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Topic Review
Stem Cells in Wound Healing
Wound healing is an intricate process involving coordinated interactions among inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. Successful tissue repair hinges on controlled inflammation, angiogenesis, and remodeling facilitated by the exchange of cytokines and growth factors. Comorbid conditions can disrupt this process, leading to significant morbidity and mortality. Stem cell therapy has emerged as a promising strategy for enhancing wound healing, utilizing cells from diverse sources such as endothelial progenitor cells, bone marrow, adipose tissue, dermal, and inducible pluripotent stem cells.
  • 150
  • 14 Mar 2024
Topic Review
Integration of Nanomaterials in Thermal Energy Storage Systems
The solar collector is one of the most cost-effective pieces of equipment used to harvest solar thermal energy. Two main types can be identified: (1) water-based solar collectors (WSCs), an already popular solution for preparing domestic hot water and heating, and (2) air solar collectors (ASCs), used to preheat fresh air and to dry or heat the air inside a room. Thermal energy storage applied to thermal energy storage (TSC) is studied in terms of design criteria, materials technologies, and  thermal conductivity. The potential of nanomaterial technology integration in phase change materials (PCMs) in terms of thermal performance improvements is higligted. The integration of diverse materials such as graphene, graphite, metal oxides, and carbon nanoparticles holds the potential to significantly enhance the thermal conductivity and latent heat value. However, some important aspects need to be further investigated as the highest possible percentage of nanomaterial in the mixture in order to avoid agglomeration.
  • 147
  • 14 Mar 2024
Topic Review
P-IOTA
The recent widespread novel network technologies for programming data planes are remarkably enhancing the customization of data packet processing. In this direction, the Programming Protocol-independent Packet Processors (P4) is envisioned as a disruptive technology, capable of configuring network devices in a highly customizable way. P4 enables network devices to adapt their behaviors to mitigate malicious attacks (e.g., denial of service). Distributed ledger technologies (DLTs), such as blockchain, allow secure reporting alerts on malicious actions detected across different areas. IOTA is a next-generation distributed ledger engineered to tackle the scalability limits while still providing the same security capabilities such as immutability, traceability, and transparency. P-IOTA integrates a P4-based data plane software-defined network (SDN) and an IOTA layer employed to notify about networking attacks. 
  • 103
  • 14 Mar 2024
Topic Review
Two-Photon Absorbing Dendrimers
Dendrimers, arborescent macromolecules exhibiting a large number of functional groups at their surface, appeared as naturally attractive targets to consider as TPA chromophores. Indeed, dendrimers are a special kind of perfectly defined hyperbranched polymers constructed stepwise from a multifunctional core at the periphery of which can be grafted a large density and variety of chromophores.
  • 213
  • 14 Mar 2024
Topic Review
Paternal Role in Pregnancy and in Birth Outcome
Recurrent pregnancy loss (RPL) is defined as three or more consecutive abortions and constitutes about 1% of all cases of pregnancy loss. RPL is a multifactorial disease and recognizes several causes, including anatomic (uterine malformations), endocrine, infectious, immunologic, genetic, and idiopathic.
  • 135
  • 14 Mar 2024
Topic Review
Digitalization and Energy in Attaining Sustainable Development
Digitalization significantly impacts energy consumption patterns, energy infrastructure, and the overall intensity of energy use. It represents a transformative force that can either increase energy demand through the proliferation of digital devices and data centers or decrease it through efficiency gains and smart energy management. The relentless advancement of digital technologies has the potential to significantly reshape the energy landscape as digital technologies become increasingly integrated into diverse sectors of the economy.
  • 339
  • 14 Mar 2024
Topic Review
TGF-β Signaling Pathways in Diabetic Retinopathy
Diabetic retinopathy (DR), a prevalent complication of diabetes mellitus affecting a significant portion of the global population, has long been viewed primarily as a microvascular disorder. However, emerging evidence suggests that it should be redefined as a neurovascular disease with multifaceted pathogenesis rooted in oxidative stress and advanced glycation end products. The transforming growth factor-β (TGF-β) signaling family has emerged as a major contributor to DR pathogenesis due to its pivotal role in retinal vascular homeostasis, endothelial cell barrier function, and pericyte differentiation. 
  • 92
  • 14 Mar 2024
Topic Review
Receptor Tyrosine Kinases in BRAF Mutant Cancers
BRAF (B-Raf, B-rapidly accelerated fibrosarcoma) mutations are clinically relevant in melanoma, non-small-cell lung cancer (NSCLC), colorectal carcinoma (CRC), and other cancers. Patients suffering from BRAF mutant cancers are experiencing a considerably poor prognosis. Receptor tyrosine kinases (RTKs), which are prominent anticancer drug targets in their own right, play a crucial role in the development of drug resistance to BRAF inhibitors and the reactivation of MAPK/ERK signal transduction, as well as the establishment of bypassing signaling pathways.
  • 172
  • 14 Mar 2024
Topic Review
Machine Learning for Neurodegenerative Diseases Detection
Neurodegenerative diseases (NDs) such as Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) are devastating conditions that can develop without noticeable symptoms, causing irreversible damage to neurons before any signs become clinically evident. NDs are a major cause of disability and mortality worldwide. Web and mobile technologies, through the use of machine learning and AI in apps and web-based tools, offer affordable, accessible screening options for cognitive deficits, showing promise in the early detection of neurodegenerative disorders with demonstrated effectiveness.
  • 116
  • 13 Mar 2024
Topic Review
IGF-II–Insulin Receptor Isoform-A Autocrine Signal in Cancer
Insulin receptor overexpression is a common event in human cancer. Its overexpression is associated with a relative increase in the expression of its isoform A (IRA), a shorter variant lacking 11 aa in the extracellular domain, conferring high affinity for the binding of IGF-II along with added intracellular signaling specificity for this ligand. Since IGF-II is secreted by the vast majority of malignant solid cancers, where it establishes autocrine stimuli, the co-expression of IGF-II and IRA in cancer provides specific advantages such as apoptosis escape, growth, and proliferation to those cancers bearing such a co-expression pattern.
  • 87
  • 13 Mar 2024
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