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Topic Review
Radiofrequency Ablation Versus Cryoablation as First-Line Treatment
Catheter ablation has been shown to be more effective at maintaining sinus rhythm and improving quality of life when compared to antiarrhythmic drugs. Radiofrequency and cryoablation are two effective methods. 
  • 145
  • 30 Aug 2023
Topic Review
Circulating Biomarkers for B-Cell Progenitor Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is a hematological disease characterized by the dysfunction of the hematopoietic system that leads to arrest at a specific stage of stem cells development, suppressing the average production of cellular hematologic components. BCP (B-cell progenitor)-ALL is a neoplasm of the B-cell lineage progenitor. BCP-ALL is caused and perpetuated by several mechanisms that provide the disease with its tumor potential and genetic and cytological characteristics. These pathological features are used for diagnosis and the prognostication of BCP-ALL. The BCP-ALL diagnostic protocol is well established. Firstly, it is necessary to demonstrate ≥ 20% lymphoblasts in bone marrow (BM) based on a BPM. Second, a hematopathological review is performed; it comprises a morphological assessment, and flow cytometric and genetic characterization.
  • 375
  • 30 Aug 2023
Topic Review
The Long-Term Cardiovascular Effects of COVID-19
COVID-19 had stormed through the world in early March of 2019, and on 5 May 2023, SARS-CoV-2 was officially declared to no longer be a global health emergency. The rise of new COVID-19 variants XBB.1.5 and XBB.1.16, a product of recombinant variants and sub-strains, has fueled a need for continued surveillance of the pandemic as they have been deemed increasingly infectious. This has caused an increase in hospitalizations, a strain in resources, and a rise of concern for public health. In addition, there is a growing population of patients experiencing cardiovascular complications as a result of post-acute sequelae of COVID-19.
  • 383
  • 30 Aug 2023
Topic Review
Artificial Intelligence Integration in Medical Imaging
Radiology, since its inception, has experienced a revolutionary journey, punctuating modern medicine with its profound influence. From the discovery of X-rays to the subsequent integration of artificial intelligence (AI) and machine learning (ML), this multifaceted discipline continually evolves, transforming itself and the healthcare ecosystem it underpins.
  • 617
  • 30 Aug 2023
Topic Review
General Characteristics and Pathophysiology of Glaucoma
Glaucoma, a group of diseases characterized by progressive retinal ganglion cell loss, cupping of the optic disc, and a typical pattern of visual field defects, is a leading cause of severe visual impairment and blindness worldwide.
  • 167
  • 30 Aug 2023
Topic Review
Role of Cardiovascular Imaging in Risk Assessment
Cardiovascular imaging is progressively assuming an increasingly pivotal role, playing a crucial part in enhancing the meticulous categorization of individuals according to their risk profiles, thus enabling the customization of precise therapeutic strategies for patients with increased cardiovascular risks. Optimal risk assessment for primary prevention remains highly challenging.
  • 404
  • 30 Aug 2023
Topic Review
Liposome-Based Carriers for CRISPR Genome Editing
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a revolutionary genome editing technology that allows the precise modification of DNA sequences. Liposomes, which are small vesicles composed of lipid bilayers, have emerged as promising carriers for delivering various therapeutic agents, including CRISPR components.
  • 247
  • 30 Aug 2023
Topic Review
The Antitumor Activity of s-Triazine Derivatives
1,3,5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen heterocyclic compounds that play an important role in anticancer drug design and development. Three s-triazine derivatives, including altretamine, gedatolisib, and enasidenib, have already been approved for refractory ovarian cancer, metastatic breast cancer, and leukemia therapy, respectively, demonstrating that the s-triazine core is a useful scaffold for the discovery of novel anticancer drugs. 
  • 258
  • 30 Aug 2023
Topic Review
Movement Disorders Secondary to Drugs
Drug-induced movement disorders affect a significant percentage of individuals, and they are commonly overlooked and underdiagnosed in clinical practice. Many comorbidities can affect these individuals, making the diagnosis even more challenging. Several variables, including genetics, environmental factors, and aging, can play a role in the pathophysiology of these conditions. 
  • 346
  • 30 Aug 2023
Topic Review
Drug Hypersensitivity Reactions
Drug hypersensitivity reactions are a serious concern in clinical practice because they can be severe and result in lifelong sequelae. An accurate diagnosis and identification of the culprit drug is essential to prevent future reactions as well as for the identification of safe treatment alternatives. 
  • 309
  • 30 Aug 2023
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