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Topic Review
Melanoma Biomarkers
Melanoma is the deadliest form of skin cancer and remains a diagnostic challenge in the dermatology clinic. Here, we categorize and review known melanoma diagnostic biomarkers into five categories including visual, histopathological, morphological, immunohistochemical, and serological/molecular biomarkers.
  • 1.2K
  • 30 Jan 2021
Topic Review
Fish by-products,Bioactive Peptide-Rich Protein Hydrolysates
The use of fish by-products is an important production opportunity for the fishing and seafood processing industries since it can possibly create additional profits while also lowering disposal costs. Benefits of utilizing secondary raw materials from fish processing are depicted in. One of the potential possibilities for greater benefit is to use these industrial wastes and low-value fish for the recovery and hydrolysis of proteins rich in bioactive peptides.
  • 1.2K
  • 16 Sep 2021
Topic Review
PH-Sensitive Cubosome Liquid Crystalline Nanocarriers
Cubosomes are soft biocontinuous nanoparticles whose 3D geometry can be engineered to render the structures responsive to pH variations, which is of large interest to the production of efficient drug delivery materials. We have reviewed the literature to provide a state of the art in this regard and shed lights on prominent perspectives and strategies for pH-sensitive cubosomes development, taking advantage of the pH changes of the biological media at targeted application sites.
  • 1.2K
  • 27 Oct 2020
Topic Review
Nanoemulsions
Nanoemulsions (NEs) are lipophilic systems with nanoscale globules that can be absorbed e.g. through the nasal mucosa, and are therefore being explored for nose-to-brain delivery of drugs. These can be either oil-in-water (o/w) or water-in-oil (w/o) emulsions. Especially, o/w NEs are a promising option for the encapsulation of lipophilic drugs, protecting them from enzymatic degradation, increasing their solubility in liquid media, modulating their drug release, and improving their bioavailability.
  • 1.2K
  • 04 Jan 2021
Topic Review
Celiac Disease
Celiac disease (CD) is a chronic enteropathy that develops in genetically susceptible individuals after the ingestion of gluten. There has been a substantial increase in CD prevalence in the last 50 years, and it is now estimated that this disease affects approximately 1% of the population in the Western world. In the large majority of cases, CD is a benign disease, characterized by the complete resolution of symptoms and a normal life expectancy after the onset of a gluten-free diet (GFD). However, failure to adhere to a strict GFD bears the risk of adverse events and increases mortality. A considerable number of studies have considered the possible association between CD and neoplasms. In particular, an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported. In this review, we summarize and discuss the current evidence on the possible association between CD and cancer.
  • 1.2K
  • 27 Oct 2020
Topic Review
Cofilin and Actin Dynamics
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons express cofilin-1 as the major isoform, but ADF and cofilin-2 are also expressed. All isoforms bind preferentially and cooperatively along ADP-subunits in F-actin, affecting the filament helical rotation, and when either alone or when enhanced by other proteins, promotes filament severing and subunit turnover.
  • 1.2K
  • 25 Oct 2021
Biography
Shafi Ahmed
Shafi Ahmed is a surgeon, teacher, futurist, innovator and entrepreneur. Shafi was born on 26 January 1969 in Sylhet District, East Pakistan (now Bangladesh) and came to the United Kingdom as a child. His father, the late Mimbor Ali, was honoured by the Bangladeshi government for his significant contribution to the liberation of Bangladesh. He was appointed as a Consultant General, Laparoscopi
  • 1.2K
  • 26 Dec 2022
Topic Review
Aflatoxins
Aflatoxins family includes a great number of lipophilic molecules produced by aerobic micro fungi belonging to the genus Aspergillus. Aflatoxins are secondary metabolites produced by the microfungi.
  • 1.2K
  • 06 Nov 2020
Topic Review
Structural Family Therapy
Structural family therapy (SFT) is a method of psychotherapy developed by Salvador Minuchin which addresses problems in functioning within a family. Structural family therapists strive to enter, or "join", the family system in therapy in order to understand the invisible rules which govern its functioning, map the relationships between family members or between subsets of the family, and ultimately disrupt dysfunctional relationships within the family, causing it to stabilize into healthier patterns. Minuchin contends that pathology rests not in the individual, but within the family system. SFT utilizes, not only a special systems terminology, but also a means of depicting key family parameters diagrammatically. Its focus is on the structure of the family, including its various substructures. In this regard, Minuchin is a follower of systems and communication theory, since his structures are defined by transactions among interrelated systems within the family. He subscribes to the systems notions of wholeness and equifinality, both of which are critical to his notion of change. An essential trait of SFT is that the therapist actually enters, or "joins", with the family system as a catalyst for positive change. Joining with a family is a goal of the therapist early on in his or her therapeutic relationship with the family. Structural and Strategic therapy are important therapeutic models to identify as many therapists use these models as the bases for treatment. Each model has its own approach using different ways in conceptualizing a problem and developing treatment plans that support the goals stated for therapy. In addition, theory-based treatment plans are the source for goal development and treatment options by identifying the presenting problem and social influences. Both these models use similar approaches and define goals with various therapeutic processes that begin with the building of therapist and client relationship. In addition, diversity and theory are identified as a major component in choosing a theory that addresses diversity issues.
  • 1.2K
  • 28 Oct 2022
Topic Review
Cholera Pit
A cholera pit was a burial place used in a time of emergency when the disease was prevalent. Such mass graves were often unmarked and were placed in remote or specially selected locations. Public fears of contagion, lack of space within existing churchyards and restrictions placed on the movements of people from location to location also contributed to their establishment and use. Many of the victims were poor and lacked the funds for memorial stones, however memorials were sometimes added at a later date.
  • 1.2K
  • 04 Nov 2022
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