Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Molecular Hybrids Targeting Tubulin Polymerization
Microtubules are cylindrical protein polymers formed from αβ-tubulin heterodimers in the cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the G2/M phase, and anomalous mitotic spindles will form. Microtubules are an important target for cancer drug action because of their critical role in mitosis. Several microtubule-targeting agents with vast therapeutic advantages have been developed, but they often lead to multidrug resistance and adverse side effects. Thus, single-target therapy has drawbacks in the effective control of tubulin polymerization. Molecular hybridization, based on the amalgamation of two or more pharmacophores of bioactive conjugates to engender a single molecular structure with enhanced pharmacokinetics and biological activity, compared to their parent molecules, has recently become a promising approach in drug development. The practical application of combined active scaffolds targeting tubulin polymerization inhibitors has been corroborated in the past few years
  • 393
  • 12 Apr 2022
Topic Review
Preparation Methods for Large-Area Perovskite Solar Cells
Solar energy is one of the most encouraging, abundant, green, and renewable sources for decreasing or even replacing traditional energy in the future. The energy provided by the sun in one hour is sufficient to supply the Earth’s needs for an entire year. The recent rapid development in perovskite solar cells (PSCs) has led to significant research interest due to their notable photovoltaic performance, currently exceeding 25% power conversion efficiency for small-area PSCs. The materials used to fabricate PSCs dominate the current photovoltaic market, especially with the rapid increase in efficiency and performance.
  • 1.2K
  • 12 Apr 2022
Topic Review
Applications of Nanostructured Materials
In the last few decades, the vast potential of nanomaterials for biomedical and healthcare applications has been extensively investigated. Several case studies demonstrated that nanomaterials can offer solutions to the current challenges of raw materials in the biomedical and healthcare fields. The different nanoparticles and nanostructured material synthesis approaches were described.
  • 3.3K
  • 11 Apr 2022
Topic Review
Tailoring Nanoadsorbent Surfaces for Recycling of LTM
A series of adsorbents were tailored for selective extraction of rare earth elements (REE) and late transition metals (LTM) via grafting of ligands bearing specific N- and S-donor functions. All obtained adsorbents showed relatively quick uptake kinetics and high adsorption capacity 0.5 to 1.8 mmol/g, depending on the function and the target metal ion. The adsorption equilibrium data analyzed and fitted well to Langmuir isotherm model revealing monolayer adsorption process on homogeneously functionalized silica nanoparticles (NPs). Most of the employed ligands demonstrated higher affinity towards LTM compared to REE, related to the nature of the functional groups and their arrangement on the surface of nanoadsorbent.
  • 453
  • 11 Apr 2022
Topic Review
Lipid-Based Nano-Sized Cargos
Bone metastasis has been considered the fatal phase of cancers, which remains incurable and to be a challenge due to the non-availability of the ideal treatment strategy. Unlike bone cancer, bone metastasis involves the spreading of the tumor cells to the bones from different origins. Bone metastasis generally originates from breast and prostate cancers. The possibility of bone metastasis is highly attributable to its physiological milieu susceptible to tumor growth. The treatment of bone-related diseases has multiple complications, including bone breakage, reduced quality of life, spinal cord or nerve compression, and pain. However, anticancer active agents have failed to maintain desired therapeutic concentrations at the target site; hence, uptake of the drug takes place at a non-target site responsible for the toxicity at the cellular level. Interestingly, lipid-based drug delivery systems have become the center of interest for researchers, thanks to their biocompatible and bio-mimetic nature. These systems possess a great potential to improve precise bone targeting without affecting healthy tissues.
  • 533
  • 11 Apr 2022
Topic Review
Fe-TiO2 Photocatalysts on Porous Platforms for Water Purification
Polyethylene glycol-modified titanium dioxide (PEG-modified TiO2) nanopowders were prepared using a fast solvothermal method under microwave irradiation, and without any further calcination processes. These nanopowders were further impregnated on porous polymeric platforms by drop-casting. The effect of adding iron with different molar ratios (1, 2, and 5%) of iron precursor was investigated. The approach developed in this work originated novel functionalized photocatalytic platforms, which were revealed to be promising for the removal of organic dyes from wastewater.
  • 647
  • 11 Apr 2022
Topic Review
Determination of Steroids by High Performance Liquid Chromatography-Fluorescence
Steroids are compounds widely available in nature and synthesized for therapeutic and medical purposes. Although several analytical techniques are available for the quantification of steroids in clinical samples, their analysis is challenging due to their low levels and complex matrices. The efficiency and quick separation of the high performance liquid chromatography (HPLC) combined with the sensitivity, selectivity, simplicity, and cost-efficiency of fluorescence, make HPLC coupled to fluorescence detection (HPLC-FLD) an ideal tool for routine measurement and detection of steroids for clinical and medical applications.
  • 1.4K
  • 11 Apr 2022
Topic Review
Applications of High Performance Liquid Chromatography with Fluorescence
Steroids are compounds widely available in nature and synthesized for therapeutic and medical purposes. Steroids can be found in various environmental samples, including water, plant, and animal samples as well as in a variety of pharmaceutical forms. Due its sensitivity and selectivity, high performance liquid chromatography with fluorescence detection (HPLC-FLD) is widely used for detection of steroids in pharmaceutical and environmental samples.
  • 996
  • 11 Apr 2022
Topic Review
PowderMEMS
PowderMEMS is a powder-based microfabrication technology for substrate-level integration of three-dimensional functional microstructures into MEMS devices. The PowderMEMS process solidifies micron-sized particles via atomic layer deposition (ALD) in pre-processed cavities on planar substrates from a wide variety of materials. Low process temperatures and the absence of organic components enable back-end-of-line compatibility. The process offers numerous degrees of freedom for the design of functional MEMSs, such as a wide choice of different material properties and the precise definition of 3D volumes at the substrate level, with a defined degree of porosity. Examples of application are the integration of rare-earth magnets and porous microfluidic structures into MEMS on wafer-level.
  • 528
  • 11 Apr 2022
Topic Review
Shot Peening and Cavitation Peening
Shot peening is a dynamically developing surface treatment used to improve the surface properties modified by tool, impact, microblasting, or shot action.
  • 940
  • 08 Apr 2022
  • Page
  • of
  • 467
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
ScholarVision Creations
Feedback