You're using an outdated browser. Please upgrade to a modern browser for the best experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Magnetic Elements for Neuromorphic Computing
Neuromorphic computing is also called cognitive or adaptive computing. Brain-inspired computers could work like neuronal networks, be more energy-efficient, and could learn and solve special mathematical problems faster than recent computers. It is assumed to be significantly more energy efficient than, and at the same time expected to outperform, conventional computers in several applications, such as data classification, since it overcomes the so-called von Neumann bottleneck. Artificial synapses and neurons can be implemented into conventional hardware using new software, but also be created by diverse spintronic devices and other elements to completely avoid the disadvantages of recent hardware architecture.
  • 901
  • 01 Dec 2021
Topic Review
Crystal-storing Histiocytosis
Crystal-storing histiocytosis (CSH) is a rare event in disorders associated with monoclonal gammopathy and is mostly associated with the accumulation of immunoglobulins (Igs) in the cytoplasm of histiocytes. 
  • 899
  • 01 Jun 2021
Topic Review
Factors Affecting NCGs Removal
Bast fiber plants require a post-harvest process to yield useable natural cellulosic fibers, denoted as retting or degumming. It encompasses the degradation of the cell wall’s non-cellulosic gummy substances (NCGs), facilitating fibers separations, setting the fiber’s quality, and determining downstream usages. Due to the inconvenience of traditional retting practices, bacterial inoculum and enzyme applications for retting gained attention. Therefore, concurrent changes of agroclimatic and socioeconomic conditions, the conventional water retting confront multiple difficulties, bast industries become vulnerable, and bacterial agents mediated augmented bio-retting processes trying to adapt to sustainability. However, this process’s success demands a delicate balance among substrates and retting-related biotic and abiotic factors. These critical factors were coupled to degrade bast fibers NCGs in bacterial retting while holistically disregarded in basic research. In this study, a set of factors were defined that critically regulates the process and requires to be comprehended to achieve optimum retting without failure. 
  • 889
  • 24 Aug 2021
Topic Review
Carbohydrates/Matrix Lignin in Mechanically Graded Bamboo Culms
The mechanical performance of bamboo is highly dependent on its structural arrangement and the properties of biomacromolecules within the cell wall. Along the radius of bamboo culms, the concentration of xylan within the fiber sheath increased, while that of cellulose and lignin decreased gradually. At cellular level, although the consecutive broad layer (Bl) of fiber revealed a relatively uniform cellulose orientation and concentration, the outer Bl with higher lignification level has higher elastic modulus (19.59–20.31 GPa) than that of the inner Bl close to the lumen area (17.07–19.99 GPa). Comparatively, the cell corner displayed the highest lignification level, while its hardness and modulus were lower than that of fiber Bl, indicating the cellulose skeleton is the prerequisite of cell wall mechanics. The obtained cytological information is helpful to understand the origin of the anisotropic mechanical properties of bamboo.
  • 850
  • 12 Jan 2022
Topic Review
Fluidic Electrochemical Paper-Based Analytical Devices by Pen/Screen-printing
This is the fabrication of integrated electrochemical fluidic paper-based analytical devices (ePADs) using a marker pen drawing and screen-printing. The analytical utility of the ePADs is demonstrated through electrochemical determination of Pb(II) and Cd(II) by anodic stripping voltammetry
  • 828
  • 26 Nov 2021
Topic Review
Mitochondria-Targeting Probes
Sulfane sulfurs, which include hydropersulfides (RSSH), hydrogen polysulfides (H2Sn, n > 1), and polysulfides (RSnR, n > 2), play important roles in cellular redox biology and are closely linked to hydrogen sulfide (H2S) signaling. While most studies on sulfane sulfur detection have focused on sulfane sulfurs in the whole cell, increasing the recognition of the effects of reactive sulfur species on the functions of various subcellular organelles has emerged, such as mitochondria. This has driven a need for organelle-targeted detection methods.
  • 826
  • 08 Mar 2023
Topic Review
Non-Viral Delivery Systems
Non-viral delivery system simply refers to the use of non-viral vectors for drugs, genes or RNA delivery into cells. Non-viral vectors are safer, less toxic non-immunogenic alternatives to the viral vectors. They are easy to design, develop, and are inexpensive. 
  • 815
  • 21 Jan 2022
Topic Review
The Peculiar Properties of Human mitoNEET
The outer mitochondrial membrane (OMM) protein mitoNEET, also known as CDGSH Fe-S domain-containing protein-1 (CISD1), is composed of 108 amino acids, encompassing a N-terminal transmembrane helix (residues 14–32) that anchors the protein to the OMM, and a cytosolic portion (residues 33–108) that has been widely investigated through X-ray crystallography, showing a unique, highly conserved folding.
  • 813
  • 05 Dec 2022
Topic Review
Supercritical Fluid Applications in Novel Antimicrobial Materials
The extraordinary properties of supercritical fluids such as high density, near-zero surface tension, and high diffusivities enable the uniqueness and numerous advantages of the materials obtained.  The application of supercritical fluids is a powerful tool in the development of novel materials with antimicrobial activity desperately needed in the time of increasing bacterial resistance to antibiotics and the dramatic appearance and spread of not only multidrug-resistant (MDR) but also pandrug-resistant (PDR) bacterial strains. MDR is defined as the resistance to at least one antibiotic from at least three different categories, while PDR is defined as non-susceptibility to all drugs in all antimicrobial categories.
  • 809
  • 06 Dec 2021
Topic Review
Gas Monitoring for Graphene Medical Diagnosis
The development of graphene and its derivatives in gas-phase biomarker detection was reviewed in terms of the detection principle and the latest detection methods and applications in several common gases, etc. 
  • 799
  • 09 Feb 2022
Topic Review
New Horizons in Structural Biology of Membrane Proteins
A third of both pro- and eukaryotic proteomes consist of membrane proteins. Housed in a milieu of hydrophobic molecules, they serve as crucial contacts of communication between the cytoplasm and non-cytosolic environments, making them essential pharmaceutical targets. While membrane proteins are notoriously difficult to investigate at any level, high-resolution structures of these targets only became feasible at the very end of the twentieth century. It was not until robust technological developments in the fields of X-ray crystallography, NMR spectroscopy and cryo-EM, that the scientific community at large, finally gained access to an ever-increasing number of atomic resolution structures, and began to rationalize how membrane proteins accommodate their function. As if the lack of structural information wasn’t enough to hamper progress, a higher level of complexity arose from the modern understanding of “one structure—one function” paradigm, a primitive simplification useful at the dawn of the scientific era, that has promptly lost credence to the complex maneuvers of membrane proteins.
  • 793
  • 26 Apr 2022
Topic Review
Heterometal Grafted Metalla-ynes and Poly(metalla-ynes)
Metalla-ynes and poly(metalla-ynes) have emerged as unique molecular scaffolds with fascinating structural features and intriguing photo-luminescence (PL) properties. Their rigid-rod conducting backbone with tunable photo-physical properties has generated immense research interests for the design and development of application-oriented functional materials.
  • 781
  • 05 Nov 2021
Topic Review
Acyl-Homoserine Lactones Improve Growth of Ginseng Seedlings
Panax ginseng is a well-known medicinal plant that achieves strong resistance against plant pathogens while growing in the wild. Due to the high market demand for ginseng as a health food source, ginseng cultivation is prevalent in South Korea. However, continuous monocropping creates problems like irregular growth or vulnerability to crop diseases. Quorum sensing (QS) deals with the intracellular communication of bacteria and plays a role in dynamic changes in the soil microbiome. Here, we investigated how acyl-homoserine lactone (AHL) signaling molecules in QS (C8, C10, and C12) improve plant growth and induce shifts in the soil microbiome. To assess the effects, we recorded root and shoot growth of ginseng seedlings and checked the changes in the soil microbiome during different time points (0, 2, 4, and 8) after 8 weeks of growth. We observed that soils treated with N-decanoyl-L-homoserine lactone (C10) showed the most pronounced effects. Very striking was that C10 had the lowest alpha diversity. Using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt2), we observed a high number of QS-related functional genes, with the highest count occurring in the untreated planted soil (W). Together with the known direct and beneficial effects of AHLs on plant development, AHLs treated mono-cropped soil showed trends in the microbiome community. 
  • 770
  • 10 Nov 2021
Topic Review
Reproducibility Evaluation of Urinary Peptide Detection Using CE-MS
In recent years, capillary electrophoresis coupled to mass spectrometry (CE-MS) has been increasingly applied in clinical research especially in the context of chronic and age-associated diseases, such as chronic kidney disease, heart failure and cancer. Biomarkers identified using this technique are already used for diagnosis, prognosis and monitoring of these complex diseases, as well as patient stratification in clinical trials. CE-MS allows for a comprehensive assessment of small molecular weight proteins and peptides (<20 kDa) through the combination of the high resolution and reproducibility of CE and the distinct sensitivity of MS, in a high-throughput system. In this study we assessed CE-MS analytical performance with regards to its inter- and intra-day reproducibility, variability and efficiency in peptide detection, along with a characterization of the urinary peptidome content. To this end, CE-MS performance was evaluated based on 72 measurements of a standard urine sample (60 for inter- and 12 for intra-day assessment) analyzed during the second quarter of 2021. Analysis was performed per run, per peptide, as well as at the level of biomarker panels. The obtained datasets showed high correlation between the different runs, low variation of the ten highest average individual log2 signal intensities (coefficient of variation, CV < 10%) and very low variation of biomarker panels applied (CV close to 1%). The findings of the study support the analytical performance of CE-MS, underlining its value for clinical application.
  • 762
  • 17 Dec 2021
Topic Review
Pectin–Zeolite-Based Wound Dressings with Controlled Albumin Release
Hypoalbuminemia is a disorder caused by low albumin production rates or an increased loss due to several possible reasons. Hypoalbuminemia can lead to poor and delayed wound healing, while it is also associated with acute myocardial infarction, heart failure, malignancies, and COVID-19. In elective surgery, patients with low albumin have high risks of postoperative wound complications. 
  • 746
  • 29 Mar 2022
Topic Review
Mannich-type substitution of KYNA derivatives
Kynurenic acid (KYNA) is an endogenous neuroprotective agent of increasing importance. Several derivatives have already been synthesized, bearing an abundance of functional groups attached to the main skeleton in different positions. Several of these compounds have already been tested in biological evaluations, with several of them targeting the same receptors and biological effects as KYNA.
  • 736
  • 15 Nov 2021
Topic Review
Voltammetric Techniques in Assessing the Food Quality
Generally, the detection of analytes or molecules present in food materials interferes with the chromophore moieties in the food. Some of the common problems with the use of conventional methods in determining food quality are low sensitivity to redox changes, turbidity, low spectrum resolution, and scattering issues related to the sample. Moreover, the miniaturization and portability of detectors are the biggest disadvantages of conventional methods. Therefore, there is a huge demand for quick, robust, selective, and easy methods, such as voltammetric methods, for determining the food’s quality. They exhibit a higher level of selectivity for the redox reactions, and a faster response. They are very simple, economical, and their portability with unlimited miniaturization has made them an ideal and popular choice for assessing the food quality compared with other analytical methods.
  • 718
  • 23 Dec 2022
Topic Review
Green Carbon Nanostructures for Functional Composite Materials
Graphene is a two-dimensional (2D) material composed of sp2 carbon monolayer arranged into a hexagonal network. Reduced graphene oxide (rGO), a carbon nanostructure from the graphene derivatives family, has been incorporated in composite materials due to its remarkable electrical conductivity, mechanical strength capacity, and low cost. Graphene oxide (GO) is typically synthesized by the improved Hummers’ method and then chemically reduced to obtain rGO.
  • 695
  • 28 Feb 2022
Topic Review
Aβ Detection by Electrochemical Sensors
Alzheimer’s disease has taken the spotlight as a neurodegenerative disease which has caused crucial issues to both society and the economy. Specifically, aging populations in developed countries face an increasingly serious problem due to the increasing budget for patient care and an inadequate labor force, and therefore a solution is urgently needed. Diverse techniques for the detection of Alzheimer’s biomarkers have been researched and developed to support early diagnosis and treatment. Among them, electrochemical biosensors and electrode modification proved their effectiveness in the detection of the Aβ biomarker at appropriately low concentrations for practice and point-of-care application. 
  • 643
  • 22 Aug 2023
Topic Review
Linear Energy Transfer Effects on Cystamine’s Radioprotective Activity
Radioprotective agents are increasingly drawing attention for their potential uses in various critical fields.  These include radiotherapy, which is crucial in cancer treatment, as well as public health medicine to safeguard against the health impacts of radiation.  Moreover, they are vital in emergency scenarios involving massive accidental radiation exposure or impending radiological crises.  Among these agents, cystamine, an organic diamino–disulfide compound, is particularly noted for its dual capabilities: it acts as a shield against radiation damage and also functions as a potent antioxidant.
  • 562
  • 17 Jan 2024
  • Page
  • of
  • 11
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of COVID-19
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Academic Video Service
Feedback