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Topic Review
Chronic Wounds
The chronicity of wounds is affected by several contributory factors, including hormonal imbalances, cytokines, invasive microbial infections, and growth factors. More importantly, bacterial infections have been implicated as the predominant feature in most chronic wound microenvironments, including Staphylococcus aureus and Pseudomonas aeruginosa. These bacteria exist in polymicrobial forms forming biofilms that afford them protection against the host’s immunity and conventional antibiotics. S. aureus biofilms are sometimes present close to the surface of chronic wounds, while P. aeruginosa biofilms appear deep within wound tissue. The recalcitrant disposition of these microbes has been implicated as one of the causalities of antimicrobial resistance.
  • 1.2K
  • 17 May 2022
Topic Review
Cobalt Catalysts for CO2 Reduction
Cobalt catalysts are very important due to their extensive applications in many industrial processes, such as Fisher–Tropsh synthesis and CO2 conversion. Electrocatalytic CO2 reduction reaction (CO2RR) is a promising strategy due to its easy operating system, simple constructions, operational at neutral pH, ambient temperature and atmospheric pressure, and low energy utilization to produce valuable chemicals and fuels such as formic acid, methane, ethanol, and carbon using renewable electricity. Therefore, CO2RR coupling with renewable energy sources can effectively achieve a carbon-neutral energy cycle and hydrocarbon products with high activity, stability, and selectivity.
  • 1.2K
  • 28 Sep 2021
Topic Review
Thiol-and Disulfide-Based Stimulus-Responsive Soft Materials
Thiols (RSH) and disulfides (RSSR) are components of many proteins, biopolymers, and biomolecules.  Many can be interconverted by simple oxidation and reduction reactions that change drastically their properties and those of host molecules of which they are a part.
  • 1.2K
  • 11 Jun 2021
Topic Review
Graphene-Based Strategies for Viral Diseases
The occurrence of new pandemic  viruses, such as SARS-CoV-1 (2003), MERS-CoV (2012) and SARS-CoV-2 (2019) has  indicated an urgent need for diagnostic tools able to reliably identify infected individuals and to determine if the infection is in the acute phase. Although nanotechnology based on graphene has been poorly applied for the rapid diagnosis of viral diseases, the extraordinary properties of graphene have been recently exploited for the diagnosis of COVID-19. Novel graphene-based field-effect transistor (GFET) biosensors were developed for the quantitative detection of viral RNA and viral spike protein. The fabrication of COVID-19 FET sensor for spike protein recognition is based on the integration of the SARS-CoV-2 spike antibody with graphene, whereas the GFET sensor for viral RNA recognition exploited the CRISPR/Cas biotechnology.
  • 1.2K
  • 27 Oct 2020
Topic Review
Silanes
Silanes, as organic-inorganic hybrid modifiers of hyperbranched polymer (HBP), are of great interest as they resulted in a tremendous improvement in HBP properties like increasing thermal, mechanical and electrical properties compared to that of organic-only moieties. The basic components of silanes are monomeric silicon (Si) compounds with four substituent groups attached to the Si atom, which can be of any combination of reactive or non-reactive inorganic or organic groups, which are the fundamental building blocks of silanes.
  • 1.2K
  • 14 Jun 2023
Topic Review
Surface-Enhanced Raman Scattering
The efficiency of the generation of Raman spectra by molecules adsorbed on some substrates (or placed at a very close distance to some substrates) may be many orders of magnitude larger than the efficiency of the generation of Raman spectra by molecules that are not adsorbed. This effect is called surface-enhanced Raman scattering (SERS). In the first SERS experiments, nanostructured plasmonic metals have been used as SERS-active materials. Later, other types of SERS-active materials have also been developed.
  • 1.2K
  • 10 Feb 2021
Topic Review
Inhalant
Inhalants are a broad range of household and industrial chemicals whose volatile vapors or pressurized gases can be concentrated and breathed in via the nose or mouth to produce intoxication, in a manner not intended by the manufacturer. They are inhaled at room temperature through volatilization (in the case of gasoline or acetone) or from a pressurized container (e.g., nitrous oxide or butane), and do not include drugs that are sniffed after burning or heating. For example, amyl nitrite (poppers), nitrous oxide and toluene – a solvent widely used in contact cement, permanent markers, and certain types of glue – are considered inhalants, but smoking tobacco, cannabis, and crack are not, even though these drugs are inhaled as smoke or vapor. While a few inhalants are prescribed by medical professionals and used for medical purposes, as in the case of inhaled anesthetics and nitrous oxide (an anxiolytic and pain relief agent prescribed by dentists), this article focuses on inhalant use of household and industrial propellants, glues, fuels, and other products in a manner not intended by the manufacturer, to produce intoxication or other psychoactive effects. These products are used as recreational drugs for their intoxicating effect. According to a 1995 report by the National Institute on Drug Abuse, the most serious inhalant use occurs among homeless children and teenagers who "... live on the streets completely without family ties." Inhalants are the only substance used more by younger teenagers than by older teenagers. Inhalant users inhale vapor or aerosol propellant gases using plastic bags held over the mouth or by breathing from a solvent-soaked rag or an open container. The practices are known colloquially as "sniffing", "huffing" or "bagging". The effects of inhalants range from an alcohol-like intoxication and intense euphoria to vivid hallucinations, depending on the substance and the dose. Some inhalant users are injured due to the harmful effects of the solvents or gases or due to other chemicals used in the products that they are inhaling. As with any recreational drug, users can be injured due to dangerous behavior while they are intoxicated, such as driving under the influence. In some cases, users have died from hypoxia (lack of oxygen), pneumonia, heart failure or arrest, or aspiration of vomit. Brain damage is typically seen with chronic long-term use of solvents as opposed to short-term exposure. Even though many inhalants are legal, there have been legal actions taken in some jurisdictions to limit access by minors. While solvent glue is normally a legal product, a Scottish court has ruled that supplying glue to children is illegal if the store knows the children intend to inhale the glue. In the US, thirty-eight of 50 states have enacted laws making various inhalants unavailable to those under the age of 18 or making inhalant use illegal.
  • 1.1K
  • 28 Nov 2022
Topic Review
Metal-Free Carbon-Based Supercapacitors-A Comprehensive Review
This state-of-the-art entry aims to highlight  advances in metal-free carbon-based supercapacitors over the last 20 years. Author discuss the various types of carbons (without metals) used (activated, nanoforms of carbon, and doped carbons) as well as key parameters in supercapacitor performance such as surface area, porosity, and functional groups.
  • 1.1K
  • 18 Jan 2021
Topic Review
Geant4-DNA Modeling of Water Radiolysis
In this work, we use the next sub-volume method (NSM) to investigate the possibility of using the compartment-based (“on-lattice”) model to simulate water radiolysis.
  • 1.2K
  • 24 Jun 2021
Topic Review
Fire-Safe Polymer Composites
Currently, polymers are competing with metals and ceramics to realize various material characteristics, including mechanical and electrical properties. Flame retardants can also be introduced to further reinforce the fire performance of polymers.
  • 1.1K
  • 09 Apr 2021
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