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Topic Review
Peptide Receptor Radionuclide Therapy (PRRT): Innovations and Improvements
Neuroendocrine neoplasms (NENs) are tumors originating from neuroendocrine cells distributed throughout the human body. With an increasing incidence over the past few decades, they represent a highly heterogeneous group of neoplasms, mostly expressing somatostatin receptors (SSTRs) on their cell surface. Peptide receptor radionuclide therapy (PRRT) has emerged as a crucial strategy for treating advanced, unresectable neuroendocrine tumors by administering radiolabeled somatostatin analogs intravenously to target SSTRs. This article will focus on the multidisciplinary theranostic approach, treatment effectiveness (such as response rates and symptom relief), patient outcomes, toxicity profile of PRRT for NEN patients and results of the most significant studies.
  • 115
  • 10 Apr 2024
Topic Review
Statistical Analysis of Intensive Care Unit COVID-19 Data
COVID-19 caused a pandemic, due to its ease of transmission and high number of infections. The evolution of the pandemic and its consequences for the mortality and morbidity of populations, especially the elderly, generated several scientific studies and many research projects. Among them, researchers have the Predictive Models of COVID-19 Outcomes for Higher Risk Patients Towards a Precision Medicine (PREMO) research project. For such a project with many data records, it is necessary to provide a smooth graphical analysis to extract value from it.
  • 1.2K
  • 10 Apr 2024
Topic Review
Processing, Quality and Elemental Safety of Fish
Fish is a food widely produced, marketed and consumed throughout the world. It is a basic component of human nutrition due to its chemical and nutritional composition, but at the same time it is highly perishable and susceptible to contamination throughout the entire food chain, compromising its quality and safety. Fishing and aquaculture products, being perishable, require adequate processing and conservation to maintain their quality and safety as much as possible until their acquisition and final consumption. Over the years, different preservation methods have been developed and used to extend the useful life of fishery products with minimal impact on their nutritional and organoleptic properties, favoring quality and safety that allow the availability of food and protection of public health.
  • 222
  • 10 Apr 2024
Topic Review
DNA Methylation in Leukemia, Myelodysplastic Syndrome, and Lymphoma
DNA methylation represents a crucial mechanism of epigenetic regulation in hematologic malignancies. The methylation process is controlled by specific DNA methyl transferases and other regulators, which are often affected by genetic alterations. Global hypomethylation and hypermethylation of tumor suppressor genes are associated with hematologic cancer development and progression. Several epi-drugs have been successfully implicated in the treatment of hematologic malignancies, including the hypomethylating agents (HMAs) decitabine and azacytidine. However, combinations with other treatment modalities and the discovery of new molecules are still the subject of research to increase sensitivity to anti-cancer therapies and improve patient outcomes. 
  • 1.6K
  • 09 Apr 2024
Topic Review
Hybrid Convolutional Neural Network–Bidirectional Long Short-Term Memory
Recognition of lying is a more complex cognitive process than truth-telling because of the presence of involuntary cognitive cues that are useful to lie recognition. Researchers have proposed different approaches in the literature to solve the problem of lie recognition from either handcrafted and/or automatic lie features during court trials and police interrogations.
  • 1.8K
  • 09 Apr 2024
Topic Review
Microbiome in Cancer Development and Treatment
Targeting the microbiome, microbiota-derived metabolites, and related pathways represents a significant challenge in oncology. Microbiome analyses have confirmed the negative impact of cancer treatment on gut homeostasis, resulting in acute dysbiosis and severe complications, including massive inflammatory immune response, mucosal barrier disruption, and bacterial translocation across the gut epithelium. Moreover, recent studies revealed the relationship between an imbalance in the gut microbiome and treatment-related toxicity. Recently, microbiota modulation via probiotic supplementation and fecal microbiota transplantation represents a new trend in cancer patient care, aiming to increase bacterial diversity, alleviate acute and long-term treatment-induced toxicity, and improve the response to various treatment modalities. A more detailed understanding of the complex relationship between the microbiome and host can significantly contribute to integrating a microbiome-based approach into clinical practice. 
  • 237
  • 08 Apr 2024
Topic Review
Blood Reference Values: Welfare Markers in Erinaceus europaeus
Understanding the blood reference values in healthy western European hedgehogs (Erinaceus europaeus) is crucial, particularly given their expanding range into human habitats where they face contaminants and potential disease agents. As bioindicators of environmental pollution and carriers of zoonotic agents, hedgehogs play a vital role in One Health studies. Their health status serves as an indicator of the well-being of wildlife populations but also directly impacts broader wildlife conservation efforts and human health.
  • 162
  • 08 Apr 2024
Topic Review
Securing Internet of Things Applications Using Key Management
The Internet of Things (IoT) emerged when everyday objects began connecting to the Internet and interacting with each other autonomously without human intervention. IoT devices follow the IEEE 802.15.4 standard to enable network connectivity for resource-constrained devices using short-range, lightweight communication protocols.
  • 172
  • 07 Apr 2024
Topic Review
The Application of Immortalized Cell Lines
Immortalized cell lines are a powerful tool for biological, biochemical, and biological growth, differentiation, and aging studies. They are also used in immunology, hematology, cancer biology, and toxicology research.
  • 259
  • 07 Apr 2024
Topic Review
Particle Swarm Optimisation in Internet of Things
The internet of things, a collection of diversified distributed nodes, implies a varying choice of activities ranging from sleep monitoring and tracking of activities, to more complex activities such as data analytics and management. With an increase in scale comes even greater complexities, leading to significant challenges such as excess energy dissipation, which can lead to a decrease in IoT devices’ lifespan. Internet of things’ (IoT) multiple variable activities and ample data management greatly influence devices’ lifespan, making resource optimisation a necessity. Existing methods with respect to aspects of resource management and optimisation are limited in their concern of devices energy dissipation.
  • 292
  • 07 Apr 2024
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