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Topic Review
White-Light Endoscopy for Gastric Cancer
Gastric cancer is an aggressive disease with low long-term survival rates. An early diagnosis is essential to offer a better prognosis and curative treatment. Upper gastrointestinal endoscopy is the main tool for the screening and diagnosis of patients with gastric pre-neoplastic conditions and early lesions. Under white-light endoscopy (WLE), early gastric cancer (EGC) should be suspected in the presence of mucosal surface irregularity and/or mucosal coloration changes.
  • 1.4K
  • 13 Jun 2023
Topic Review
Secondary Metabolism's Main Biosynthetic Pathways in Solid-State Fermentation
Microbial secondary metabolites are low-molecular-weight compounds synthesized by microorganisms after the growth phase. Secondary metabolites are not directly involved in microbial growth. Solid-state fermentation (SSF) is a process whereby microorganisms grow in the absence of free water or with low water content. It has been used since ancient times to obtain fermented foods such as koji, bread, and cheeses.
  • 1.4K
  • 13 Oct 2023
Topic Review
Fragmentation of Human Embryos
Embryo fragmentation represents a phenomenon generally characterized by the presence of membrane-bound extracellular cytoplasm into the perivitelline space. 
  • 1.4K
  • 18 Feb 2022
Topic Review
Homologous Recombination Repair Deficiency
Homologous recombination repair deficiency (HRD) can be observed in virtually all cancer types. Cells possess a complex set of non-redundant and partially overlapping pathways to detect and repair DNA damage. In cancer, DNA damage repair (DDR) is frequently disrupted, leading to genomic instability. One of the pathways that is regularly altered in cancer is HR. HR is an important pathway for the repair of double-strand DNA breaks (DSBs) during the S and G2 phase of the cell cycle, i.e., after DNA replication has occurred. HR is considered a relatively error-free process because it uses an intact sister chromatid to guide DNA repair. HR deficiency (HRD) leads to enhanced reliance on alternative pathways involved in DSB repair, i.e., classical NHEJ, alternative end joining, and single-strand annealing. These pathways repair DSBs without a homologous DNA template, resulting in characteristic genomic scars across the genome.
  • 1.4K
  • 25 May 2021
Topic Review
Rhus trilobata Nutt. (Anacardiaceae)
Rhus trilobata (RHTR) is a medicinal plant with cytotoxic activity in different cancer cell lines. However, the active compounds in this plant against ovarian cancer are unknown. In this study, we aimed to evaluate the antineoplastic activity of RHTR and identify its active metabolites against ovarian cancer. The aqueous extract (AE) and an active fraction (AF02) purified on C18-cartridges/ethyl acetate decreased the viability of SKOV-3 cells at 50 and 38 μg/mL, respectively, compared with CHO-K1 (> 50 μg/mL) in MTT assays and generated changes in the cell morphology with apoptosis induction in Hemacolor® and TUNEL assays (p ≤ 0.05, ANOVA). The metabolite profile of AF02 showed a higher abundance of flavonoid and lipid compounds compared with AE by UPLC-MS. Gallic acid and myricetin were the most active compounds in RHTR against SKOV-3 cells at 50 and 166 μg/mL, respectively (p ≤ 0.05, ANOVA). Antineoplastic studies in Nu/Nu female mice with subcutaneous SKOV-3 cells xenotransplant revealed that 200 mg/kg/i.p. of AE and AF02 inhibited ovarian tumor lesions from 37.6% to 49% after 28 days (p ≤ 0.05, ANOVA). In conclusion, RHTR has antineoplastic activity against ovarian cancer through a cytostatic effect related to gallic acid and myricetin. Therefore, RHTR could be a complementary treatment for this pathology.
  • 1.4K
  • 05 Nov 2021
Topic Review
The Village Fund Program in Indonesia
This study analyzes the Indonesian Village Fund (VF) Program by mapping each VF-related activity to all 17 SDGs (Sustainable Development Goals), and then determines an SDG-based VF allocation in 2018, 2019, and 2020. This study used data from all villages in Indonesia and is the most comprehensive study in Indonesia to address the knowledge gap between VF allocation and SDGs by analyzing the distribution of the use of the VF. The objectives of this paper are: (1) to provide the extent of VF usage to provide evidence on whether this utilization was aligned with the targeted SDGs, and (2) to provide information regarding village activities funded by the VF that were linked to each SDG. The results from this analysis can be used to encourage the Government to socialize and provide an understanding of SDGs to village leaders. Moreover, since Indonesia has developed Village SDGs, which are based on national SDG targets and localization of global SDGs to adapt to local culture as well as social and environmental conditions, it is recommended that other developing countries could formulate similar strategies to help achieve their national SDG targets and to develop rural areas in a more targeted way by prioritizing the most relevant issues. The study shares lessons learned from Indonesian experience in managing fiscal policy to more than 70,000 autonomous villages through the village fund program in the last five years. 
  • 1.4K
  • 01 Dec 2021
Topic Review
Colchicine in Combating COVID-19 Cytokine Storm
Despite the advance in the management of Coronavirus disease 2019 (COVID-19), the global pandemic is still ongoing with a massive health crisis. COVID-19 manifestations may range from mild symptoms to severe life threatening ones. The hallmark of the disease severity is related to the overproduction of pro-inflammatory cytokines manifested as a cytokine storm. Based on its anti-inflammatory activity through interfering with several pro and anti-inflammatory pathways, colchicine had been proposed to reduce the cytokine storm and subsequently improve clinical outcomes.
  • 1.4K
  • 11 Feb 2022
Topic Review
Natural Products against Breast Cancer
Breast cancer (BC) is the second leading cause of death among women, and it has become a global health issue due to the increasing number of cases. Different treatment options, including radiotherapy, surgery, chemotherapy and anti-estrogen therapy, aromatase inhibitors, anti-angiogenesis drugs, and anthracyclines, are available for BC treatment. However, due to its high occurrence and disease progression, effective therapeutic options for metastatic BC are still lacking. Considering this scenario, there is an urgent need for an effective therapeutic strategy to meet the current challenges of BC. Natural products have been screened as anticancer agents as they are cost-effective, possess low toxicity and fewer side effects, and are considered alternative therapeutic options for BC therapy. Natural products showed anticancer activities against BC through the inhibition of angiogenesis, cell migrations, proliferations, and tumor growth; cell cycle arrest by inducing apoptosis and cell death, the downstream regulation of signaling pathways (such as Notch, NF-κB, PI3K/Akt/mTOR, MAPK/ERK, and NFAT-MDM2), and the regulation of EMT processes. Natural products also acted synergistically to overcome the drug resistance issue, thus improving their efficacy as an emerging therapeutic option for BC therapy. 
  • 1.4K
  • 01 Jun 2022
Topic Review
Osteoimmunology in Periodontitis
Periodontitis is one of the most common oral diseases resulting in gingival inflammation and tooth loss. Growing evidence indicates that it results from dysbiosis of the oral microbiome, which interferes with the host immune system, leading to bone destruction. Immune cells activate periodontal ligament cells to express the receptor activator of nuclear factor kappa-B (NF-κB) ligand (RANKL) and promote osteoclast activity. Osteocytes have active roles in periodontitis progression in the bone matrix. Local proteins are involved in bone regeneration through functional immunological plasticity.
  • 1.4K
  • 02 Jun 2022
Topic Review
Insights into Immunogenic Cell Death
Immunogenic cell death (ICD) is a type of regulated cell death (RCD), increasingly studied in recent years, due to its therapeutic implication in several diseases associated with immune system dysfunction. The new and increasingly studied concept of immunogenic cell death (ICD) revealed a previously unknown perspective of the various regulated cell death (RCD) modalities, elucidating their immunogenic properties and rendering obsolete the notion that immune stimulation is solely the outcome of necrosis. A distinct characteristic of ICD is the release of danger-associated molecular patterns (DAMPs) by dying and/or dead cells. These are evolutionary conserved stress signals, recognized primarily by innate immune system receptors. The immunogenicity of DAMPs characterizes ICD, rendering them potential prognostic, diagnostic clinical tools and/or possible therapeutic targets.
  • 1.4K
  • 14 Jul 2022
Topic Review
AMPT
Alpha-methyl-p-tyrosine (AMPT) is a tyrosine hydroxylase enzyme inhibitor and is therefore a drug involved in inhibiting the catecholamine biosynthetic pathway. AMPT inhibits tyrosine hydroxylase whose enzymatic activity is normally regulated through the phosphorylation of different serine residues in regulatory domain sites. Catecholamine biosynthesis starts with dietary tyrosine, which is hydroxylated by tyrosine hydroxylase and it is hypothesized that AMPT competes with tyrosine at the tyrosine-binding site, causing inhibition of tyrosine hydroxylase. It has been used in the treatment of pheochromocytoma. It has been demonstrated to inhibit the production of melanin.
  • 1.4K
  • 25 Oct 2022
Topic Review
The PD-1/PD-L1 Pathway
Binding of the immune checkpoint programmed cell death protein 1 (PD-1) to its ligand programmed death-ligand 1 (PD-L1) downregulates the adaptive immune response. PD-L1 is regularly expressed by antigen presenting cells. During an acute immune response, effector T cells transiently upregulate PD-1. In contrast, chronic immune stimulation leads to continuous expression of PD-1 on effector T cells. The latter also occurs in the tumor microenvironment, where PD-L1 can be expressed by tumor cells. The PD-1/PD-L1 pathway is an excellent example for the clinical application of biomarker research in the context of comparative immuno-oncology. Initial comparator studies on this pathway were mainly conducted on cells and tissues derived from mice and humans. This resulted in the discovery of anti PD-1 or anti-PD-L1 immune checkpoint therapy that is widely applied for the treatment of human cancers. The use of monoclonal antibodies directed against PD-1 or PD-L1 as therapeutic agents restores the anti-cancer immune response. In recent years, investigations on these molecules have been extended to canine cancers and confirm the expression of PD-1 and PD-L1 in several canine tumors. Whether immune checkpoint therapy may be a possible treatment option for those canine cancers remains to be revealed in future clinical trials.
  • 1.4K
  • 02 Dec 2022
Topic Review
Envy-Free Cake-Cutting
An envy-free cake-cutting is a kind of fair cake-cutting. It is a division of a heterogeneous resource ("cake") that satisfies the envy-free criterion, namely, that every partner feels that their allocated share is at least as good as any other share, according to their own subjective valuation. When there are only two partners, the problem is easy and has been solved in Biblical times by the divide and choose protocol. When there are three or more partners, the problem becomes much more challenging. Two major variants of the problem have been studied: Connected pieces, e.g. if the cake is a 1-dimensional interval then each partner must receive a single sub-interval. If there are n partners, only n−1 cuts are needed. General pieces, e.g. if the cake is a 1-dimensional interval then each partner can receive a union of disjoint sub-intervals.
  • 1.4K
  • 02 Dec 2022
Topic Review
Extrahepatic Manifestations in Hepatitis C Virus Infection
Hepatitis C is a liver infection caused by the hepatitis C virus and is a major health problem that contributes to the global burden of chronic disease. Chronic infection can lead to liver cancer and death from end-organ damage. Despite the introduction of novel anti-viral therapy, the disease burden is still high. 
  • 1.4K
  • 30 Dec 2022
Topic Review
Juglans regia Linn.
Juglans regia Linn. belongs to the family Juglandaceae and is an aromatic transient tree that grows in abundance in the North-Western Himalayas of Kashmir that produces most of the world’s walnuts, accounting for around 88% of total walnut production.
  • 1.4K
  • 08 Feb 2023
Topic Review
Lichens, Mosses, and Vascular Plants in Biodeterioration
Biodeterioration is defined as the alteration of a given substrate due to a combination of physical and chemical factors produced by living organisms when attached to such materials. This phenomenon attracts scientific research attention due to its risk in causing destruction to outdoor cultural rock heritage sites. Trees and shrubs are the most harmful plant life forms, for example, Ficus carica, Ailanthus altissima, and Capparis spinosa, while regarding building materials, those characterized by high porosity, such as andesite and argillaceous limestone, are more vulnerable to plant colonization.
  • 1.4K
  • 20 Feb 2023
Topic Review
E-Commerce
E-commerce platforms enable companies of all sizes to sell their items and promote their brand to a broader audience. The e-commerce sector is continually developing, as new technology and methods of purchasing and selling services and items are developed. 
  • 1.4K
  • 08 May 2023
Topic Review
Geoinformatics
The geoinformatics is the programming of applications, spatial data structures, and analyses of objects and space-time phenomena referred to the Earth surface, together with designing, developing, and maintaining the software and web services intended for modelling and analysing the spatial data.
  • 1.4K
  • 19 Jun 2023
Topic Review
Initiatives for Reducing the Carbon Footprints at Ports
Seaport activities account for 3% of global carbon emissions, and as an important industrialised economic centre, ports engage in numerous industrial and financial activities that could increase their greenhouse gas (GHG) emissions and carbon footprints (CF). The 13th sustainable development goal (SDG) states that these activities must be balanced with environmental considerations.
  • 1.4K
  • 06 Dec 2023
Topic Review
Comparative Study of Keccak SHA-3 Implementations
SHA-3, a pivotal component in modern cryptography, has spawned numerous implementations across diverse platforms and technologies. This text aims to provide valuable insights into selecting and optimizing Keccak SHA-3 implementations. It encompasses an in-depth analysis of hardware, software, and software–hardware (hybrid) solutions. Researchers assess the strengths, weaknesses, and performance metrics of each approach. Critical factors, including computational efficiency, scalability, and flexibility, are evaluated across different use cases. Researchers investigate how each implementation performs in terms of speed and resource utilization. This text aims to improve the knowledge of cryptographic systems, aiding in the informed design and deployment of efficient cryptographic solutions. By providing a comprehensive overview of SHA-3 implementations, it offers a clear understanding of the available options and equips professionals and researchers with the necessary insights to make informed decisions in their cryptographic endeavors.
  • 1.4K
  • 15 Dec 2023
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