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Topic Review
Complement System Activation and Functions
The complement system is an essential component of innate immunity. Acting as a first line of defence, the complement system recognises and aids in the elimination of pathogens. Complement proteins also play key roles in homeostasis and they support the inductive of the adaptive immune response.
  • 1.3K
  • 23 Mar 2021
Topic Review
CDK4/6 and MAPK
Despite the development of targeted therapies and novel inhibitors, cancer remains an undefeated disease. Resistance mechanisms arise quickly and alternative treatment options are urgently required. Protein kinases as signaling switchboards are frequently deregulated in cancer and signify vulnerable nodes and potential therapeutic targets.
  • 1.3K
  • 14 Dec 2020
Topic Review
Sensory Neurons
Four sensory systems (vestibular, lateral line, electroreception, auditory) are unique and project exclusively to the brainstem of vertebrates. All sensory neurons depend on a common set of genes (Eya1, Sox2, Neurog1, Neurod1) that project to a dorsal nucleus and an intermediate nucleus, which differentiate into the vestibular ear, lateral line and electroreception in vertebrates. 
  • 1.3K
  • 23 Sep 2021
Topic Review
Combinatory Antimicrobial Photodynamic Therapy (c-aPDT)
Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics to combat localized infections. Thanks to the expanding versatility of photosensitizers and the many possible combinations with other antimicrobial treatments, aPDT is evolving from a conceptually simple methodology towards a much more sophisticated, integrated, and innovative technology.
  • 1.3K
  • 11 Feb 2022
Topic Review
Autophagy in Eye Diseases
Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. 
  • 1.3K
  • 23 Apr 2021
Topic Review
Stress in the Aviation Industry
Stress in the aviation industry is a common phenomenon composed of three sources: physiological stressors, psychological stressors, and environmental stressors. Professional pilots can experience stress in flight, on the ground during work-related activities, and during personal time because of the influence of their occupation. An airline pilot can be an extremely stressful job due to the workload, responsibilities and safety of the thousands of passengers they transport around the world. Chronic levels of stress can negatively impact one's health, job performance and cognitive functioning. Being exposed to stress does not always negatively influence humans because it can motivate people to improve and help them adapt to a new environment. Unfortunate accidents start to occur when a pilot is under excessive stress, as it dramatically affects his or her physical, emotional, and mental conditions. Stress "jeopardizes decision-making relevance and cognitive functioning" and it is a prominent cause of pilot error. Being a pilot is considered a unique job that requires managing high workloads and good psychological and physical health. Unlike the other professional jobs, pilots are considered to be highly affected by stress levels. One study states that 70% of surgeons agreed that stress and fatigue don't impact their performance level, while only 26% of pilots denied that stress influences their performance. Pilots themselves realize how powerful stress can be, and yet many accidents and incidents continues to occur and have occurred, such as Asiana Airlines Flight 214, American Airlines Flight 1420, and Polish Air Force Tu-154.
  • 1.3K
  • 28 Sep 2022
Topic Review
Long-Term Space Nutrition
Nutrition has many important functions in space travel, from providing enough nutrients and meeting the metabolic needs of a healthy body to enhancing an individual’s emotional well-being. Nutrition also plays a key role in offsetting many negative effects of space travel, such as radiation exposure, immune deficiency, oxidative stress, and bone and muscle loss.
  • 1.3K
  • 30 Jan 2022
Topic Review
Alcohol Craving
Craving is a multidimensional phenomenon involving an intense urge to consume substances. It is perceived as an individual experience of “wanting” a drug that may result in motivational and drug-seeking behavioral patterns. Alcohol craving has been extensively studied due to its clinical implications in the development and maintenance of alcohol use disorder (AUD). Craving is considered one of the mechanisms that promote relapse after treatment discharge and even after a prolonged period of abstinence. To better understand the magnitude of the relationship between craving and relapse, it is fundamental to explore factors associated with alcohol craving as it may help in the development of more efficient treatment approaches to prevent relapse in AUD patients.
  • 1.3K
  • 28 Sep 2020
Topic Review
Dyscalculia
Dyscalculia (/ˌdɪskælˈkjuːliə/) is a disability resulting in difficulty learning or comprehending arithmetic, such as difficulty in understanding numbers, learning how to manipulate numbers, performing mathematical calculations and learning facts in mathematics. It is sometimes informally known as "math dyslexia", though this can be misleading as dyslexia is a different condition from dyscalculia. Dyscalculia is associated with dysfunction in the region around the intraparietal sulcus and potentially also the frontal lobe. Dyscalculia does not reflect a general deficit in cognitive abilities or difficulties with time, measurement, and spatial reasoning. Estimates of the prevalence of dyscalculia range between 3 and 6% of the population. In 2015 it was established that 11% of children with dyscalculia also have ADHD. Dyscalculia has also been associated with Turner syndrome and people who have spina bifida. Mathematical disabilities can occur as the result of some types of brain injury, in which case the term acalculia is used instead of dyscalculia which is of innate, genetic or developmental origin.
  • 1.3K
  • 14 Oct 2022
Topic Review
Neurobiological Mechanisms of Dreaming
Dream research has advanced significantly over the last twenty years, thanks to the new applications of neuroimaging and electrophysiological techniques. Many findings pointed out that mental activity during sleep and wakefulness shared similar neural bases. On the other side, recent studies have highlighted that dream experience is promoted by significant brain activation, characterized by reduced low frequencies and increased rapid frequencies. Additionally, several studies confirmed that the posterior parietal area and prefrontal cortex are responsible for dream experience. Further, early results revealed that dreaming might be manipulated by sensory stimulations that would provoke the incorporation of specific cues into the dream scenario. Recently, transcranial stimulation techniques have been applied to modulate the level of consciousness during sleep, supporting previous findings and adding new information about neural correlates of dream recall. Overall, although multiple studies suggest that both the continuity and activation hypotheses provide a growing understanding of neural processes underlying dreaming, several issues are still unsolved. The impact of state-/trait-like variables, the influence of circadian and homeostatic factors, and the examination of parasomnia-like events to access dream contents are all opened issues deserving further deepening in future research.
  • 1.3K
  • 01 Mar 2021
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