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Topic Review
Material Design in Implantable Biosensors
The impressive development in biosensing devices has led to the creation of man-made implantable devices that are temporarily or permanently introduced into the human body, and thus, diminishing the pain and discomfort of the person. Biosensors in the in vivo environment are required to have specific features, including biocompatibility (minimal immune response or biofouling), biodegradability, reliability, high accuracy, and miniaturization (flexible, stretchable, lightweight, and ultra-thin). However, the performance of implantable biosensors is limited by body responses and insufficient power supplies (due to minimized batteries/electronics and data transmission without wires).
  • 534
  • 13 Apr 2023
Topic Review
Maté (Drink)
User:RMCD bot/subject notice Maté or mate (/ˈmæteɪ/), also known as chimarrão or cimarrón, is a traditional South American caffeine-rich infused drink, that was consumed by the Guaraní and Tupí peoples. It is the National Beverage in Argentina, Uruguay and Paraguay. It is also consumed in the Bolivian Chaco, Southern Chile, Southern Brazil, Syria—the largest importer in the world—and Lebanon, where it was brought from Argentina by immigrants. It is prepared by steeping dried leaves of yerba mate (Ilex paraguariensis, known in Portuguese as erva-mate) in hot water and is served with a metal straw from a shared hollow calabash gourd. The straw is called a bombilla in Spanish, a bomba in Portuguese, and a bombija or, more generally, a masassa (straw) in Arabic. The straw is traditionally made of silver. Modern, commercially available straws are typically made of nickel silver (called alpaca), stainless steel, or hollow-stemmed cane. The gourd is known as a mate or a guampa; while in Brazil, it has the specific name of cuia, or also cabaça (the name for Indigenous-influenced calabash gourds in other regions of Brazil, still used for general food and drink in remote regions). Even if the water is supplied from a modern thermos, the infusion is traditionally drunk from mates or cuias. The maté leaves are dried, chopped, and ground into a powdery mixture called yerba, "erva" in Portuguese, which means "herb". The bombilla functions as both a straw and a sieve. The submerged end is flared, with small holes or slots that allow the brewed liquid in, but block the chunky matter that makes up much of the mixture. A modern bombilla design uses a straight tube with holes, or a spring sleeve to act as a sieve. "Tea-bag" type infusions of maté (Spanish: mate cocido, Portuguese: chá mate) have been on the market in many South American countries for many years under such trade names as "Taragüi" in Argentina, "Pajarito" and "Kurupí" in Paraguay, and Matte Leão and "Mate Real" in Brazil.
  • 1.8K
  • 03 Nov 2022
Topic Review
Mass Spectrometry in Determination of Pesticide Residues
The extensive use of pesticides represents a risk to human health. Consequently, legal frameworks have been established to ensure food safety, including control programs for pesticide residues. In this context, the performance of analytical methods acquires special relevance. Such methods are expected to be able to determine the largest number of compounds at trace concentration levels in complex food matrices, which represents a great analytical challenge. Technical advances in mass spectrometry (MS) have led to the development of more efficient analytical methods for the determination of pesticides. 
  • 1.5K
  • 15 Jun 2022
Topic Review
Mass Spectrometry Imaging of Biomaterials
The science related to biomaterials and tissue engineering accounts for a growing part of our knowledge. Surface modifications of biomaterials, their performance in vitro, and the interaction between them and surrounding tissues are gaining more and more attention. Mass Spectrometry Imaging (MSI) techniques are able to measure the information about molecular composition simultaneously from biomaterial and adjacent tissue. That is why it can answer the questions connected with biomaterial characteristics and their biological influence.
  • 140
  • 27 Sep 2023
Topic Review
Mass Concentration
In chemistry, the mass concentration ρi (or γi) is defined as the mass of a constituent mi divided by the volume of the mixture V. For a pure chemical the mass concentration equals its density (mass divided by volume); thus the mass concentration of a component in a mixture can be called the density of a component in a mixture. This explains the usage of ρ (the lower case Greek letter rho), the symbol most often used for density.
  • 1.8K
  • 12 Oct 2022
Topic Review
Mars Oxygen ISRU Experiment
The Mars Oxygen In-Situ Resource Utilization Experiment (MOXIE) is a technology demonstration on the NASA Mars 2020 rover Perseverance investigating the production of oxygen on Mars. On April 20, 2021, MOXIE produced oxygen from carbon dioxide in the Martian atmosphere by using solid oxide electrolysis. This was the first experimental extraction of a natural resource from another planet for human use. The technology may be scaled up for use in a human mission to the planet to provide breathable oxygen, oxidizer, and propellant; water may also be produced by combining the produced oxygen with hydrogen. The experiment was a collaboration between the Massachusetts Institute of Technology, the Haystack Observatory, the NASA/Caltech Jet Propulsion Laboratory, and other institutions.
  • 615
  • 28 Nov 2022
Topic Review
Marine-Derived Phenolic Compounds
Phenolic metabolites are organic compounds with at least one or more hydroxyl groups attached to arylic systems with simple variations to highly polymerized molecules.
  • 1.7K
  • 10 Mar 2022
Topic Review
Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery
Indole is a multifunctional active pharmacophore and a heterocyclic compound widely present in natural and synthetic compounds with biological activity. Indole alkaloids from natural sources display diverse mechanisms and structures and exert anticancer potential through various antiproliferation mechanisms. Thus, indole alkaloids play a significant role in the discovery of new anticancer drugs. Scientists have subsequently isolated various new bisindole alkaloids from marine organisms, especially deep-water sponges. They are usually extracted with organic solvents (e.g., methanol, ethyl acetate). And the extracts were concentrated and partitioned between organic and aqueous phases. The organic phase is separated with chromatography separation technology, including silica gel column chromatography, high-performance liquid chromatography, etc. Most marine-derived bisindoles exist in solid form, which makes it convenient for us to determine their absolute configuration by single crystal. A number of marine-derived bisindoles exhibit strong and varied biological activities. Due to their unique biological activities and chemical structures, they have become a research focal point in pharmaceutical chemistry as lead compounds for new drug development. It is noteworthy that many drugs based on marine-derived bisindoles have been approved or are currently in clinical research, such as midostaurin, lestaurtinib, and enzastaurin. These drug molecules have shown potent selective anti-tumor effects.
  • 308
  • 06 Mar 2024
Topic Review
Marine Verongiid Demosponge Lanthella Basta
Marine sponges were among the first multicellular organisms on our planet and have survived to this day thanks to their unique mechanisms of chemical defense and the specific design of their skeletons, which have been optimized over millions of years of evolution to effectively inhabit the aquatic environment. Ianthella basta (Pallas, 1766) is one of the largest, fan-shaped marine demosponges that can reach up to 2.5 m both in height; and the body of which is a micro-reticular, durable structure that determines the ideal filtration function of this organism. Calcite biomineral is responsible for nano-tuning the chitinous skeletal fibers of this sponge species.
  • 619
  • 07 Dec 2021
Topic Review
Marine Sponges of the Genus Callyspongia
In this entry, information about the common metabolites of the Callyspongia genus were grouped, as well as studies of the biological activity of these compounds. Through NMR data, 212 metabolites were identified from genus Callyspongia (15 species and Callyspongia sp.), belonging to classes such as polyacetylenes, terpenoids, steroids, alkaloids, polyketides, simple phenols, phenylpropanoids, nucleosides, cyclic peptides, and cyclic depsipep-tides. A total of 109 molecules have been reported with bioactive activity, mainly cytotoxic and antimicrobial (antibacterial and antifungal) action. 
  • 671
  • 16 Dec 2021
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