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Topic Review
Age-Related Macular Degeneration (AMD)
Age-related macular degeneration (AMD) is a common irreversible sight-threatening disease characterized by progressive degeneration of the central retina, preferentially involving the retinal photoreceptors, the retinal pigment epithelium (RPE), the Bruch’s membrane (BM), or the choroidal microcirculation in the macular region.
  • 1.1K
  • 22 Sep 2021
Topic Review
Pre-clinical Cerebral Perfusion MRI Techniques
Alterations to the cerebral microcirculation have been recognized to play a crucial role in the development of neurodegenerative disorders. However, the exact role of the microvascular alterations in the pathophysiological mechanisms often remains poorly understood. The early detection of changes in microcirculation and cerebral blood flow (CBF) can be used to get a better understanding of underlying disease mechanisms. This could be an important step towards the development of new treatment approaches. Animal models allow for the study of the disease mechanism at several stages of development, before the onset of clinical symptoms, and the verification with invasive imaging techniques. Specifically, pre-clinical magnetic resonance imaging (MRI) is an important tool for the development and validation of MRI sequences under clinically relevant conditions. This article reviews MRI strategies providing indirect non-invasive measurements of microvascular changes in the rodent brain that can be used for early detection and characterization of neurodegenerative disorders. The perfusion MRI techniques: Dynamic Contrast Enhanced (DCE), Dynamic Susceptibility Contrast Enhanced (DSC) and Arterial Spin Labeling (ASL), will be discussed, followed by less established imaging strategies used to analyze the cerebral microcirculation: Intravoxel Incoherent Motion (IVIM), Vascular Space Occupancy (VASO), Steady-State Susceptibility Contrast (SSC), Vessel size imaging, SAGE-based DSC, Phase Contrast Flow (PC) Quantitative Susceptibility Mapping (QSM) and quantitative Blood-Oxygenation-Level-Dependent (qBOLD). We will emphasize the advantages and limitations of each strategy, in particular on applications for high-field MRI in the rodent’s brain. 
  • 1.1K
  • 02 Jun 2021
Topic Review
Forensic Podiatry
Forensic Podiatry is a subdiscipline of forensic science in which specialized podiatric knowledge including foot and lower limb anatomy, musculoskeletal function, deformities and diseases of the foot, ankle, lower extremities, and at times, the entire human body is used in the examination of foot-related evidence in the context of a criminal investigation. Forensic Podiatry has been defined as: The application of sound and researched podiatry knowledge and experience in forensic investigations, to show the association of an individual with a scene of crime, or to answer any other legal question concerned with the foot or footwear that requires knowledge of the functioning foot. Those who specialize in this field need to have gained knowledge and experience in podiatry and also in forensic science and practice. Forensic Podiatry is usually used to assist in the process of human identification, but can also be employed to help address issues relating to questions that have arisen within the context of forensic enquiry. Such questions could include whether or not a shoe could have had multiple wearers, what the effects of a shoe not fitting correctly could have been, whether or not someone could have placed their foot into a shoe that was too small for the postulated wearer's foot and other matters involving the podiatric interpretation of relevant evidential materials.
  • 1.1K
  • 01 Dec 2022
Topic Review
Fowler’s Syndrome
Fowler’s syndrome is characterized by a large bladder capacity, reduced sensation, increased maximal urethral closure pressure, and detrusor underactivity.
  • 1.1K
  • 22 Apr 2021
Topic Review
Environmental Factors as Inducers of Oxidative Stress
Prolonged elevated oxidative stress (OS) possesses negative effect on cell structure and functioning, and is associated with the development of numerous disorders. 
  • 1.1K
  • 30 Aug 2022
Topic Review
Coriandrum sativum L.
Coriandrum sativum (C. sativum), belonging to the Apiaceae (Umbelliferae) family, is widely recognized for its uses in culinary and traditional medicine. C. sativum contains various phytochemicals such as polyphenols, vitamins, and many phytosterols, which account for its properties including anticancer, anti-inflammatory, antidiabetic, and analgesic effects.
  • 1.1K
  • 13 Jan 2022
Topic Review
Almond Allergens
Tree nuts are considered an important food in healthy diets. However, for part of the world’s population, they are one of the most common sources of food allergens causing acute allergic reactions that can become life-threatening. They are part of the Big Eight food groups which are responsible for more than 90% of food allergy cases in the United States, and within this group, almond allergies are persistent and normally severe and life-threatening. Almond is generally consumed raw, toasted or as an integral part of other foods. Its dietary consumption is generally associated with a reduced risk of cardiovascular diseases. Several almond proteins have been recognized as allergens. Six of them, namely Pru du 3, Pru du 4, Pru du 5, Pru du 6, Pru du 8 and Pru du 10, have been included in the WHO-IUIS list of allergens. Nevertheless, further studies are needed in relation to the accurate characterization of the already known almond allergens or putative ones and in relation to the IgE-binding properties of these allergens to avoid misidentifications.
  • 1.1K
  • 30 Sep 2021
Topic Review
Brain Tumor MR Image Segmentation
The precise segmentation of brain tumor images is a vital step towards accurate diagnosis and effective treatment of brain tumors. Magnetic Resonance Imaging (MRI) can generate brain images without tissue damage or skull artifacts, providing important discriminant information for clinicians in the study of brain tumors and other brain diseases. Segmentation methods of brain tumor MR image are mainly divided into three categories according to different segmentation principles: traditional segmentation methods, traditional machine learning-based segmentation methods and deep learning-based segmentation methods.
  • 1.1K
  • 23 Sep 2021
Topic Review
Farnsworth-Munsell 100 Hue Test
The Farnsworth-Munsell 100 Hue Color Vision test is a test of the human visual system often used to test for color blindness. The system was developed by Dean Farnsworth in the 1940s and it tests the ability to isolate and arrange minute differences in various color targets with constant value and chroma that cover all the visual hues described by the Munsell color system. There are several variations of the test, one featuring 100 color hues and one featuring 15 color hues. Originally taken in an analog environment with physical hue tiles, the test is now taken from computer consoles. An accurate quantification of color vision accuracy is particularly important to designers, photographers and colorists, who all rely on accurate color vision to produce quality content.
  • 1.1K
  • 01 Dec 2022
Topic Review
Imaging Findings of Mass-Forming Intrahepatic Cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, with mass-forming growth pattern being the most common. The typical imaging appearance of mass-forming ICC (mICC) consists of irregular ring enhancement in the arterial phase followed by the progressive central enhancement on portal venous and delayed phases. However, atypical imaging presentation in the form of hypervascular mICC might also be seen, which can be attributed to distinct pathological characteristics. Ancillary imaging features such as lobular shape, capsular retraction, segmental biliary dilatation, and vascular encasement favor the diagnosis of mICC.
  • 1.1K
  • 07 May 2022
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