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Topic Review
Therapeutic Potential of MSC-EVs in Neurodegenerative Disorders
The application of mesenchymal stem cells (MSCs) represents a new promising approach for treating neurodegenerative diseases. Growing evidence suggests that the therapeutic effects of MSCs are due to the secretion of neurotrophic molecules through extracellular vesicles. The extracellular vesicles produced by MSCs (MSC-EVs) have valuable innate properties deriving from parental cells and could be exploited as cell-free treatments for many neurological diseases.
  • 1.4K
  • 23 Feb 2023
Topic Review
Surgical Coaptation Techniques in Peripheral Nerve Injuries
Peripheral nerve injuries requiring surgical repair affect over 100,000 individuals in the US annually. Three accepted methods of peripheral repair include end-to-end, end-to-side, and side-to-side neurorrhaphy, each with its own set of indications.
  • 1.4K
  • 23 Feb 2023
Topic Review
Nrf2 Activation in Neurodegenerative Diseases
Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and loss of nerve cells. Oxidative stress has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders since neuron cells are particularly vulnerable to oxidative damage. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is strictly related to anti-inflammatory and antioxidative cell response; therefore, its activation and the consequent enhancement of the related cellular pathways have been proposed as a potential therapeutic approach.
  • 1.4K
  • 12 Apr 2023
Topic Review
Microplastics in the Aquatic Environment
Microplastics, or microbeads, are plastic particles < 5 mm diameter, and they include nano-sized particles (1 nm). Their size has been miniaturized or fragmented enough that there might be a need for the use of microscopy techniques to study them. In many cases, microplastics continue to carry the chemical structure of their parent plastic with minimum alterations due to exposure to varied environments.
  • 1.4K
  • 30 Jun 2021
Topic Review
Selective Serotonin Reuptake Inhibitors
Selective serotonin reuptake inhibitors (SSRIs) are an essential pharmacological treatment for patients with unmanageable premenstrual syndrome (PMS) and premenstrual dysmorphic disorder (PMDD). SSRIs can be taken either continuously or in the luteal phase to reduce the symptoms of PMS and PMDD. Most SSRIs exhibit equal efficacy for the treatment of PMS and PMDD, so a provider’s choice of SSRI should be based on anticipated side effects and the patient’s response to the drug.
  • 1.4K
  • 23 Aug 2021
Topic Review
Rosemary (Rosmarinus officinalis)
Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory repute, is employed in traditional medicines in many countries. Rosemary contains carnosic acid (CA) and carnosol (CS), abietane-type phenolic diterpenes, which account for most of its biological and pharmacological actions, although claims have also been made for contributions of another constituent, rosmarinic acid. 
  • 1.4K
  • 28 Jan 2022
Topic Review
Chromatin Profiling Techniques
The genetic architecture of complex traits is multifactorial. Genome-wide association studies (GWASs) have identified risk loci for complex traits and diseases that are disproportionately located at the non-coding regions of the genome. On the other hand, we have just begun to understand the regulatory roles of the non-coding genome, making it challenging to precisely interpret the functions of non-coding variants associated with complex diseases. Additionally, the epigenome plays an active role in mediating cellular responses to fluctuations of sensory or environmental stimuli. However, it remains unclear how exactly non-coding elements associate with epigenetic modifications to regulate gene expression changes and mediate phenotypic outcomes. Therefore, finer interrogations of the human epigenomic landscape in associating with non-coding variants are warranted.
  • 1.4K
  • 21 Jul 2021
Topic Review
Microglia as Therapeutic Target for Radiation-Induced Brain Injury
Radiation-induced brain injury (RIBI) after radiotherapy has become an increasingly important factor affecting the prognosis of patients with head and neck tumor. With the delivery of high doses of radiation to brain tissue, microglia rapidly transit to a pro-inflammatory phenotype, upregulate phagocytic machinery, and reduce the release of neurotrophic factors. 
  • 1.4K
  • 12 Aug 2022
Topic Review
The NK-1 Receptor Signaling in the Eye
Neurokinin-1 receptor (NK1R) signaling pathways play a crucial role in a number of biological processes in the eye. Specifically, in the ocular surface, their activity modulates epithelial integrity, inflammation, and generation of pain, while they have a role in visual processing in the retina. The NK1R is broadly expressed in the eye, in both ocular and non-ocular cells, such as leukocytes and neurons. 
  • 1.4K
  • 30 Nov 2022
Topic Review
Hyaluronic Acid-Based Nanosystems and Inflammation
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has a well-known ability to bind with the cluster of differentiation 44 (CD44) receptor on classically activated M1 macrophages. HA-nanosystems can be used for targeted drug delivery to counter inflammation and, subsequently, pain.
  • 1.4K
  • 26 Apr 2023
Topic Review
Retrospective Memory
Retrospective memory is the memory of people, words, and events encountered or experienced in the past. It includes all other types of memory including episodic, semantic and procedural. It can be either implicit or explicit. In contrast, prospective memory involves remembering something or remembering to do something after a delay, such as buying groceries on the way home from work. However, it is very closely linked to retrospective memory, since certain aspects of retrospective memory are required for prospective memory.
  • 1.4K
  • 06 Dec 2022
Topic Review
Application of CRISPR-Cas in Parkinson’s Disease
In 1987, bacteria were found to insert 32-nt (nucleotide) spacer sequences into 29-nt repeat sequences in CRISPR loci whenever they came into contact with phage DNA, leading to the discovery of the CRISPR-Cas system. The CRISPR-Cas-based technology can be employed as a new genome-editing tool in various organisms. The new gene-editing technique holds great promise for research and therapy of neurodegenerative diseases (NDs), such as Parkinson's disease (PD), for which there are currently no effective disease-modifying treatments.
  • 1.4K
  • 01 Jul 2022
Topic Review
Targeting the Neural Circuits for Treating Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease accompanied by cognitive and behavioral symptoms. These AD-related manifestations result from the alteration of neural circuitry by aggregated forms of amyloid-β (Aβ) and hyperphosphorylated tau, which are neurotoxic. From a neuroscience perspective, identifying neural circuits that integrate various inputs and outputs to determine behaviors can provide insight into the principles of behavior. Therefore, it is crucial to understand the alterations in the neural circuits associated with AD-related behavioral and psychological symptoms. Interestingly, it is well known that the alteration of neural circuitry is prominent in the brains of patients with AD. 
  • 1.4K
  • 28 Apr 2022
Topic Review Video Peer Reviewed
Depression in Elderly People
Depression is not a sign of weakness, nor a lack of will or laziness. It is not a simple “being sad” or bored, but rather a pathology that needs intervention, treatment, and monitoring by professionals with expertise in mental health. It is a disorder that impacts the lives of people who do not receive timely help affecting not only the individual himself in his feelings, thoughts, and behaviors but also harming his relationships and daily life and is prevalent among elderly people. Depression manifests through multiple symptoms, is caused by numerous factors, and is preventable with specific practices. It is described as the “most frequent mental health problem worldwide,” has a higher prevalence in women, is different from mourning and sadness, and needs to be addressed to avoid extreme situations, such as suicide.
  • 1.4K
  • 31 May 2023
Topic Review
Ferritinophagy and α-Synuclein
A major hallmark of Parkinson’s disease (PD) is the fatal destruction of dopaminergic neurons within the substantia nigra pars compacta. This event is preceded by the formation of Lewy bodies, which are cytoplasmic inclusions composed of α-synuclein protein aggregates. A triad contribution of α-synuclein aggregation, iron accumulation, and mitochondrial dysfunction plague nigral neurons, yet the events underlying iron accumulation are poorly understood. Elevated intracellular iron concentrations up-regulate ferritin expression, an iron storage protein that provides cytoprotection against redox stress. The intrinsically disordered synaptic protein, α-synuclein, is the principal component of neuronal Lewy bodies (LB) and Lewy neurites (LN), which are cytoplasmic inclusions that hallmark α-synucleinopathies.
  • 1.4K
  • 11 Mar 2022
Topic Review
Ageing, Microglia and Mitochondria in Parkinson’s Disease Neurodegeneration
Parkinson’s disease (PD) is an age-related chronic, progressive, multi-system, neurodegenerative disease with an incidence second only to Alzheimer’s disease. A PD diagnosis requires the presence of two core motor features, including diminished movement (bradykinesia), tremor, muscle rigidity, or postural instability, difficulty initiating voluntary movement (akinesia), involuntary eye movements, and blinking, which can take up to 15-20 years to become evident. There is now an increasing level of evidence linking mitochondrial dysfunction, including elevated oxidative stress, reactive oxygen species (ROS) and impaired cellular energy production, with the overactivation and escalation of a microglial mediated proinflammatory immune response, as naturally occurring and damaging interlinked bidirectional and self-perpetuating cycles that share common pathological processes in aging and PD. This research proposes that both chronic inflammation, microglial activation and neuronal mitochondrial impairment should be considered as concurrently influencing each other along a continuum, rather than as separate and isolated linear metabolic events that affect specific aspects of neural processing and brain function.
  • 1.4K
  • 18 Jul 2023
Topic Review
Nutrition in Chronic Pain Management
A poor nutritional status such as malnutrition, unhealthy dietary behaviors, and a suboptimal dietary intake can play a significant role in the occurrence, development, and prognosis of chronic pain. The relationship between nutrition and chronic pain is complex and may involve many underlying mechanisms such as oxidative stress, inflammation, and glucose metabolism. As such, pain management requires a comprehensive and interdisciplinary approach that includes nutrition. Nutrition is the top modifiable lifestyle factor for chronic non-communicable diseases including chronic pain.
  • 1.4K
  • 26 Oct 2022
Topic Review
Experimental Models for Neonatal Hypoxic-Ischemic Encephalopathy
Representing an important cause of long–term disability, term neonatal hypoxic-ischemic encephalopathy (HIE) urgently needs further research aimed at repurposing existing drug as well as developing new therapeutics. Since various experimental in vitro and in vivo models of HIE have been developed with distinct characteristics, it becomes important to select the appropriate preclinical screening cascade for testing the efficacy of novel pharmacological treatments.
  • 1.4K
  • 05 May 2022
Topic Review
Network Biology Approaches in Alzheimer’s Disease
Alzheimer’s disease (AD) is a polygenic multifactorial neurodegenerative disease that is without a cure. There are some symptomatic treatments to manage the psychological symptoms but none of these drugs can halt disease progression. Additionally, many anti-AD drugs failed in late stages of clinical trials and many hypotheses surfaced to explain these failures, including the lack of clear understanding of disease pathways and processes. Different epigenetic factors have been implicated in AD pathogenesis; thus, they could serve as promising AD diagnostic biomarkers. Additionally, network biology approaches have been suggested as effective tools to study AD on the systems level and discover multi-target-directed ligands as novel treatments for AD.
  • 1.4K
  • 22 Feb 2023
Topic Review
Early Motor Signs in Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a clinical condition characterized by social communication and interaction deficits, as well as by restricted interests and repetitive behaviors. A growing number of literature data suggest the presence of early impairments in the motor development of children with autism spectrum disorder, which could be often recognized even before the appearance of the classical social communication deficits of autism. 
  • 1.4K
  • 16 Mar 2022
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