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Topic Review
Stereotactic Body Radiation Therapy in Gynecologic Oligometastases
Stereotactic body radiation therapy (SBRT) allows for the high-precision delivery of a large dose of radiation to a small area. SBRT has shown overall survival benefits in a variety of oligometastatic cancers. No prospective randomized study specifically evaluated the impact of SBRT in recurrent or oligometastatic gynecologic cancer (ROMGC). SBRT has been shown to provide excellent local control with low toxicity in gynecologic oligometastases, even in chemorefractory disease. 
  • 242
  • 21 Jul 2023
Topic Review
Impact of Sex Hormones on Hepatocellular Carcinoma
Several chronic liver diseases are characterized by a clear gender disparity. Among them, hepatocellular carcinoma (HCC) shows significantly higher incidence rates in men than in women. The different epidemiological distribution of risk factors for liver disease and HCC only partially accounts for these gender differences. In fact, the liver is an organ with recognized sexual dysmorphism and is extremely sensitive to the action of androgens and estrogens. Sex hormones act by modulating the risk of developing HCC and influencing its aggressiveness, response to treatments, and prognosis. Furthermore, androgens and estrogens are able to modulate the action of other factors and cofactors of liver damage (e.g., chronic HBV infection, obesity), significantly influencing their carcinogenic power.
  • 425
  • 21 Jul 2023
Topic Review
Extracellular Succinate
Extracellular succinate induces cellular changes and tissue adaptation or damage by ligating cell surface succinate receptor-1 (SUCNR-1) and activating downstream signaling pathways and transcriptional programs.
  • 385
  • 21 Jul 2023
Topic Review
Kiwifruit’s Allergy in Children
Kiwifruit allergy is an emerging pathological condition in both general and pediatric populations with a wide range of symptoms linked to variable molecular patterns, justifying systemic and cross-reactions with other allergens (i.e., latex, pollen, and fruit). Skin prick test (SPT), specific serum IgE (Act d 1, Act d 2, Act d 5, Act d 8, and Act d 10) directed against five out of thirteen molecular allergens described in the literature, and oral test challenge with kiwifruit are available for defining diagnosis. 
  • 338
  • 21 Jul 2023
Topic Review
Antiplatelet Therapies in Current Clinical Practice
Antiplatelet therapy plays a crucial role in a number of cardiovascular disorders.
  • 165
  • 21 Jul 2023
Topic Review
Redefining Precision Management of r/r Large B-Cell Lymphoma
The treatment paradigms for patients with relapsed large B-cell lymphoma are expanding. Chimeric antigen receptor technology (CAR-T) has revolutionized the management of these patients. Novel bispecific antibodies and antibody–drug conjugates, used as chemotherapy-free single agents or in combination with other novel therapeutics, have been quickly introduced into the real-world setting. With such a paradigm shift, patients have an improved chance of better outcomes with unpredictable complete remission rates. 
  • 1.4K
  • 21 Jul 2023
Topic Review
Molecular, Cellular and Genetic Aspects of Peri-Implantitis
Peri-implantitis is a multi-factorial disease with an inflammatory background that occurs in both soft and hard tissues surrounding implants. A wide array of cells stands behind peri-implantitis, as well as cytokines and their genetic variations that take part in the process. Recently, growing interest in this topic has led to the introduction of specific new diagnostic tools to enable a better understanding of patients’ responses to treatment and, in turn, to even enable prediction of the risk of developing peri-implant disease.
  • 354
  • 21 Jul 2023
Topic Review
Oxidative Stress in Obstructive Sleep Apnea Syndrome
Obstructive sleep apnea syndrome (OSAS) is a disease that affects 2% of men and 4% of women of middle age. It is a major health public problem because untreated OSAS could lead to cardiovascular, metabolic, and cerebrovascular complications.
  • 447
  • 21 Jul 2023
Topic Review
Clinical Applications of Polypodium leucotomos (Fernblock®) in Oncodermatology
Exposure to sun radiation leads to higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition to ultraviolet radiation (UVR), recent research indicates that infrared radiation (IR) and visible light (VIS) can play an important role in the pathogenesis of some of these processes. Detrimental effects associated with sun exposure are well known, but new studies have shown that DNA damage continues to occur long after exposure to solar radiation has ended. Regarding photoprotection strategies, natural substances are emerging for topical and oral photoprotection. In this sense, Fernblock®, a standardized aqueous extract of the fern Polypodium Leucotomos (PLE), has been widely administered both topically and orally with a strong safety profile. Thus, this extract has been used extensively in clinical practice, including as a complement to photodynamic therapy (PDT) for treating actinic keratoses (AKs) and field cancerization.
  • 409
  • 21 Jul 2023
Topic Review
Stem/Progenitor Cells and Therapy in BPD
Bronchopulmonary dysplasia (BPD) is a chronic lung disease commonly seen in preterm infants, and is triggered by infection, mechanical ventilation, and oxygen toxicity. Among other problems, lifelong limitations in lung function and impaired psychomotor development may result. Despite major advances in understanding the disease pathologies, successful interventions are still limited to only a few drug therapies with a restricted therapeutic benefit, and which sometimes have significant side effects. As a more promising therapeutic option, mesenchymal stem cells (MSCs) have been in focus for several years due to their anti-inflammatory effects and their secretion of growth and development promoting factors.
  • 434
  • 21 Jul 2023
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