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Topic Review
Implications of Phosphatase and Tensin Homolog in NSCLC
Lung cancer remains one of the major human malignancies affecting both men and women worldwide, with non-small cell lung cancer (NSCLC) being the most prevalent type. Multiple mechanisms have been identified that favor tumor growth as well as impede the efficacy of therapeutic regimens in lung cancer patients. Among tumor suppressor genes that play critical roles in regulating cancer growth, the phosphatase and tensin homolog (PTEN) constitutes one of the important family members implicated in controlling various functional activities of tumor cells, including cell proliferation, apoptosis, angiogenesis, and metastasis.
  • 301
  • 29 Aug 2023
Topic Review
Heterogeneity of Colorectal Cancer Liver Metastasis
Colorectal cancer (CRC) is a disease with a high incidence and mortality rate. The number of new CRC cases worldwide reached 1.93 million in 2020, ranking third after breast cancer and lung cancer. The number of CRC-related deaths reached 940,000, making it the second most deadly tumor globally. In China, according to the 2016 national cancer statistics published by the National Cancer Center, a total of 4.06 million tumor patients were diagnosed in 2016, with approximately 408,000 being CRC patients. Among these cases, approximately 196,000 CRC patients died, accounting for 8.10% of the total.
  • 301
  • 05 Jan 2024
Topic Review
Circular RNAs Modulate Cancer Hallmark and Molecular Pathways
Circular RNAs (circRNAs) are noncoding products of backsplicing of pre-mRNAs which have been established to possess potent biological functions. Due to their circular nature, the are characterized by high stability. Dysregulated circRNA expression has been linked to diseases including different types of cancer.
  • 300
  • 10 Mar 2022
Topic Review
Mechanical Stretch Induced Skin Regeneration
Skin soft tissue expansion is one of the most basic and commonly used techniques in plastic surgery to obtain excess skin for a variety of medical uses. However, skin soft tissue expansion is faced with many problems, such as long treatment process, poor skin quality, high retraction rate, and complications. Therefore, a deeper understanding of the mechanisms of skin soft tissue expansion is needed. 
  • 300
  • 06 Sep 2022
Topic Review
Enzymatical Processes
Enzymatical processes topic wants to enhance the central role of enzymes, the real workers from whose silent and tireless work depends the well-being of all cells in fact, intra-cellular reactions that take place in the cells are facilitated and therefore accelerated by enzymes.
  • 299
  • 08 Nov 2022
Topic Review
Ferroptosis Meets Cell-Cell Contacts
Ferroptosis is a regulated form of cell death characterized by iron-dependency and increased lipid peroxidation. Initially assumed to be selectively induced in tumour cells, there is increasing evidence that ferroptosis plays an important role in pathophysiology and numerous cell types and tissues. Deregulated ferroptosis has been linked to human diseases, such as neurodegenerative diseases, cardio-vascular disorders, and cancer. Along these lines, ferroptosis is a promising pathway to overcome therapy resistance of cancer cells. It is therefore of utmost importance to understand the cellular signalling pathways and the molecular mechanisms underlying ferroptosis regulation including context-specific effects mediated by the neighbouring cells through cell-cell contacts. 
  • 299
  • 04 May 2023
Topic Review
Immune and Tumor Microenvironment in Gliomas
Gliomas are the most common primary brain tumors. These cancers are universally fatal with limited treatment options. Glioma cells co-opt non-cancerous cells present in normal brain tissue. This manipulation results in a complex network of cell interactions. This interplay is further complicated by variations depending on specific mutations in glioma cells.
  • 299
  • 01 Jun 2023
Topic Review
HERV-K Modulates the Immune Response in ALS Patients
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects both lower motor neurons in brainstem and spinal cord and upper motor neurons in motor cortex. 
  • 299
  • 11 Jul 2023
Topic Review
Influence of Heat Stress on Chicken Immune System
Heat stress (HS) in poultry husbandry is an important stressor and with increasing global temperatures its importance will increase. The negative effects of stress on the quality and quantity of poultry production are described in a range of research studies.
  • 299
  • 16 Aug 2023
Topic Review
Tumor Microenvironment in Glioblastoma Niches
Among gliomas, malignant gliomas and more specifically glioblastomas (GBM) are a challenge in their diagnosis and treatment. Monocytes have been proved to actively participate in tumor growth, giving rise to the support of tumor-associated macrophages (TAMs). In GBM, TAMs represent up to one-half of the tumor mass cells, including both infiltrating macrophages and resident brain microglia. Infiltrating macrophages/monocytes constituted ~ 85% of the total TAM population, they have immune functions, and they can release a wide array of growth factors and cytokines in response to those factors produced by tumor and non-tumor cells from the tumor microenvironment (TME). This cell population has been increasingly studied in GBM TME to understand its role in tumor progression and therapeutic resistance. 
  • 298
  • 07 Apr 2023
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