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Topic Review
Structural Characteristics of Selaginella Biflavonoid
Despite the many strategies employed to slow the spread of cancer, the development of new anti-tumor drugs and the minimization of side effects have been major research hotspots in the anti-tumor field. Natural drugs are a huge treasure trove of drug development, and they have been widely used in the clinic as anti-tumor drugs. Selaginella species in the family Selaginellaceae are widely distributed worldwide, and they have been well-documented in clinical practice for the prevention and treatment of cancer. Biflavonoids are the main active ingredients in Selaginella, and they have good biological and anti-tumor activities, which warrant extensive research. The promise of biflavonoids from Selaginella (SFB) in the field of cancer therapy is being realized thanks to new research that offers insights into the multi-targeting therapeutic mechanisms and key signaling pathways.
  • 363
  • 08 May 2023
Topic Review
Hyperbaric Oxygen Therapy in Treating Surgical Site Infections
Hyperbaric oxygen therapy (HBOT) can result in rapid healing and epithelialization of various wounds and has potential beneficial effects in the treatment of surgical site infections (SSIs) or other similar infections following cardiac, neuromuscular scoliosis, coronary artery bypass, and urogenital surgeries. Moreover, it was a safe therapeutic procedure in most cases. The mechanisms related to the antimicrobial activity of HBOT include direct bactericidal effects through the formation of reactive oxygen species (ROS), the immunomodulatory effect of HBOT that increase the antimicrobial effects of the immune system, and the synergistic effects of HBOT with antibiotics. 
  • 514
  • 08 May 2023
Topic Review
SARS-CoV-2 in Thyroid Disorders
A properly functioning thyroid gland is crucial for health, influencing growth, neuronal development, reproduction and as a key regulator of energy metabolism, although thyroid disorders/diseases are extremely common and affect 200 million people worldwide. Viral infection may represent one of the major environmental factors related to common thyroid disorders, including subacute thyroiditis (SAT), nonthyroidal illness syndrome (NTIS) and autoimmune thyroid diseases (AITDs) including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT).
  • 445
  • 08 May 2023
Topic Review
Disulfiram
The literature has suggested that disulfiram (DSM) may be a potent drug in the armamentarium of physicians who treat chronic Lyme disease. The use of disulfiram in the treatment of Lyme disease started with a researcher who determined that DSM is bactericidal to spirochete. 
  • 586
  • 08 May 2023
Topic Review
Artificial Intelligence in Digestive Healthcare
With modern society well entrenched in the digital area, the use of Artificial Intelligence (AI) to extract useful information from big data has become more commonplace in our daily lives than we perhaps realize. A number of medical specialties such as Gastroenterology rely heavily on medical images to establish disease diagnosis and patient prognosis, as well as to monitor disease progression. Moreover, some such imaging techniques have been adapted so that they can potentially deliver therapeutic interventions. The digitalization of medical imaging has paved the way for important advances in this field, including the design of AI solutions to aid image acquisition and analysis.
  • 498
  • 08 May 2023
Topic Review
miRNAs’ Cross-Involvement in Skin Allergies
Skin inflammation is a common underlying feature of atopic dermatitis, allergic contact dermatitis and chronic spontaneous urticaria. miRNAs are involved in the pathogenesis and regulation of atopic dermatitis and can reveal an atopic predisposition or indicate disease severity. In chronic spontaneous urticaria, different miRNAs which are over-expressed during urticaria exacerbations not only play a role in the possible response to therapy or remission, but also serve as a marker of chronic autoimmune urticaria and indicate associations with other autoimmune diseases. In allergic contact dermatitis, miRNAs are upregulated in inflammatory lesions and expressed during the sensitization phase of allergic response. Several miRNAs have been identified as potential biomarkers of these chronic skin conditions, but they are also possible therapeutic targets.
  • 261
  • 08 May 2023
Topic Review
Pathogenesis of Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a very complex world health problem. Approximately 905,677 new cases and 830,180 HCC-related deaths were reported in 2020. The estimation of more than 1 million deaths caused by HCC by 2030 has been predicted. The pathogenesis of hepatocellular carcinoma (HCC) is a multifactorial process that has not yet been fully investigated.
  • 391
  • 08 May 2023
Topic Review
The Link between 4-Hydroxynonenal and Schizophrenia
The significant complexity of the brain can lead to the development of serious neuropsychiatric disorders, including schizophrenia. A number of mechanisms are involved in the etiopathogenesis of schizophrenia, pointing to its complexity and opening a new perspective on studying this disorder. HNE (4-hydroxynonenal) is an essential molecule that significantly impacts cell function and survival. For this reason, it is assumed that HNE might play a role in the pathophysiology of schizophrenia and other disorders.
  • 392
  • 08 May 2023
Topic Review
Strokes in the ICU
The mortality and neurological sequelae are worse in patients with in-hospital stroke than in those with community-onset stroke. The leading cause of this tragic situation is the delay in emergent treatment.
  • 337
  • 08 May 2023
Topic Review
Origins of Metabolic Syndrome
Metabolic syndrome (MetS) is defined by a cluster of several cardio-metabolic risk factors, specifically visceral obesity, hypertension, dyslipidemia, and impaired glucose metabolism, which together increase risks of developing future cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D).
  • 316
  • 08 May 2023
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