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Topic Review
Targeted Microbubbles for Immunotherapy Applications
Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically stabilized by a phospholipid monolayer shell. In cancer immunotherapy, the microbubble shell can be engineered through the bioconjugation of molecular ligands to facilitate the delivery and uptake of drugs, genes, or cells. This approach allows for precise control of immune stimulation and improves the delivery and pharmacokinetics of immunomodulatory agents at the target site. It has emerged as an attractive strategy for treating various cancer immunotherapy modalities, including monoclonal antibodies, immune checkpoint inhibitors, adoptive cell transfer, cytokine therapy, and vaccines.
  • 407
  • 20 Jun 2023
Topic Review
Hyaluronic Acid-Mediated Phenolic Compound Nanodelivery for Cancer Therapy
Phenolic compounds are bioactive phytochemicals showing a wide range of pharmacological activities, including anti-inflammatory, antioxidant, immunomodulatory, and anticancer effects. Moreover, they are associated with fewer side effects compared to most currently used antitumor drugs. Combinations of phenolic compounds with commonly used drugs have been largely studied as an approach aimed at enhancing the efficacy of anticancer drugs and reducing their deleterious systemic effects. In addition, some of these compounds are reported to reduce tumor cell drug resistance by modulating different signaling pathways. However, often, their application is limited due to their chemical instability, low water solubility, or scarce bioavailability. Nanoformulations, including polyphenols in combination or not with anticancer drugs, represent a suitable strategy to enhance their stability and bioavailability and, thus, improve their therapeutic activity. 
  • 368
  • 20 Jun 2023
Topic Review
Mechanism of Heterogeneous Alkaline Deacetylation of Chitin
Chitosan can be obtained from chitin chemically or by using enzymatic preparations. From a chemical point of view, both acids and alkalis can be used to deacetylate chitin. However, alkaline deacetylation is used more often since glycosidic bonds are very sensitive to an acidic environment, in which they are destroyed. A mechanism for the chitin deacetylation reaction is proposed, taking into account its kinetic features in which the decisive role is assigned to the effects of hydration. It has been shown that the rate of chitin deacetylation increases with a decrease in the degree of hydration of hydroxide ions in a concentrated alkali solution. When the alkali concentration is less than the limit of complete hydration, the reaction practically does not occur. Hypotheses have been put forward to explain the decrease in the rate of the reaction in the second flat portion of the kinetic curve. The first hypothesis is the formation of “free” water, leading to the hydration of chitin molecules and a decrease in the reaction rate. The second hypothesis postulates the formation of a stable amide anion of chitosan, which prevents the nucleophilic attack of the chitin macromolecule by hydroxide ions.
  • 848
  • 19 Jun 2023
Topic Review
Nanoparticles as Drug Delivery Systems
The application of inventions or products from nanotechnology has revolutionised all aspects of everyday life ranging from medical applications to its impact on the food industry. Nanoparticles have made it possible to significantly extend the shelf lives of food product, improve intracellular delivery of hydrophobic drugs and improve the efficacy of specific therapeutics such as anticancer agents. 
  • 714
  • 19 Jun 2023
Topic Review
Nanotechnology Applications in Sepsis
Sepsis is a clinical syndrome characterized by physiological, pathological, and biochemical abnormalities induced by an invading pathogen, causing dysregulated host immune response and resulting as ultimately responsible for life-threatening organ dysfunction. It is a leading cause of morbidity and mortality, affecting all age groups and representing a significant global burden.
  • 260
  • 19 Jun 2023
Topic Review
Hydrogels Based on Supramolecular Strategies
Supramolecular structures are of great interest due to their applicability in various scientific and industrial fields. The sensible definition of supramolecular molecules is being set by investigators who, because of the different sensitivities of their methods and observational timescales, may have different views on as to what constitutes these supramolecular structures. The supramolecular interaction between some materials and guest molecules has endowed gels with the capacity for reversible gel−sol transformation. A plausible example has to do with self-healing, which is one of the most intriguing characteristics of biological or artificial systems, such as the particular and specific applications described below, due to its intrinsic importance. Thermodynamic stability plays an important role, for example, in the preparation of ophthalmic hydrogels and metallo-supramolecular hydrogels.
  • 988
  • 19 Jun 2023
Topic Review
Types of Synthetic Materials in Bone Grafts
To decide which material is most appropriate for a given procedure, it is necessary not only to have a good understanding of the biological function (osteogenesis, osteoinduction, and osteoconduction) of each material but also to consider the patient condition, as this is an essential criterion for the incorporation of any bone graft. Bone grafts are evolving and undergoing innumerable changes and there has long been talk of synthetic bone grafts and bone substitutes to the detriment of autologous, allogeneic, or even xenogeneic grafts.
  • 326
  • 19 Jun 2023
Topic Review
Biological Activity of the 3-Heteroaryl Fluoroquinolone Hybrids
There are promising studies in the area of 3-heteroaryl hybrids. The latter can be synthesized via different convinient methods with the formation of new derivatives with five-membered and fused heterocycles or creation of bis-fluoroquinolones with variable linking moieties. These novel compounds revealed not only good antimicrobial properties compared to the parent molecules but were also widely investigated as anticancer agents with promising activity.
  • 225
  • 19 Jun 2023
Topic Review
Functional Materials for Carbon-Based Perovskite Solar Cells Fabrication
Perovskite solar cells (PSCs) have rapidly developed into one of the most attractive photovoltaic technologies, exceeding power conversion efficiencies of 25% and as the most promising technology to complement silicon-based solar cells. Among different types of PSCs, carbon-based, hole-conductor-free PSCs (C-PSCs), in particular, are seen as a viable candidate for commercialization due to the high stability, ease of fabrication, and low cost. 
  • 344
  • 16 Jun 2023
Topic Review
Nanomaterial-Modified Electrodes for Electrochemical Biosensors
Electrochemical biosensors are superior technologies that are used to detect or sense biologically and environmentally significant analytes in a laboratory environment, or even in the form of portable handheld or wearable electronics. 
  • 522
  • 16 Jun 2023
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