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Topic Review
Biography
Topic Review
Lipid-Based Nanocarrier Systems
Nanotechnology-based tools have played a major role in this. The implementation of this multifaceted nanotechnology concept encourages the advancement of innovative strategies and materials for improving patient compliance.
491
03 Apr 2023
Topic Review
Cutaneous Inflammation
Skin inflammation occurs as an immune response to various stimuli such as ultraviolet light, irritants, or any type of skin barrier injury. Finding safe and effective drugs to combat skin inflammation remains a research challenge.
491
06 May 2023
Topic Review
Microwave Therapy for Cellulite
Microwave therapy has proven to be a safe treatment for improving cellulite appearance and reducing body circumferences.
489
27 Jan 2022
Topic Review
Physical Therapies in Wound Healing and Assisted Scarring
Wound healing (WH) is a complex multistep process in which a failure could lead to a chronic wound (CW). CW is a major health problem and includes leg venous ulcers, diabetic foot ulcers, and pressure ulcers. CW is difficult to treat and affects vulnerable and pluripathological patients. On the other hand, excessive scarring leads to keloids and hypertrophic scars causing disfiguration and sometimes itchiness and pain. Treatment of WH includes the cleaning and careful handling of injured tissue, early treatment and prevention of infection, and promotion of healing. Treatment of underlying conditions and the use of special dressings promote healing.
488
06 May 2023
Topic Review
Pruritus in Chronic Kidney Disease
Chronic kidney disease-associated pruritus (CKDaP) is an often under-diagnosed and under-recognized condition, despite its considerable prevalence within the chronic kidney disease (CKD) population. Universally accepted guidelines are also lacking. The true prevalence of CKDaP worldwide therefore remains unknown, although its negative impact on mortality and health-related quality of life outcomes is very clear. The pathophysiological mechanisms leading to the onset of CKDaP are only partly understood. CKDaP is currently believed to be caused by a multifactorial process, from local skin changes, metabolic alterations, the development of neuropathy and dysregulation of opioid pathways, and psychological factors. Much work has been carried out towards a more systematic and structured approach to clinical diagnosis. Various tools are now available to assess the severity of CKDaP. Many of these tools require greater validation before they can be incorporated into the guidelines and into routine clinical practice. Further efforts are also needed in order to increase the awareness of clinicians and patients so that they can identify the CKDaP signs and symptoms in a timely manner.
485
31 Aug 2022
Topic Review
Chronic Kidney Disease-Associated Pruritus
Pruritus is a distressing condition associated with end-stage renal disease (ESRD), advanced chronic kidney disease (CKD), as well as maintenance dialysis and adversely affects the quality of life (QOL) of these patients.
484
05 Aug 2021
Topic Review
Skin Disease‘s Effect on Quality of Life
Acne, atopic dermatitis (AD), and psoriasis are all chronic dermatologic conditions that greatly impact the lives of pediatric patients and their caregivers. The visible nature of these diseases negatively affects the self-image of children early in life as well as their relationships with their families and peers. Physicians recognize the importance of addressing both the physical and mental symptoms of their patients but are currently not equipped with clear guidelines to manage long-term psychosocial comorbidities in pediatric dermatologic patients. A PubMed and Google Scholar search of key words was conducted to explore self-image in pediatric patients with acne, AD, and psoriasis. Chronic skin diseases put pediatric patients at risk for strained family relationships, poor self-image, psychiatric comorbidities, stigmatization, and eventual suicidal behavior. A limitation of this study is a lack of a validated measure of quality of life in the pediatric population that fulfills enough criteria to evaluate long term quality of life in children and adults. Possible management options, including connecting patients with the same diagnosis and allocating resources to parents and teachers to better understand these chronic skin conditions, may provide pediatric patients with the support they need to develop resilience in the face of these challenges.
484
06 Dec 2021
Topic Review
Clinical and Dermoscopic Characteristics of Cutaneous Sarcomas
Under the umbrella of cutaneous sarcomas (CS), a heterogeneous group of rare, malignant, mesenchymal neoplasia, such as dermatofibrosarcoma protuberans, atypical fibroxanthoma, cutaneous undifferentiated pleomorphic sarcoma, cutaneous angiosarcoma and leiomyosarcoma is included. Clinical presentation and histopathological examination are the cornerstone of CS diagnosis and classification. CS are characterized by mostly unspecific dermatoscopic patterns. Dermatofibrosarcoma protuberans, Kaposi’s sarcoma, and in a lesser degree, cutaneous angiosarcoma, may display distinct dermatoscopic features, facilitating their early clinical recognition. In conclusion, dermatoscopy, in conjunction with the overall clinical context, may aid towards suspicion of CS.
483
26 Jul 2023
Topic Review
Drug-Associated Bullous Pemphigoid
Bullous pemphigoid (BP), the most common autoimmune blistering disease, is characterized by the presence of autoantibodies targeting BP180 and BP230 in the basement membrane zone. This leads to the activation of complement-dependent and independent pathways, resulting in proteolytic cleavage at the dermoepidermal junction and an eosinophilic inflammatory response. Dipeptidyl peptidase 4 inhibitors (DPP4i) are the most frequently reported drugs related to BP and, therefore, have been extensively investigated. They may potentially trigger BP through the impaired proteolytic degradation of BP180, combined with immune dysregulation. Other drugs, including immune checkpoint inhibitors, biologics, diuretics and cardiovascular and neuropsychiatric agents, have also been associated with BP development but present poorly understood pathogenic mechanisms.
483
07 Dec 2023
Topic Review
The Trinity of Skin: A Neuro–Endocrine–Immune Organ
For a long time, skin was thought to be no more than the barrier of human's body. However, in the last few decades, studies into the idea of skin as an independent functional organ have gradually deepened people's understanding of skin and its functions.
480
30 May 2022
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