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Topic Review
Dioxin
Dioxins and related compounds are environmental xenobiotics that are dangerous to human life, due to the accumulation and persistence in the environment and in the food chain. Cancer, reproductive and developmental issues, and damage to the immune system and endocrine system are only a few examples of the impact of such substances in everyday life. 
  • 1.4K
  • 06 Jan 2022
Topic Review
Cystine and Theanine
Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine. It is one of the strongest antioxidants in the body and important for adjusting immune function. Cystine and theanine (γ-glutamylethylamide) provide substrates of GSH, cysteine and glutamic acid, promoting the synthesis of GSH.
  • 1.4K
  • 11 Jan 2022
Topic Review
Nanomaterials for Optical Coherence Tomography in Nanodentistry
There is already a societal awareness of the growing impact of nanoscience and nanotechnology, with nanomaterials (with at least one dimension less than 100 nm) now incorporated in items as diverse as mobile phones, clothes or dentifrices. In the healthcare area, nanoparticles of biocompatible materials have already been used for cancer treatment or bioimaging enhancement. Nanotechnology in dentistry, or nanodentistry, has already found some developments in dental nanomaterials for caries management, restorative dentistry and orthodontic adhesives. 
  • 1.4K
  • 01 Mar 2022
Topic Review
Enterocin as a Biopreservative for Raw Meat Products
Food preservation is a method used to handle and treat food products to slow down food spoilage and subsequently reduce the risk of foodborne illness. Nowadays, the demand for natural preservatives over chemical preservatives in food is increasing due to the awareness of consuming healthy food products without the risk of harmful side effects. Thus, the research and development of preservation techniques, referred to as biopreservation, is growing rapidly. In biopreservation methods, microorganisms that are known as lactic acid bacteria (LAB) and their antimicrobial substances are used to extend shelf life and maintain the nutritional value of foods. Among the most studied LAB are from the genus Enterococcus, which produces a bacteriocin called enterocin. Bacteriocins are ribosomal-synthesized antimicrobial peptides that are capable of inhibiting the growth of pathogenic bacteria that cause spoilage in food. LAB is generally regarded as safe (GRAS) for human consumption. 
  • 1.4K
  • 11 Apr 2022
Topic Review
Impact of Insecticide Resistance on Vector Competence
The capacity of insects to transmit pathogens is known as vector competence (VC). Evidence indicates that insecticide exposure and resistance increase the risk of pathogen transmission. Under this context, adverse effects such as epidemics in human populations or economic repercussions on crops will increase while current vector control efforts become entirely ineffective. However, studies also point to opposite effects where IR or exposure to insecticides reduces VC. To determine the impact of insecticide resistance (IR) on VC precisely, it is essential to establish reproducible experimental designs to reduce the presence of confusing variables that make the interpretation of results difficult. Therefore, although there is evidence related to the influence of IR on VC, more research is necessary.
  • 1.4K
  • 22 Apr 2022
Topic Review
Breeding Diploid F1 Hybrid Potatoes
Diploid potatoes can be converted from an outbreeding species, in which self-pollination is prevented by a gametophytic self-incompatibility system, into one where self-pollination is possible, either through a dominant self-incompatibility inhibitor gene (Sli) or knockout mutations in the incompatibility locus.
  • 1.4K
  • 29 Apr 2022
Topic Review
German University of Administrative Sciences, Speyer
The German University of Administrative Sciences Speyer (German: Deutsche Universität für Verwaltungswissenschaften Speyer; sometimes referred to as Speyer University), is a national graduate school for administrative sciences and public management located in Speyer, Rhineland-Palatinate, Germany . Founded in 1947 by the French occupational authorities as a grande école, today it is operated under the joint responsibility of both the Federal Republic (Bund) and all 16 German states (Länder). It runs four Master's programs, grants doctoral degrees and habilitations, offers a postgraduate certificate program, and administers programs of executive education. The school is a major training ground for German and international senior government officials. Noted alumni and faculty include former President of Germany Roman Herzog, current Minister of Justice Christine Lambrecht, former President of the Bundesbank Helmut Schlesinger, former Prosecutor General of Germany Alexander von Stahl, and CEO of BASF Jürgen Strube. The school was founded in 1947 as the State Academy of Administrative Sciences Speyer (Staatliche Akademie für Verwaltungswissenschaften Speyer). In 1950 it was renamed the School of Administrative Sciences Speyer (Hochschule für Verwaltungswissenschaften Speyer) and after reunification became the German School of Administrative Sciences Speyer (Deutsche Hochschule für Verwaltungswissenschaften Speyer).
  • 1.4K
  • 14 Oct 2022
Topic Review
Sortilin/Neurotensin Receptor-3 in Cancer
The multifunctional role of sortilin in cancers development The development of cancerous tumors is known to be the consequence of the overexpression of growth factors. Unfortunately, when treated with radiotherapy or chemical therapy, some tumors can metastasize as a result of the weakening of cancer cell–cell interactions in the tumor tissue, leading to the dissemination of cancer cells in the circulation. Both mechanisms of cancer growth and metastasis are regulated by a large panel of circulating activators from several neuropeptides to membrane-bound factors released by matrix metalloprotease (MMP)-dependent shedding, such as Epidermal Growth Factor Receptor (EGFR) ligands. One of the most studied neuropeptides involved in cancer progression is neurotensin (NTS), the three known receptors of which (two G-protein coupled receptors, NTSR1 and NTSR2, and a type I receptor, NTSR3) are expressed in numerous cancers and particularly in digestive cancers. Interestingly, NTSR3, also previously identified as Sortilin, is shed from the plasma membrane, leading to the release of a soluble form of sortilin (sSortilin). However, growing evidence indicates the emerging role of membrane-bound Sortilin/NTSR3 and its soluble counterpart in cancer cell proliferation and dissemination.
  • 1.4K
  • 21 Oct 2022
Topic Review
Ethical Arguments Regarding Torture
Ethical arguments have arisen regarding torture, and its debated value to society. Despite worldwide condemnation and the existence of treaty provisions that forbid it, some countries still use it. The ethical assertion that torture is a tool is at question.
  • 1.4K
  • 01 Nov 2022
Topic Review
Bücker Bü 131
The Bücker Bü 131 "Jungmann" (freshman, young man) was a German 1930s basic training aircraft which was used by the Luftwaffe during World War II.
  • 1.4K
  • 03 Nov 2022
Topic Review
Archery Games
These novelty forms of archery are generally regarded as amusements, and, as such, are not governed by organizationally-sanctioned rules.
  • 1.4K
  • 04 Nov 2022
Topic Review
Physiological Roles of CoQ10 in Humans
Coenzyme Q10 (CoQ10) is a compound with a crucial role in mitochondrial bioenergetics and membrane antioxidant protection. Despite the ubiquitous endogenous biosynthesis, specific medical conditions are associated with low circulating CoQ10 levels. However, previous studies of oral CoQ10 supplementation yielded inconsistent outcomes. In this text, previous CoQ10 trials are reviewed, either single or in combination with other nutrients, and stratified the study participants according to their metabolic statuses and medical conditions. The CoQ10 supplementation trials in elders reported many favorable outcomes. However, the single intervention was less promising when the host metabolic statuses were worsening with the likelihood of multiple nutrient insufficiencies, as in patients with an established diagnosis of metabolic or immune-related disorders. On the contrary, the mixed CoQ10 supplementation with other interacting nutrients created more promising impacts in hosts with compromised nutrient reserves. Furthermore, the results of either single or combined intervention will be less promising in far-advanced conditions with established damage, such as neurodegenerative disorders or cancers. With the limited high-level evidence studies on each host metabolic category, it could only be concluded that the considerations of whether to take supplementation varied by the individuals’ metabolic status and their nutrient reserves. Further studies are warranted.
  • 1.4K
  • 15 Nov 2022
Topic Review
Regulation of Nanotechnology
Because of the ongoing controversy on the implications of nanotechnology, there is significant debate concerning whether nanotechnology or nanotechnology-based products merit special government regulation. This mainly relates to when to assess new substances prior to their release into the market, community and environment. Nanotechnology refers to an increasing number of commercially available products – from socks and trousers to tennis racquets and cleaning cloths. Such nanotechnologies and their accompanying industries have triggered calls for increased community participation and effective regulatory arrangements. However, these calls have presently not led to such comprehensive regulation to oversee research and the commercial application of nanotechnologies, or any comprehensive labeling for products that contain nanoparticles or are derived from nano-processes. Regulatory bodies such as the United States Environmental Protection Agency and the Food and Drug Administration in the U.S. or the Health and Consumer Protection Directorate of the European Commission have started dealing with the potential risks posed by nanoparticles. So far, neither engineered nanoparticles nor the products and materials that contain them are subject to any special regulation regarding production, handling or labelling.
  • 1.4K
  • 29 Nov 2022
Topic Review
Chronic Autoimmune Gastritis
Helicobacter pylori (HP) infection and the autoimmune inflammation of the gastric mucosa are recognized as the leading etiological factors of chronic atrophic gastritis, a disease associated with an increased risk of stomach cancer development. Additionally, in relation to HP-associated gastritis, there is international and national consensus on the diagnosis and treatment of infection; however, with regard to autoimmune inflammation, clinicians have faced diagnostic difficulties. At the same time, autoimmune inflammation of the gastric mucosa, in addition to the formation of atrophy and an increase in the risk of stomach cancer, carries additional risks, both in relation to neoplasms (neuroendocrine tumors) and in relation to the deficiency of a number of micronutrients with the involvement of other organs and systems.
  • 1.4K
  • 30 Nov 2021
Topic Review
Screening of Medicinal Plants
Secondary metabolites, used as a single compound or as a mixture, are medicines that can be effective and safe even when synthetic drugs fail. They may even potentiate or synergize the effects of other compounds in the medicine. To meet the positive demands, heterologous expression of the genes involved in the biosynthesis of the potent compound will help in the production on the required scale. Further modifications to enhance the ADME properties of the compounds will have a significant advantage in the drug’s biological activities and bioavailability.
  • 1.4K
  • 30 Oct 2020
Topic Review
Permafrost Carbon Cycle
The permafrost carbon cycle is a sub-cycle of the larger global carbon cycle. Permafrost is defined as subsurface material that remains below 0o C (32o F) for at least two consecutive years. Because permafrost soils remain frozen for long periods of time, they store large amounts of carbon and other nutrients within their frozen framework during that time. Permafrost represents a large carbon reservoir that is seldom considered when determining global terrestrial carbon reservoirs. Recent and ongoing scientific research however, is changing this view. The permafrost carbon cycle (Arctic Carbon Cycle) deals with the transfer of carbon from permafrost soils to terrestrial vegetation and microbes, to the atmosphere, back to vegetation, and finally back to permafrost soils through burial and sedimentation due to cryogenic processes. Some of this carbon is transferred to the ocean and other portions of the globe through the global carbon cycle. The cycle includes the exchange of carbon dioxide and methane between terrestrial components and the atmosphere, as well as the transfer of carbon between land and water as methane, dissolved organic carbon, dissolved inorganic carbon, particulate inorganic carbon and particulate organic carbon.
  • 1.4K
  • 04 Nov 2022
Topic Review
Guidelines for Using Antipruritic Drugs in Dogs
Pruritus is defined as an unpleasant sensation that provokes the desire to scratch. Pruritus is a common clinical sign of many skin disorders and is the most common complaint in canine dermatology. Pruritic skin diseases can affect the quality of life (QoL) of dogs and their owners. The first indication for the use of antipruritic drugs is, of course, allergies, notably canine atopic dermatitis (AD). However, in pruritic infections or parasitic dermatoses, the speed of action and the level of efficacy of etiological treatments vary and, to improve the QoL of both the dog and the owner, the use of an additional symptomatic antipruritic drugs in addition to etiological treatment sometimes makes sense after obtaining a clear diagnosis.
  • 1.4K
  • 13 Apr 2022
Topic Review
Alveolar Macrophages
At the early stages of life development, alveoli are colonized by embryonic macrophages, which become resident alveolar macrophages (ResAM) and self-sustain by local division. Genetic and epigenetic signatures and, to some extent, the functions of ResAM are dictated by the lung microenvironment, which uses cytokines, ligand-receptor interactions, and stroma cells to orchestrate lung homeostasis. 
  • 1.4K
  • 05 Nov 2021
Topic Review
HERC Ubiquitin Ligases in Cancer
HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3–HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell proliferation, cell migration, and immune responses. Accumulating evidence also shows that this family plays critical roles in cancer. In this review, we provide an integrated view of the role of these ligases in cancer, highlighting their bivalent functions as either oncogenes or tumor suppressors, depending on the tumor type.
  • 1.4K
  • 21 Oct 2020
Topic Review
Cerebellar Ataxias
The terminology of cerebellar ataxias (CAs) embraces a ubiquitous deficit in 3 elemental domains: (a) limbs’ motor symptoms, (b) oculomotor symptoms, and (c) cognitive/emotional symptoms occurring in patients showing cerebellar dysfunction. Patients with CAs develop inaccuracy and clumsiness limb movements, characterized by dysmetria, tremor and adiadochokinesis. Posture is irregular and gait is unstable. Ocular movements lack accuracy. Cerebellar patients also show similar deficits in executive functions, linguistic processing, spatial cognition and affect regulation. Recent physiological studies have clarified that cerebellar outputs are modified by the release or facilitation of Purkinje cell-mediated inhibition on the cerebellar nucleus neurons. Thus, impairments in the formation of output signals elicit asthenia and adventitious movements, described by Holmes. These output signals are formed under controls of the internal forward model, embedded in the cerebellum. The deficits in the predictive computation for voluntary movements explains a range of characteristics accompanied by dysmetria. We argue that the impairments in the cerebellar outputs signals and the dysfunction in the internal forward model are fundamental mechanisms explaining the deficits in the 3 domains.
  • 1.4K
  • 02 Jul 2021
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