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Topic Review
Ventx Family and Its Functional Similarities with Nanog
The Ventx family is one of the subfamilies of the ANTP (antennapedia) superfamily and belongs to the NK-like (NKL) subclass. Ventx is a homeobox transcription factor and has a DNA-interacting domain that is evolutionarily conserved throughout vertebrates. It has been extensively studied in Xenopus, zebrafish, and humans. The Ventx family contains transcriptional repressors widely involved in embryonic development and tumorigenesis in vertebrates. Several studies have documented that the Ventx family inhibited dorsal mesodermal formation, neural induction, and head formation in Xenopus and zebrafish. Moreover, Ventx2.2 showed functional similarities to Nanog and Barx1, leading to pluripotency and neural-crest migration in vertebrates. Among them, Ventx protein is an orthologue of the Ventx family in humans. Studies have demonstrated that human Ventx was strongly associated with myeloid-cell differentiation and acute myeloid leukemia. 
  • 504
  • 09 Mar 2022
Topic Review
Venture Capital and IPO Underpricing
IPO underpricing refers to the phenomenon that the initial public offering price of a stock is significantly lower than the initial market closing price of the listing, and this phenomenon is widespread in the capital market. It is generally believed that information asymmetry is one of the main reasons for IPO underpricing. In order to make up for investors who are at an information disadvantage, stock issuers will actively reduce the issuance price of stocks to promote the successful issuance of the stocks. The majority of companies listed on ChiNext are high-technology companies with high growth potential, and a large number of empirical studies have shown that venture capital plays a role in signaling high-quality equity offerings in the corporate process. This is because venture capital plays a monitoring and certification role, which means venture capitalists can determine which R&D activities are more likely to be successful, and they can provide investors with accurate information about R&D investment and whether the information disclosed at the IPO is true.
  • 706
  • 09 Jul 2021
Topic Review
Ventricular Septal Rupture
Ventricular septal rupture is a serious mechanical complication of myocardial infarction (MI) with an unfavorable prognosis.
  • 393
  • 29 Aug 2022
Topic Review
Ventricular Fibrillation
A perennial task is to prevent the occurrence and/or recurrence of most frequent or life-threatening cardiac arrhythmias such as atrial fibrillation (AF) and ventricular fibrillation (VF). VF may be lethal in cases without an implantable cardioverter defibrillator or with failure of this device. Incidences of AF, even the asymptomatic ones, jeopardize the patient’s life due to its complication, notably the high risk of embolic stroke. Therefore, there has been a growing interest in subclinical AF screening and searching for novel electrophysiological and molecular markers. Considering the worldwide increase in cases of thyroid dysfunction and diseases, including thyroid carcinoma, we aimed to explore the implication of thyroid hormones in pro-arrhythmic signaling in the pathophysiological setting. The present review provides updated information about the impact of altered thyroid status on both the occurrence and recurrence of cardiac arrhythmias, predominantly AF. Moreover, it emphasizes the importance of both thyroid status monitoring and AF screening in the general population, as well as in patients with thyroid dysfunction and malignancies. Real-world data on early AF identification in relation to thyroid function are scarce. Even though symptomatic AF is rare in patients with thyroid malignancies, who are under thyroid suppressive therapy, clinicians should be aware of potential interaction with asymptomatic AF. It may prevent adverse consequences and improve the quality of life. This issue may be challenging for an updated registry of AF in clinical practice. Thyroid hormones should be considered a biomarker for cardiac arrhythmias screening and their tailored management because of their multifaceted cellular actions.
  • 749
  • 28 Oct 2020
Topic Review
Ventricular Arrhythmias in Left Ventricular Assist Device Patient
Left ventricular assist devices (LVAD) are used in the treatment of advanced left ventricular heart failure. LVAD can serve as a bridge to orthotopic heart transplantation or as a destination therapy in cases where orthotopic heart transplantation is contraindicated. Ventricular arrhythmias are frequently observed in patients with LVAD. 
  • 181
  • 23 Feb 2024
Topic Review
Ventilatory Modes and Settings of Ventilators
The choice of a ventilator model for a single patient is usually based on parameters such as size (portability), presence or absence of battery and ventilatory modes. In each mode, there is always a control or independent variable, which is programmed into the ventilator and remains constant throughout the inspiratory cycle, regardless of the variability in the patient’s ventilatory pattern. The control variables are usually pressure and volume. However, there are special cases, such as hybrid modes (average volume-assured pressure support -AVAPS (Average Volume-Assured Pressure Support)- or intelligent volume-assured pressure support—iVAPS-) in which the control variable (pressure) is modified in a predetermined pressure range depending on the estimation of a parameter (tidal volume).
  • 340
  • 10 May 2023
Topic Review
Ventilator-Associated Pneumonia
Ventilator-associated pneumonia (VAP) is defined as pneumonia not present or incubating at the time of admission and occurring after more than 48 hours of mechanical ventilation (MV). This is the second-most common healthcare-associated infection (HAI) in neonatal intensive care units (NICUs). VAP is associated with increased morbidity and mortality, an increased length of stay in the NICU and hospital costs.
  • 149
  • 31 Jan 2024
Topic Review
Ventilation-Perfusion Mismatch in the Acute Respiratory Distress Syndrome
Acute respiratory distress syndrome (ARDS) is a heterogenous condition that is characterized by the development of inflammatory pulmonary edema and life-threatening hypoxemia, and it accounts for nearly 25% of patients who require mechanical ventilation. Acute respiratory distress syndrome (ARDS) remains an important clinical challenge with a mortality rate of 35–45%. It is being increasingly demonstrated that the improvement of outcomes requires a tailored, individualized approach to therapy, guided by a detailed understanding of each patient’s pathophysiology. In patients with ARDS, disturbances in the physiological matching of alveolar ventilation (V) and pulmonary perfusion (Q) (V/Q mismatch) are a hallmark derangement. The perfusion of collapsed or consolidated lung units gives rise to intrapulmonary shunting and arterial hypoxemia, whereas the ventilation of non-perfused lung zones increases physiological dead-space, which potentially necessitates increased ventilation to avoid hypercapnia.
  • 878
  • 12 Jan 2023
Topic Review
Ventilation Systems in Wetland Plant Species
Ventilation systems rely on a passive molecular diffusion process, on pressurized gas flow, or Venturi-induced convection. 
  • 345
  • 06 Jul 2022
Topic Review
Ventilation System
An additional window frame with a ventilation function is applied to the existing window. Thus, when the window is closed, a cavity, which is created between window frames, serves as an air path for ventilation. The additional frame has the same material and finishing as the existing frame, thereby ensuring design consistency. On the outside, the frame does not show any application of the mechanical system. Another advantage of the proposed system is that, as the width is 65 mm, it occupies as small an area as possible and minimally affects the view from the inside. Polyvinyl chloride (PVC), a generally used material for windows, is used for the ventilation system, and this system is formed in a "U"-shape consistent with the existing window frame. This system can be attached or detached on the existing window frame and does not generate either a gap or a distance in the process of installation for airtightness. The cavity is 45 mm in width, 20 mm in depth, and 1940 mm in height and serves as an air path connected to the outdoor air intake and the indoor air supply outlet.
  • 760
  • 26 Oct 2020
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