Summary

Gastrointestinal disease is a very common and frequently occurring disease, with a wide range of types and a total incidence of about 20% of the population. The cause of gastrointestinal disease is the imbalance between the protective mechanism and the injury mechanism of the human body. While traditional medicine kills harmful bacteria in the stomach, it also kills the beneficial bacteria necessary for the stomach. Although the symptoms are alleviated and inflammation is eliminated, the reduction of beneficial bacteria reduces the gastrointestinal immunity. Once the drug is stopped, it is easy to re-infect. There are many reasons for stomach problems, including genetics, environment, diet, drugs, bacterial infections, etc., as well as smoking and excessive alcohol consumption. This collection of entries aims to collect various items related to the topic of gastrointestinal diseases, such as clinical care, case cases, disease research, etc., to help people increase their knowledge and understanding of this common disease

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Entries
Topic Review
Gastric Outlet Obstruction Management
Gastric outlet obstruction (GOO) poses a common and challenging clinical scenario, characterized by mechanical blockage in the pylorus, distal stomach, or duodenum, resulting in symptoms such as nausea, vomiting, abdominal pain, and early satiety. Its diverse etiology encompasses both benign and malignant disorders. The spectrum of treatment modalities extends from conservative approaches to more invasive interventions, incorporating procedures like surgical gastroenterostomy (SGE), self-expandable metallic stents (SEMSs) placement, and the advanced technique of endoscopic ultrasound-guided gastroenterostomy (EUS-GE). While surgery is favored for longer life expectancy, stents are preferred in malignant gastric outlet stenosis. The novel EUS-GE technique, employing a lumen-apposing self-expandable metal stent (LAMS), combines the immediate efficacy of stents with the enduring benefits of gastroenterostomy. 
  • 705
  • 17 Feb 2024
Topic Review
PI3K/AKT/mTOR and MAPK Pathways in Gastric Cancer
Gastric cancer (GC) is the fourth leading cause of death worldwide, with more than 1 million cases diagnosed every year. Helicobacter pylori represents the main risk factor, being responsible for 78% of the cases. Increased amounts of salt, pickled food, red meat, alcohol, smoked food, and refined sugars negatively affect the stomach wall, contributing to GC development.
  • 714
  • 08 Feb 2024
Topic Review
Pathogenesis of Helicobacter pylori
Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the gastric mucosa and is associated with various gastrointestinal disorders. H. pylori is a pervasive pathogen, infecting nearly 50% of the world’s population, and presents a substantial concern due to its link with gastric cancer, ranking as the third most common cause of global cancer-related mortality. 
  • 900
  • 07 Feb 2024
Topic Review
Probiotic Bacillus subtilis in Human Applications
Bacillus subtilis has been used for more than 50 years in many different industrial applications, including farming, precision fermentation, and probiotic supplements. It is particularly attractive as a probiotic because of its ability to form shelf-stable, acid-resistant spores that lend to diverse applications in the food system. B. subtilis is the most ubiquitous species of the genus and can be isolated from a broad variety of environments including animal and human gastrointestinal (GI) tracts.
  • 773
  • 02 Feb 2024
Topic Review
MAFLD and Chronic Viral Hepatitis
Metabolic dysfunction-associated fatty liver disease (MAFLD) has now affected nearly one-third of the global population and has become the number one cause of chronic liver disease in the world because of the obesity pandemic. Chronic hepatitis resulting from hepatitis B virus (HBV) and hepatitis C virus (HCV) remain significant challenges to liver health even in the 21st century. The co-existence of MAFLD and chronic viral hepatitis can markedly alter the disease course of individual diseases and can complicate the management of each of these disorders. A thorough understanding of the pathobiological interactions between MAFLD and these two chronic viral infections is crucial for appropriately managing these patients.
  • 451
  • 30 Jan 2024
Topic Review
Gastrointestinal Disease Classification
Gastrointestinal (GI) tract diseases are on the rise in the world. These diseases can have fatal consequences if not diagnosed in the initial stages. WCE (wireless capsule endoscopy) is the advanced technology used to inspect gastrointestinal diseases such as ulcerative-colitis, polyps, esophagitis, and ulcers. WCE produces thousands of frames for a single patient’s procedure for which manual examination is tiresome, time-consuming, and prone to error; therefore, an automated procedure is needed.
  • 451
  • 26 Jan 2024
Topic Review
Viral Liver Disease and Intestinal Gut–Liver Axis
The intestinal microbiota is closely related to liver diseases via the intestinal barrier and bile secretion to the gut. Impairment of the barrier can translocate microbes or their components to the liver where they can contribute to liver damage and fibrosis.
  • 435
  • 26 Jan 2024
Topic Review
Short Bowel Syndrome (SBS)
Short bowel syndrome (SBS) is a malabsorptive condition that is most often caused by a massive resection of the small intestine. Its prevalence is 3–4 per million and occurs in about 15% of adult patients undergoing an intestinal resection, either massive (3/4) or from multiple sequential resections (1/4). SBS and intestinal failure (IF) are not necessarily synonymous. Intestinal failure describes the state when an individual’s gastrointestinal function is inadequate to maintain his or her nutrient and hydration status without intravenous or enteral supplementation. 
  • 634
  • 22 Jan 2024
Topic Review
Drug-Induced Acute Pancreatitis in Adults
Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by the activation of digestive enzymes in the pancreatic tissue. The main causes of AP are cholelithiasis and alcohol abuse; less commonly, it can be caused by drugs, with a prevalence of up to 5%. Causal associations between drugs and pancreatitis are largely based on case reports or case series with limited evidence.
  • 802
  • 09 Jan 2024
Topic Review
Nutritional Strategies to Mitigate Post-Weaning Challenges in Pigs
The pig-farming industry faces significant challenges in ensuring the health and growth of piglets, particularly during the weaning phase. This critical period involves multiple stressors, such as environmental changes, dietary shifts, and social separation, which can adversely affect the piglet’s digestive health, immune system, and overall well-being.
  • 775
  • 02 Jan 2024
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