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Topic Review
Transarterial Chemoembolization for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. It is principally associated with liver cirrhosis and chronic liver disease. The major risk factors for the development of HCC include viral infections (HBV, HCV), alcoholic liver disease (ALD,) and non-alcoholic fatty liver disease (NAFLD). The optimal treatment choice is dictated by multiple variables such as tumor burden, liver function, and patient’s health status. Surgical resection, transplantation, ablation, transarterial chemoembolization (TACE), and systemic therapy are potentially useful treatment strategies. TACE is considered the first-line treatment for patients with intermediate stage HCC. 
  • 826
  • 24 Mar 2022
Topic Review
Transarterial Chemoembolilzation
Transarterial chemoembolization (TACE) is widely recommended as a first-line treatment for intermediate-stage HCC. TACE is based on the predominantly arterial vascularization of HCC compared to the surrounding normal liver parenchyma, and aims to induce tumor necrosis by injecting chemotherapy agents with blockade of the arterial blood supply of tumor. 
  • 380
  • 16 Nov 2020
Topic Review
Transactional Analysis
Transactional analysis (TA) is a psychoanalytic theory and method of therapy wherein social interactions (or “transactions”) are analyzed to determine the ego state of the communicator (whether parent-like, childlike, or adult-like) as a basis for understanding behavior. In transactional analysis, the communicator is taught to alter the ego state as a way to solve emotional problems. The method deviates from Freudian psychoanalysis which focuses on increasing awareness of the contents of subconsciously held ideas. Eric Berne developed the concept and paradigm of transactional analysis in the late 1950s.
  • 997
  • 20 Oct 2022
Topic Review
Trans-Regulatory KLF14 Gene
Krüpple-Like family of transcription factor-14 (KLF14) is a master trans-regulatory gene that has multiple biological regulatory functions and is involved in many pathological mechanisms. It controls the expressions of several other genes which are involved in multiple regulatory functions. 
  • 322
  • 28 Jun 2023
Topic Review
Tranexamic Acid in Melasma and Sun-Induced Hyperpigmentation Treatment
Tranexamic acid (TXA) has anti-plasmin activity and has been shown when administered orally to be effective against melasma, for which it is considered first-line pharmacotherapy. Several studies have shown that topically applied TXA is also effective against melasma and skin hyperpigmentation caused by sunburn and inflammation. The TXA concentration in the epidermis and dermis/vasculature has been estimated from its distribution in the skin after closed application, and topically applied TXA has thus been shown to act on neutrophils and mast cells in the dermis and on the vascular system.
  • 627
  • 04 Nov 2022
Topic Review
Tranexamic Acid in Anterior Cruciate Ligament Reconstruction
There are several papers that investigate the use of tranexamic acid (TXA) in anterior cruciate ligament reconstructions (ACLR) or other arthroscopic procedures, that show favorable results and little to no complications. In our systematic review we show that TXA use in arthroscopic ACLR decreases postoperative blood loss and pain. Some evidence of improvement in functional scores were observed, but we believe that needs to be addressed in specific long-term result studies.
  • 308
  • 12 Jan 2022
Topic Review
Tranditional Use and Nutritional Value of Lansium domesticum
Lansium domesticum (Langsat, Meliaceae) is a tropical fruit mainly found in Southeast Asian countries, particularly in Thailand, Malaysia, Indonesia, and the Philippines.
  • 1.7K
  • 21 Apr 2022
Topic Review
Trainning of Female Soccer Players
Women’s soccer has increased in popularity and participation during the last decade. Soccer is considered a contact sport and such impact has had consequences through both a greater skill level and physical demands throughout training and matches. Some of the physical demands for female soccer players during matches have been reported, with total distances covered reaching 10 km, 1.7 km of which was completed at high speed (>18 km·h−1). In addition, female players perform between 1350 and 1650 changes of activity, such as passing, tackling, trapping and dribbling. Despite its growing popularity, female players are exposed to greater training volumes and competition demands than ever before and, therefore, a better understanding of female players’ physical performance changes is needed to design appropriate training programs.
  • 600
  • 31 Jan 2021
Topic Review
Training Simulators for Gastrointestinal Endoscopy
Gastrointestinal (GI) endoscopy is the gold standard in the detection and treatment of early and advanced GI cancers. However, conventional endoscopic techniques are technically demanding and require visual-spatial skills and significant hands-on experience. GI endoscopy simulators represent a valid solution to allow doctors to practice in a pre-clinical scenario.
  • 1.4K
  • 09 Apr 2021
Topic Review
Training Muscle Capacities in Hypoxic Conditions
Training muscle capacities in hypoxic conditions increases some manifestations, such as hypertrophy and muscle strength, due to a change in the muscle phenotype as a result of the activation of hypoxia-inducible factors (HIF). Despite the proven benefits of resistance training in hypoxic conditions that allow conjecture regarding the effectiveness in facilitating muscular capacities in different populations, there is still controversy regarding the difference between resistance training in hypoxia and normoxia. 
  • 377
  • 18 Jan 2023
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