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Topic Review
Internet Use for Older Adults during COVID-19 Pandemic
Older adults were advised to avoid social activities during the outbreak of COVID-19. Consequently, they no longer received the social and emotional support they had gained from such activities. Internet use might be a solution to remedy the situation. The research revealed that Internet use for communication purposes seems to be associated with better mental health in older adults during the COVID-19 pandemic.
  • 570
  • 06 Apr 2022
Topic Review
Palliative Care in Older People with Multimorbidities
Although numerous studies have been conducted on the needs of cancer patients at the end of their life, there is a lack of studies focused on older patients with non-oncological complex chronic multipathologies. Examining these needs would help to gain a greater understanding of the profile of this specific population within the palliative care (PC) pathway and how the health and care systems can address them. Substantial changes are needed in health and care systems at the institutional level to provide more specialized PC environments and systematized PC processes for multimorbid older patients. It is vital to understand and address the needs of multimorbid older patients and their caregivers given that the number of these patients is growing, which may challenge current healthcare systems. 
  • 305
  • 06 Apr 2022
Topic Review
Gender Differences in Cannabis Use
Gender differences in psychiatric disorders and drug use are well known. Cannabis is the most widely used illegal drug among young people. In recent years, its use has been related to the development of psychiatric pathologies; however, few studies have incorporated the gender perspective as of yet. Men have a higher prevalence using cannabis; however, women show a faster transition from recreational use to compulsive use, higher levels of craving with more relapses, and higher prevalence of dual pathology. Clinical studies clearly show the existence of gender differences in psychiatric symptoms associated with cannabis use. Although these results are not conclusive, they seem to indicate a higher vulnerability of women in the development of psychosis and anxiety, while men seem to be more vulnerable to developing depressive symptoms with long-term cannabis misuses. 
  • 808
  • 02 Apr 2022
Topic Review
Effectiveness of Constraint-Induced Movement Therapy for Balance
Constraint-induced movement therapy (CIMT) is one of the most popular treatments for enhancing upper and lower extremity motor activities and participation in patients following a stroke. However, the effect of CIMT on balance is unclear and needs further clarification. Recent evidence indicate that CIMT interventions can improve balance-related motor function better than neuro developmental treatment, modified forced-use therapy and conventional physical therapy in patients after a stroke.
  • 447
  • 02 Apr 2022
Topic Review
Human Behavior in Plasmodium knowlesi Malaria Infection
P. knowlesi is a zoonotic disease transmitted by the Anopheles mosquito, which harbors the Plasmodium parasite. Previously, the disease was believed to occur only among the Macaca fascicularis and M. nemestrina monkeys, found largely in southeast Asia.
  • 294
  • 02 Apr 2022
Topic Review
Frequent Psychiatric and Neuropsychiatric Symptoms of Post-COVID-19 Syndrome
The World Health Organization (WHO) has defined a post-COVID-19 condition. Some of these symptoms can be categorized as psychiatric and neuropsychiatric  post COVID-19 symptoms if they appeared in the aftermath of COVID-19, including depression, anxiety, post-traumatic stress disorder, somatic symptoms disorders such as hyperventilation syndrome, fatigue, cognitive and sleep disorders. Psychiatric and neuropsychiatric post-COVID-19 present mental health specialists with difficult challenges because of its complexity and the multiple ways in which it integrates into a singular somatic context. 
  • 482
  • 01 Apr 2022
Topic Review
Anti-Depressant Properties of Crocin Molecules in Saffron
Saffron is a valued herb, obtained from the stigmas of the C. sativus Linn (Iridaceae), with therapeutic effects. It has been described in pharmacopoeias to be variously acting, including as an anti-depressant, anti-carcinogen, and stimulant agent. The therapeutic effects of saffron are harbored in its bioactive molecules, notably crocins, the subject of this research. Crocins have been demonstrated to act as a monoamine oxidase type A and B inhibitor. Furthermore, saffron petal extracts have experimentally been shown to impact contractile response in electrical field stimulation. Other research suggests that saffron also inhibits the reuptake of monoamines, exhibits N-methyl-d-aspartate antagonism, and improves brain-derived neurotrophic factor signaling. A host of experimental studies found saffron/crocin to be similarly effective as fluoxetine and imipramine in the treatment of depression disorders. Saffron and crocins propose a natural solution to combat depressive disorders. However, some hurdles, such as stability and delivery, need to be overcome.
  • 691
  • 01 Apr 2022
Topic Review
Ocular Surface Infection Mediated Molecular Stress Responses
Infection mediated ocular surface stress responses are activated as early defense mechanisms in response to host cell damage. Integrated stress responses initiate the host response to different types of infections and modulate the transcription of key genes and translation of proteins. The crosstalk between host and pathogen results in profound alterations in cellular and molecular homeostasis triggering specific stress responses in the infected tissues. The amplitude and variations of such responses are partly responsible for the disease severity and clinical sequelae. Understanding the etiology and pathogenesis of ocular infections is important for early diagnosis and effective treatment.
  • 309
  • 01 Apr 2022
Topic Review
COVID-19 Pneumonia and Lung Cancer
Oncological patients are more prone to present severe forms of COVID-19 pneumonia and are subject to worse complications. Radiologists have the challenging role of suggesting a differential diagnosis with lung cancer and treatment-induced lung diseases or suggesting an overlap between these pathologies. Despite similarities or overlapping findings, the combination of clinics and some specific radiological findings, which are also identified by comparison with previous and follow-up CT scans, may guide differential diagnosis.
  • 972
  • 01 Apr 2022
Topic Review
Glioblastoma Cells
Glioblastoma multiforme (GBM) is the most common brain cancer in adults. GBM starts from a small fraction of poorly differentiated and aggressive cancer stem cells (CSCs) responsible for aberrant proliferation and invasion. Due to extreme tumor heterogeneity, actual therapies provide poor positive outcomes, and cancers usually recur. Therefore, alternative approaches, possibly targeting CSCs, are necessary against GBM.
  • 869
  • 31 Mar 2022
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