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Topic Review
The Genetics of Hereditary Angioedema
Hereditary angioedema is a rare inherited disorder characterized by recurrent episodes of the accumulation of fluids outside of the blood vessels, causing rapid swelling of tissues in the hands, feet, limbs, face, intestinal tract, or airway.
  • 1.1K
  • 23 Jun 2021
Topic Review
Glioblastoma Pathogenesis
Glioblastoma is one of the most common and detrimental forms of solid brain tumor, with over 10,000 new cases reported every year in the United States. Despite aggressive multimodal treatment approaches, the overall survival period is reported to be less than 15 months after diagnosis. A widely used approach for the treatment of glioblastoma is surgical removal of the tumor, followed by radiotherapy and chemotherapy. While there are several drugs available that are approved by the Food and Drug Administration (FDA), significant efforts have been made in recent years to develop new chemotherapeutic agents for the treatment of glioblastoma.
  • 1.1K
  • 28 Dec 2020
Topic Review
Extroversion and Neuroticism at Work
Extroversion and Neuroticism. Many studies have linked personality traits to the way in which workers carry out their tasks, with the aim of optimizing employee performance. Understanding this relationship is very useful for both recruiting members of staff and assigning them to positions that best fit their personality. It is generally accepted that there are five principal traits or factors that can be used to catalog the structure of each individual personality.
  • 1.1K
  • 06 Feb 2021
Topic Review
Intrinsically Photosensitive Retinal Ganglion Cells
Intrinsically photosensitive retinal ganglion cells (ipRGCs), also called photosensitive retinal ganglion cells (pRGC), or melanopsin-containing retinal ganglion cells (mRGCs), are a type of neuron in the retina of the mammalian eye. The presence of ipRGCs were first noted in 1923 when rodless, coneless mice still responded to a light stimulus through pupil constriction, suggesting that rods and cones are not the only light-sensitive neurons in the retina. It wasn't until the 1980s that advancements in research on these cells began. Recent research has shown that these retinal ganglion cells, unlike other retinal ganglion cells, are intrinsically photosensitive due to the presence of melanopsin, a light-sensitive protein. Therefore they constitute a third class of photoreceptors, in addition to rod and cone cells.
  • 1.1K
  • 04 Nov 2022
Topic Review
AMP-activated Protein Kinase
We live and to do so we must breathe and eat, so are we a combination of what we eat and breathe? Here we will consider this question, and the role in this respect of the AMP-activated protein kinase (AMPK). Emerging evidence suggests that AMPK facilitates central and peripheral reflexes that coordinate breathing and oxygen supply, and contributes to central regulation of feeding and food choice. We propose, therefore, that oxygen supply to the body is aligned with not only the quantity we eat, but also nutrient-based diet selection, and that the cell-specific expression pattern of AMPK subunit isoforms is critical to appropriate system alignment in this respect. If this is the case, then aberrant cell-specific changes in the expression of AMPK subunit isoforms could give rise, in part, to known associations between a wide variety of conditions associated with metabolic disorder.
  • 1.1K
  • 10 May 2021
Topic Review
EPR Effect for Cancer Treatment
The EPR effect was first discovered by Maeda and colleagues in solid murine tumors. The polymer-drug conjugates were i.v. administered, and 10-to-100-fold higher concentrations were achieved relative to free drug administration. The concentration of nanodrugs builds up in tumors due to the EPR effect, reaching several times higher than that of plasma due to the lack of lymphatic drainage. 
  • 1.1K
  • 23 Jun 2021
Topic Review
Prognostic Biomarkers of CLL
Chronic lymphocytic leukemia (CLL) is an extremely heterogeneous disease. With the advent of oral targeted agents (Tas) the treatment of CLL has undergone a revolution, which has been accompanied by an improvement in patient’s survival and quality of life. 
  • 1.1K
  • 27 Apr 2021
Topic Review
Rapid Eye Movement Sleep Behavior Disorder
Rapid eye movement (REM) sleep without atonia (RSWA) is the polysomnographic (PSG) hallmark of REM sleep behavior disorder (RBD), a feature essential for the diagnosis of this condition.
  • 1.1K
  • 24 Jun 2022
Topic Review
Flavonoids
Flavonoids are health supplements commonly known in their tablet forms. Crops are rich in various sub-classes of flavonoids that could be used for human consumption. The biosynthesis and transport of flavonoids are major factors contributing to the accumulation of flavonoids in crops. On the other hand, the bioavailability of flavonoids to the human body governs the beneficial effects of the flavonoids on human health.
  • 1.1K
  • 05 Nov 2020
Topic Review
Phytochemicals and Nano-Phytopharmaceuticals
Nanomedicines emerged from nanotechnology and have been introduced to bring advancements in treating multiple diseases. Nano-phytomedicines are synthesized from active phytoconstituents or plant extracts. Advancements in nanotechnology also help in the diagnosis, monitoring, control, and prevention of various diseases. The field of nanomedicine and the improvements of nanoparticles has been of keen interest in multiple industries, including pharmaceutics, diagnostics, electronics, communications, and cosmetics. In herbal medicines, these nanoparticles have several attractive properties that have brought them to the forefront in searching for novel drug delivery systems by enhancing efficacy, bioavailability, and target specificity. 
  • 1.1K
  • 17 May 2022
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