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Topic Review
Genesis of Endotheliopathy
Endotheliopathy, according to the “two-activation theory of the endothelium”, is triggered by the activated complement system in critical illnesses, such as sepsis, diabetes and polytrauma, leading to two distinctly different molecular dysfunctions: (1) the activation of the inflammatory pathway due to the release of inflammatory cytokines, such as interleukins, interferons and tumor necrosis factors, and (2) the activation of the microthrombotic pathway due to the exocytosis of hemostatic factors, including ultra-large von Willebrand factor (ULVWF) multimers and FVIII. These lead to inflammation and microthrombogenesis. The former produces inflammatory diseases, and the latter produces endotheliopathy-associated vascular microthrombotic disease (EA-VMTD), which orchestrates not only TTP-like syndrome characterized by the triad of consumptive thrombocytopenia, microangiopathic hemolytic anemia and multiorgan dysfunction syndrome, but also many other endotheliopathic syndromes. The diagnostic features of EA-VMTD are well established now and therapeutic strategies are being formulated. 
  • 805
  • 11 Oct 2022
Topic Review
The Role of the Cerebellum in Spatial Navigation
Although the function of the cerebellum has typically been associated with motor functions, several recent studies point to the cerebellum being involved in various cognitive functions, including spatial navigation. More specifically, clinical and neuroimaging evidence  suggests a functional and anatomical distinction between sensorimotor and cognitive cerebellum. The latter includes lobule VI, Crus I and II and lobule VIIB of the posterior lobe, which have been linked to different aspects of executive functions.
  • 805
  • 18 May 2022
Topic Review
Agaricus blazei ,Grifola frondosa Extracts
Extracts of the mushrooms also appear to be safe in preclinical and clinical studies. Whereas special focus has been on their antitumor effects, the mushrooms' anti-allergic properties have also been investigated. The anti-allergic mechanism was amelioration of a skewed Th1/Th2 balance. Here, a brief review is given of the preclinical and clinical findings with AbM and GF.
  • 805
  • 30 Oct 2020
Topic Review
HA Filler-Induced Vascular Occlusion
Biocompatible hyaluronic acid (HA, hyaluronan) gel implants have altered the therapeutic landscape of surgery and medicine, fostering an array of innovative products that include viscosurgical aids, synovial supplements, and drug-eluting nanomaterials. However, it is perhaps the explosive growth in the cosmetic applications of injectable dermal fillers that has captured the brightest spotlight, emerging as the dominant modality in plastic surgery and aesthetic medicine. The popularity surge with which injectable HA fillers have risen to in vogue status has also brought a concomitant increase in the incidence of once-rare iatrogenic vaso-occlusive injuries ranging from disfiguring facial skin necrosis to disabling neuro-ophthalmological sequelae. As researchers' understanding of the pathophysiology of these injuries has evolved, supplemented by more than a century of astute observations, the formulation of novel therapeutic and preventative strategies has permitted the amelioration of this burdensome complication.
  • 805
  • 07 Sep 2022
Topic Review
Mitochondria in WAT and BAT
Adipose tissue (AT) dysregulation is a key process in the pathophysiology of obesity and its cardiometabolic complications. Mitochondria are cytoplasmic organelles that play a critical role in the energy metabolism of all eukaryotic cells and generate energy in the form of adenosine triphosphate (ATP). 
  • 804
  • 14 Apr 2023
Topic Review
Potential Nutraceuticals in Alzheimer’s Disease
Alzheimer’s disease (AD) incidence is increasing worldwide at an alarming rate. Considering this increase, prevention efforts, stemming from scientific research, health education, and public policies, are critical. Clinical studies evidenced that healthy lifestyles along with natural multitarget and disease-modifying agents have a preventative impact on AD or mitigate symptoms in diagnosed patients.
  • 804
  • 29 Mar 2022
Topic Review
Acute Heart Failure Syndrome
A working definition of heart failure (HF) in children is “a progressive clinical and pathophysiological syndrome caused by cardiovascular and noncardiovascular abnormalities that results in characteristic signs and symptoms including edema, respiratory distress, growth failure, and exercise intolerance and accompanied by circulatory, neurohormonal, and molecular derangements”.
  • 804
  • 17 May 2021
Topic Review
Antibiotic Resistance in Helicobacter pylori
H. pylori is a “fastidious” microorganism; culture methods are time-consuming and technically challenging. The advent of molecular biology techniques has enabled the identification of molecular mechanisms underlying the observed phenotypic resistance to antibiotics in H. pylori.
  • 804
  • 12 Oct 2021
Topic Review
Substance Dependence
Substance dependence, also known as drug dependence, is a biopsychological situation where-by an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance, because of an adaptive state that has developed with the individual from psychoactive substance consumption, which results in the experience of withdrawal, which necessitates the re-consumption of the drug. A drug addiction, a distinct concept from substance dependence, is defined as compulsive, out-of-control drug use, despite negative consequences. An addictive drug is a drug which is both rewarding and reinforcing. ΔFosB, a gene transcription factor, is now known to be a critical component and common factor in the development of virtually all forms of behavioral and drug addictions, but not dependence. The International Classification of Diseases classifies substance dependence as a mental and behavioural disorder. Within the framework of the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), substance dependence is redefined as a drug addiction, and can be diagnosed without the occurrence of a withdrawal syndrome. It was described accordingly: "When an individual persists in use of alcohol or other drugs despite problems related to use of the substance, substance dependence may be diagnosed. Compulsive and repetitive use may result in tolerance to the effect of the drug and withdrawal symptoms when use is reduced or stopped. This, along with Substance Abuse are considered Substance Use Disorders." In the DSM-5 (released in 2013), substance abuse and substance dependence have been merged into the category of substance use disorders and they no longer exist as individual diagnoses.
  • 804
  • 25 Oct 2022
Topic Review
Immobilization and Stabilization of Bacteriophages
Phages are effective at targeting and killing bacterial strains of interest and have yielded encouraging results when administered as part of a tailored treatment to severely ill patients as a last resort.  The incorporation of bacteriophages into therapeutic formulations typically involves encapsulating them within a stabilizing substance. Immobilization refers to the chemical, physio-chemical or electrostatic binding of bacteriophages to a surface. 
  • 803
  • 21 May 2021
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