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Topic Review
Quercetin a Natural Therapeutic Candidate
This manuscript was provided as a comprehensive review of the anti-influenza virus effect of quercetin and its derivatives with critical evaluation. We provided different classifications and focused on viral pathogenesis, animal models, human studies, in silico and docking studies and molecular pathways of quercetin and derivatives effects comprehensively which is not included in similar articles. This review is a multidisciplinary collection of cell biology, biotechnology, drug development, and virus investigation.
  • 1.2K
  • 11 Jan 2021
Topic Review
Judo-Specific Training
Reaching peak judo performance requires the optimal development of technical-tactical, physical, physiological and psychological abilities. High-intensity interval training (HIIT), including general and specific movements, is a training method often used in judo to simultaneously improve multiple aspects of performance. Combat simulation (randori) or throwing technique exercises (uchi-komi, technique repetition without throwing the partner and nage-komi, throwing technique repetition throwing the partner) as specific training methods are regularly used in judo. HIIT using uchi-komi as exercise and performed in all-out mode improves anaerobic and aerobic fitness while allowing technical skill development for judo athletes.
  • 1.2K
  • 05 Nov 2020
Topic Review
Nanoemulsions
Nanoemulsions (NEs) are lipophilic systems with nanoscale globules that can be absorbed e.g. through the nasal mucosa, and are therefore being explored for nose-to-brain delivery of drugs. These can be either oil-in-water (o/w) or water-in-oil (w/o) emulsions. Especially, o/w NEs are a promising option for the encapsulation of lipophilic drugs, protecting them from enzymatic degradation, increasing their solubility in liquid media, modulating their drug release, and improving their bioavailability.
  • 1.2K
  • 04 Jan 2021
Topic Review
5-HT2A Receptor Ligands Against Depression
According to the World Health Organization, depression is a multifactorial disorder that affects around 350 million people worldwide. The most widespread monoamine of the CNS-serotonin (5-HT) is believed to play a vital role in the pathomechanism of this condition, and the importance of the neurotransmitter is elevated by the "serotonin hypothesis", linking the presence of the depression-like symptoms with diminished 5-HT concentration in certain brain regions. Serotonin acts its biological effects via numerous receptors. Out of all seven types of serotonin receptors, the serotonin 2A receptor has been identified as a most promising molecular target valuable for the treatment of mood disorders. Recent medicinal chemistry findings on the structure and function of the serotonin 2A (5-HT2A) receptor facilitated design and discovery of novel anti-depressants. 
  • 1.2K
  • 14 Feb 2022
Topic Review
Celiac Disease
Celiac disease (CD) is a chronic enteropathy that develops in genetically susceptible individuals after the ingestion of gluten. There has been a substantial increase in CD prevalence in the last 50 years, and it is now estimated that this disease affects approximately 1% of the population in the Western world. In the large majority of cases, CD is a benign disease, characterized by the complete resolution of symptoms and a normal life expectancy after the onset of a gluten-free diet (GFD). However, failure to adhere to a strict GFD bears the risk of adverse events and increases mortality. A considerable number of studies have considered the possible association between CD and neoplasms. In particular, an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported. In this review, we summarize and discuss the current evidence on the possible association between CD and cancer.
  • 1.2K
  • 27 Oct 2020
Topic Review
Xenograft Model in Animal Models of Cancer
Animal models of cancer may be classified in a variety of ways. Most simply, they are either spontaneous or induced and mammalian or non-mammalian. Alternatively, they may be categorized by the method of inducing cancer occurrence. A xenograft model involves the transplantation of cancer cells from one species (e.g., human) into a host animal of a different species (e.g., mouse).
  • 1.2K
  • 18 Oct 2022
Topic Review
Commercial Targeted Libraries in Drug Design
After the identification of a biological target (enzyme, receptor, protein and so on), the focus of the early phase of drug discovery rests on the identification of leads or compounds that exhibit pharmacological activity against this specific target. Compounds of interest are most often discovered in pre-existing libraries of compounds that can be either virtual or physical. Computer-aided methods which have become increasingly important over the years in drug development utilize virtual compound libraries. While physical compound libraries reach the number of millions of molecules, virtual compound libraries created by large pharmaceutical companies can range from 107 to 1018 molecules. Investigations of these libraries identifies specific molecules, synthetic pathways and focus on a specific chemical space. Targeted libraries are often smaller and are focused towards a specific chemical space. They are created by using relevant biological information with the aim to decrease the processing time associated with larger libraries while maintaining the most relevant chemical space where lead compounds can be found. Due to the fact that they required less computational or wet-lab labor to process they have become very popular with smaller laboratories which try to compete in the drug-development sector. Many modern vendors of compounds today offer such libraries, but the quality of the procedure used to define desired chemical space and select compounds is questionable.
  • 1.2K
  • 25 May 2022
Topic Review
Brain Tumor MR Image Segmentation
The precise segmentation of brain tumor images is a vital step towards accurate diagnosis and effective treatment of brain tumors. Magnetic Resonance Imaging (MRI) can generate brain images without tissue damage or skull artifacts, providing important discriminant information for clinicians in the study of brain tumors and other brain diseases. Segmentation methods of brain tumor MR image are mainly divided into three categories according to different segmentation principles: traditional segmentation methods, traditional machine learning-based segmentation methods and deep learning-based segmentation methods.
  • 1.2K
  • 23 Sep 2021
Topic Review
Gut Microbiome
The gut microbiome can play important role in maintaining homeostasis in the human body. An imbalance in the gut microbiome can lead to pro-inflammatory immune responses and the initiation of disease processes, including cancer. The research results prove some strains of probiotics by modulating intestinal microbiota and immune response can be used for cancer prevention or/and as adjuvant treatment during anticancer chemotherapy.
  • 1.2K
  • 15 Jan 2021
Topic Review
Mismatch Negativity
Mismatch negativity (MMN) is a component of the difference waveform derived from passive auditory oddball stimulation.
  • 1.2K
  • 19 May 2021
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