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Topic Review
Polypodiopsida and Nanotechnology
The species belonging to the Polypodiopsida class have been part of human culture since the beginning of civilization, often being utilized due to the presence of antimicrobial substances (such as alkaloids, terpenes as tannins, saponins, anthraquinones, cardiac glycosides, etc.). Application of the ferns in nanotechnology is presented with practical examples.
  • 571
  • 21 Sep 2022
Topic Review
Porphyromonas gingivalis during Periodontitis Pathogenesis
Periodontitis is a non-communicable chronic inflammatory disease characterized by the progressive and irreversible breakdown of the soft periodontal tissues and resorption of teeth-supporting alveolar bone. The etiology of periodontitis involves dysbiotic shifts in the diversity of microbial communities inhabiting the subgingival crevice, which is dominated by anaerobic Gram-negative bacteria, including Porphyromonas gingivalis. Indeed, P. gingivalis is a keystone pathogen with a repertoire of attributes that allow it to colonize periodontal tissues and influence the metabolism, growth rate, and virulence of other periodontal bacteria. The pathogenic potential of P. gingivalis has been traditionally analyzed using classical biochemical and molecular approaches.
  • 446
  • 31 Jan 2023
Topic Review
Porphyromonas gingivalis in Cancer Development
A periodontal pathogen, namely, Porphyromonas gingivalis, was found to be associated with all three types of cancers: oral squamous cell carcinoma (OSCC), colorectal cancer (CRC), and pancreatic ductal adenocarcinoma (PDAC).
  • 208
  • 25 Jan 2024
Topic Review
Porphyromonas gingivalis on Biomaterials
It was found that Porphyromonas gingivalis (P. gingivalis) was frequently found at the peri-implantitis site. P. gingivalis is a Gram-negative, obligately anaerobic, non-motile, and non-spore-forming bacterium with several virulence factors: hyaluronidase and chondroitin sulfatase enzymes, lipopolysaccharide (LPS) capsule, fimbriae, collagenase, and aminopeptidase.
  • 490
  • 02 Sep 2022
Topic Review Peer Reviewed
Prototheca spp. in Bovine Infections
Prototheca microalgae, although still considered uncommon etiologic agents, represent an insidious intruder, threatening cattle herd health and determining productive losses. Increasing numbers of clinical cases globally identified would indicate these microalgae as emerging pathogens. They can be isolated from a wide variety of environmental and non-environmental sources, due also to their ability to produce biofilm. This ability to spread and contaminate a huge variety of substrates, as well as the high resistance to elevated temperatures, renders Prototheca prevention a very hard task. In addition, early infection signs are subtle and difficult to detect. The poor response to conventional antimycotic drugs represents an additional challenge when facing this infection. Although it would seem unrealistic to completely eradicate the exposure risk of cows to these microalgae, the adoption of proper on-farm protocols and management, with the highest attention to hygiene measures, would be beneficial in reducing the magnitude of this problem. Keeping the attention focused on early diagnosis, together with the development of new, alternative, and effective agents and formulations, would be strongly advised to prevent, treat, and control Prototheca infections.
  • 814
  • 11 Sep 2023
Topic Review
Prunella vulgaris L.
Prunella vulgaris L. (PV) is a well-known renewable drug resource full of different groups of biologically active substances with a wide range of pharmacological actions and applications in medicine.
  • 334
  • 09 Aug 2023
Topic Review
Pseudomonas aeruginosa Cytotoxins
Pseudomonas aeruginosa is one of the most virulent opportunistic Gram-negative bacterial pathogens in humans. It causes many acute and chronic infections with morbidity and mortality rates as high as 40%. P. aeruginosa owes its pathogenic versatility to a large arsenal of cell-associated and secreted virulence factors which enable this pathogen to colonize various niches within hosts and protect it from host innate immune defenses. Induction of cytotoxicity in target host cells is a major virulence strategy for P. aeruginosa during the course of infection. P. aeruginosa has invested heavily in this strategy, as manifested by a plethora of cytotoxins that can induce various forms of cell death in target host cells.
  • 463
  • 11 Jan 2023
Topic Review
Pseudomonas aeruginosa Infections
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which causes many severe acute and chronic infections with high morbidity, and mortality rates as high as 40%. What makes P. aeruginosa a particularly challenging pathogen is its high intrinsic and acquired resistance to many of the available antibiotics. 
  • 319
  • 12 Jan 2023
Topic Review
Pseudomonas aeruginosa Metallophores
The human pathogen Pseudomonas aeruginosa (P. aeruginosa) causes several infections, both acute and chronic, mainly in hosts with compromised immunity and in patients suffering from cystic fibrosis. The pathogenesis of this bacterium is caused by several factors.
  • 351
  • 30 Nov 2022
Topic Review
Pseudomonas syringae as a Bacterial Plant Pathogen
Plant diseases caused by the pathogen Pseudomonas syringae are serious problems for various plant species worldwide. Accurate detection and diagnosis of P. syringae infections are critical for the effective management of these plant diseases.
  • 374
  • 22 May 2023
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