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Topic Review
CAPSTONE (Spacecraft)
Cislunar Autonomous Positioning System Technology Operations and Navigation Experiment (CAPSTONE) is a lunar orbiter that will test and verify the calculated orbital stability planned for the Gateway space station. The spacecraft is a 12-unit CubeSat that will also test a navigation system that will measure its position relative to NASA's Lunar Reconnaissance Orbiter (LRO) without relying on ground stations.
  • 1.4K
  • 11 Oct 2022
Topic Review
Fiat BR.20
The Fiat BR.20 Cicogna (Italian: "stork") was a low-wing twin-engine medium bomber that was developed and manufactured by Italian aircraft company Fiat. It holds the distinction of being the first all-metal Italian bomber to enter service; at the time, it was regarded as one of the most modern medium bombers in the world. The BR.20 has its origins in a request by the Regia Aeronautica (Italian Royal Air Force) issued during 1934 for a new medium bomber capable of high speeds, long range, and satisfactory payload, reliability, and flight characteristics compared to contemporaries. Among the companies that chose to respond was Fiat, which completed its design for the competition during 1935. On 10 February 1936, the first prototype (serial number M.M.274) conducted its maiden flight. Flight testing proceeded at a rapid pace; during September 1936, initial deliveries of the type commenced to the Regia Aeronautica. During summer 1937, the BR.20 received its baptism of fire when a number were operated by the Aviazione Legionaria during the Spanish Civil War; the BR-20 came to form the backbone of Nationalist bombing operations, along with the German-built Heinkel He 111. It was also used in combat during the 1930s with relative success by the Japanese during the Second Sino-Japanese War. During 1939, a modified long-range BR.20 version (designated BR.20L) named Santo Francesco under the command of Maner Lualdi performed a highly publicised non-stop flight from Rome to Addis Ababa, Ethiopia. Upon the entry of Italy into the Second World War during mid-1940, the BR.20 served as the standard medium bomber of the Regia Aeronautica, however, by that point, the type was already approaching obsolescence. By 1942, the aircraft was mostly used for maritime patrol and operational training for bomber crews. The BR.20 was produced from the mid-1930s until the end of the Second World War. More than 500 were produced before the end of the war.
  • 1.4K
  • 31 Oct 2022
Topic Review
Hedgehog Signaling for Basal Cell Carcinoma
Basal Cell Carcinoma (BCC) is the most commonly diagnosed cancer worldwide. While the survivability of BCC is high, many patients are excluded from clinically available treatments due to health risks or personal choice. Further, patients with advanced or metastatic disease have severely limited treatment options. The dysregulation of the Hedgehog (Hh) signaling cascade drives onset and progression of BCC. As such, the modulation of this pathway has driven advancements in BCC research.
  • 1.4K
  • 23 Nov 2022
Topic Review
Chicago Stock Exchange
The Chicago Stock Exchange (CHX) is a stock exchange in Chicago , Illinois, US. The exchange is a national securities exchange and self-regulatory organization, which operates under the oversight of the U.S. Securities and Exchange Commission (SEC). The Chicago Stock Exchange is currently located at 440 South LaSalle Street (FOUR40). Founded on March 21, 1882, the Chicago Stock Exchange merged with the regional stock exchanges St. Louis Stock Exchange, Cleveland Stock Exchange and Minneapolis-St. Paul Stock Exchange to form the Midwest Stock Exchange in 1949. In 1959, the New Orleans Stock Exchange became part of the Midwest Stock Exchange, and in the early 1960s the Midwest Stock Exchange Service Corporation was established to provide centralized accounting for member firms. In 1993 it changed its name back to the Chicago Stock Exchange.
  • 1.4K
  • 23 Nov 2022
Topic Review
Extracellular Vesicle-microRNAs as Diagnostic Biomarkers in Preterm Neonates
Neonates born prematurely (<37 weeks of gestation) are at a significantly increased risk of developing inflammatory conditions associated with high mortality rates, including necrotizing enterocolitis, bronchopulmonary dysplasia, and hypoxic-ischemic brain damage.
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  • 15 Feb 2023
Topic Review
Novel Manufacturing Methods for Textile-Reinforced Concrete
Textile-reinforced concrete (TRC) is a composite material consisting of a concrete matrix with a high-performance reinforcement made of technical textiles. TRC offers unique mechanical properties for the construction industry, enabling the construction of lightweight, material-minimized structures with high load-bearing potential. In addition, compared with traditional concrete design, TRC offers unique possibilities to realize free-form, double-curved structures. 
  • 1.4K
  • 25 Oct 2023
Topic Review
Magnetic Flux Leakage Testing Technique of Oil Pipelines
Magnetic flux leakage testing (MFL) is the most widely used nondestructive testing technology in the safety inspection of oil and gas pipelines. 
  • 1.4K
  • 17 Nov 2023
Topic Review
Physiotherapeutic Scoliosis-Specific Exercise Methodologies for Adolescent Idiopathic Scoliosis
Due to the multifactorial etiology of scoliosis, a comprehensive treatment plan is essential for conservative management. Physiotherapeutic scoliosis-specific exercise (PSSE) methods have lately gained popularity for the conservative treatment of scoliosis. Inappropriate management of adolescent idiopathic scoliosis (AIS) could result in serious health problems. Conservative interventions that aid in stabilizing spine curvature and improving esthetics are preferred for scoliosis treatment. Bracing has traditionally been the mainstay of treatment, but growing evidence suggests that PSSE physiotherapy allows effective management of idiopathic adolescent scoliosis. Currently, there are the following PSSE physiotherapy schools in Europe: Schroth, SEAS, BSPTS, FED, FITS, Lyon, Side Shift, and DoboMed. The methodologies of these schools are similar, in that they focus on applying corrective exercises in three planes, developing stability and balance, breathing exercises, and posture awareness. Although high-quality research supporting the effectiveness of PSSE physiotherapy in the treatment of AIS is lacking, existing evidence indicates that PSSE physiotherapy helps to stabilize spinal deformity and improve patients’ quality of life.
  • 1.4K
  • 05 Aug 2022
Topic Review Video
The Link between Cardiovascular Disease and Exosomes
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In recent decades, clinical research has made significant advances, resulting in improved survival and recovery rates for patients with CVD. Despite this progress, there is substantial residual CVD risk and an unmet need for better treatment. The complex and multifaceted pathophysiological mechanisms underlying the development of CVD pose a challenge for researchers seeking effective therapeutic interventions. Consequently, exosomes have emerged as a new focus for CVD research because their role as intercellular communicators gives them the potential to act as noninvasive diagnostic biomarkers and therapeutic nanocarriers. In the heart and vasculature, cell types such as cardiomyocytes, endothelial cells, vascular smooth muscle, cardiac fibroblasts, inflammatory cells, and resident stem cells are involved in cardiac homeostasis via the release of exosomes. Exosomes encapsulate cell-type specific miRNAs, and this miRNA content fluctuates in response to the pathophysiological setting of the heart, indicating that the pathways affected by these differentially expressed miRNAs may be targets for new treatments.
  • 1.4K
  • 04 May 2023
Topic Review
Hyperlipidemic Rabbit Models
Hyperlipidemia is a major risk factor for atherosclerotic diseases. Experimental animals play an important role in elucidating the molecular mechanisms of the pathophysiology of hyperlipidemia as well as in drug development. Rabbits are one of the most suitable models to study human hyperlipidemia because many features of the lipoprotein metabolism of rabbits are similar to those of humans. Currently, three types of rabbit models are commonly used for studying hyperlipidemia: (1) diet-induced hyperlipidemic rabbits, (2) spontaneous hyperlipidemic rabbits, and (3) gene-manipulated rabbits (transgenic and knockout rabbits).
  • 1.4K
  • 07 Jan 2021
Topic Review
Genetics of Azoospermia
Azoospermia affects 1% of men, and it can be due to: (i) hypothalamic-pituitary dysfunction, (ii) primary quantitative spermatogenic disturbances, (iii) urogenital duct obstruction. Known genetic factors contribute to all these categories, and genetic testing is part of the routine diagnostic workup of azoospermic men. The diagnostic yield of genetic tests in azoospermia is different in the different etiological categories, with the highest in Congenital Bilateral Absence of Vas Deferens (90%) and the lowest in Non-Obstructive Azoospermia (NOA) due to primary testicular failure (~30%). Whole-Exome Sequencing allowed the discovery of an increasing number of monogenic defects of NOA with a current list of 38 candidate genes. These genes are of potential clinical relevance for future gene panel-based screening.
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  • 11 May 2021
Topic Review
UORFs for Stress-Tolerant Crops Development
Gene-editing technology, based on the clustered regularly interspaced short palindromic repeats (CRISPR) platform, has emerged as a revolutionary tool for targeted gene mutation, and has received attention as a game changer in the global biotechnology market.
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  • 11 May 2021
Topic Review
Video Surveillance Systems
Video surveillance systems are widely deployed with large systems for use in strategic places such as home security, public transportation, banks, ATM centers, city centers, airports, and public roads, and play a vital role in protecting critical infrastructures. As various attacks are possible in these systems, identifying attacks and considering suitable security measures are essential. In this paper, we present a detailed review of existing and possible threats in video surveillance, CCTV, and IP-camera systems.
  • 1.4K
  • 22 Jun 2021
Topic Review
Rumex dentatus L.
Herbicide resistance in weeds is a global threat to sustaining food security. In India, herbicide-resistant Phalaris minor was the major problem in wheat for more than two decades, but the continuous use of metsulfuron-methyl (an ALS inhibitor) to control broadleaf weeds has resulted in the evolution of ALS inhibitor-resistant Rumex dentatus L. This review summarizes the current scenario of herbicide resistance in R. dentatus, along with its ecology and management perspectives. Studies have provided valuable insights on the emergence pattern of R. dentatus under different environments in relation to tillage, cropping systems, nutrients, and irrigation. Moreover, R. dentatus has exhibited higher emergence under zero tillage, with high infestation levels in rice-wheat compared to other wheat-based cropping systems (sorghum-wheat). Alternative herbicides for the management of resistant R. dentatus include pendimethalin, 2,4-D, carfentrazone, isoproturon, and metribuzin. Although the pre-emergence application of pendimethalin is highly successful in suppressing R. dentatus, but its efficiency is questionable under lower field soil moisture and heavy residue load conditions. Nevertheless, the biological data may be utilized to control R. dentatus. Therefore, herbicide rotation with suitable spray techniques, collecting weed seeds at differential heights from wheat, crop rotation, alternate tillage practices, and straw retention are recommended for addressing the resistance issue in R. dentatus in North India conditions. Overall, we discuss the current state of herbicide resistance in R. dentatus, the agronomic factors affecting its population, its proliferation in specific cropping systems (rice-wheat), and management strategies for containing an infestation of a resistant population. 
  • 1.4K
  • 29 Jun 2021
Topic Review
Grouting in Coal Mass
Pre-grouting as an effective means for improving the stability of roadways can reduce maintenance costs and maintain safety in complex mining conditions. In the Guobei coal mine in China, a cement pre-grouting technique was adopted to enhance the overall strength of soft coal mass and provide sufficient support for the roadway. However, there are very limited studies about the effect of grouting on the overall strength of coal in the laboratory.
  • 1.4K
  • 31 Aug 2021
Topic Review
The Glycerolipid/NEFA Cycle
Lipotoxicity and glucotoxicity emerged as established mechanisms participating in the pathophysiology of obesity-related type 2 diabetes in general, and in the loss of β-cell function in particular. Glycerolipid/free fatty acid cycle as a protective pathway mediating active storage and recruitment of lipids.
  • 1.4K
  • 29 Mar 2022
Topic Review
Estrogens and Androgens in Plants
Steroids are a group of compounds to which a number of crucial metabolism-controlling hormones belong. The group of steroid hormones that are present and active in animals and humans (mammalian steroid hormones) is large and includes, among others, corticosteroids, which control, for example, water and mineral management and sex hormones—i.e., androgens, estrogens, progesterone, which are responsible for development and reproduction.  Ecdysteroids are mainly known as being the steroid hormones of arthropods that regulate ecdysis and development. In plants, the steroid regulators include the brassinosteroids, which are hormones that have a multidirectional activity and are engaged in plant growth, development, and its response to environmental stresses.
  • 1.4K
  • 11 Jan 2022
Topic Review
Extreme Birth Weight and Metabolic Syndrome in Children
Small and large birth weights (BWs) for gestational age (GA) represent extremes, but the correlation between extreme BW and metabolic syndrome (MetS) has not been fully elucidated. 
  • 1.4K
  • 15 Feb 2022
Topic Review
Strontium Functionalization of Biomaterials for Bone Tissue Engineering
Strontium (Sr) is a trace element taken with nutrition and found in bone in close connection to native hydroxyapatite. Sr is involved in a dual mechanism of coupling the stimulation of bone formation with the inhibition of bone resorption, as reported in the literature. Interest in studying Sr has increased in the last decades due to the development of strontium ranelate (SrRan), an orally active agent acting as an anti-osteoporosis drug. However, the use of SrRan was subjected to some limitations starting from 2014 due to its negative side effects on the cardiac safety of patients. In this scenario, an interesting perspective for the administration of Sr is the introduction of Sr ions in biomaterials for bone tissue engineering (BTE) applications. This strategy has attracted attention thanks to its positive effects on bone formation, alongside the reduction of osteoclast activity, proven by in vitro and in vivo studies.
  • 1.4K
  • 07 Mar 2022
Topic Review
Bilinear Filtering
Bilinear filtering is a texture filtering method used to smooth textures when displayed larger or smaller than they actually are. Most of the time, when drawing a textured shape on the screen, the texture is not displayed exactly as it is stored, without any distortion. Because of this, most pixels will end up needing to use a point on the texture that is "between" texels – assuming the texels are points (as opposed to, say, squares) – in the middle (or on the upper left corner, or anywhere else; it does not matter, as long as it is consistent) of their respective "cells". Bilinear filtering uses these points to perform bilinear interpolation between the four texels nearest to the point that the pixel represents (in the middle or upper left of the pixel, usually).
  • 1.4K
  • 02 Nov 2022
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