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Topic Review
Biography
Topic Review
Mutual Regulatory Mechanisms between N6-metyladenosine Modification and miRNAs
N6-metyladenosine (m6A), one of the most common RNA methylation modifications in mammals, has attracted extensive attentions owing to its regulatory roles in a variety of physiological and pathological processes. As a reversible epigenetic modification on RNAs, m6A is dynamically mediated by the functional interplay among the regulatory proteins of methyltransferases, demethylases and methyl-binding proteins. It has become increasingly clear that m6A modification is associated with the production and function of microRNAs (miRNAs).
521
10 Feb 2023
Topic Review
Regulation of Central and Peripheral Blood Pressure
Pressure in the primary arteries near the heart and the brain is known as central blood pressure (CBP), while that in the peripheral arteries is known as peripheral blood pressure (PBP). Usually, CBP and PBP are correlated. However, various types of shocks and cardiovascular disorders interfere with their regulation, and consequently, their correlation is lost. Therefore, understanding blood pressure in normal and disease conditions is essential for managing shock-related cardiovascular implications and improving treatment outcomes.
663
10 Feb 2023
Topic Review
Risk Factors of Sleep Apnea
Obstructive sleep apnea (OSA), a condition in which there is a recurrent collapse of the upper airway while sleeping, is a widespread disease affecting 5% to 10% people worldwide. Despite several advances in the treatment modalities for OSA, morbidity and mortality remain a concern. Common symptoms include loud snoring, gasping for air during sleep, morning headache, insomnia, hypersomnia, attention deficits, and irritability. Obese individuals, male gender, older age (65+), family history, smoking, and alcohol consumption are well recognized risk factors of OSA.
409
09 Feb 2023
Topic Review
Risk-Reducing Bilateral Salpingo-Oophorectomy
Risk-reducing bilateral salpingo-oophorectomy (RRBSO) is the gold standard preventative option for BRCA mutation carriers at high risk for ovarian and breast cancer. RRBSO involves the surgical removal of both ovaries, as well as fallopian tubes, as fallopian tubes are increasingly being recognized as the site of origin for the most common and lethal form of ovarian cancer, high-grade serous ovarian cancer. Guidelines from the National Comprehensive Cancer Network (NCCN) reccomend people with BRCA1 mutations to indergo RRBSO between the ages of 35 to 40 and upon completion of childbearing. Since the onset of ovarian cancer among BRCA2 mutations carriers is approximately 8 to 10 years later than in BRCA1 mutations carriers, the recommended timing of RRBSO is delayed to ages 40 to 45. Despite the effectiveness of undergoing RRBSO at the recommended age, it also induces immediate surgical menopause with an abrupt and significant decline in levels of sex hormones. As a result, surgical menopause is associated with various adverse physical, mental, and cognitive health outcomes.
351
09 Feb 2023
Topic Review
Cerebrovascular Diseases and COVID-19
Neurons are the basic building blocks of the human body’s neurological system. Atrophy is defined by the disintegration of the connections between cells that enable them to communicate. Peripheral neuropathy and demyelinating disorders, as well as cerebrovascular illnesses and central nervous system (CNS) inflammatory diseases, have all been linked to brain damage, including Parkinson’s disease (PD). It turns out that these diseases have a direct impact on brain atrophy. However, it may take some time after the onset of one of these diseases for this atrophy to be clearly diagnosed. With the emergence of the Coronavirus disease 2019 (COVID-19) pandemic, there were several clinical observations of COVID-19 patients.
384
08 Feb 2023
Topic Review
Air Pollution on Chronic Rhinosinusitis and Asthma
Redox regulation participates in the control of various aspects of metabolism. Reactive oxygen and nitrogen species participate in many reactions under physiological conditions. When these species overcome the antioxidant defense system, a distressed status emerges, increasing biomolecular damage and leading to functional alterations. Air pollution is one of the exogenous sources of reactive oxygen and nitrogen species. Ambient airborne particulate matter (PM) is important because of its complex composition, which includes transition metals and organic compounds. Once in contact with the lungs’ epithelium, PM components initiate the synthesis of inflammatory mediators, macrophage activation, modulation of gene expression, and the activation of transcription factors, which are all related to the physiopathology of chronic respiratory diseases, including cancer.
421
08 Feb 2023
Topic Review
COVID-19 Prevention and Treatment Approaches
COVID-19 is an infectious disease declared as a pandemic on 11 March 2020 by the World Health Organization (WHO). As the pandemic evolved, so did the search for potential prophylactic and therapeutic agents. Several therapies have been developed, including vaccines, antivirals, monoclonal antibodies, and others.
504
08 Feb 2023
Topic Review
Racial Disparities and Respiratory Infectious Diseases in USA
In the U.S., racial disparities are present among children, with Hispanic and Black children carrying the burden of infectious respiratory disease occurrence. Several factors are contributory to these outcomes among Hispanic and Black children, including higher rates of poverty; higher rates of chronic conditions, such as asthma and obesity; and seeking care outside of the home. However, vaccinations can be used to reduce the risk of infection among Black and Hispanic children. Whether a child is very young or a teen, racial disparities are present in occurrence rates of infectious respiratory diseases, with the burden resting among minorities. Therefore, it is important for parents to be aware of the risk of infectious diseases and to be aware of resources, such as vaccines.
330
07 Feb 2023
Topic Review
Preterm Birth and Exposure to Endocrine Disrupting Chemicals
Endocrine disrupting chemicals (EDCs) are defined by the Endocrine Society as “exogenous chemicals, or mixtures of chemicals, that interfere with any aspect of hormone action.” They are often widely present in many communities and can alter various hormonal processes in the body. Preterm birth (PTB) is a problem of international concern, as it is the leading cause of death in children younger than 5 years old, and the frequency is increasing in countries with reliable data
266
06 Feb 2023
Topic Review
SCUBA Diving in Adult Congenital Heart Disease
The classification of scuba diving as a skill sport has profound implications for the evaluation of fitness-to-dive in adult patients with congenital heart disease (ACHD). The spectrum of ACHD and its associated complications range from conditions conventionally considered as incompatible with scuba diving (e.g., pulmonary hypertension, cyanosis and ventricular hypertrophy) to other conditions which may be compatible with recreational scuba diving.
680
06 Feb 2023
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