Topic Review
MALDI–TOF Mass Spectrometry in Microbiology
Mass spectrometry (MS) is an analytical technique that has emerged as a powerful tool in clinical microbiology for identifying peptides and proteins, which makes it a promising tool for microbial identification. Matrix assisted laser desorption ionization–time of flight MS (MALDI–TOF MS) offers a cost- and time-effective alternative to conventional methods, such as bacterial culture and even 16S rRNA gene sequencing, for identifying viruses, bacteria and fungi and detecting virulence factors and mechanisms of resistance. 
  • 1.6K
  • 24 Nov 2021
Topic Review
Basal Septal Hypertrophy
Hypertension plays a dominant role in the development of left ventricular (LV) remodeling and heart failure, in addition to being the main risk factor for coronary artery disease.
  • 1.6K
  • 18 Apr 2022
Topic Review
Antifungal Therapy
Antifungals (also referred to as antimycotics) are the type of antibiotics used to treat fungal infections. In contrast to bacteria, fungi are eukaryotic organisms; thus fungal cells are very similar to our own cells. Because of this there is a limited number of selective targets and the current arsenal of antifungal drugs is very limited, which contributes to high mortality rates. In addition, development of resistance against current antifungals poses additional challenges. Clearly, new antifungal agents are urgently needed. 
  • 1.6K
  • 22 Oct 2020
Topic Review
Extrusion Bioprinting for Skin Applications
Skin is a large and complex organ that serves protective and regulatory functions and is responsible for communication between the external environment and the inner organism. To fulfill these functions, skin has evolved as an organ with a complex anatomy derived from both the ectoderm (epidermis) and mesoderm (dermis). The skin includes not only these two major compartments but also important appendages, including hair follicles, sweat and sebaceous glands, nerve endings, and blood vessels, all of which have intricate spatial arrangements that render fabrication of the full skin organ challenging.
  • 1.6K
  • 26 Oct 2020
Topic Review
Arbutin
Arbutin is a compound with a structure in which one molecule of D-glucose is bound to hydroquinone.
  • 1.6K
  • 18 Aug 2021
Topic Review
Neuroinflammatory Diseases
Frequent diseases of the CNS, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and psychiatric disorders (e.g., schizophrenia), elicit a neuroinflammatory response that contributes to the neurodegenerative disease process itself. The immune and nervous systems use the same mediators, receptors, and cells to regulate the immune and nervous systems as well as neuro-immune interactions. In various neurodegenerative diseases, peripheral inflammatory mediators and infiltrating immune cells from the periphery cause exacerbation to current injury in the brain. Acetylcholine (ACh) plays a crucial role in the peripheral and central nervous systems, in fact, other than cells of the CNS, the peripheral immune cells also possess a cholinergic system. 
  • 1.6K
  • 28 Apr 2021
Topic Review
Lung Cancer
Currently, lung cancer is a disease that acquired an impressive change in the clinical manangement due to the recent inovations regarding targeted therapies and immunne check point inhibitors.
  • 1.6K
  • 17 Apr 2021
Topic Review
Muscle
Muscle is a soft tissue found in most animals, and is one of the four basic animal tissues, along with nervous tissue, epithelium, and connective tissue. Muscle cells contain protein filaments called myofilaments of actin and myosin that slide past one another, producing a contraction that changes both the length and the shape of the cell. Muscles function to produce force and motion. They are primarily responsible for maintaining and changing posture, locomotion, as well as movement of internal organs, such as the contraction of the heart and the movement of food through the digestive system via peristalsis. Muscle tissue is derived from the embryonic mesodermal germ layer in a process known as myogenesis. There are three types of muscle, of which skeletal and cardiac muscle are striated and smooth muscle is not. Muscle action can be classified as being either voluntary or involuntary. Cardiac and smooth muscles contract without conscious thought and are termed involuntary, whereas the skeletal muscles contract upon command. Skeletal muscles in turn can be divided into fast and slow twitch fibers. Muscles are predominantly powered by the oxidation of fats and carbohydrates, but anaerobic chemical reactions are also used, particularly by fast twitch fibers. These chemical reactions produce adenosine triphosphate (ATP) molecules that are used to power the movement of the myosin heads. The term muscle is derived from the Latin musculus meaning "little mouse" perhaps because of the shape of certain skeletal muscles or because contracting muscles look like mice moving under the skin.
  • 1.6K
  • 22 Oct 2022
Topic Review
Phlegm Syndrome
Phlegm is defined as a viscous and turbid pathological factor that is formed due to an imbalance in body fluid in traditional East Asian medicine (TEAM) and accumulates in certain parts of the body as the form of condensation.
  • 1.6K
  • 12 Oct 2021
Topic Review
Age Related Macular Degeneration
Age related macular degeneration (AMD) is a disease associated with aging of the central area of the retina called the macula. It results in a progressive loss of central vision.In western countries, AMD is the leading cause of severe vision loss in people over the age of 50. About 25 to 30 million people suffer from AMD. Due to the aging of the population, this figure could double in the next 35 years.
  • 1.6K
  • 09 Nov 2020
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