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1 The review shows that the medicinal mushrooms AbM and GF possess valuable antiallergic properties, which sould be exploited as supplementary drugs for allergy and asthma. + 993 word(s) 993 2020-05-13 11:46:12 |
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Hetland, G.; Tangen, J.; Mahmood, F.; Mirlashari, M.R.; Nissen-Meyer, L.S.H.; Nentwich, I.; Therkelsen, S.P.; Tjønnfjord, G.E.; Johnson, E. Agaricus blazei ,Grifola frondosa Extracts. Encyclopedia. Available online: (accessed on 25 April 2024).
Hetland G, Tangen J, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, et al. Agaricus blazei ,Grifola frondosa Extracts. Encyclopedia. Available at: Accessed April 25, 2024.
Hetland, Geir, Jon-Magnus Tangen, Faiza Mahmood, Mohammad Reza Mirlashari, Lise Sofie Haug Nissen-Meyer, Ivo Nentwich, Stig Palm Therkelsen, Geir Erland Tjønnfjord, Egil Johnson. "Agaricus blazei ,Grifola frondosa Extracts" Encyclopedia, (accessed April 25, 2024).
Hetland, G., Tangen, J., Mahmood, F., Mirlashari, M.R., Nissen-Meyer, L.S.H., Nentwich, I., Therkelsen, S.P., Tjønnfjord, G.E., & Johnson, E. (2020, May 18). Agaricus blazei ,Grifola frondosa Extracts. In Encyclopedia.
Hetland, Geir, et al. "Agaricus blazei ,Grifola frondosa Extracts." Encyclopedia. Web. 18 May, 2020.
Agaricus blazei ,Grifola frondosa Extracts

Extracts of the mushrooms also appear to be safe in preclinical and clinical studies. Whereas special focus has been on their antitumor effects, the mushrooms' anti-allergic properties have also been investigated. The anti-allergic mechanism was amelioration of a skewed Th1/Th2 balance. Here, a brief review is given of the preclinical and clinical findings with AbM and GF.

Antiallergic Agaricus blazei Grifola frondosa mushrooms clinical studies


During the last 40 years medicinal effects of the related Basidiomycetes mushrooms, Agaricus blazei Murill (AbM) and Grifola frondosa (GF) from Brazilian and Eastern traditional medicine, respectively, have been documented scientifically.

2. Antiallergic Effects

An Agaricus blazei (AbM) extract has been shown[1] to inhibit induced anaphylactic reaction, including passive immunization, i.e., ear-swelling, in a mouse model by a treatment effect on the mast cell reaction (Table 1). In another mouse allergic asthma model with orally administered AbM extract, reduced levels were observed of specific immunoglobulin (Ig)E, IgG1 and bronchial eosinophils owing to amelioration of skewed T helper cell (Th)1/Th2 balance[2]. This was confirmed by us with the AbM-based and GF-containing extract, AndosanTM, in the similar ovalbumin (OVA)-induced allergic sensitization mouse model, in which specific IgE and IgG1 were also reduced and Th1 response increased relative to Th2[3]. By use of this OVA sensitization mouse model for allergy, the mechanism behind the reduced specific IgE and improved Th1/Th2 balance was found to be AbM promotion of epithelial cell-induced macrophage (MΦ) activation and  naïve T cells differentiation to Th1 cells[4]. Recently, we undertook a placebo-controlled randomized clinical study where blood donors with self-reported and specific IgE-confirmed birch allergy and asthma, were given AndosanTM orally for 2 months prior to the pollen season. They had less general allergy and asthma ailments and used less medication for the diseases[5]. This was caused by reduced specific IgE levels and reduced mast cell sensitization, as shown indirectly by the basophil activation test, a surrogate for mast cell activation (Table 2)[5].

Table 1. Anti-allergic Effects of Agaricus blazei Murill and Grifola frondosa (*Human study).

Product, Admin.

Study In, Of



Author, Year

AbM mycelia water extract incl. HE, GF, p.o. (Andosan)

Placebo-ctr RCT in blood donors, Pollen allergy & asthma (n = 60)

↓ General symptoms, and medication

↓ Spec. IgE, reduced basophil sensitivity

*Mahmood et al., 2019[5]

Water AbM extract, p.o.

Mice, Allergy

↓ OVA sensitization

↓ Spec. IgE, improv. Th1/Th2 balance via MF activ. by epithelial cc, diff. promotion of naïve T cc to Th1 cc

Bouike et al., 2011[4]

AbM mycelia water extract incl. HE, GF, p.o. (Andosan)

Mice, Allergy

↓ OVA sensitization

↓ Spec. IgE, IgG1 and improved Th1/Th2 balance

Ellertsen & Hetland 2009[3]

AbM water extract, p.o.

Mice, Asthma

↓ Spec. IgE, IgG1 and bronchial eosinophils

Amelioration of skewed Th1/Th2 balance

Takimoto et al., 2008[2]

AbM water extract, p.o.

Mice, Anaphylaxis

Inhib. of induced anaphylactic reaction and ear swelling

Treatment of mast cell mediated anaphylactic reaction

Choi et al., 2006[1]

GF alcohol extract and ergosterol, p.o.

Mice, Allergic inflammation

Inhib. mast cc degranulation, alleviated anaphylactic cutaneous response

↓ Type 1 allergic reaction by suppression of mast cc degranulation

Kawai et al., 2019[6]

GF polysacch, p.o.

Mice, AD

Inhib. AD-like skin lesion

↓ IgE, mast cc infiltr., cytokine express. controlling Th1/Th2

Park et al., 2015[7]

Abbreviations: immunoglobulin (Ig), ovalbumin (OVA), atopic dermatitis (AD),Grifola frondosa (GF).Form Hetland et al., 2020[8] .

Table 2. Basophil maximal (peak) reactivity during intervention in birch pollen allergic blood donors before and after the pollen season


Bet v 1 conc.




Peak before

Peak after

Peak before

Peak after






1 (5.2 %)



1 (4.1)


7 (36.8)


4 (16.6)

1 (4.1)


11 (57.8)

17 (89.4)

20 (83.3)

19 (79.1)



2 (10.5)


3 (12.5)


9.52 ±5.12

0.90* ±0.06

2.50 ±0.69


5.38^ ±4.12



19 (100%)

19 (100)

24 (100)

24 (100)

*p=0.004 vs. before pollen season, ^p=0.062 vs. before pollen season. Abbreviation: Bet v 1 is the major birch pollen allergen. Modified from Mahmood et al, 2019[5].

Moreover, in mice with orally administered GF polysaccharide or extract (Table 1), antiallergic effects have also been observed: Atopic dermatitis-like skin lesions and mast cell degranulation were inhibited due to alleviated anaphylactic cutaneous response[6][7]. This was found to be caused by reduced IgE and mast cell infiltration, a cytokine expression that ameliorated the Th1/Th2 imbalance[7], and a reduced type I allergic response by suppression of mast cell degranulation[6]. Hence, GF polysaccharides could be used as a novel therapeutic drug instead of corticosteroids or as supplementary treatment[7].

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Update Date: 30 Oct 2020