Topic Review
Prevention and Diagnosis of Ovarian Cancer
Ovarian cancer (OC) is the female genital malignancy with the highest lethality. Patients present a poor prognosis mainly due to the late clinical presentation allied with the common acquisition of chemoresistance and a high rate of tumour recurrence. Effective screening, accurate diagnosis, and personalised multidisciplinary treatments are crucial for improving patients’ survival and quality of life.
  • 213
  • 07 Feb 2024
Topic Review
Immunomodulatory Function of Vitamin D
Hashimoto’s thyroiditis (HT), also known as chronic autoimmune thyroiditis, is the most prevalent organ-specific autoimmune disorder. Hashimoto’s thyroiditis (HT) is marked by self-tissue destruction as a consequence of an alteration in the adaptive immune response that entails the evasion of immune regulation. Vitamin D carries out an immunomodulatory role that appears to promote immune tolerance.
  • 212
  • 15 Mar 2024
Topic Review
Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas
Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and β-catenin staining) features. Moreover, ILC displays a poor response to neoadjuvant therapy, a different metastatic pattern compared to invasive breast carcinoma of no special type, as well as unique molecular characteristics. In addition to the classic variant of invasive lobular carcinoma, several other well-recognized variants exist, including classic, alveolar, tubulolobular, solid, pleomorphic, signet-ring, and mixed. 
  • 210
  • 10 Oct 2023
Topic Review
Hereditary Angioedema during Pregnancy
Hereditary angioedema (HAE) is a genetic condition that is characterized by recurrent episodes of swelling in various subcutaneous and mucosal tissues, including the skin, upper respiratory system, and gastrointestinal tract. The prevalence of HAE is estimated to be 1:30,000–80,000, and approximately 200,000 people are estimated to be affected by HAE worldwide.
  • 209
  • 18 Aug 2023
Topic Review
Coping Strategies in Italian Teachers after COVID-19
Teaching is a mentally and physically demanding profession that can be a source of stress and burnout. The COVID-19 pandemic put further pressure on teachers who had to face sudden challenges, such as online teaching and difficulties in holding students’ attention in virtual environments. Research has demonstrated that the negative effects of stress factors on teachers’ wellbeing can be modulated by coping strategies. 
  • 208
  • 20 Feb 2024
Topic Review
Impact of COVID-19 on Hospital Profit Compensation Activities
The impact of the 2019 coronavirus disease (COVID-19) pandemic is still being felt, and little is known about the impact on hospital operations of the loss of outpatients and inpatients due to COVID-19 in many counties. Therefore exploring whether hospitals have adopted profit-compensation activities following the first wave of the COVID-19 outbreak in China in 2020. 2616589 inpatient records for 2018, 2019, and 2020 were extracted from 36 tertiary hospitals in a western province; a difference-in-difference event study design was used to estimate the dynamic impact of COVID-19 on total inpatient costs before and after the last confirmed case. An increase in mean total costs per patient of between 8.7% and 16.7% can be found in the first 25 weeks after urban reopening and return to normal hospitalization. It indicates that hospitals experienced profit compensating activity after the first wave of the outbreak in China in 2020, driven by the reduction in hospital admissions during that wave.
  • 206
  • 12 May 2023
Topic Review
COVID-19 Pandemic And Mental Health
When “hijacked” by compulsive behaviors that affect the reward and stress centers of the brain, functional changes in the dopamine circuitry occur as the consequence of pathological brain adaptation. As a brain correlate of mental health, dopamine has a central functional role in behavioral regulation from healthy reward-seeking to pathological adaptation to stress in response to adversity.
  • 206
  • 21 Nov 2023
Topic Review
Prioritizing the Patient’s Needs of Missed Nursing Care
Missed nursing care refers to essential nursing activities or tasks that are omitted or not completed as planned during a patient’s care. This omission can result from various factors, such as staffing shortages, time constraints, or communication issues, and it can potentially compromise the quality of patient care and safety. Identifying and addressing missed nursing care is crucial to ensure optimal patient outcomes and the well-being of healthcare professionals. 
  • 206
  • 25 Jan 2024
Topic Review
Common Bean Phaseolus vulgaris L. (Fabaceae) for Sportspeople
The third-largest land plant family, Fabaceae (Papilionaceae), includes trees, shrubs, and perennial or annual herbaceous plants containing both numerous beneficial constituents (e.g., proteins, carbohydrates, dietary fibre) and antinutrients (e.g., saponins, tannins, phytic acid, gossypol, lectins). The consumption of leguminous plants allows sports people to complete their requirements for nourishment but, on the other hand, it contributes to digestive system ailments.
  • 206
  • 19 Dec 2023
Topic Review
Indoor Electronic Travel Aid for Visually Impaired Individuals
Most navigation aids for visually impaired individuals require users to pay close attention and actively understand the instructions or feedback of guidance, which impose considerable cognitive loads in long-term usage. The “Aerial Guide Dog”, a helium balloon aerostat drone designed for indoor guidance, which leverages gentle tugs in real time for directional guidance, ensuring a seamless and intuitive guiding experience. The introduced Aerial Guide Dog has been evaluated in terms of directional guidance and path following in the pilot study, focusing on assessing its accuracy in orientation and the overall performance in navigation.
  • 205
  • 18 Jan 2024
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