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Topic Review
AN69 Membrane in Hemodialysis Patients
Patients undergoing hemodialysis (HD) experience serious cardiovascular complications, through malnutrition, inflammation, and atherosclerosis. Amputation for peripheral arterial disease (PAD) is more prevalent in patients undergoing HD than in the general population. In addition, revascularization procedures in dialysis patients are often associated with subsequent amputation and high mortality rates. To improve the prognosis of dialysis patients, malnutrition and inflammation must be properly treated, which necessitates a better understanding of the characteristics of dialysis membranes. Herein, the characteristics of several dialysis membranes were studied, with a special reference to the AN69 membrane, noting several similarities to low-density lipoprotein (LDL)-apheresis, which is also applicable for the treatment of PAD. Both systems (LDL-apheresis and AN69) have anti-inflammatory and anti-thrombogenic effects because they use a negatively charged surface for extracorporeal adsorptive filtration from the blood/plasma, and contact phase activation. The concomitant use of both these therapeutic systems may have additive therapeutic benefits in HD patients. 
  • 472
  • 14 Feb 2023
Topic Review
Anaesthesia in Veterinary Oncology
Anaesthesia plays an important role in diagnosis procedures and the treatment and pain management of oncological patients. However, studies suggest that anaesthetic drugs may increase the risk of tumour dissemination in the perioperative period by directly and indirectly suppressing the immune system, which is primarily responsible for controlling tumour growth. 
  • 254
  • 06 Dec 2023
Topic Review
Anal Squamous Cell Carcinoma
Anal squamous cell carcinoma (ASCC) is a rare malignancy, with most cases associated with human papilloma virus and an increased incidence in immunocompromised patients.
  • 482
  • 23 Jun 2021
Topic Review
Anal Stenosis
Anal stenosis (AS) is defined as anatomical or functional narrowing of the anal canal, which can result from inflammatory bowel diseases, radiation therapy, congenital malformations, or excisional hemorrhoidectomy. The anatomical AS is related to the increased fibrous scar tissue forming, which disables stretching of the anal canal. The leading cause of the anatomical AS is excisional hemorrhoidectomy that is often the chosen treatment for grade III and IV hemorrhoidal disease.
  • 2.1K
  • 18 Apr 2022
Topic Review
Analgosedation and Periprocedural Care for Gastrointestinal Endoscopy
The number and complexity of endoscopic gastrointestinal diagnostic and therapeutic procedures is globally increasing. Procedural analgosedation during gastrointestinal endoscopic procedures has become the gold standard of gastrointestinal endoscopies. Patient satisfaction and safety are important for the quality of the technique. The ideal analgosedation technique should enable the satisfaction of the patient, their maximum safety and, at the same time, cost-effectiveness. Although propofol is the gold standard and the most used general anesthetic for endoscopies, its use is not without risks such as pain at the injection site, respiratory depression, and hypotension. New studies are looking for alternatives to propofol, and drugs like remimazolam and ciprofol are in the focus of researchers’ interest. New monitoring techniques are also associated with them. The optimal technique of analgosedation should provide good analgesia and sedation, fast recovery, comfort for the endoscopist, patients’ safety, and will have financial benefits. The future will show whether these new drugs have succeeded in these goals.
  • 449
  • 27 Feb 2023
Topic Review
Analysis of Running in Wilson’s Disease
Wilson’s disease (WD) is a rare, recessively inherited deficit of copper transportation leading to increased serum levels of free copper and progressive copper intoxication of multiple organs. In the central nervous system (CNS) the basal ganglia, the cerebellum as well as brainstem nuclei are mainly disturbed. A broad spectrum of neurological symptoms as parkinsonian gait, tremor, dysarthria, dystonia, and chorea results.
  • 550
  • 19 Jan 2022
Topic Review
Analysis of Spinal Cord Injuries
The CatWalk system (CW) is an automated and exceptionally reliable system for assessing gait abnormalities and motor coordination. CW is a good tool for both studying improvements in the walking of animals after suffering a peripheral nerve and spinal cord lesion and to select the best therapies and procedures after tissue destruction, given that it provides objective and quantifiable data.
  • 502
  • 27 Aug 2021
Topic Review
Analysis of the Classification Systems for Thoracolumbar Fractures
Spinal fractures represent a category of traumatic lesions with a significant impact both medical and social aspects of life. Within this category, thoracolumbar fractures (TLF) form a particular subcategory due to their location with specific biomechanics—the transition from thoracic physiologic kyphosis (fixed) to lumbar lordosis (mobile). Lesions at this level may have severe consequences such as complete/partial motor deficit, local pain or kyphosis.
  • 355
  • 30 May 2022
Topic Review
Analytical Assessment of Biosimilars
The analytical assessment includes testing physicochemical and functional attributes to establish a claim of biosimilarity. How closely a biosimilar candidate should match the reference product will remain questionable since a reference product is approved based on whatever quality attributes it presents; a biosimilar candidate, on the other hand, must match these quality attributes, even if the reference product’s attributes are not the most desirable.
  • 1.6K
  • 27 Apr 2022
Topic Review
Analytical Methodologies for Determination of Vancomycin
Vancomycin is regarded as the last resort of defense for a wide range of infections due to drug resistance and toxicity. The detection of vancomycin in plasma has always aroused particular concern because the performance of the assay affects the clinical treatment outcome. With the update of technology, bioassay, immunoassay, LC appreared in sequence with respective characteristic. 
  • 467
  • 02 Nov 2022
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