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Tang, P. WNT4 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4599 (accessed on 28 September 2026).
Tang P. WNT4 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4599. Accessed September 28, 2026.
Tang, Peter. "WNT4 Gene" Encyclopedia, https://encyclopedia.pub/entry/4599 (accessed September 28, 2026).
Tang, P. (2020, December 24). WNT4 Gene. In Encyclopedia. https://encyclopedia.pub/entry/4599
Tang, Peter. "WNT4 Gene." Encyclopedia. Web. 24 December, 2020.
WNT4 Gene
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/wnt4

Wnt family member 4: The WNT4 gene belongs to a family of WNT genes that play critical roles in development before birth. WNT genes provide instructions for making proteins that participate in chemical signaling pathways in the body. These pathways control the activity of certain genes and regulate the interactions between cells during embryonic development.

genes

References

  1. Bernard P, Harley VR. Wnt4 action in gonadal development and sexdetermination. Int J Biochem Cell Biol. 2007;39(1):31-43.Review.
  2. Biason-Lauber A, De Filippo G, Konrad D, Scarano G, Nazzaro A, Schoenle EJ.WNT4 deficiency--a clinical phenotype distinct from the classicMayer-Rokitansky-Kuster-Hauser syndrome: a case report. Hum Reprod. 2007Jan;22(1):224-9.
  3. Biason-Lauber A, Konrad D, Navratil F, Schoenle EJ. A WNT4 mutation associatedwith Müllerian-duct regression and virilization in a 46,XX woman. N Engl J Med.2004 Aug 19;351(8):792-8.
  4. Biason-Lauber A, Konrad D. WNT4 and sex development. Sex Dev.2008;2(4-5):210-8. doi: 10.1159/000152037.
  5. Biason-Lauber A. WNT4, RSPO1, and FOXL2 in sex development. Semin Reprod Med. 2012 Oct;30(5):387-95. doi: 10.1055/s-0032-1324722.
  6. Clément-Ziza M, Khen N, Gonzales J, Crétolle-Vastel C, Picard JY, Tullio-PeletA, Besmond C, Munnich A, Lyonnet S, Nihoul-Fékété C. Exclusion of WNT4 as a majorgene in Rokitansky-Küster-Hauser anomaly. Am J Med Genet A. 2005 Aug15;137(1):98-9.
  7. Jordan BK, Mohammed M, Ching ST, Délot E, Chen XN, Dewing P, Swain A, Rao PN, Elejalde BR, Vilain E. Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Am J Hum Genet. 2001 May;68(5):1102-9.
  8. Jääskeläinen M, Prunskaite-Hyyryläinen R, Naillat F, Parviainen H, Anttonen M,Heikinheimo M, Liakka A, Ola R, Vainio S, Vaskivuo TE, Tapanainen JS. WNT4 isexpressed in human fetal and adult ovaries and its signaling contributes toovarian cell survival. Mol Cell Endocrinol. 2010 Apr 12;317(1-2):106-11. doi:10.1016/j.mce.2009.11.013.
  9. Mandel H, Shemer R, Borochowitz ZU, Okopnik M, Knopf C, Indelman M, Drugan A, Tiosano D, Gershoni-Baruch R, Choder M, Sprecher E. SERKAL syndrome: anautosomal-recessive disorder caused by a loss-of-function mutation in WNT4. Am J Hum Genet. 2008 Jan;82(1):39-47. doi: 10.1016/j.ajhg.2007.08.005.
  10. Philibert P, Biason-Lauber A, Rouzier R, Pienkowski C, Paris F, Konrad D,Schoenle E, Sultan C. Identification and functional analysis of a new WNT4 genemutation among 28 adolescent girls with primary amenorrhea and müllerian ductabnormalities: a French collaborative study. J Clin Endocrinol Metab. 2008Mar;93(3):895-900. doi: 10.1210/jc.2007-2023.
  11. Prunskaite-Hyyryläinen R, Shan J, Railo A, Heinonen KM, Miinalainen I, Yan W, Shen B, Perreault C, Vainio SJ. Wnt4, a pleiotropic signal for controlling cellpolarity, basement membrane integrity, and antimüllerian hormone expressionduring oocyte maturation in the female follicle. FASEB J. 2014 Apr;28(4):1568-81.doi: 10.1096/fj.13-233247.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Peter Tang
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Entry Collection: MedlinePlus
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Update Date: 24 Dec 2020
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