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Topic Review
Brassinosteroids
Steroids are a pivotal class of hormones with a key role in growth modulation and signal transduction in multicellular organisms. Synthetic steroids are widely used to cure large array of viral, fungal, bacterial, and cancerous infections. Brassinosteroids (BRs) are a natural collection of phytosterols, which have structural similarity with animal steroids. BRs are dispersed universally throughout the plant kingdom. These plant steroids are well known to modulate a plethora of physiological responses in plants leading to improvement in quality as well as yield of food crops. Moreover, they have been found to play imperative role in stress-fortification against various stresses in plants. Over a decade, BRs have conquered worldwide interest due to their diverse biological activities in animal systems.
  • 1.4K
  • 30 Jun 2021
Topic Review
Sublethal Cell Death Signaling
An important role of cell death pathways is to protect tissues and minimize disease by limiting the transference of potentially oncogenic mutations to daughter clones. However, there is increasing evidence demonstrating that activation of sublethal cell death signaling pathways, in particular apoptotic signaling, in the absence of direct DNA damaging stimuli, can promote genomic instability in cells that fail to die. This may increase the risk of the formation of subsequent neoplasms. Apoptosis-mediated mutagenesis occurs indirectly via sublethal activation of caspases and apoptotic nucleases (specifically CAD). On the other hand, cells surviving sublethal necroptotic signaling did not acquire mutations, most likely due to caspase-independent pathways, although the possibility of mutagenesis under conditions of oxidative stress are still elusive. It may therefore be possible for necroptosis-inducing anti-cancer drugs to be less likely than apoptosis-inducing or DNA damaging drugs to trigger therapy-related cancers.
  • 1.4K
  • 12 Jul 2021
Topic Review
Chromatin Dysregulation of Prostate Cancer
The dysregulation of chromatin and epigenetics has been defined as the overarching cancer hallmark. By disrupting transcriptional regulation in normal cells and mediating tumor progression by promoting cancer cell plasticity, this process has the ability to mediate all defined hallmarks of cancer.
  • 1.4K
  • 13 Jul 2021
Topic Review
Safety Leadership
Safety leadership is a process where the leader, through interaction with followers, tries to achieve safety standards set by the organization, increases safety awareness, and encourages safe behaviour.
  • 1.4K
  • 26 Jul 2021
Topic Review
Amyloid Beta Oligomers
Amyloid beta (Aβ) oligomers are the most neurotoxic aggregates causing neuronal death and cognitive damage. A detailed elucidation of the aggregation pathways from oligomers to fibril formation is crucial to develop therapeutic strategies for Alzheimer’s disease (AD). This review mainly focused on future perspective of Aβ peptide research using computer simulations.
  • 1.4K
  • 27 Oct 2021
Topic Review
A Novel Composited Electromagnetic Linear Actuator
Electromagnetic linear actuators, as key executive components, have a vital impact on the performance of fully flexible variable valve trains. The research results show that the maximum starting force of the composited electromagnetic linear actuator (CELA) with the end-passive self-holding ability is 574.92 N while the holding force can approach 229.25 N. Moreover, the CELA is proven to have excellent dynamic characteristics and control precision under different motion modes and to have an improved adaptability to the complex working conditions of internal combustion engines.
  • 1.4K
  • 11 Jan 2022
Topic Review
Barrier Membranes in Regenerative Procedures
Guided tissue regeneration (GTR) and guided bone regeneration (GBR) became common procedures in the corrective phase of periodontal treatment. In order to obtain good quality tissue neo-formation, most techniques require the use of a membrane that will act as a barrier, having as a main purpose the blocking of cell invasion from the gingival epithelium and connective tissue into the newly formed bone structure. Different techniques and materials have been developed, aiming to obtain the perfect barrier membrane. The membranes can be divided according to the biodegradability of the base material into absorbable membranes and non-absorbable membranes. The use of absorbable membranes is extremely widespread due to their advantages, but in clinical situations of significant tissue loss, the use of non-absorbable membranes is often still preferred.
  • 1.4K
  • 28 Jan 2022
Topic Review
Ligands of the Gi Protein-Coupled Adenosine A3 Receptor
Ligands of the Gi protein-coupled adenosine A3 receptor (A3R) are receiving increasing interest as attractive therapeutic tools for the treatment of a number of pathological conditions of the central and peripheral nervous systems (CNS and PNS, respectively). Their safe pharmacological profiles emerging from clinical trials on different pathologies (e.g., rheumatoid arthritis, psoriasis and fatty liver diseases) confer a realistic translational potential to these compounds, thus encouraging the investigation of highly selective agonists and antagonists of A3R. 
  • 1.4K
  • 06 Apr 2022
Topic Review
Framework for Building Resilient Water and Infrastructure Systems
Planning and developing resilient socio-technical and natural systems to cope with and respond to unprecedented changes has been one of the top goals of government bodies, researchers, and practitioners worldwide. 
  • 1.4K
  • 24 Apr 2022
Topic Review
Water Resources Research in the Souss-Massa Basin, Morocco
Most recent studies confirm a decreasing trend in water resources availability in the northern African region; the high competition between the sectors that use this vital resource, and the changing climate are considered as the main factors behind this situation. Under such very dynamic interactions between the natural resources, climate and the socioeconomic sectors, scientists from different perspectives have a challenging task to provide up-to-date and reliable insights to guide potential sustainable management strategies. Through the case of the Souss-Massa, the present research provides state of the art scientific research on water resources. The maps of publications analyzed showed that researchers working in the area focus more on the study of the quality, chemical processing and the impacts of climate change on the availability of water resources. The results showed that Souss-Massa is a region where an important amount of research on climate and water has been carried out. Hence, to keep up with the rapid evolution of land use and other anthropogenic actions in the basin there remain several gaps in knowledge and constraints to address.
  • 1.4K
  • 07 May 2022
Topic Review
Gamified English Vocabulary Applications
Learning vocabulary through mobile applications has gained momentum in recent years. The use of smart mobile devices was getting increasingly widespread as the mobile Internet develops at a rapid pace, and numerous English vocabulary learning applications were developed to help learners expand their English vocabulary through mobile learning. English vocabulary learning apps were generally incorporated with gamification to assist users in acquiring and recollecting new vocabulary. Time constraints, rewards, feedback, characters, and challenges were all universal game components in vocabulary learning applications, allowing the process to be enjoyable and game-like.
  • 1.4K
  • 27 May 2022
Topic Review
Superconductivity and Hydrogen Economy
Hydrogen as an energy carrier is a promising alternative to fossil fuels, and it becomes more and more popular in developed countries as a carbon-free fuel. The low boiling temperature of hydrogen (20 K or −253.15 °C) provides a unique opportunity to implement superconductors with a critical temperature above 20 K such as MgB2 or high-temperature superconductors. Superconductors increase efficiency and reduce the loss of energy, which could compensate for the high price of LH2 to some extent. Norway is one of the pioneer countries with adequate infrastructure for using liquid hydrogen in the industry, especially in marine technology where a superconducting propulsion system can make a remarkable impact on its economy. Using superconductors in the motor of a propulsion system can increase its efficiency from 95% to 98% when the motor operates at full power. The difference in efficiency is even greater when the motor does not work at full power.
  • 1.4K
  • 19 Oct 2022
Topic Review
Something Old
"Something old" is the first line of a traditional rhyme that details what a bride should wear at her wedding for good luck: The old item provided protection for the baby to come. The item borrowed from another happy bride provided good luck. The colour blue was a sign of fidelity. The sixpence—a silver British coin—was a symbol of prosperity or acted as a ward against evil done by frustrated suitors.
  • 1.4K
  • 19 Oct 2022
Topic Review
Evolution of an Atherosclerotic Plaque
Atherosclerosis is a condition mediated by immune mechanisms, which is realized by the accumulation of lipoproteins in the wall of arterial vessels, leading to its focal thickening and the formation of atherosclerotic plaques in medium- and large-caliber arteries. Lipids, inflammatory infiltrates, smooth muscle cells, and connective tissue composes an atherosclerotic plaque, and a fibrous cap covers it. Damage to the latter leads to the fact that the internal contents of the plaque interact directly with the blood, which can cause thrombosis, and in the case of fragmentation of both the plaque and the blood clot on its surface—embolism in the distal vascular bed.
  • 1.4K
  • 20 Oct 2022
Topic Review
Risk Factors for Thoracic Aortic Dissection
Thoracic aortic aneurysms involving the root and/or the ascending aorta enlarge over time until an acute tear in the intimal layer leads to a highly fatal condition, an acute aortic dissection (AAD). These Stanford type A AADs, in which the tear occurs above the sinotubular junction, leading to the formation of a false lumen in the aortic wall that may extend to the arch and thoracoabdominal aorta. Type B AADs originate in the descending thoracic aorta just distal to the left subclavian artery. Genetic variants and various environmental conditions that disrupt the aortic wall integrity have been identified that increase the risk for thoracic aortic aneurysms and dissections (TAD). 
  • 1.4K
  • 04 Nov 2022
Topic Review
Specialists’ Dual Practice within Public Hospital Setting
In line with the commitment of the Malaysian government and Ministry of Health (MOH) to prevent the brain drain of specialists from public hospitals, they have been permitted to perform dual practice within the public hospital setting (DPH) since 2007. DPH allowed them to hold jobs in both public and private practices within the same public hospitals that they are affiliated to, permitting these specialists to treat public and private patients. Nevertheless, the information regarding DPH in Southeast Asia region is still limited. In Malaysia, public specialists are allowed to perform DPH, which is also known as Full Paying Patient (FPP) Service. FPP Service as DPH has been well-governed and regulated by the MOH while serving as a means to retain specialists in the public healthcare system by providing them with opportunities to obtain additional income. Such a policy has also reduced the financial burden of the government in subsidizing healthcare.
  • 1.4K
  • 04 Nov 2022
Topic Review
Development of Antifouling Strategies for Marine Applications
Marine biofouling is an undeniable challenge for aquatic systems since it is responsible for several environmental and ecological problems and economic losses. Several strategies have been developed to mitigate fouling-related issues in marine environments, including thermal stress, osmotic shock, deoxygenation, and the development of marine coatings using nanotechnology and biomimetic models, as well as the incorporation of natural compounds, peptides, bacteriophages, or specific enzymes on surfaces. 
  • 1.4K
  • 07 Jul 2023
Topic Review
Antioxidant Compounds of Mushrooms as Neuroprotective Agents
Mushrooms have been used for their nutritional value and medicinal properties. They therefore represent not only a food but also a precious source of biologically active compounds that act as nutraceuticals. Numerous studies have shown that edible mushrooms possess anticancer, anti-atherosclerotic, hypocholesterolemic, hypolipidemic, antiviral, antimicrobial, immunostimulant, anti-inflammatory, antioxidant, and anti-aging effects. The antioxidant properties of edible mushrooms are mainly related to their content in phenolic compounds and polysaccharides. Among polyphenol groups, phenolic acids are the main antioxidants, whereas the major antioxidant effects of polysaccharides are attributed to beta-glycans. These compounds show significant reactive oxygen species (ROS) scavenging activity and are also able to stimulate the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) enzymes.
  • 1.4K
  • 27 Jun 2023
Topic Review
Plant–Nanoparticle Interactions
The relationship between plants and nanoparticles (NPs) has been the subject of extensive research interest. Nanoparticles and their interactive effects on plants have raised concern regarding their harmful aspects. There are complex mechanisms evolved in plants for controlling the uptake, accumulation, and mobilization of nanoparticles that need to be discussed further, especially in the context of proteomics and genetic level.
  • 1.4K
  • 16 Aug 2023
Topic Review Peer Reviewed
Co-Creating Interdisciplinary Integrated Powerful Knowledge
Interdisciplinary and integrated powerful knowledge (IIPK) is the outcome of integrating multiple disciplinary perspectives and approaches to tackle challenging real-world issues. Using many disciplinary fields, IIPK is essential for problem solving, innovation, and technical breakthroughs that require careful, imaginative, and innovative application of a wide range of disciplinary knowledge. It is especially relevant when addressing socio-scientific issues, which require a comprehensive understanding of scientific, social, and ethical dimensions. Collaborative and interdisciplinary work among people with diverse backgrounds and expertise is necessary to advance IIPK, including professionals from different academic fields, policymakers, stakeholders, and community members who bring various perspectives and values to the table. The co-creation of IIPK could inform policy making, support informed decision making, and lead to more comprehensive, effective, and sustainable solutions. Theoretical underpinnings and practical applications of co-creating IIPK are discussed here based on several principles with the potential to impact current practices. The co-creation and dissemination of IIPK could use multiple platforms, such as scholarly articles, encyclopedias, and media, including social media. These platforms provide scope for co-creating powerful knowledge through a people participatory approach, which would lead to changes in practices.
  • 1.4K
  • 17 Oct 2023
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