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Topic Review
MAPK Signaling in Fruit Ripening and Quality Formation
Fleshy fruit ripening is a unique biological process that involves dramatic changes in a diverse array of cellular metabolisms. The regulation of these metabolisms is essentially mediated by cellular signal transduction of internal (e.g., hormones) and external cues (i.e., environmental stimuli). Mitogen-activated protein kinase (MAPK) signaling pathways play crucial roles in a diverse array of biological processes, such as plant growth, development and biotic/abiotic responses. Accumulating evidence suggests that MAPK signaling pathways are also implicated in fruit ripening and quality formation.
  • 125
  • 12 Mar 2024
Topic Review
Stone Construction Materials of the Vera Cruz Church
As part of the restoration project of the 13th century Vera Cruz Church (Segovia, Spain), a preliminary study of the stones used in its construction—dolostones of the Montejo de la Vega Fm of Santonian age (Upper Cretaceous)—and the possible location of the quarry of the provenance of these stones was carried out. For this purpose, a comparative analysis was performed between the currently active quarry of La Vera Cruz n° 88 and the historical quarry of Zamarramala. The samples were characterized using a multidisciplinary approach, combining X-ray diffraction (XRD), polarized optical microscopy (POM), and scanning electron microscopy with microanalysis (SEM-EDX). 
  • 172
  • 12 Mar 2024
Topic Review
Open Radio Access Networks
The open radio access network (RAN) aims to bring openness and intelligence to the traditional closed and proprietary RAN technology and offer flexibility, performance improvement, and cost-efficiency in the RAN’s deployment and operation.
  • 224
  • 12 Mar 2024
Topic Review
Anticancer Effects of Bee Venom and Its Components
Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities. Today, a large number of studies are focused on the antitumor effects of BV, which are mainly attributed to its basic polypeptide melittin (MEL). 
  • 137
  • 12 Mar 2024
Topic Review
Advancements and Challenges in IoT and Network Simulators
The Internet of Things (IoT) has emerged as an important concept, bridging the physical and digital worlds through interconnected devices. Although the idea of interconnected devices predates the term “Internet of Things”, which was coined in 1999 by Kevin Ashton, the vision of a seamlessly integrated world of devices has been accelerated by advancements in wireless technologies, cost-effective computing, and the ubiquity of mobile devices. In this regard, Cloud infrastructures are crucial for orchestrating and collecting data from these ubiquitous devices.
  • 406
  • 12 Mar 2024
Topic Review
Lightning-Induced Wildfire Modeling
Wildfire causes environmental, economic, and human problems or losses.
  • 189
  • 12 Mar 2024
Topic Review
Nucleic Acid Amplification Techniques in SARS-CoV-2 Detection
The urgent need for accurate COVID-19 diagnostics has led to the development of various SARS-CoV-2 detection technologies. Real-time reverse transcriptase polymerase chain reaction (RT-qPCR) remains a reliable viral gene detection technique, while other molecular methods, including nucleic acid amplification techniques (NAATs) and isothermal amplification techniques, provide diverse and effective approaches. Serological assays, detecting antibodies in response to viral infection, are crucial for disease surveillance. Saliva-based immunoassays show promise for surveillance purposes. The efficiency of SARS-CoV-2 antibody detection varies, with IgM indicating recent exposure and IgG offering prolonged detectability. Various rapid tests, including lateral-flow immunoassays, present opportunities for quick diagnosis, but their clinical significance requires validation through further studies.
  • 79
  • 12 Mar 2024
Topic Review
Polysaccharide Sequence Determination
NMR analysis combined with statistical modeling offers a useful approach to investigate the microstructures of biobased polymers. In particular, this approach may be used to study the microstructures of polysaccharides. If the polysaccharides are composed of two or three monosaccharide units, and the NMR spectral features are sensitive to the different sequence placements of these units, then a detailed analysis of a polysaccharide (or its fractions) can be made by NMR with the help of statistical modeling.   
  • 252
  • 12 Mar 2024
Topic Review
Regulation of NcRNAs on Ferroptosis
Ferroptosis is a non-apoptotic mode of cell death driven by membrane lipid peroxidation and is characterized by elevated intracellular levels of Fe2+, ROS, and lipid peroxidation. Studies have shown that ferroptosis is related to the development of multiple diseases, such as cancer, neurodegenerative diseases, and acute myeloid leukemia. Ferroptosis plays a dual role in the occurrence and development of these diseases. Ferroptosis mainly involves iron metabolism, ROS, and lipid metabolism. Various mechanisms, including epigenetic regulation, have been reported to be deeply involved in ferroptosis. Abnormal epigenetic modifications have been reported to promote tumor onset or other diseases and resistance to chemotherapy drugs. 
  • 91
  • 12 Mar 2024
Topic Review
Eye-Tracking Analysis of Proposed Signage Design
The road transport system is expanding considerably in developing countries. Villages are connecting to major cities for business, education, health, and many other reasons because of road development and smooth transportation. There has been a rise in the number of road accidents observed, caused by abruptly appearing dividers on roads and a lack of required signage systems.
  • 93
  • 12 Mar 2024
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