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Topic Review
Antiviral Drugs against COVID-19
Several FDA-approved available antiviral drugs, alone or in combination, have been screened clinically for their extended use since the early phase of the current pandemic to find a safe and effective treatment option against COVID-19, and many clinical trials of these antiviral drugs are still ongoing. However, an in-depth understanding is required from current clinical literature reports to execute integrated approaches between computational and experimental methods to guarantee high success rates of repositioned drugs. Moreover, multiple challenges associated with repurposed drugs have been identified, including dose adjustments, route of administration, acute/chronic toxicity, appropriate delivery systems, etc..
  • 908
  • 27 Sep 2021
Topic Review
Antiviral Functional Foods
Functional foods optimize the immune system capacity to prevent and control pathogenic viral infections. Functional foods prevention of non-communicable disease can be translated into protecting against respiratory viral infections and COVID-19. Foods with antiviral properties include fruits, vegetables, fermented foods and probiotics, olive oil, fish, nuts and seeds, herbs, roots, fungi, amino acids, peptides, and cyclotides. 
  • 1.4K
  • 10 Oct 2020
Topic Review
Antiviral Properties of Seaweeds
Bioactive compounds from seaweed’s currently receive major attention from pharmaceutical companies as they express several interesting biological activities which are beneficial for humans. The structural diversity of seaweed metabolites provides diverse biological activities which are expressed through diverse mechanisms of actions. This research mainly focuses on the antiviral activity of seaweed’s extracts, highlighting the mechanisms of actions of some seaweed molecules against infection caused by different types of enveloped viruses: influenza, Lentivirus (HIV-1), Herpes viruses, and coronaviruses. Seaweed metabolites with antiviral properties can act trough different pathways by increasing the host’s defense system or through targeting and blocking virus replication before it enters host cells. Several studies have already established the large antiviral spectrum of seaweed’s bioactive compounds. 
  • 731
  • 04 Jul 2022
Topic Review
Antivirals on the Cardiovascular Conditions
The COVID-19 pandemic has resulted in a complex clinical challenge, caused by a novel coronavirus, partially similar to previously known coronaviruses but with a different pattern of contagiousness, complications, and mortality. Safety profiles of antivirals are largely questioned and addressed by health agencies, in consideration of COVID-19 cardiac and pro-thrombotic complications generally experienced by predisposed subjects.
  • 735
  • 25 Feb 2022
Topic Review
Anxiety and Depression in Children with Chronic Headache
It has been observed that there is a higher-than-expected risk of anxiety and depression in children with chronic headache and also an increased risk for the persistence of headache in patients with anxiety and depression. The relationship between chronic headache and psychological co-morbidities is complex, interrelated and bi-directional. The close relationship between the disorders is evident in patients attending clinics with chronic headache, but it is also observed in population-based studies. The evidence for the co-existence of these disorders and the possible shared pathophysiologic, clinical and epidemiological characteristics are illustrated. 
  • 314
  • 24 Apr 2023
Topic Review Peer Reviewed
Anxiety, Depression, and Other Emotional Disorders during the COVID-19 Pandemic: A Narrative Review of the Risk Factors and Risk Groups
The COVID-19 pandemic has affected many aspects of our lives, including mental health. Identifying risk factors and risk groups associated with anxiety, depression, and other emotional disorders for reasons related to the COVID-19 pandemic is highly relevant. This narrative review aims to summarize the evidence to date on risk factors for emotional disorders during the COVID-19 pandemic in order to identify the risk groups of people in need of early psychiatric and psychological assistance, point out the controversial data on the influence of risk factors on emotional disorders in COVID-19, and finally offer recommendations for alleviating symptoms of anxiety, depression, and other emotional disorders in such people. According to the current literature, being under the age of 40, being female, having contact with a COVID-infected person, and watching the news about COVID-19 for more than 3 h a day all increase the likelihood of anxiety, depression, and sleep disturbances. Healthcare workers, particularly nurses, working in the COVID-19 hot zone suffer more from sleep disorders, anxiety, and depression. It is also noted that people with a previous psychiatric history, in addition to increased risks of anxiety and depression, have an increased risk of relapse during the COVID-19 pandemic. The same is true for people who have had episodes of substance abuse in the past. Aside from socioeconomic factors, the mental wellbeing of those who have had COVID-19 is also impacted by biological factors (using anti-COVID-19 drugs, COVID-19-associated immunothrombosis and venous thromboembolism, interferon-gamma-related cytokine storm, etc.), resulting in a wide range of acute and long-term cognitive disorders. During the restricted resource time, the aforementioned risk groups should be prioritized for prevention, early identification, and proper treatment of potential emotional disorders. The risk factors that were found in this narrative review, as well as how they interact and change over time, will help understand why some studies of at-risk groups do not agree with each other, justify new preventive measures, and strengthen existing programs to keep people’s mental health in check during this pandemic and other emergencies.
  • 718
  • 10 Mar 2023
Topic Review
AOAart
AOAart.cn (Autistic or Artistic? Art) is an organisation created by the Beijing Rehabilitation Association of Autistic Children, which allows autistic individuals to express their originality and personality through art. The society aims to raise awareness of autism whilst supporting the individuals in their realization of self-value and to become part of a community with their own power, thus regaining pride and dignity for autistic people. The aim of AOAart is to regain pride and dignity for autistic people, support autistic people in their realization of self-value and to return to the community with their own power, and, through social interaction with autistic people, stimulate humanistic reflection and to rethink about human conditions and values.
  • 315
  • 10 Oct 2022
Topic Review
Aortic and Visceral Aneurysms
Aortic and visceral aneurysms affect large arterial vessels, including the thoracic and abdominal aorta, as well as visceral arterial branches, such as the splenic, hepatic, and mesenteric arteries, respectively. 
  • 234
  • 20 Sep 2023
Topic Review
Aortic Dissection
Acute aortic syndromes (AAS) represent a spectrum of interrelated disorders characterized by the disruption of the aortic integrity, and are associated with high morbidity and mortality. These conditions include aortic dissection (AD), accounting for the majority of AAS (80%), intramural hematoma (IMH, ~15%), and penetrating aortic ulcer (PAU, ~5%).
  • 729
  • 21 Feb 2023
Topic Review
Aortic Elasticity and Cardiovascular Risk Stratification
Cardiovascular risk stratification is a cornerstone of preventive cardiology, aiming to identify individuals at a higher risk for adverse events. In line with this, aortic elastic properties have gained recognition as crucial indicators of vascular health and predictors of cardiovascular outcomes.
  • 239
  • 08 Mar 2024
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