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Topic Review
Varna Necropolis
The so-called Varna Necropolis (Bulgarian: Варненски некропол) (also Varna Cemetery) is a burial site from 4569–4340 BC in the western industrial zone of Varna (approximately half a kilometre from Lake Varna and 4 km from the city centre), internationally considered one of the key archaeological sites in world prehistory. There were other necropoles dating from later Greek and Roman periods around the ancient city. The oldest gold treasure in the world, dating from this period, was discovered at the site.
  • 2.7K
  • 28 Oct 2022
Topic Review
Various Uses of Lycopene
Lycopene is a carotenoid abundantly found in red vegetables. This natural pigment displays an important role in human biological systems due to its excellent antioxidant and health-supporting functions, which show a protective effect against cardiovascular diseases, hypertension, cancers, and diabetes.
  • 1.2K
  • 28 Feb 2022
Topic Review
Various Protein Kinase Inhibitors as Anticancer Agents
Protein kinases (PTKs) are enzymes that regulate the biological activity of proteins by phosphorylation of certain amino acid residues. This reaction causes a conformational change from an inactive to an active form of the protein, which is one of the most important regulatory mechanisms of the cell cycle and transduction of external signals. Dysregulation of protein kinases activity is implicated in the processes of carcinogenesis and the progression of various solid cancers. Therefore, protein kinases are prime targets for the development of selective anticancer drugs.
  • 2.0K
  • 22 Apr 2022
Topic Review
Various Monetary Aggregates Impact on the Real Economy
Monetary policy elements in Romania were adjusted on the basis of volatility indicators for the annual inflation rate, which for August 2022 increased by 0.3% from the previous month’s level (from 13% to 13.3%). On the other hand, the influence of rising inflation through the consumer index and trade shocks was felt at the European level in the euro area, with the inflation rate reaching 10% in September 2022.
  • 284
  • 12 Dec 2023
Topic Review
Various Microglial Receptors Interact with α-Synuclein
Synucleinopathies are a set of devastating neurodegenerative diseases that share a pathologic accumulation of the protein α-synuclein (α-syn). This accumulation causes neuronal death resulting in irreversible dementia, deteriorating motor symptoms, and devastating cognitive decline. α-Syn is an intrinsically disordered 140-amino acid protein consisting of an amphipathic N-terminus (residues 1–60), hydrophobic central region (residues 61–95), and acidic C-terminus (residues 86–140). Synucleinopathies are characterized by the accumulation of α-syn in the CNS. The structural form of the accumulation varies across different patients and different conditions. While the etiology of these conditions remains largely unknown, microglia, the resident immune cells of the central nervous system (CNS), have been consistently implicated in the pathogenesis of synucleinopathies. Microglia are generally believed to be neuroprotective in the early stages of α-syn accumulation and contribute to further neurodegeneration in chronic disease states.
  • 356
  • 23 May 2023
Topic Review
Various Factors on Calcium Enrichment in Edible Mushrooms
Calcium is one of the essential minerals that enhances various biological activities, including the regulation of blood pressure, the prevention of osteoporosis and colorectal adenomas. Calcium-enriched edible mushrooms can be considered as one of the important daily sources of calcium in foods. Calcium accumulation in edible mushrooms is an effective way to enhance its activities because the organic state of calcium metabolites in edible mushrooms can be formed from the original inorganic calcium.
  • 987
  • 20 Mar 2023
Topic Review
Various Attachments for Implant Overdentures
This study presents an overview of the biomechanical and biomolecular aspects of various attachments for implant overdenture. We focused on the following topics: attachment systems, retention of various attachments, stress distribution with different attachments, the design and fabrication of attachments, digital techniques in overdenture attachments, and the effects of attachments in peri-implant health. We found that plastic resin is commonly used for ball and bar attachments, whereas nylon resin is commonly used in locator attachments. The locator system offers a valuable attachment option for implant-retained overdenture. Attachment retention reduces while lateral force increases with implant inclination in overdenture. The higher the retention of an overdenture attachment, the higher the transferred stresses. Additionally, clip loading produces more stress in implants and precision elements than bar-retained dentures. As such, we conclude that the ball and locator systems the best overdenture systems due to their superior tissue response, survival rate, and patient satisfaction.
  • 6.0K
  • 03 Nov 2021
Topic Review
Various Antibiotic Interactions with Warfarin
Warfarin is the most widely used oral anticoagulant in North America and in the world. It has a long-established efficacy for the prevention of thromboembolic events in patients with cardiovascular risk factors such as chronic atrial fibrillation, prosthetic heart valves, venous thromboembolism, and coronary artery disease. 
  • 329
  • 09 Aug 2023
Topic Review
Various Adeno-Associated Viruses Serotypes in Gene Therapy
Depending on their serotype, adeno-associated viruses (AAVs) can have specific tropism for specific organs and tissues of the body. There are different AAV serotypes that vary in many aspects. A variety of AAV features have made it an appealing viral vector candidate to be used in gene therapy applications. 
  • 321
  • 06 May 2023
Topic Review
Variola Virus, Variolation, Cowpox Virus, and Vaccination
Cowpox viruses (CPXVs) exhibit the broadest known host range among the Poxviridae family and have caused lethal outbreaks in various zoo animals and pets across 12 Eurasian countries, as well as an increasing number of human cases. Modern CPXV isolates can not be equated to historical isolates of "cow-pox", which have been instrumental to the eradication of smallpox, which is caused by the closely related variola virus.
  • 395
  • 22 Feb 2023
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