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Topic Review
Multiplex Immunohistochemistry/Immunofluorescence (mIHC/IF) Techniques
Multiplex imaging techniques and digital image analysis are powerful tools that could overcome some issues concerning tumour-microenvironment studies. This novel approach to biomarker assessment offers a better understanding of the complicated interactions between tumour cells and their environment. Multiplex labelling enables the detection of multiple markers simultaneously and the exploration of their spatial organisation. 
  • 1.4K
  • 02 Sep 2022
Topic Review
Migraine
Studies suggest that migraine pain has a vascular component. The prevailing dogma is that peripheral vasoconstriction activates baroreceptors in central, large arteries. Dilatation of central vessels stimulates nociceptors and induces cortical spreading depression. Studies investigating nitric oxide (NO) donors support the indicated hypothesis that pain is amplified when acutely administered. We provide an alternate hypothesis which, if substantiated, may provide therapeutic opportunities for attenuating migraine frequency and severity. We suggest that in migraines, heightened sympathetic tone results in progressive central microvascular constriction. Suboptimal parenchymal blood flow, we suggest, activates nociceptors and triggers headache pain onset. Administration of NO donors could paradoxically promote constriction of the microvasculatureas a consequence of larger upstream central artery vasodilatation. Inhibitors of NO production are reported to alleviate migraine pain. We describe how constriction of larger upstream arteries, induced by NO synthesis inhibitors, may result in a compensatory dilatory response of the microvasculature. The restoration of central capillary blood flow may be the primary mechanism for pain relief. Attenuating the propensity for central capillary constriction and promoting a more dilatory phenotype may reduce frequency and severity of migraines. We propose consideration of two dietary nutraceuticals for reducing migraine risk: L-arginine and aged garlic extracts.
  • 1.4K
  • 25 Dec 2020
Topic Review
Cervical Epithelial Cells
Using Raman microscopy, we investigated epithelial cervical cells collected from 96 women with squamous cell carcinoma (SCC) or belonging to groups I, IIa, IIID-1 and IIID-2 according to Munich III classification (IIID-1 and IIID-2 corresponding to Bethesda LSIL and HSIL groups, respectively). All women were tested for human papillomavirus (HPV) infection using PCR. Subcellular resolution of Raman microscopy enabled to understand phenotypic differences in a heterogeneous population of cervical cells in the following groups: I/HPV−, IIa/HPV−, IIa/HPV−, LSIL/HPV−, LSIL/HPV+, HSIL/HPV−, HSIL/HPV+ and cancer cells (SCC/HPV+). We showed for the first time that the glycogen content in the cytoplasm decreased with the nucleus size of cervical cells in all studied groups apart from the cancer group. For the subpopulation of large-nucleus cells HPV infection resulted in considerable glycogen depletion compared to HPV negative cells in IIa, LSIL (for both statistical significance, ca. 45%) and HSIL (trend, 37%) groups. We hypothesize that accelerated glycogenolysis in large-nucleus cells may be associated with the increased protein metabolism for HPV positive cells. Our work underlines unique capabilities of Raman microscopy in single cell studies and demonstrate potential of Raman-based methods in HPV diagnostics.
  • 1.4K
  • 29 Oct 2020
Topic Review
Autism and LGBT Identities
Although it is not known exactly what causes one to be on the autism spectrum or what causes one's sexual orientation or gender identity, a few limited studies into autistic people have shown higher rates of LGBT identities and feelings among autistic people than the general population.
  • 1.4K
  • 01 Nov 2022
Topic Review
Pathological Lying
Pathological lying, also known as mythomania and pseudologia fantastica, is a mental disorder in which the person habitually or compulsively lies. The reason for such lies often serves no obvious purpose other than to paint oneself as a hero or victim depending on the circumstance. It was first described in the medical literature in 1895 by Anton Delbrück (de). Although it is a controversial topic, pathological lying has been defined as "falsification entirely disproportionate to any discernible end in view, may be extensive and very complicated, and may manifest over a period of years or even a lifetime". A firm concept of the behaviour does not exist, nor any diagnostic criteria that health professionals accept widely; resulting in controversy regarding what it truly means to be a pathological liar. Theories to explain the root causes include stress, an attempt to shift a locus of control to an internal one, and issues relating to low self-esteem.
  • 1.4K
  • 27 Sep 2022
Topic Review
Ultrasound Examination in Nail Apparatus Assessment in Psoriasis
The assessment of psoriatic nail changes in everyday practice is based exclusively on clinical symptoms that do not reflect the entire disease process in the nail apparatus. The use of imaging methods, especially widely available and inexpensive ultrasonography, creates the possibility of additional revealing and assessing grayscale of morphological changes of the ventral nail plate, nail bed, and matrix, as well as the attachment of the finger extensor tendon to the distal phalanx. What is more, it enables the assessment of inflammation severity in the power Doppler technique. A qualitative classification of nail plate morphological changes corresponding to the severity of psoriatic nail changes has been developed so far and attempts are being made to develop a quantitative method to assess not only the presence of changes but also the severity of inflammation. 
  • 1.4K
  • 20 May 2022
Topic Review
Rigenera® Micrografts in Oral Regeneration
Biomaterials derive either from nature or synthesized in the laboratory using chemical approaches utilizing metallic components, polymers, ceramics, or composite materials. They are often used and adapted for medical applications. A biomaterial is also defined as autograft, allograft, or xenograft used as a transplant material. In the last decade also tissue engineering and stem cells were deeply studied trying to make better autologous biomaterials ready to be used in regenerative procedures. Micrografts are a new concept of biomaterial, they are enriched of progenitor cells that are a particular type of stem cell excellent in enhancing the regenerative potential. Moreover, another advantage is the easy handling and tissue availability.
  • 1.4K
  • 29 Oct 2020
Topic Review
Monoclonal Gammopathies of Neurological Significance
Monoclonal gammopathies of neurological significance include a widespread range of manifestations, ranging from slowly progressive sensitive demyelinating polyneuropathy with anti-MAG antibody to subacute rapidly progressive forms as in POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes)  or neurolymphomatosis.
  • 1.4K
  • 21 Mar 2022
Topic Review
Theranostic Radiopharmaceuticals
Theranostic Radiopharmaceuticals (Radiotheranostics) is a term in the medical field to define the combination of therapeutic and diagnostic techniques by a suitable radiopharmaceutical agent. Radionuclides are isotopes that emit radiation or have excess nuclear energy, making them chemically unstable and tend to change into another atom. Various types of radiation can be emitted by radionuclides e.g. alpha particles, beta particles, and gamma energy. In radiotheranostics, a pharmaceutical agent (drug) is needed to be a carrier molecule that introduces the radionuclide to its target. Radionuclides are then used as a source of radiation in radiotheranostics that are responsible for diagnosing or treating various diseases.
  • 1.4K
  • 24 May 2022
Topic Review
Arsenic Induced Neurotoxicity
Arsenic is a ubiquitous environmental contaminant widely distributed in the surrounding environmental compartments. Exposure to inorganic arsenic is known to cause major neurological effects such as cytotoxicity, chromosomal aberration, damage to cellular DNA and genotoxicity. On the other hand, long-term exposure to arsenic may cause neurobehavioral effects in the juvenile stage, which may have detrimental effects in the later stages of life. Thus, it is important to understand the toxicology and underlying molecular mechanism of arsenic which will help to mitigate its detrimental effects.
  • 1.4K
  • 11 Mar 2022
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