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Topic Review
WO3 and Ionic Liquids -1
Although only recently ILs started to be used to enhance the performances of metal oxides based electrochemical gas sensors (with reference, in particular, to WO3 based sensors), the recognition of their role has been clearly asserted. In fact, not only ILs heavily influence the structure of WO3 nanoparticles when used in the synthetic step (nanoplates, nanorods, nanospheres, etc.), but their residues eventually present on nanoparticles surface can improve the sensed gas adsorption, thus yielding better performances. 
  • 744
  • 29 Oct 2020
Topic Review
WO3 Nanostructures for Energy Storage
Electrochemical energy storage devices are one of the main protagonists in the ongoing technological advances in the energy field, whereby the development of efficient, sustainable, and durable storage systems aroused a great interest in the scientific community. Batteries, electrical double layer capacitors (EDLC), and pseudocapacitors are characterized in depth in the literature as the most powerful energy storage devices for practical applications. Pseudocapacitors bridge the gap between batteries and EDLCs, thus supplying both high energy and power densities, and transition metal oxide (TMO)-based nanostructures are used for their realization. Among them, WO3 nanostructures inspired the scientific community, thanks to WO3’s excellent electrochemical stability, low cost, and abundance in nature. 
  • 239
  • 09 May 2023
Topic Review
WNT5A Gene
Wnt family member 5A: The WNT5A gene is part of a large family of WNT genes, which play critical roles in development starting before birth. These genes provide instructions for making proteins that participate in chemical signaling pathways in the body.
  • 397
  • 24 Dec 2020
Topic Review
WNT4 Gene
Wnt family member 4: The WNT4 gene belongs to a family of WNT genes that play critical roles in development before birth. WNT genes provide instructions for making proteins that participate in chemical signaling pathways in the body. These pathways control the activity of certain genes and regulate the interactions between cells during embryonic development.
  • 433
  • 24 Dec 2020
Topic Review
WNT10A Gene
WNT family member 10A.
  • 369
  • 24 Dec 2020
Topic Review
Wnt/β-Catenin Target Genes
The Wnt/β-catenin cell–cell signaling pathway is one of the most basic and highly conserved pathways for intercellular communications regulating key steps during development, differentiation, and cancer. In colorectal cancer (CRC), in particular, aberrant activation of the Wnt/β-catenin pathway is believed to be responsible for perpetuating the disease from the very early stages of cancer development. A large number of downstream target genes of β-catenin-T-cell factor (TCF), including oncogenes, were detected as regulators of CRC development.
  • 511
  • 08 Apr 2021
Topic Review
Wnt/β-Catenin Signaling Pathway in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide due to its high rates of tumor recurrence and metastasis. Aberrant Wnt/β-catenin signaling has been shown to play a significant role in HCC development, progression and clinical impact on tumor behavior.
  • 467
  • 17 Jan 2023
Topic Review
Wnt/β-Catenin Signaling in Liver Cancers
Liver cancer is among the leading global healthcare issues associated with high morbidity and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), hepatoblastoma (HB), and several other rare tumors. Progression has been witnessed in understanding the interactions between etiological as well as environmental factors and the host in the development of liver cancers. However, the pathogenesis remains poorly understood, hampering the design of rational strategies aiding in preventing liver cancers. Accumulating evidence demonstrates that aberrant activation of the Wnt/β-catenin signaling pathway plays an important role in the initiation and progression of HCC, CCA, and HB. Targeting Wnt/β-catenin signaling potentiates a novel avenue for liver cancer treatment, which may benefit from the development of numerous small-molecule inhibitors and biologic agents in this field.
  • 464
  • 29 Sep 2021
Topic Review
WNT Signalling in Dental Pathologies
Great efforts have been made over the past decades to discover new therapeutic targets for a big variety of human pathologies. Most of the studies dealing with severe pathological conditions such as cancers and tissue malformations are focused on the role of either widely recognized master controlling genes such as ras and myc or pivotal components of key signalling pathways, among which Wnt and Notch. However, these genes and molecules are fundamental for paired embryogenesis as well as for tissue and organ homeostasis and regeneration, where they regulate cell proliferation, migration, differentiation and apoptosis. The precise timing and localization of their activation are important to ensure the appropriate cellular functions in physiological conditions. Thus, their indiscriminate targeting is not desirable, due to both the high risk of severe side effects and the certainty of broad phenotypic consequences. On the contrary, optimal therapeutic targets should be selected based on their tissue, time and pathology specific roles. Here, we suggest a paradigmatic example of such target molecules that could be represented by the Wnt/b-catenin signalling components Bcl9 and Bcl9l. 
  • 1.1K
  • 05 Nov 2020
Topic Review
Wnt Signalling in Alzheimer’s Brain
The Wnt signalling system is essential for both the developing and adult central nervous system. It regulates numerous cellular functions ranging from neurogenesis to blood brain barrier biology. Dysregulated Wnt signalling can thus have significant consequences for normal brain function, which is becoming increasingly clear in Alzheimer's disease (AD), an age-related neurodegenerative disorder that is the most prevalent form of dementia. AD exhibits a range of pathophysiological manifestations including aberrant amyloid precursor protein processing, tau pathology, synapse loss, neuroinflammation and blood brain barrier breakdown, which have been associated to a greater or lesser degree with abnormal Wnt signalling. 
  • 779
  • 23 Jan 2021
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