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Topic review
Updated time: 09 Jun 2021
Submitted by: Yves SY Hsieh
Definition: (1,3;1,4)-β-D-Glucans, also named as mixed-linkage glucans, are unbranched non-cellulosic polysaccharides containing both (1,3)- and (1,4)-β-linkages. The linkage ratio varies depending upon species origin and has a significant impact on the physicochemical properties of the (1,3;1,4)-β-D-glucans.
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Topic review
Updated time: 28 Jun 2021
Submitted by: Agata Zieba
Definition: The fatty acid amide hydrolase enzyme (FAAH) belongs to the serine hydrolase superfamily. It is involved in the degradation of biologically active lipids. Enzyme inhibitors may exhibit analgesic, anti-inflammatory, anxiolytic, and antidepressant activity. Importantly, blockade of FAAH does not cause undesirable side effects of direct cannabinoid agonists. Due to that fact, its blockade became an emerging strategy in the treatment of several central nervous system (CNS) and peripheral diseases. The development of novel effective FAAH inhibitors became a key focus in drug design.
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Topic review
Updated time: 01 May 2021
Submitted by: Peter Tang
Definition: 10q26 deletion syndrome is a condition that results from the loss (deletion) of a small piece of chromosome 10 in each cell. The deletion occurs on the long (q) arm of the chromosome at a position designated 10q26.
Entry Collection : MedlinePlus
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Topic review
Updated time: 21 Jul 2021
Submitted by: Isabel Casimiro
Definition: Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12-LOXs) primarily oxygenate the 12th carbon of its substrates.
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Topic review
Updated time: 21 Apr 2021
Submitted by: Xiaohong Yan
Definition: Long introm-spliced hairpin RNA (ihpRNA) constructs which contained inverted repeats of the phytoene desaturase (PDS) separated by an intron, had been shown to very effective in triggering PDS silencing in Brassica napus. Using the PDS gene as a target control, it was shown that the RCA-mediated long ihpRNA construct was signicantly effective in triggering gene silence in B. napus.
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Topic review
Updated time: 10 May 2021
Submitted by: Catherine Yang
Definition: 15q13.3 microdeletion is a chromosomal change in which a small piece of chromosome 15 is deleted in each cell. The deletion occurs on the long (q) arm of the chromosome at a position designated q13.3. This chromosomal change increases the risk of intellectual disability, seizures, behavioral problems, and psychiatric disorders. However, some people with a 15q13.3 microdeletion do not appear to have any associated features.
Entry Collection : MedlinePlus
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Topic review
Updated time: 10 May 2021
Submitted by: Catherine Yang
Definition: 15q24 microdeletion is a chromosomal change in which a small piece of chromosome 15 is deleted in each cell. The deletion occurs on the long (q) arm of the chromosome at a position designated q24.
Entry Collection : MedlinePlus
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Topic review
Updated time: 10 Apr 2021
Submitted by: Catherine Yang
Definition: 16p11.2 deletion syndrome is a disorder caused by a deletion of a small piece of chromosome 16. The deletion occurs near the middle of the chromosome at a location designated p11.2.
Entry Collection : MedlinePlus
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Topic review
Updated time: 23 Dec 2020
Submitted by: Catherine Yang
Definition: 16p11.2 duplication is a chromosomal change in which a small amount of genetic material within chromosome 16 is abnormally copied (duplicated). The duplication occurs near the middle of the chromosome at a location designated p11.2. This duplication can have a variety of effects. Common characteristics that occur in people with a 16p11.2 duplication include a low weight; a small head size (microcephaly); and developmental delay, especially in speech and language. Affected individuals also have an increased risk of behavioral problems. However, some people with the duplication have no identified physical or behavioral abnormalities.
Entry Collection : MedlinePlus
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Topic review
Updated time: 23 Dec 2020
Submitted by: Catherine Yang
Definition: 16p12.2 microdeletion is a chromosomal change in which a small amount of genetic material on chromosome 16 is deleted. The deletion occurs on the short (p) arm of the chromosome at a location designated p12.2. Common characteristics that have been described in people with a 16p12.2 microdeletion include developmental delay, delayed speech, intellectual disability that ranges from mild to profound, weak muscle tone (hypotonia), slow growth resulting in short stature, an usually small head (microcephaly), malformations of the heart, recurrent seizures (epilepsy), and psychiatric and behavioral problems.
Entry Collection : MedlinePlus
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