
  26. Tabart, J.; Kevers, C.; Pincemail, J.; Defraigne, J.-O.; Dommes, J. Comparative antioxidant capacities of phenolic compounds measured by various tests. Food Chem. 2009, 113, 1226–1233.
  27. Saura-Calixto, F. Concept and health-related properties of nonextractable polyphenols: The missing dietary polyphenols. J. Agric. Food Chem. 2012, 60, 11195–11200.
  28. Durazzo, A. Extractable and non-extractable polyphenols: An overview. In Non-Extractable Polyphenols and Carotenoids; Royal Society of Chemistry: London, UK, 2018; pp. 37–45.
  29. Durazzo, A.; Turfani, V.; Narducci, V.; Azzini, E.; Maiani, G.; Carcea, M. Nutritional characterisation and bioactive components of commercial carobs flours. Food Chem. 2014, 153, 109–113.
  30. Diaconeasa, Z.; Leopold, L.; Rugină, D.; Ayvaz, H.; Socaciu, C. Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice. Int. J. Mol. Sci. 2015, 16, 2352–2365.
  31. Gupta, P.; De, A. Diabetes mellitus and its herbal treatment. Int. J. Res. Pharm. Biomed. Sci. 2012, 3, 706–721.
  32. Ríos, J.L.; Francini, F.; Schinella, G.R. Natural products for the treatment of type 2 diabetes mellitus. Planta Med. 2015, 81, 975–994.
  33. Jacob, B.; Narendhirakannan, R. Role of medicinal plants in the management of diabetes mellitus: A review. 3 Biotech 2019, 9, 4.
  34. Zengin, G.; Mollica, A.; Aktumsek, A.; Picot, C.M.N.; Mahomoodally, M.F. In vitro and in silico insights of Cupressus sempervirens, Artemisia absinthium and Lippia triphylla: Bridging traditional knowledge and scientific validation. Eur. J. Integr. Med. 2017, 12, 135–141.
  35. Liu, N.Q.; van der Kooy, F.; Verpoorte, R. Artemisia afra: A potential flagship for African medicinal plants? S. Afr. J. Bot. 2009, 75, 185–195.
  36. Nedjimi, B.; Beladel, B. Assessment of some chemical elements in wild Shih (Artemisia herba-alba Asso) using INAA technique. J. Appl. Res. Med. Aromat. Plants 2015, 2, 203–205.
  37. Al-Khazraji, S.M.; Al-Shamaony, L.A.; Twaij, H.A.A. Hypoglycaemic effect of Artemisia herba alba. I. Effect of different parts and influence of the solvent on hypoglycaemic activity. J. Ethnopharmacol. 1993, 40, 163–166.
  38. Cruz, E.C.; Andrade-Cetto, A. Ethnopharmacological field study of the plants used to treat type 2 diabetes among the Cakchiquels in Guatemala. J. Ethnopharmacol. 2015, 159, 238–244.
  39. Tag, H.; Kalita, P.; Dwivedi, P.; Das, A.K.; Namsa, N.D. Herbal medicines used in the treatment of diabetes mellitus in Arunachal Himalaya, Northeast, India. J. Ethnopharmacol. 2012, 141, 786–795.
  40. Rafe, M.R. A review of five traditionally used anti-diabetic plants of Bangladesh and their pharmacological activities. Asian Pac. J. Trop. Med. 2017, 10, 933–939.
  41. Saha, S.; Verma, R. Inhibitory potential of traditional herbs on α-amylase activity. Pharm. Biol. 2012, 50, 326–331.
  42. Sudha, P.; Zinjarde, S.S.; Bhargava, S.Y.; Kumar, A.R. Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants. BMC Complement. Altern. Med. 2011, 11, 5.
  43. Ocvirk, S.; Kistler, M.; Khan, S.; Talukder, S.H.; Hauner, H. Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh—An ethnobotanical survey. J. Ethnobiol. Ethnomedicine 2013, 9, 43.
  44. Kusirisin, W.; Srichairatanakool, S.; Lerttrakarnnon, P.; Lailerd, N.; Suttajit, M.; Jaikang, C.; Chaiyasut, C. Antioxidative activity, polyphenolic content and anti-glycation effect of some Thai medicinal plants traditionally used in diabetic patients. Med. Chem. 2009, 5, 139–147.
  45. Jokar, A.; Masoomi, F.; Sadeghpour, O.; Nassiri-Toosi, M.; Hamedi, S. Potential therapeutic applications for Terminalia chebula in Iranian traditional medicine. J. Tradit Chin Med. 2016, 36, 250–254.
  46. Tarak, D.; Namsa, N.D.; Tangjang, S.; Arya, S.C.; Rajbonshi, B.; Samal, P.K.; Mandal, M. An inventory of the ethnobotanicals used as anti-diabetic by a rural community of Dhemaji district of Assam, Northeast India. J. Ethnopharmacol. 2011, 138, 345–350.
  47. Sharma, V. Microscopic studies and preliminary pharmacognostical evaluation of Euphorbia neriifolia L. Leaves. Ind. J. Nat. Prod. Resour. 2013, 4, 348–357.
  48. Goyal, M.; Sasmal, D.; Nagori, B.P. Review on medicinal plants used by local community of Jodhpur district of Thar desert. Int. J. Pharmacol. 2011, 7, 333–339.
  49. Shahreen, S.; Banik, J.; Hafiz, A.; Rahman, S.; Zaman, A.T.; Shoyeb, M.A.; Chowdhury, M.H.; Rahmatullah, M. Antihyperglycemic activities of leaves of three edible fruit plants (Averrhoa carambola, Ficus hispida and Syzygium samarangense) of Bangladesh. Afr. J. Tradit. Complement. Altern. Med. 2012, 9, 287–291.
  50. Hossan, M.S.; Hanif, A.; Khan, M.; Bari, S.; Jahan, R.; Rahmatullah, M. Ethnobotanical survey of the Tripura tribe of Bangladesh. Am. Eurasian J. Sustain. Agric. 2009, 3, 253–261.
  51. Kim, S.J.; Jang, Y.W.; Hyung, K.E.; Lee, D.K.; Hyun, K.H.; Park, S.Y.; Park, E.S.; Hwang, K.W. Therapeutic effects of methanol extract from Euphorbia kansui radix on imiquimod-induced psoriasis. J. Immunol. Res. 2017, 2017, 7052560.
  52. Dineshkumar, B.; Analava, M.; Manjunatha, M. Antidiabetic and hypolipidaemic effects of few common plants extract in type 2 diabetic patients at Bengal. Int. J. Diabetes Metabol. 2010, 18, 59–65.
  53. Patil, R.N.; Patil, R.Y.; Ahirwar, B.; Ahirwar, D. Evaluation of antidiabetic and related actions of some Indian medicinal plants in diabetic rats. Asian Pac. J. Trop. Med. 2011, 4, 20–23.
  54. Hegazy, G.A.; Alnoury, A.M.; Gad, H.G. The role of Acacia arabica extract as an antidiabetic, antihyperlipidemic, and antioxidant in streptozotocin-induced diabetic rats. Saudi Med J 2013, 34, 727–733.
  55. Geetha, G.; Gopinathapillai, P.K.; Sankar, V. Anti diabetic effect of Achyranthes rubrofusca leaf extracts on alloxan induced diabetic rats. Pak. J. Pharma. Sci. 2011, 24, 193–199.
  56. Ahmed, D.; Kumar, V.; Verma, A.; Gupta, P.S.; Kumar, H.; Dhingra, V.; Mishra, V.; Sharma, M. Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. Stem bark (ALEx) on streptozotocin induced diabetic rats. BMC Complement Altern Med 2014, 14, 243.
  57. Patel, P.A.; Parikh, M.P.; Johari, S.; Gandhi, T.R. Antihyperglycemic activity of Albizzia lebbeck bark extract in streptozotocin-nicotinamide induced type II diabetes mellitus rats. Ayu 2015, 36, 335–340.
  58. Kumar, R.; Sharma, B.; Tomar, N.R.; Roy, P.; Gupta, A.K.; Kumar, A. In vivo evaluation of hypoglycemic activity of Aloe spp. And identification of its mode of action on GLUT-4 gene expression in vitro. Appl Biochem Biotechnol 2011, 164, 1246–1256.
  59. Noor, A.; Gunasekaran, S.; Vijayalakshmi, M.A. Improvement of insulin secretion and pancreatic β-cell function in streptozotocin-induced diabetic rats treated with. Pharmacogn. Res 2017, 9, S99–S104.
  60. Rahmatullah, M.; Hosain, M.; Rahman, S.; Akter, M.; Rahman, F.; Rehana, F.; Munmun, M.; Kalpana, M.A. Antihyperglycaemic and antinociceptive activity evaluation of methanolic extract of whole plant of Amaranthus tricolour L. (Amaranthaceae). Afr J Tradit Complement Altern Med 2013, 10, 408–411.
  61. Kamtchouing, P.; Sokeng, S.D.; Moundipa, P.F.; Watcho, P.; Jatsa, H.B.; Lontsi, D. Protective role of anacardium occidentale extract against streptozotocin-induced diabetes in rats. J Ethnopharmacol 1998, 62, 95–99.
  62. Jaiswal, Y.S.; Tatke, P.A.; Gabhe, S.Y.; Vaidya, A.B. Antidiabetic activity of extracts of Anacardium occidentale Linn. leaves on n-streptozotocin diabetic rats. J Tradit Complement Med 2017, 7, 421–427.
  63. Akhtar, N.; Khan, B.A.; Majid, A.; Khan, H.M.; Mahmood, T.; Gulfishan, S.T. Pharmaceutical and biopharmaceutical evaluation of extracts from different plant parts of indigenous origin for their hypoglycemic responses in rabbits. Acta Pol. Pharm. 2011, 68, 919–925.
  64. Dheer, R.; Bhatnagar, P. A study of the antidiabetic activity of Barleria prionitis Linn. Indian J. Pharmacol. 2010, 42, 70–73.
  65. Ojezele, M.O.; Abatan, O.M. Hypoglycaemic and coronary risk index lowering effects of Bauhinia thoningii in alloxan induced diabetic rats. Afr. Health Sci. 2011, 11, 85–89.
  66. Vasconcelos, C.F.; Maranhão, H.M.; Batista, T.M.; Carneiro, E.M.; Ferreira, F.; Costa, J.; Soares, L.A.; Sá, M.D.; Souza, T.P.; Wanderley, A.G. Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea martius bark extract on streptozotocin-induced diabetes in wistar rats. J. Ethnopharmacol. 2011, 137, 1533–1541.
  67. Al-Attar, A.M.; Zari, T.A. Influences of crude extract of tea leaves, Camellia sinensis, on streptozotocin diabetic male albino mice. Saudi J. Biol. Sci. 2010, 17, 295–301.
  68. Prakasam, A.; Sethupathy, S.; Pugalendi, K.V. Influence of Casearia esculenta root extract on protein metabolism and marker enzymes in streptozotocin-induced diabetic rats. Pol. J. Pharm. 2004, 56, 587–593.
  69. Agnihotri, A.; Singh, V. Effect of Tamarindus indica Linn. and Cassia fistula Linn. Stem bark extracts on oxidative stress and diabetic conditions. Acta Pol. Pharm. 2013, 70, 1011–1019.
  70. Lodha, S.R.; Joshi, S.V.; Vyas, B.A.; Upadhye, M.C.; Kirve, M.S.; Salunke, S.S.; Kadu, S.K.; Rogye, M.V. Assessment of the antidiabetic potential of Cassia grandis using an in vivo model. J. Adv. Pharm. Technol. Res. 2010, 1, 330–333.
  71. Singh, S.N.; Vats, P.; Suri, S.; Shyam, R.; Kumria, M.M.L.; Ranganathan, S.; Sridharan, K. Effect of an antidiabetic extract of catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats. J. Ethnopharmacol. 2001, 76, 269–277.
  72. Al-Shaqha, W.M.; Khan, M.; Salam, N.; Azzi, A.; Chaudhary, A.A. Anti-diabetic potential of Catharanthus roseus Linn. And its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats. BMC Complement. Altern. Med. 2015, 15, 379.
  73. Aragão, D.M.; Guarize, L.; Lanini, J.; da Costa, J.C.; Garcia, R.M.; Scio, E. Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats. J. Ethnopharmacol. 2010, 128, 629–633.
  74. Nabeel, M.A.; Kathiresan, K.; Manivannan, S. Antidiabetic activity of the mangrove species Ceriops decandra in alloxan-induced diabetic rats. J. Diabetes 2010, 2, 97–103.
  75. Gorelick, J.; Kitron, A.; Pen, S.; Rosenzweig, T.; Madar, Z. Anti-diabetic activity of Chiliadenus iphionoides. J. Ethnopharmacol. 2011, 137, 1245–1249.
  76. Lu, Z.; Jia, Q.; Wang, R.; Wu, X.; Wu, Y.; Huang, C.; Li, Y. Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different cinnamon barks. Phytomedicine 2011, 18, 298–302.
  77. Agarwal, V.; Sharma, A.K.; Upadhyay, A.; Singh, G.; Gupta, R. Hypoglycemic effects of Citrullus colocynthis roots. Acta Pol. Pharm. 2012, 69, 75–79.
  78. Amin, A.; Tahir, M.; Lone, K.P. Effect of Citrullus colocynthis aqueous seed extract on beta cell regeneration and intra-islet vasculature in alloxan induced diabetic male albino rats. J. Pak. Med. Assoc. 2017, 67, 715–721.
  79. Punitha, I.S.R.; Rajendran, K.; Shirwaikar, A. Alcoholic stem extract of Coscinium fenestratum regulates carbohydrate metabolism and improves antioxidant status in streptozotocin-nicotinamide induced diabetic rats. Evid.-Based Complement. Altern. Med. 2005, 2, 375–381.
  80. Arjun, P.; Shivesh, J.; Alakh, N.S. Antidiabetic activity of aqueous extract of Eucalyptus citriodorahook. in alloxan induced diabetic rats. Pharmacogn. Mag. 2009, 5, 51–54.
  81. Kang, M.H.; Lee, M.S.; Choi, M.K.; Min, K.S.; Shibamoto, T. Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats. J. Agric. Food Chem. 2012, 60, 2517–2524.
  82. Okokon, J.E.; Umoh, E.E.; Etim, E.I.; Jackson, C.L. Antiplasmodial and antidiabetic activities of ethanolic leaf extract of Heinsia crinata. J. Med. Food 2009, 12, 131–136.
  83. Venkatesh, S.; Madhava Reddy, B.; Dayanand Reddy, G.; Mullangi, R.; Lakshman, M. Antihyperglycemic and hypolipidemic effects of Helicteres isora roots in alloxan-induced diabetic rats: A possible mechanism of action. J. Nat. Med. 2010, 64, 295–304.
  84. Tripathi, U.N.; Chandra, D. Anti-hyperglycemic and anti-oxidative effect of aqueous extract of Momordica charantia pulp and trigonella foenum graecum seed in alloxan-induced diabetic rats. Indian J. Biochem. Biophys. 2010, 47, 227–233.
  85. Ma, C.; Yu, H.; Xiao, Y.; Wang, H. Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and jnk in type 2 diabetes mellitus rats. Pharm. Biol. 2017, 55, 2170–2177.
  86. Gupta, R.; Mathur, M.; Bajaj, V.K.; Katariya, P.; Yadav, S.; Kamal, R.; Gupta, R.S. Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. J. Diabetes 2012, 4, 164–171.
  87. Villarruel-López, A.; López-de la Mora, D.A.; Vázquez-Paulino, O.D.; Puebla-Mora, A.G.; Torres-Vitela, M.R.; Guerrero-Quiroz, L.A.; Nuño, K. Effect of Moringa oleifera consumption on diabetic rats. BMC Complement. Altern. Med. 2018, 18, 127.
  88. Kesari, A.N.; Gupta, R.K.; Watal, G. Hypoglycemic effects of murraya koenigii on normal and alloxan-diabetic rabbits. J. Ethnopharmacol. 2005, 97, 247–251.
  89. Pandey, J.; Maurya, R.; Raykhera, R.; Srivastava, M.N.; Yadav, P.P.; Tamrakar, A.K. Murraya koenigii (L.) spreng. ameliorates insulin resistance in dexamethasone-treated mice by enhancing peripheral insulin sensitivity. J. Sci. Food Agric. 2014, 94, 2282–2288.
  90. Luo, C.; Zhang, W.; Sheng, C.; Zheng, C.; Yao, J.; Miao, Z. Chemical composition and antidiabetic activity of Opuntia milpa alta extracts. Chem. Biodivers. 2010, 7, 2869–2879.
  91. Vujicic, M.; Nikolic, I.; Kontogianni, V.G.; Saksida, T.; Charisiadis, P.; Orescanin-Dusic, Z.; Blagojevic, D.; Stosic-Grujicic, S.; Tzakos, A.G.; Stojanovic, I. Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity. Br. J. Nutr. 2015, 113, 770–782.
  92. Montefusco-Pereira, C.V.; de Carvalho, M.J.; de Araújo Boleti, A.P.; Teixeira, L.S.; Matos, H.R.; Lima, E.S. Antioxidant, anti-inflammatory, and hypoglycemic effects of the leaf extract from Passiflora nitida kunth. Appl. Biochem. Biotechnol. 2013, 170, 1367–1378.
  93. Jain, S.; Bhatia, G.; Barik, R.; Kumar, P.; Jain, A.; Dixit, V.K. Antidiabetic activity of Paspalum scrobiculatum Linn. in alloxan induced diabetic rats. J. Ethnopharmacol. 2010, 127, 325–328.
  94. Lima, C.R.; Vasconcelos, C.F.; Costa-Silva, J.H.; Maranhão, C.A.; Costa, J.; Batista, T.M.; Carneiro, E.M.; Soares, L.A.; Ferreira, F.; Wanderley, A.G. Anti-diabetic activity of extract from Persea americana Mill. Leaf via the activation of protein kinase B (PKB/AKT) in streptozotocin-induced diabetic rats. J. Ethnopharmacol. 2012, 141, 517–525.
  95. Ezejiofor, A.N.; Okorie, A.; Orisakwe, O.E. Hypoglycaemic and tissue-protective effects of the aqueous extract of Persea americana seeds on alloxan-induced albino rats. Malays. J. Med. Sci. 2013, 20, 31–39.
  96. Mard, S.A.; Jalalvand, K.; Jafarinejad, M.; Balochi, H.; Naseri, M.K. Evaluation of the antidiabetic and antilipaemic activities of the hydroalcoholic extract of Phoenix dactylifera palm leaves and its fractions in alloxan-induced diabetic rats. Malays. J. Med. Sci. 2010, 17, 4–13.
  97. Giribabu, N.; Karim, K.; Kilari, E.K.; Salleh, N. Phyllanthus niruri leaves aqueous extract improves kidney functions, ameliorates kidney oxidative stress, inflammation, fibrosis and apoptosis and enhances kidney cell proliferation in adult male rats with diabetes mellitus. J. Ethnopharmacol. 2017, 205, 123–137.
  98. Shabeer, J.; Srivastava, R.S.; Singh, S.K. Antidiabetic and antioxidant effect of various fractions of Phyllanthus simplex in alloxan diabetic rats. J. Ethnopharmacol. 2009, 124, 34–38.
  99. Teugwa, C.M.; Mejiato, P.C.; Zofou, D.; Tchinda, B.T.; Boyom, F.F. Antioxidant and antidiabetic profiles of two African medicinal plants: Picralima nitida (apocynaceae) and Sonchus oleraceus (asteraceae). BMC Complement. Altern. Med. 2013, 13, 175.
  100. Nabi, S.A.; Kasetti, R.B.; Sirasanagandla, S.; Tilak, T.K.; Kumar, M.V.; Rao, C.A. Antidiabetic and antihyperlipidemic activity of Piper longum root aqueous extract in stz induced diabetic rats. BMC Complement. Altern. Med. 2013, 13, 37.
  101. Bhadoriya, S.S.; Ganeshpurkar, A.; Bhadoriya, R.P.S.; Sahu, S.K.; Patel, J.R. Antidiabetic potential of polyphenolic-rich fraction of Tamarindus indica seed coat in alloxan-induced diabetic rats. J. Basic Clin. Physiol. Pharm. 2018, 29, 37–45.
  102. Nalamolu, K.R.; Nammi, S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. Seeds in streptozotocin-induced diabetic rats. BMC Complement. Altern. Med. 2006, 6, 17.
  103. Nagappa, A.N.; Thakurdesai, P.A.; Rao, N.V.; Singh, J. Antidiabetic activity of Terminalia catappa Linn fruits. J. Ethnopharmacol. 2003, 88, 45–50.
  104. Mowla, A.; Alauddin, M.; Rahman, M.A.; Ahmed, K. Antihyperglycemic effect of Trigonella foenum-graecum (fenugreek) seed extract in alloxan-induced diabetic rats and its use in diabetes mellitus: A brief qualitative phytochemical and acute toxicity test on the extract. Afr. J. Tradit. Complement. Altern. Med. 2009, 6, 255–261.
  105. Joshi, D.V.; Patil, R.R.; Naik, S.R. Hydroalcohol extract of Trigonella foenum-graecum seed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats. Pharm. Biol. 2015, 53, 201–211.
  106. Feshani, A.M.; Kouhsari, S.M.; Mohammadi, S. Vaccinium arctostaphylos, a common herbal medicine in iran: Molecular and biochemical study of its antidiabetic effects on alloxan-diabetic wistar rats. J. Ethnopharmacol. 2011, 133, 67–74.
  107. Michael, U.A.; David, B.U.; Theophine, C.O.; Philip, F.U.; Ogochukwu, A.M.; Benson, V.A. Antidiabetic effect of combined aqueous leaf extract of Vernonia amygdalina and metformin in rats. J. Basic Clin. Pharm. 2010, 1, 197–202.
  108. Herrera, C.; García-Barrantes, P.M.; Binns, F.; Vargas, M.; Poveda, L.; Badilla, S. Hypoglycemic and antihyperglycemic effect of Witheringia solanacea in normal and alloxan-induced hyperglycemic rats. J. Ethnopharmacol. 2011, 133, 907–910.
  109. Meenakshi, P.; Bhuvaneshwari, R.; Rathi, M.A.; Thirumoorthi, L.; Guravaiah, D.C.; Jiji, M.J.; Gopalakrishnan, V.K. Antidiabetic activity of ethanolic extract of Zaleya decandra in alloxan-induced diabetic rats. Appl. Biochem. Biotechnol. 2010, 162, 1153–1159.
  110. Jarald, E.E.; Joshi, S.B.; Jain, D.C. Antidiabetic activity of extracts and fraction of Zizyphus mauritiana. Pharm. Biol. 2009, 47, 328–334.
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