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Topic Review
Effectiveness of Riboflavin on Migraine
Riboflavin (vitamin B2) is an essential water-soluble vitamin that helps prevent various medical conditions, such as sepsis, ischemia, and some cancers. Riboflavin’s biological effects, including antioxidant, anti-aging, anti-inflammatory, and anti-nociceptive effects, have been extensively studied. The pathophysiology of migraines is linked to oxidative stress with mitochondrial dysfunction, and neuroinflammation by the glial cell network.
  • 1.3K
  • 05 Aug 2021
Topic Review
Magnetoencephalography
Magnetoencephalography (MEG) is a functional brain imaging technique that measures magnetic flux on the surface of the head associated with underlying neuronal electrical dipoles.
  • 1.3K
  • 08 Mar 2021
Topic Review
Extraction, Isolation and Characterization of Bioactive Compounds
Diverse medicinal plants such as those from the genus Artemisia have been employed globally for centuries by individuals belonging to different cultures. Universally, Artemisia species have been used to remedy various maladies that range from simple fevers to malaria. 
  • 1.3K
  • 03 Dec 2021
Topic Review
Biomarkers in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and one of the leading causes of cancer-related death worldwide. HCC is highly heterogeneous, both within the tumor and among individuals, which is closely related to the HCC surveillance, diagnosis, prognosis, and treatment response. With the advances of next-generation sequencing, the genomic landscape of HCC has been identified which vastly improves our understanding of genetic and epigenetic changes and their interaction during HCC development.
  • 1.3K
  • 28 Sep 2022
Topic Review
High-Density Lipoprotein
High-density lipoprotein (HDL), the smallest and most dense lipoprotein, is composed of a central hydrophobic non-polar lipid core, consisting of primarily triacylglycerols and cholesterol esters.
  • 1.3K
  • 29 Jan 2022
Topic Review
Classification of the Luting Materials
A dental luting material aids in the retention and stability of indirect restorations on the prepared tooth structure. The luting materials can generally be classified by their chemical compositions, bonding mechanisms or clinical indications.
  • 1.3K
  • 15 Nov 2022
Topic Review
Cannabis Sativa Revisited
Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynamic changes of the immune system. At the moment, there is a gap in our understanding of the cellular, genetic, and molecular mechanisms involved in sepsis. One of the systems intensely studied in recent years is the endocannabinoid signaling pathway, as light was shed over a series of important interactions of cannabinoid receptors with biochemical pathways, specifically for sepsis. Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levels. In detail, the entry shows the important mechanisms modulated by the endocannabinoid signaling pathway, as well as of the molecular and cellular links it has with sepsis. At the same time, the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression will be presented.
  • 1.3K
  • 04 Jul 2022
Topic Review
Patent Foramen Ovale
A patent foramen ovale (PFO) is a commonly discovered potential opening between the right atrium (RA) and left atrium (LA) on routine echocardiographic surveillance in an otherwise asymptomatic infant or child. The importance of a PFO in some critical congenital heart defects (CHD), especially in neonates, is well recognized. 
  • 1.3K
  • 24 Apr 2022
Topic Review
L-Citrulline
L-citrulline (CIT) is an organic compound and a non-essential amino acid, and the body can synthesize it endogenously. Diet is a poor source of CIT and endogenous synthesis the its main source in the body. Watermelon is the principal source of that amino acid in the diet; the name citrulline comes from Citrullus lanatus (Thunb.), the scientific name for watermelon. CIT concentration in watermelon depends on the type of cultivir and usually ranges between 0.7 and 3.6 g/kg of fresh weight. CIT is present in both the flesh and in the ring.
  • 1.3K
  • 06 May 2021
Topic Review
Anatomical-MRI Correlations in Hypertrophic Cardiomyopathy Adults and Children
Hypertrophic Cardiomyopathy (HCM) is the most frequent hereditary cardiovascular disease and the leading cause of sudden cardiac death in young individuals. Advancements in CMR imaging have allowed for earlier identification and more accurate prognosis of HCM. CMR has been validated as a technique with high sensitivity and specificity, very few contraindications, a low risk of side effects, and is overall a good tool to be employed in the management of HCM patients.
  • 1.3K
  • 11 Mar 2022
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